Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

Human Genetics

Volumn 97, Issue 6, 1996, Pages 750-754

  Schulz, Vincent P ^a,c   Zakian, Virginia A ^a,b,c   Ogburn, Charles E ^b   McKay, John ^b   Jarzebowicz, Amy A ^b   Edland, Steven D ^b   Martin, George M ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REPETITIVE DNA;

ADULT; ARTICLE; CASE REPORT; CELL AGING; CELL DIVISION; CONTROLLED STUDY; DNA REPLICATION; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; RESTRICTION FRAGMENT; TELOMERE; WERNER SYNDROME;

EID: 0029971241     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02346184     Document Type: Article

References (30)

1. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89:10114-10118
2. Brown WT (1990) Genetic diseases of premature aging as models of senescence. Annu Rev Gerontol Geriatr 10:23-42
3. Chang M, Burmer GC, Sweasy J, Loeb LA, Edelhoff S, Disteche CM, Yu CE, Anderson L, Oshima J, Nakura J, Miki T, Kamino K, Ogihara T, Schellenberg GD, Martin GM (1994) Evidence against DNA polymerase β as a candidate gene for Werner syndrome. Hum Genet 93:507-512
4. Collins K, Kobayashi R, Greider CW (1995) Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 81:677-686
5. Denhardt DT (1966) A membrane-filter technique for the detection of complementary DNA Biochem Biophys Res Commun 23: 641-646
6. Epstein CJ, Martin GM, Schultz AL, Motulsky AG (1966) Werner's syndrome: a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine 45:177-221
7. Faragher RG, Kill IR, Hunter JA, Pope FM, Tannock C, Shall S (1993) The gene responsible for Werner syndrome may be a cell division "counting" gene. Proc Natl Acad Sci USA 90: 12030-12034
8. Feldman HA (1988) Families of lines: random effects in linear regression analysis. J Appl Physiol 64:1721-1732
9. Fukuchi K, Martin GM, Monnat RJ Jr (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci USA 86:5893-5897
10. Fukuchi K, Tanaka K, Kumahara Y, Marumo K, Pride MB, Martin GM, Monnat RJ Jr (1990) Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum Genet 84:249-252
11. Goto M, Rubenstein M, Weber J, Woods K, Drayna D (1992) Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature 355:735-738
12. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460
13. Johnston RF, Pickett SC, Barker DL (1990) Autoradiography using storage phosphor technology. Electrophoresis 11:355-360
14. Kruk PA, Rampino NJ, Bohr VA (1995) DNA damage and repair in telomeres: relation to aging. Proc Natl Acad Sci USA 92: 258-262
15. Laird NM, Ware JH (1982) Random-effects models for longitudinal data. Biometrics 38:963-974
16. Lange T de, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE (1990) Structure and variability of human chromosome ends. Mol Cell Biol 10:518-527
17. Martin GM (1994) Genetic modulation of telomeric terminal restriction-fragment length: relevance for clonal aging and late-life disease (editorial). Am J Hum Genet 55:866-869
18. Martin GM, Sprague CA, Epstein CJ (1970) Replicative life-span of cultivated human cells: effects of donor's age, tissue and genotype. Lab Invest 23:86-92
19. Martin GM, Sprague CA, Norwood TH, Pendergrass WR (1974) Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia. Am J Pathol 74:137-154
20. McCormick-Graham M, Romero DP (1995) Ciliate telomerase RNA structural features. Nucleic Acids Res 23:1091-1097
21. McKusick VA (1994) Mendelian inheritance in man: a catalog of human genes and genetic disorders, 11th edn. Johns Hopkins University Press, Baltimore
22. Nakura J, Wijsman EM, Miki T, Kamino K, Yu C-E, Oshima J, Fukuchi K, Weber JL, Piussan C, Melaragno MI, Epstein CJ, Scappaticci S, Fraccaro M, Matsumura T, Murano S, Yoshida S, Fujiwara Y, Saida T, Ogihara T, Martin GM, Schellenberg GD (1994) Homozygosity mapping of the Werner syndrome locus (WRN). Genomics 23:600-608
23. Oshima J, Campisi J, Tannock TCA, Martin GM (1995) Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol 162:277-283
24. Rünger TM, Bauer C, Dekant B, Moller K, Sobotta P, Czerny C, Poot M, Martin GM (1994) Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J Invest Dermatol 102:45-48
25. Sadakane Y, Maeda K, Kuroda Y, Hori K (1994) Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome. Biochem Biophys Res Commun 200:219-225
26. Salk D, Au K, Hoehn H, Martin GM (1981) Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet 30:92-107
27. Salzberg S, Levi Z, Aboud M, Goldberger A (1977) Isolation and characterization of DNA-DNA and DNA-RNA. Biochemistry 16:25-29
28. Schellenberg GD, Martin GM, Wijsman EM, Nakura J, Miki T, Ogihara T (1992) Homozygosity mapping and Werner's syndrome. Lancet 339:1002
29. Slagboom PE, Droog S, Boomsma DI (1994) Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 55:876-882
30. Tannock TC, Cook RF (1988) A case of a delusional psychotic syndrome in the setting of Werner's syndrome (adult progeria). Br J Psychiatry 152:703-704