Fyn and PTP-PEST-mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation

Journal of Experimental Medicine

Volumn 199, Issue 1, 2004, Pages 99-111

  Badour, Karen ^b   Zhang, Jinyi ^b   Shi, Fabio ^b   Leng, Yan ^b   Collins, Michael ^b   Siminovitch, Katherine A ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b NONE

Author keywords

Actin cytoskeletal arrangement; Lymphocyte activation; Tyrosine phosphorylation; WASp

Indexed keywords

ACTIN; GENE PRODUCT; NUCLEAR FACTOR; PROLINE SERINE THREONINE PHOSPHATASE INTERACTING PROTEIN 1; PROTEIN CDC42; PROTEIN KINASE FYN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN Y291; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DEPHOSPHORYLATION; EFFECTOR CELL; GENE IDENTIFICATION; GENE MUTATION; GENETIC TRANSCRIPTION; IMMUNOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SYNAPSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WISKOTT ALDRICH SYNDROME;

ANIMALS; CROSSES, GENETIC; GENE DELETION; HUMANS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; WISKOTT-ALDRICH SYNDROME; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 0347915637     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030976     Document Type: Article

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