Protein kinase C θ is critical for the development of in vivo T helper (Th)2 cell but not Th-1 cell responses

Journal of Experimental Medicine

Volumn 200, Issue 2, 2004, Pages 181-189

  Marsland, Benjamin J ^a   Soos, Timothy J ^b   Späth, Gerald ^b   Littman, Dan R ^b   Kopf, Manfred ^a  

^a ETH ZURICH   (Switzerland)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Asthma; Leishmania; Nippostrongylus; PKC ; Th2 cell

Indexed keywords

ALLERGEN; ANTIGEN; IMMUNOGLOBULIN E; PROTEIN KINASE C; T LYMPHOCYTE RECEPTOR;

AIRWAY; ALLERGIC ASTHMA; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS HYPERREACTIVITY; CELLULAR IMMUNITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENDRITIC CELL; EOSINOPHILIA; HOST SUSCEPTIBILITY; IMMUNOGLOBULIN PRODUCTION; IN VIVO STUDY; INHALATION; LEISHMANIA MAJOR; MOUSE; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, CD28; BRONCHOALVEOLAR LAVAGE FLUID; CELL DIFFERENTIATION; CELL DIVISION; CELL SEPARATION; COCULTURE TECHNIQUES; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; ISOENZYMES; LEISHMANIA MAJOR; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PEPTIDES; PROTEIN KINASE C; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS; TRANSGENES;

EID: 3242790172     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20032229     Document Type: Article

References (40)

1. Grakoui, A., S. Bromley, C. Sumen, M. Davis, A. Shaw, P. Allen, and M. Dustin. 1999. The immunological synapse: a molecular machine controlling T cell activation. Science. 285:221-227.
2. Bromley, S., W. Burack, K. Johnson, K. Somersalo, T. Sims, C. Sumen, M. Davis, A. Shaw, P. Allen, and M. Dustin. 2001. The immunological synapse. Annu. Rev. Immunol. 19:375-396.
3. Baier, G., D. Telford, L. Giampa, K. Coggeshall, G. Baier-Bitterlich, N. Isakov, and A. Altman. 1993. Molecular cloning and characterization of PKC theta, a human member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268:4997-5004.
4. Baier, G. 2003. The PKC gene module: molecular biosystematics to resolve its T cell functions. Immunol. Rev. 192:64-79.
5. Villalba, M., N. Coudronniere, M. Deckert, E. Teixeiro, P. Mas, and A. Altman. 2000. A novel functional interaction between Vav and PKC-theta is required for TCR-induced T cell activation. Immunity. 12:151-160.
6. Monks, C., B. Freiberg, H. Kupfer, N. Sciaky, and A. Kupfer. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature. 395:82-86.
7. Huang, J., P.-F. Lo, T. Zal, N. Gascoigne, B. Smith, S. Levin, and H. Grey. 2002. CD28 plays a critical role in the segregation of PKC-theta within the immunologic synapse. Proc. Natl. Acad. Sci. USA. 99:9369-9373.
8. Bi, K., Y. Tanaka, N. Coudronniere, S. Hong, K. Sugie, M.J. van Stipdonk, and A. Altman. 2001. Antigen-induced translocation of PKC theta to membrane rafts is required for T cell activation. Nat. Immunol. 2:556-563.
9. Liu, Y., S. Witte, Y.-C. Liu, M. Doyle, C. Elly, and A. Altman. 2000. Regulation of protein kinase C theta function during T cell activation by Lck-mediated tyrosine phosphorylation. J. Biol. Chem. 275:3603-3609.
10. Sun, Z., C. Arendt, W. Ellmeier, E. Schaeffer, M. Sunshine, L. Gandhi, J. Annes, D. Petrzilka, A. Kupfer, P. Schwartzberg, et al. 2000. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature. 404:402-407.
11. Pfeifhofer, C., K. Kofler, T. Gruber, N. Tabrizi, C. Lutz, K. Maly, M. Leitges, and G. Baier. 2003. Protein kinase C θ affects calcium mobilization and NFAT cell activation in primary mouse T cells. J. Exp. Med. 197:1525-1535.
12. Das, J., C.-H. Chen, L. Yang, L. Cohn, P. Ray, and A. Ray. 2001. A critical role for NF-κB in Gata3 expression and Th2 differentiation in allergic airway inflammation. Nat. Immunol. 2:45-50.
13. Artis, D., S. Shapira, N. Mason, K. Speirs, M. Goldschmidt, J. Caamano, H.-C. Liou, C. Hunter, and P. Scott. 2002. Differential requirement for NF-κB family members in control of helminth infection and intestinal inflammation. J. Immunol. 169:4481-4487.
14. Yang, L., L. Cohn, D. Zhang, R. Homer, A. Ray, and P. Ray. 1998. Essential role of nuclear factor κB in the induction of eosinophilia in allergic airway inflammation. J. Exp. Med. 188:1739-1750.
15. Sica, A., L. Dorman, V. Viggiano, M. Cippitelli, P. Ghosh, N. Rice, and H. Young. 1997. Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J. Biol. Chem. 272:30412-30420.
16. Yoshimoto, T., H. Nagase, T. Ishida, J. Inoue, and H. Nariuchi. 1997. Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB. Eur. J. Immunol. 27:3461-3470.
17. Rengarajan, J., B. Tang, and L. Glimcher. 2002. NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naive T(H)cells. Nat. Immunol. 3:48-54.
18. Yoshida, H., H. Nishina, H. Takimoto, L. Marengere, A. Wakeham, D. Bouchard, Y. Kong, T. Ohteki, A. Shahinian, M. Bachmann, et al. 1998. The transcription factor NFATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 8:115-124.
19. Titus, R., M. Marchand, T. Boon, and J. Louis. 1985. A limiting dilution assay for quantifying Leishmania major in tissues of infected mice. Parasite Immunol. 7:545-555.
20. Ruedl, C., M. Bachmann, and M. Kopf. 2000. The antigen dose determines T helper subset development by regulation of CD40 ligand. Eur. J. Immunol. 30:2056-2064.
21. Lebman, D., and R. Coffman. 1988. Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures. J. Exp. Med. 168:853-862.
22. Yamaguchi, Y., T. Suda, J. Suda, M. Eguchi, Y. Miura, N. Harada, A. Tominaga, and K. Takatsu. 1988. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J. Exp. Med. 167:43-56.
23. Dent, L., M. Strath, A. Mellor, and C. Sanderson. 1990. Eosinophilia in transgenic mice expressing interleukin 5. J. Exp. Med. 172:1425-1431.
24. Walter, D., J. McIntire, G. Berry, A. McKenzie, D. Donaldson, R. DeKruyff, and D. Umetsu. 2001. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J. Immunol. 167:4668-4675.
25. Scott, P., P. Natovitz, R. Coffman, E. Pearce, and A. Sher. 1988. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med. 168:1675-1684.
26. Sadick, M., R. Locksley, C. Tubbs, and H. Raff. 1986. Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate IFN-gamma in response to Leishmania antigens in vitro. J. Immunol. 136:655-661.
27. Heinzel, F., M. Sadick, B. Holaday, R. Coffman, and R. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59-72.
28. Reiner, S., and R. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
29. Le Gros, G., S. Ben-Sasson, R. Seder, F. Finkelman, and W. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921-929.
30. Li, B., C. Tournier, R. Davis, and R. Flavell. 1999. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. EMBO J. 18:420-432.
31. Heinzel, F., R. Rerko, F. Hatam, and R. Locksley. 1993. IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J. Immunol. 150:3924-3931.
32. Powers, G., A. Abbas, and R. Miller. 1988. Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations. J. Immunol. 140:3352-3357.
33. Ben-Sasson, S., G. LeGros, D. Conrad, F. Finkelman, and W. Paul. 1990. Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphocytes. Proc. Natl. Acad. Sci. USA. 87:1421-1425.
34. Cote-Sierra, J., G. Foucras, L. Guo, L. Chiodetti, H. Young, J. Hu-Li, J. Zhu, and W. Paul. 2004. Interleukin 2 plays a central role in Th2 differentiation. Proc. Natl. Acad. Sci. USA. 101:3880-3885.
35. Kom, T., K.-D. Fischer, I. Girkontaite, G. Köllner, K. Toyka, and S. Jung. 2003. Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming. J. Neuroimmunol. 139:17-26.
36. Fowell, D., K. Shinkai, X. Liao, A. Beebe, R. Coffman, D. Littman, and R. Locksley. 1999. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity. 11:399-409.
37. Yao, L., Y. Kawakami, and T. Kawakami. 1994. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. USA. 91:9175-9179.
38. Altman, A., N. Isakov, and G. Baier. 2000. Protein kinase C theta: a new essential superstar on the T-cell stage. Immunol. Today. 21:567-573.
39. Kane, L., P. Andres, K. Howland, A. Abbas, and A. Weiss. 2001. Akt provides the CD28 costimulatory signal for upregulation of IL-2 and IFN-gamma but not Th2 cytokines. Nat. Immunol. 2:37-44.
40. Bauer, B., N. Krumböck, F. Fresser, F. Hochholdinger, M. Spitaler, A. Simm, F. Uberall, B. Schraven, and G. Baier. 2001. Complex formation and cooperation of protein kinase C-theta and Akt1/protein kinase B-alpha in the NF-kappaB transactivation cascade in jurkat T cells. J. Biol. Chem. 276:31627-31634.