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Volumn 116, Issue 7, 2003, Pages 1349-1357

Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms

Author keywords

Ageing; Cellular senescence; Microinjection; Oncoprotein; Telomerase

Indexed keywords

CELL PROTEIN; DNA; NEUTRALIZING ANTIBODY; ONCOPROTEIN; PROTEIN P16; PROTEIN P21; PROTEIN P53; TELOMERASE;

EID: 0037383795     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00331     Document Type: Review
Times cited : (52)

References (50)
  • 1
    • 0029145379 scopus 로고
    • Evidence for a critical telomere length in senescent human fibroblasts
    • Allsopp, R. C. and Harley, C. B. (1995). Evidence for a critical telomere length in senescent human fibroblasts. Exp. Cell Res. 219, 130-136.
    • (1995) Exp. Cell Res. , vol.219 , pp. 130-136
    • Allsopp, R.C.1    Harley, C.B.2
  • 5
    • 0028261160 scopus 로고
    • Escape from senescence in human diploid fibroblasts induced directly by mutant p53
    • Bond, J. A., Wyllie, F. S. and Wynford-Thomas. D. (1994). Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 9, 1885-1889.
    • (1994) Oncogene , vol.9 , pp. 1885-1889
    • Bond, J.A.1    Wyllie, F.S.2    Wynford-Thomas, D.3
  • 6
    • 0029024691 scopus 로고
    • Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1
    • Bond, J. A., Blaydes, J. P., Rowson, J., Haughton, M. F., Smith, J. R., Wynford-Thomas, D. and Wyllie, F. S. (1995). Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1. Cancer Res. 55, 2404-2409.
    • (1995) Cancer Res. , vol.55 , pp. 2404-2409
    • Bond, J.A.1    Blaydes, J.P.2    Rowson, J.3    Haughton, M.F.4    Smith, J.R.5    Wynford-Thomas, D.6    Wyllie, F.S.7
  • 7
    • 0029841549 scopus 로고    scopus 로고
    • Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence
    • Bond, J., Haughton, M., Blaydes, J., Gire, V., Wynford-Thomas, D. and Wyllie, F. (1996). Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence. Oncogene 13, 2097-2104.
    • (1996) Oncogene , vol.13 , pp. 2097-2104
    • Bond, J.1    Haughton, M.2    Blaydes, J.3    Gire, V.4    Wynford-Thomas, D.5    Wyllie, F.6
  • 8
    • 0032912802 scopus 로고    scopus 로고
    • Control of replicative life span in human cells: Barriers to clonal expansion intermediate between M1 senescence and M2 crisis
    • Bond, J. A., Haughton, M. F., Rowson, J. M., Gire, V., Wynford-Thomas, D. and Wyllie, F. S. (1999). Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis. Mol. Cell. Biol. 19, 3103-3114.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3103-3114
    • Bond, J.A.1    Haughton, M.F.2    Rowson, J.M.3    Gire, V.4    Wynford-Thomas, D.5    Wyllie, F.S.6
  • 10
    • 0034028836 scopus 로고    scopus 로고
    • Tumor suppressors and oncogenes in cellular senescence
    • Bringold, F. and Serrano, M. (2000). Tumor suppressors and oncogenes in cellular senescence. Exp. Gerontol. 35, 317-329.
    • (2000) Exp. Gerontol. , vol.35 , pp. 317-329
    • Bringold, F.1    Serrano, M.2
  • 11
    • 0022335895 scopus 로고
    • A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Guildford progeria syndrome
    • Brown, W. T., Kieras, F. J., Houck, G. E., Jr, Dutkowski, R. and Jenkins, E. C. (1985). A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Guildford progeria syndrome. Adv. Exp. Med. Biol. 190, 229-244.
    • (1985) Adv. Exp. Med. Biol. , vol.190 , pp. 229-244
    • Brown, W.T.1    Kieras, F.J.2    Houck G.E., Jr.3    Dutkowski, R.4    Jenkins, E.C.5
  • 12
    • 0030609861 scopus 로고    scopus 로고
    • CIP1/Waf1 gene in normal diploid human fibroblasts
    • CIP1/Waf1 gene in normal diploid human fibroblasts. Science 277, 831-834.
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wenyi, W.2    Sedivy, J.M.3
  • 13
    • 0035069410 scopus 로고    scopus 로고
    • Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains
    • Choi, D., Whittier, P. S., Oshima, J. and Funk, W. D. (2001). Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains. FASEB. J. 15, 1014-1020.
    • (2001) FASEB J. , vol.15 , pp. 1014-1020
    • Choi, D.1    Whittier, P.S.2    Oshima, J.3    Funk, W.D.4
  • 15
    • 0033816629 scopus 로고    scopus 로고
    • Uncoupling between phenotypic senescence and cell cycle arrest in ageing p21-deficient fibroblasts
    • Dulic, V., Beney, G.-E., Frebourg, G., Drullinger, L. F. and Stein, G. H. (2000). Uncoupling between phenotypic senescence and cell cycle arrest in ageing p21-deficient fibroblasts. Mol. Cell. Biol. 20, 6741-6754.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 6741-6754
    • Dulic, V.1    Beney, G.-E.2    Frebourg, G.3    Drullinger, L.F.4    Stein, G.H.5
  • 16
    • 0013907774 scopus 로고    scopus 로고
    • Werner syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process
    • Epstein, C. J., Martin, G. M., Schultz, A. L. and Motulsky, A. G. (1996). Werner syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine 45, 177-221.
    • (1996) Medicine , vol.45 , pp. 177-221
    • Epstein, C.J.1    Martin, G.M.2    Schultz, A.L.3    Motulsky, A.G.4
  • 18
    • 0032499255 scopus 로고    scopus 로고
    • Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein
    • Filatov, L., Golubovskaya, V., Hurt, J. C., Byrd, L. L., Phillips, J. M. and Kaufmann, W. K. (1998). Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein. Oncogene 16, 1825-1838.
    • (1998) Oncogene , vol.16 , pp. 1825-1838
    • Filatov, L.1    Golubovskaya, V.2    Hurt, J.C.3    Byrd, L.L.4    Phillips, J.M.5    Kaufmann, W.K.6
  • 19
    • 0024465870 scopus 로고
    • Mutator phenotype of Werner syndrome is characterised by extensive deletions
    • Fukuchi, K., Martin, G. M. and Monnat, R. J., Jr (1989). Mutator phenotype of Werner syndrome is characterised by extensive deletions. Proc. Natl. Acad. Sci. USA 86, 5893-5897.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5893-5897
    • Fukuchi, K.1    Martin, G.M.2    Monnat R.J., Jr.3
  • 20
    • 0031935827 scopus 로고    scopus 로고
    • Re-initiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
    • Gire, V. and Wynford-Thomas, D. (1998). Re-initiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol. Cell. Biol. 18, 1611-1621.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1611-1621
    • Gire, V.1    Wynford-Thomas, D.2
  • 22
    • 0032146147 scopus 로고    scopus 로고
    • Werner helicase is localized to transcriptionally active nucleoli of cycling cells
    • Gray, M. D., Wang, L., Youssoufian, H., Martin, G. M. and Oshima, J. (1998). Werner helicase is localized to transcriptionally active nucleoli of cycling cells. Exp. Cell. Res. 242, 487-494.
    • (1998) Exp. Cell. Res. , vol.242 , pp. 487-494
    • Gray, M.D.1    Wang, L.2    Youssoufian, H.3    Martin, G.M.4    Oshima, J.5
  • 23
    • 0026024632 scopus 로고
    • The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
    • Halbert, C. L., Demers, G. W. and Galloway, D. A. (1991). The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J. Virol. 65, 473-478.
    • (1991) J. Virol. , vol.65 , pp. 473-478
    • Halbert, C.L.1    Demers, G.W.2    Galloway, D.A.3
  • 25
    • 0031686571 scopus 로고    scopus 로고
    • The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease
    • Huang, S., Li, B., Gray, M. D., Oshima, J., Mian, I. S. and Campisi, J. (1998). The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease. Nat. Genet. 20, 114-116.
    • (1998) Nat. Genet. , vol.20 , pp. 114-116
    • Huang, S.1    Li, B.2    Gray, M.D.3    Oshima, J.4    Mian, I.S.5    Campisi, J.6
  • 26
    • 0034832956 scopus 로고    scopus 로고
    • Regulation of cellular senescence by p53
    • Itahana, K., Dimri, G. and Campisi, J. (2001). Regulation of cellular senescence by p53. Eur. J. Biochem. 268, 2784-2791.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 2784-2791
    • Itahana, K.1    Dimri, G.2    Campisi, J.3
  • 27
    • 0029062595 scopus 로고
    • Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants
    • Lin, J., Teresky, A. K. and Levine, A. J. (1995). Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants. Oncogene 10, 2387-2390.
    • (1995) Oncogene , vol.10 , pp. 2387-2390
    • Lin, J.1    Teresky, A.K.2    Levine, A.J.3
  • 29
    • 0014816132 scopus 로고
    • Replicative life span of cultivated human cells
    • Martin, G. M., Sprague, C. C. and Epstein, C. J. (1970). Replicative life span of cultivated human cells. Lab. Invest. 23, 86-92.
    • (1970) Lab. Invest. , vol.23 , pp. 86-92
    • Martin, G.M.1    Sprague, C.C.2    Epstein, C.J.3
  • 30
    • 0032825111 scopus 로고    scopus 로고
    • What geriatricians should know about the Werner syndrome
    • Martin, G. M., Oshima, J., Gray, M. D. and Pool, M. (1999). What geriatricians should know about the Werner syndrome. J. Am. Geriatr. Soc. 47, 1136-1144.
    • (1999) J. Am. Geriatr. Soc. , vol.47 , pp. 1136-1144
    • Martin, G.M.1    Oshima, J.2    Gray, M.D.3    Pool, M.4
  • 31
    • 0032510327 scopus 로고    scopus 로고
    • Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
    • McConnell, B. B., Starborg, M., Brookes, S. and Peters, G. (1998). Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr. Biol. 12, 351-354.
    • (1998) Curr. Biol. , vol.12 , pp. 351-354
    • McConnell, B.B.1    Starborg, M.2    Brookes, S.3    Peters, G.4
  • 32
    • 0025352187 scopus 로고
    • Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
    • Morgenstern, J. P. and Land, H. (1990). Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18, 3587-3596.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 3587-3596
    • Morgenstern, J.P.1    Land, H.2
  • 34
    • 0034639725 scopus 로고    scopus 로고
    • The establishment of telomerase-immortalised cell lines representing human chromosome instability syndromes
    • Ouellette, M. M., McDaniel, L. D., Wright, W. E., Shay, J. W. and Schultz, R. A. (2000). The establishment of telomerase-immortalised cell lines representing human chromosome instability syndromes. Hum. Mol. Genet. 9, 403-411.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 403-411
    • Ouellette, M.M.1    McDaniel, L.D.2    Wright, W.E.3    Shay, J.W.4    Schultz, R.A.5
  • 35
    • 0020455613 scopus 로고
    • Werner's syndrome: A review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations
    • Salk, D. (1982). Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations. Hum. Genet. 62, 1-5.
    • (1982) Hum. Genet. , vol.62 , pp. 1-5
    • Salk, D.1
  • 36
    • 0019440557 scopus 로고
    • Cytogenetics of Werner's syndrome cultured skin fibroblasts: Variegated translocation mosaicism
    • Salk, D., Au, K., Hoehn, H. and Martin, G. M. (1981). Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet. Cell Genet. 30, 92-107.
    • (1981) Cytogenet. Cell Genet. , vol.30 , pp. 92-107
    • Salk, D.1    Au, K.2    Hoehn, H.3    Martin, G.M.4
  • 37
    • 0029971241 scopus 로고    scopus 로고
    • Accelerated loss of telomere repeats may not explain accelerated replicative decline in Werner syndrome cells
    • Schulz, V. P., Zakian, V. A., Ogburn, C. E., McKay, J., Jarzebowicz, A. A., Edland, S. D. and Martin, G. M. (1996). Accelerated loss of telomere repeats may not explain accelerated replicative decline in Werner syndrome cells. Hum. Genet. 97, 750-754.
    • (1996) Hum. Genet. , vol.97 , pp. 750-754
    • Schulz, V.P.1    Zakian, V.A.2    Ogburn, C.E.3    McKay, J.4    Jarzebowicz, A.A.5    Edland, S.D.6    Martin, G.M.7
  • 38
    • 0035880025 scopus 로고    scopus 로고
    • Unwinding the molecular basis of the Werner syndrome
    • Shen, J.-C. and Loeb, L. A. (2001). Unwinding the molecular basis of the Werner syndrome. Mech. Ageing Dev. 122, 921-944.
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 921-944
    • Shen, J.-C.1    Loeb, L.A.2
  • 39
  • 40
    • 0033545238 scopus 로고    scopus 로고
    • Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization
    • Shiratori, M., Sakamoto, S., Suzuki, N., Tokutake, Y., Kawabe, Y., Enomoto, T., Sugimoto, M., Goto, M., Matsumoto, T. and Furuichi, Y. (1999). Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization. J. Cell Biol. 144, 1-9.
    • (1999) J. Cell Biol. , vol.144 , pp. 1-9
    • Shiratori, M.1    Sakamoto, S.2    Suzuki, N.3    Tokutake, Y.4    Kawabe, Y.5    Enomoto, T.6    Sugimoto, M.7    Goto, M.8    Matsumoto, T.9    Furuichi, Y.10
  • 41
    • 0032884774 scopus 로고    scopus 로고
    • Cell cycle checkpoint evasion and protracted cell cycle arrest in X-irradiated small cell lung carcinoma cells
    • Smith, P. J., Wiltshire, M., Chin, S. F., Rabbitts, P. and Souès, S. (1999). Cell cycle checkpoint evasion and protracted cell cycle arrest in X-irradiated small cell lung carcinoma cells. Int. J. Radiat. Biol. 75, 1137-1147.
    • (1999) Int. J. Radiat. Biol. , vol.75 , pp. 1137-1147
    • Smith, P.J.1    Wiltshire, M.2    Chin, S.F.3    Rabbitts, P.4    Souès, S.5
  • 42
    • 0025150387 scopus 로고
    • Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
    • Stein, G. H., Beeson, M. and Gordon, L. (1990). Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249, 666-669.
    • (1990) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 43
    • 0028915250 scopus 로고
    • Characterisation of epitopes on human p53 using phage-displayed peptide libraries: Insights into antibody-peptide interactions
    • Stephen, C. W., Helminen, P. and Lane, D. P. (1995). Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions. J. Mol. Biol. 248, 58-78.
    • (1995) J. Mol. Biol. , vol.248 , pp. 58-78
    • Stephen, C.W.1    Helminen, P.2    Lane, D.P.3
  • 44
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended reproductive life span
    • Vaziri, H. and Benchimol, S. (1998). Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended reproductive life span. Curr. Biol. 8, 279-282.
    • (1998) Curr. Biol. , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 46
    • 0034114544 scopus 로고    scopus 로고
    • Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
    • Webley, K., Bond, J. A., Jones, C. J., Blaydes, J. P., Craig, A., Hupp, T. and Wynford-Thomas, D. (2000). Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol. Cell. Biol. 20, 2803-2808.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2803-2808
    • Webley, K.1    Bond, J.A.2    Jones, C.J.3    Blaydes, J.P.4    Craig, A.5    Hupp, T.6    Wynford-Thomas, D.7
  • 47
    • 0035989631 scopus 로고    scopus 로고
    • Historical claims and current interpretations of replicative aging
    • Wright, W. E. and Shay, J. W. (2002). Historical claims and current interpretations of replicative aging. Nat. Biotechnol. 20, 682-688.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 682-688
    • Wright, W.E.1    Shay, J.W.2


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