An age-induced switch to a hyper-recombinational state

Science

Volumn 301, Issue 5641, 2003, Pages 1908-1911

  McMurray, Michael A ^a   Gottschling, Daniel E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORRELATION METHODS; GENES; YEAST;

GENOMIC INSTABILITY;

TUMORS;

AGE; CANCER; GENOME;

AGING; ARTICLE; CANCER; CARCINOGENESIS; CELL AGING; CONTROLLED STUDY; DIPLOIDY; GENETIC RECOMBINATION; GENETIC STABILITY; HETEROZYGOSITY LOSS; NONHUMAN; PRIORITY JOURNAL; PROGENY; SACCHAROMYCES CEREVISIAE;

AGING; CELL AGING; DIPLOIDY; DNA REPLICATION; DNA, FUNGAL; DNA, RIBOSOMAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE DELETION; GENES, FUNGAL; HISTONE DEACETYLASES; LOSS OF HETEROZYGOSITY; MULTIENZYME COMPLEXES; MUTATION; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0141819143     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1087706     Document Type: Article

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28. We thank D. Andersen, S. Biggins, R. G. Gardner, F. van Leeuwen, T. Reis, G. R. Smith, A. E. Stellwagen, and M. C. Yao for critical reading of the manuscript and B. J. Brewer for insight and advice. Supported by an NSF predoctoral fellowship to M.A.M. and by a National Institutes of Health grant (no. GM43893) and an Ellison Medical Foundation Senior Scholar Award to D.E.G.