-
1
-
-
0023663101
-
Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
-
Mellon, I., Spivak, G. & Hanawalt, P. C. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell 51, 241-249 (1987).
-
(1987)
Cell
, vol.51
, pp. 241-249
-
-
Mellon, I.1
Spivak, G.2
Hanawalt, P.C.3
-
2
-
-
0027370604
-
Lack of Transcription-coupled repair in mammalian ribosomal RNA genes
-
Christians, F. C. & Hanawalt, P. C. Lack of Transcription-coupled repair in mammalian ribosomal RNA genes. Biochemistry 32, 10512-10518 (1993).
-
(1993)
Biochemistry
, vol.32
, pp. 10512-10518
-
-
Christians, F.C.1
Hanawalt, P.C.2
-
3
-
-
0031014596
-
Lack of gene- and strand-specific DNA repair in RNA polymerase III-transcribed human tRNA genes
-
Dammann, R. & Pfeifer, G. P. Lack of gene- and strand-specific DNA repair in RNA polymerase III-transcribed human tRNA genes. Mol. Cell. Biol. 17, 219-229 (1997).
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 219-229
-
-
Dammann, R.1
Pfeifer, G.P.2
-
4
-
-
0037376173
-
Divide and conquer: Nucleotide excision repair battles cancer and ageing
-
Mitchell, J. R., Hoeijmakers, J. H. & Niedernhofer, L. J. Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr. Opin. Cell Biol. 15, 232-240 (2003).
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 232-240
-
-
Mitchell, J.R.1
Hoeijmakers, J.H.2
Niedernhofer, L.J.3
-
5
-
-
0029785723
-
Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis
-
Ljungman, M. & Zhang, F. Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis. Oncogene 13, 823-831 (1996).
-
(1996)
Oncogene
, vol.13
, pp. 823-831
-
-
Ljungman, M.1
Zhang, F.2
-
6
-
-
0031416213
-
Transcription abnormalities potentiate apoptosis of normal human fibroblasts
-
Andera, L. & Wasylyk, B. Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Mol. Med. 3, 852-863 (1997).
-
(1997)
Mol. Med.
, vol.3
, pp. 852-863
-
-
Andera, L.1
Wasylyk, B.2
-
7
-
-
0033590624
-
Inhibition of RNA polymerase II as a trigger for the p53 response
-
Ljungman, M., Zhang, F. F., Chen, F., Rainbow, A. J. & McKay, B. C. Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene 18, 583-592 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 583-592
-
-
Ljungman, M.1
Zhang, F.F.2
Chen, F.3
Rainbow, A.J.4
McKay, B.C.5
-
8
-
-
12944300387
-
Differential role of transcription-coupled repair in UVB-induced G(2) arrest and apoptosis in mouse epidermis
-
van Oosten, M. et al. Differential role of transcription-coupled repair in UVB-induced G(2) arrest and apoptosis in mouse epidermis. Proc. Natl Acad. Sci. USA 97, 11268-11273 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 11268-11273
-
-
Van Oosten, M.1
-
9
-
-
0035725421
-
The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes
-
Brash, D. E. et al. The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes. J. Invest. Derm. 117, 1234-1240 (2001).
-
(2001)
J. Invest. Derm.
, vol.117
, pp. 1234-1240
-
-
Brash, D.E.1
-
10
-
-
0035723355
-
Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes
-
Queille, S., Drougard, C., Sarasin, A. & Daya-Grosjean, L. Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes. J. Invest. Derm. 117, 1162-1170 (2001).
-
(2001)
J. Invest. Derm.
, vol.117
, pp. 1162-1170
-
-
Queille, S.1
Drougard, C.2
Sarasin, A.3
Daya-Grosjean, L.4
-
11
-
-
0035845852
-
P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts
-
McKay, B. C., Becerril, C. & Ljungman, M. P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts. Oncogene 20, 6805-6808 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 6805-6808
-
-
McKay, B.C.1
Becerril, C.2
Ljungman, M.3
-
12
-
-
0041345730
-
Blockage of transcription as a trigger for p53 accumulation by 2-acetylaminofluorene DNA-adducts
-
van Gijssel, H. E., Mullenders, L. H., van Oosterwijk, M. F. & Meerman, J. H. Blockage of transcription as a trigger for p53 accumulation by 2-acetylaminofluorene DNA-adducts. Life Sci. 73, 1759-1771 (2003).
-
(2003)
Life Sci.
, vol.73
, pp. 1759-1771
-
-
Van Gijssel, H.E.1
Mullenders, L.H.2
Van Oosterwijk, M.F.3
Meerman, J.H.4
-
13
-
-
0042916149
-
Smoking, DNA repair capacity and risk of nonsmall cell lung cancer
-
Shen, H. et al. Smoking, DNA repair capacity and risk of nonsmall cell lung cancer. Int. J. Cancer 107, 84-88 (2003).
-
(2003)
Int. J. Cancer
, vol.107
, pp. 84-88
-
-
Shen, H.1
-
14
-
-
0036801661
-
Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer
-
Park, J. Y. et al. Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. Cancer Epidemiol. Biomarkers Prev. 11, 993-997 (2002).
-
(2002)
Cancer Epidemiol. Biomarkers Prev.
, vol.11
, pp. 993-997
-
-
Park, J.Y.1
-
15
-
-
0034332586
-
Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: A molecular epidemiologic study
-
Wei, Q. et al. Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. J. Natl Cancer Inst. 92, 1764-1772 (2000).
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 1764-1772
-
-
Wei, Q.1
-
16
-
-
0029832418
-
Reduced DNA repair capacity in lung cancer patients
-
Wei, Q. Y., Cheng, L., Hong, W. K. & Spitz, M. R. Reduced DNA repair capacity in lung cancer patients. Cancer Res. 56, 4103-4107 (1996).
-
(1996)
Cancer Res.
, vol.56
, pp. 4103-4107
-
-
Wei, Q.Y.1
Cheng, L.2
Hong, W.K.3
Spitz, M.R.4
-
17
-
-
4544388821
-
Reduced DNA repair of benzo(a)pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients
-
in the press
-
Shi, Q. et al. Reduced DNA repair of benzo(a)pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. Carcinogenesis (in the press).
-
Carcinogenesis
-
-
Shi, Q.1
-
18
-
-
1642400578
-
DNA repair and breast carcinoma susceptibility in women
-
Ramos, J. M. et al. DNA repair and breast carcinoma susceptibility in women. Cancer 100, 1352-1357 (2004).
-
(2004)
Cancer
, vol.100
, pp. 1352-1357
-
-
Ramos, J.M.1
-
19
-
-
0027109075
-
p53, guardian of the genome
-
Lane, D. p53, guardian of the genome. Nature 358, 15-16 (1992).
-
(1992)
Nature
, vol.358
, pp. 15-16
-
-
Lane, D.1
-
20
-
-
0034039040
-
Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
-
Ljungman, M. Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress. Neoplasia 2, 208-225 (2000).
-
(2000)
Neoplasia
, vol.2
, pp. 208-225
-
-
Ljungman, M.1
-
21
-
-
0028030791
-
UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle
-
Yamaizumi, M. & Sugano, T. UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene 9, 2775-2784 (1994).
-
(1994)
Oncogene
, vol.9
, pp. 2775-2784
-
-
Yamaizumi, M.1
Sugano, T.2
-
22
-
-
0031426286
-
Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes
-
Dumaz, N. et al. Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes. Mol. Carcinogen. 20, 340-347 (1997).
-
(1997)
Mol. Carcinogen.
, vol.20
, pp. 340-347
-
-
Dumaz, N.1
-
23
-
-
0032490853
-
WAF1 and bax expression: Implications for DNA repair, UV sensitivity and the induction of apoptosis
-
WAF1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis. Oncogene 17, 545-555 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 545-555
-
-
McKay, B.C.1
Ljungman, M.2
Rainbow, A.J.3
-
24
-
-
0032482435
-
Photoproducts in transcriptionally active DNA induce signal transduction to delay U. V.-responsive genes for collagenase and metallothionein
-
Blattner, C., Bender, K., Herrlich, P. & Rahmsdorf, H. Photoproducts in transcriptionally active DNA induce signal transduction to delay U. V.-responsive genes for collagenase and metallothionein. Oncogene 16, 2827-2834 (1998).
-
(1998)
Oncogene
, vol.16
, pp. 2827-2834
-
-
Blattner, C.1
Bender, K.2
Herrlich, P.3
Rahmsdorf, H.4
-
25
-
-
0242331219
-
Nucleotide excision repair and its interplay with transcription
-
van Hoffen, A., Balajee, A. S., van Zeeland, A. A. & Mullenders, L. H. Nucleotide excision repair and its interplay with transcription. Toxicology 193, 79-90 (2003).
-
(2003)
Toxicology
, vol.193
, pp. 79-90
-
-
Van Hoffen, A.1
Balajee, A.S.2
Van Zeeland, A.A.3
Mullenders, L.H.4
-
26
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
de Boer, J. et al. Premature aging in mice deficient in DNA repair and transcription. Science 296, 1276-1279 (2002).
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
De Boer, J.1
-
27
-
-
0032085182
-
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy
-
de Boer, J. et al. A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. Mol. Cell 1, 981-990 (1998).
-
(1998)
Mol. Cell
, vol.1
, pp. 981-990
-
-
De Boer, J.1
-
28
-
-
0033565649
-
Mouse model for the DNA repair/basal transcription disorder trichotiodystrophy reveals cancer predisposition
-
de Boer, J. et al. Mouse model for the DNA repair/basal transcription disorder trichotiodystrophy reveals cancer predisposition. Cancer Res. 59, 3489-3494 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 3489-3494
-
-
De Boer, J.1
-
29
-
-
0034659755
-
Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression
-
Garssen, J. et al. Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression. J. Immunol. 164, 6199-6205 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 6199-6205
-
-
Garssen, J.1
-
30
-
-
0035921573
-
Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation
-
Ljungman, M., O'Hagan, H. M. & Paulsen, M. T. Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation. Oncogene 20, 5964-5971 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 5964-5971
-
-
Ljungman, M.1
O'Hagan, H.M.2
Paulsen, M.T.3
-
31
-
-
0034993222
-
Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress
-
Klibanov, S. A., O'Hagan, H. M. & Ljungman, M. Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress. J. Cell Sci. 114, 1867-1873 (2001).
-
(2001)
J. Cell Sci.
, vol.114
, pp. 1867-1873
-
-
Klibanov, S.A.1
O'Hagan, H.M.2
Ljungman, M.3
-
32
-
-
1642481261
-
Phosphorylation and nuclear accumulation are distinct events contributing to the activation of p53
-
O'Hagan, H. M. & Ljungman, M. Phosphorylation and nuclear accumulation are distinct events contributing to the activation of p53. Mutat. Res. 546, 7-15 (2004).
-
(2004)
Mutat. Res.
, vol.546
, pp. 7-15
-
-
O'Hagan, H.M.1
Ljungman, M.2
-
33
-
-
0030612360
-
MDM2-arbiter of p53's destruction
-
Lane, D. P. & Hall, P. A. MDM2-arbiter of p53's destruction. Trends Biochem. Sci. 22, 372-374 (1997).
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 372-374
-
-
Lane, D.P.1
Hall, P.A.2
-
34
-
-
0031724593
-
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
-
Freedman, D. A. & Levine, A. J. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 18, 7288-7293 (1998).
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 7288-7293
-
-
Freedman, D.A.1
Levine, A.J.2
-
35
-
-
0034282102
-
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
-
Boyd, S. D., Tsai, K. Y. & Jacks, T. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nature Cell Biol. 2, 563-568 (2000).
-
(2000)
Nature Cell Biol.
, vol.2
, pp. 563-568
-
-
Boyd, S.D.1
Tsai, K.Y.2
Jacks, T.3
-
36
-
-
0034282220
-
The MDM2 RING-finger domain is required to promote p53 nuclear export
-
Geyer, R. K., Yu, Z. K. & Maki, C. G. The MDM2 RING-finger domain is required to promote p53 nuclear export. Nature Cell Biol. 2, 569-573 (2000).
-
(2000)
Nature Cell Biol.
, vol.2
, pp. 569-573
-
-
Geyer, R.K.1
Yu, Z.K.2
Maki, C.G.3
-
37
-
-
0035196861
-
Identification of p53 sequence elements that are required for MDM2-mediated nuclear export
-
Gu, J. J., Nie, L. H., Wiederschain, D. & Yuan, Z. M. Identification of p53 sequence elements that are required for MDM2-mediated nuclear export. Mol. Cell. Biol. 21, 8533-8546 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 8533-8546
-
-
Gu, J.J.1
Nie, L.H.2
Wiederschain, D.3
Yuan, Z.M.4
-
38
-
-
0035201820
-
C-terminal ubiquitination of p53 contributes to nuclear export
-
Lohrum, M. A. E., Woods, D. B., Ludwig, R. L., Balint, E. & Vousden, K. H. C-terminal ubiquitination of p53 contributes to nuclear export. Mol. Cell. Biol. 21, 8521-8532 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 8521-8532
-
-
Lohrum, M.A.E.1
Woods, D.B.2
Ludwig, R.L.3
Balint, E.4
Vousden, K.H.5
-
39
-
-
0032939925
-
Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
-
Blattner, C., Sparks, A. & Lane, D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol. Cell. Biol. 19, 3704-3713 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3704-3713
-
-
Blattner, C.1
Sparks, A.2
Lane, D.3
-
40
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
Ashcroft, M., Taya, Y. & Vousden, K. H. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20, 3224-3233 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3224-3233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
-
41
-
-
0034682243
-
Proneness to UV-induced apoptosis in human fibroblasts defective in transcription coupled repair is associated with the lack of Mdm2 transactivation
-
Conforti, G., Nardo, T., D'Incalci, M. & Stefanini, M. Proneness to UV-induced apoptosis in human fibroblasts defective in transcription coupled repair is associated with the lack of Mdm2 transactivation. Oncogene 19, 2714-2720 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2714-2720
-
-
Conforti, G.1
Nardo, T.2
D'Incalci, M.3
Stefanini, M.4
-
42
-
-
0036044958
-
Inhibition of transcription results in accumulation of wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity
-
Blagosklonny, M., Demidenko, Z. & Fojo, T. Inhibition of transcription results in accumulation of wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity. Cell Cycle 1, 67-74 (2002).
-
(2002)
Cell Cycle
, vol.1
, pp. 67-74
-
-
Blagosklonny, M.1
Demidenko, Z.2
Fojo, T.3
-
43
-
-
3843086271
-
Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2
-
O'Hagan, H. M. & Ljungman, M. Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2. Oncogene 23, 5505-5512 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 5505-5512
-
-
O'Hagan, H.M.1
Ljungman, M.2
-
44
-
-
0030666852
-
Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis
-
Koumenis, C. & Giaccia, A. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Mol. Cell. Biol. 17, 7306-7316 (1997).
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 7306-7316
-
-
Koumenis, C.1
Giaccia, A.2
-
45
-
-
0033554609
-
RNA synthesis block by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells
-
Poele, R. H. T., Dkorokov, A. L. & Joel, S. P. RNA synthesis block by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene 18, 5765-5772 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 5765-5772
-
-
Poele, R.H.T.1
Dkorokov, A.L.2
Joel, S.P.3
-
46
-
-
0344011603
-
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other streases
-
Rubbi, C. P. & Milner, J. Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other streases. EMBO J. 22, 6068-6077 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 6068-6077
-
-
Rubbi, C.P.1
Milner, J.2
-
48
-
-
0034915032
-
Control of p53 Ubiquitination and nuclear export by MDM2 and ARF
-
Zhang, Y. & Xiong, Y. Control of p53 Ubiquitination and nuclear export by MDM2 and ARF. Cell Growth Diff. 12, 175-186 (2001).
-
(2001)
Cell Growth Diff.
, vol.12
, pp. 175-186
-
-
Zhang, Y.1
Xiong, Y.2
-
49
-
-
0023735773
-
Nucleolar changes after microinjection of antibodies to RNA polymerase I into the nucleus of mammalian cells
-
Benavente, R., Reimer, G., Rose, K. M., Hugle-Dorr, B. & Scheer, U. Nucleolar changes after microinjection of antibodies to RNA polymerase I into the nucleus of mammalian cells. Chromosoma 97, 115-123 (1988).
-
(1988)
Chromosoma
, vol.97
, pp. 115-123
-
-
Benavente, R.1
Reimer, G.2
Rose, K.M.3
Hugle-Dorr, B.4
Scheer, U.5
-
50
-
-
0030005052
-
Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains
-
Haaf, T. & Ward, D. C. Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains. Exp. Cell Res. 224, 163-173 (1996).
-
(1996)
Exp. Cell Res.
, vol.224
, pp. 163-173
-
-
Haaf, T.1
Ward, D.C.2
-
51
-
-
2942744364
-
Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs
-
O'Hagan, H. M. & Ljungman, M. Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs. Exp. Cell Res. 297, 548-559 (2004).
-
(2004)
Exp. Cell Res.
, vol.297
, pp. 548-559
-
-
O'Hagan, H.M.1
Ljungman, M.2
-
52
-
-
0033559256
-
A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
-
Stommel, J. M. et al. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18, 1660-1672 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 1660-1672
-
-
Stommel, J.M.1
-
53
-
-
0035827335
-
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
-
Zhang, Y. P. & Xiong, Y. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science 292, 1910-1915 (2001).
-
(2001)
Science
, vol.292
, pp. 1910-1915
-
-
Zhang, Y.P.1
Xiong, Y.2
-
54
-
-
3042664521
-
Binding of RNA to p53 regulates its oligomerization and DNA-binding activity
-
Yoshida, Y. et al. Binding of RNA to p53 regulates its oligomerization and DNA-binding activity. Oncogene 23, 4371-4379 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 4371-4379
-
-
Yoshida, Y.1
-
55
-
-
2342471907
-
Regulation of ultraviolet light-induced gene expression by gene size
-
McKay, B. C. et al. Regulation of ultraviolet light-induced gene expression by gene size. Proc. Natl Acad. Sci. USA 101, 6582-6586 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6582-6586
-
-
McKay, B.C.1
-
56
-
-
0037019177
-
Lack of functional pRb results in attenuated recovery of mRNA synthesis and increased apoptosis following UV radiation in human breast cancer cells
-
Billecke, C. A. et al. Lack of functional pRb results in attenuated recovery of mRNA synthesis and increased apoptosis following UV radiation in human breast cancer cells. Oncogene 21, 4481-4489 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 4481-4489
-
-
Billecke, C.A.1
-
57
-
-
0033836606
-
The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis
-
McKay, B. C., Chen, F., Perumalswami, C. R., Zhang, F. F. & Ljungman, M. The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis. Mol. Biol. Cell 11, 2543-2551 (2000).
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 2543-2551
-
-
McKay, B.C.1
Chen, F.2
Perumalswami, C.R.3
Zhang, F.F.4
Ljungman, M.5
-
58
-
-
0033170538
-
Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet light
-
McKay, B. & Ljungman, M. Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet light. Neoplasia 1, 276-284 (1999).
-
(1999)
Neoplasia
, vol.1
, pp. 276-284
-
-
McKay, B.1
Ljungman, M.2
-
59
-
-
0142029128
-
Inhibition of p53, p21 and Bax by pifithrin-α does not affect UV induced apoptotic response in CS-B cells
-
Proietti De Santis, L. et al. Inhibition of p53, p21 and Bax by pifithrin-α does not affect UV induced apoptotic response in CS-B cells. DNA Repair 2, 891-900 (2003).
-
(2003)
DNA Repair
, vol.2
, pp. 891-900
-
-
Proietti De Santis, L.1
-
60
-
-
0036646113
-
UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53
-
Chouinard, N., Valerie, K., Rouabhia, M. & Huot, J. UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53. Biochem. J. 365, 133-145 (2002).
-
(2002)
Biochem. J.
, vol.365
, pp. 133-145
-
-
Chouinard, N.1
Valerie, K.2
Rouabhia, M.3
Huot, J.4
-
61
-
-
0036772564
-
Ultraviolet light-induced apoptosis is associated with S-phase in primary human fibroblasts
-
McKay, B., Beceml, C., Spronck, J. & Ljungman, M. Ultraviolet light-induced apoptosis is associated with S-phase in primary human fibroblasts. DNA Repair 1, 811-820 (2002).
-
(2002)
DNA Repair
, vol.1
, pp. 811-820
-
-
McKay, B.1
Beceml, C.2
Spronck, J.3
Ljungman, M.4
-
62
-
-
0036844340
-
Recombinational repair and restart of damaged replication forks
-
McGlynn, P. & Lloyd, R. G. Recombinational repair and restart of damaged replication forks. Nature Rev. Mol. Cell Biol. 3, 859-870 (2002).
-
(2002)
Nature Rev. Mol. Cell Biol.
, vol.3
, pp. 859-870
-
-
McGlynn, P.1
Lloyd, R.G.2
-
63
-
-
0032474904
-
p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage
-
Bissonnette, N. & Hunting, D. J. p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage. Oncogene 16, 3461-3469 (1998).
-
(1998)
Oncogene
, vol.16
, pp. 3461-3469
-
-
Bissonnette, N.1
Hunting, D.J.2
-
64
-
-
0037369235
-
Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis
-
Porter, L. A., Cukier, I. H. & Lee, J. M. Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis. Blood 101, 1928-1933 (2003).
-
(2003)
Blood
, vol.101
, pp. 1928-1933
-
-
Porter, L.A.1
Cukier, I.H.2
Lee, J.M.3
-
65
-
-
0032516880
-
Effects of nonbulky DNA base damages on Escherichia coli RNA polymerase-mediated elongation and promoter clearance
-
Viswanathan, A. & Doetsch, P. W. Effects of nonbulky DNA base damages on Escherichia coli RNA polymerase-mediated elongation and promoter clearance. J. Biol. Chem. 273, 21276-21281 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21276-21281
-
-
Viswanathan, A.1
Doetsch, P.W.2
-
66
-
-
0035977062
-
Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II
-
Tornaletti, S., Maeda, L. S., Lloyd, D. R., Reines, D. & Hanawalt, P. C. Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II. J. Biol. Chem. 276, 45367-45371 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45367-45371
-
-
Tornaletti, S.1
Maeda, L.S.2
Lloyd, D.R.3
Reines, D.4
Hanawalt, P.C.5
-
67
-
-
1842685197
-
Effect of 8-oxoguanine on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II
-
Tornaletti, S., Maeda, L. S., Kolodner, R. D. & Hanawalt, P. C. Effect of 8-oxoguanine on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II. DNA Repair (Amst) 3, 483-494 (2004).
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 483-494
-
-
Tornaletti, S.1
Maeda, L.S.2
Kolodner, R.D.3
Hanawalt, P.C.4
-
68
-
-
0034646516
-
Transcription-coupled repair of 8-oxoGuanine: Requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome
-
Le Page, F. et al. Transcription-coupled repair of 8-oxoGuanine: Requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome. Cell 101, 159-171 (2000).
-
(2000)
Cell
, vol.101
, pp. 159-171
-
-
Le Page, F.1
-
69
-
-
0041928171
-
Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates
-
Yanamadala, S. & Ljungman, M. Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates. Mol. Cancer Res. 1, 747-754 (2003).
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 747-754
-
-
Yanamadala, S.1
Ljungman, M.2
-
70
-
-
0029665878
-
4-methylthymine, or the cisplatin-d(GpG) adduct
-
4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl Acad. Sci. USA 93, 6443-6447 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 6443-6447
-
-
Duckett, D.R.1
-
71
-
-
0035161816
-
Functional interactions and signaling properties of mammalian DNA mismatch repair proteins
-
Bellacosa, A. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell Death Differ. 8, 1076-1092 (2001).
-
(2001)
Cell Death Differ.
, vol.8
, pp. 1076-1092
-
-
Bellacosa, A.1
-
72
-
-
0033607055
-
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
-
Duckett, D. R., Bronstein, S. M., Taya, Y. & Modrich, P. hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage. Proc. Natl Acad. Sci. USA 96, 12384-12388 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 12384-12388
-
-
Duckett, D.R.1
Bronstein, S.M.2
Taya, Y.3
Modrich, P.4
-
73
-
-
0032851842
-
Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
-
Hickman, M. J. & Samson, L. D. Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc. Natl Acad. Sci. USA 96, 10764-10769 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 10764-10769
-
-
Hickman, M.J.1
Samson, L.D.2
-
74
-
-
0028106162
-
Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template
-
Donahue, B. A., Yin, S., Taylor, J. S., Reines, D. & Hanawalt, P. C. Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template. Proc. Natl Acad. Sci. USA 91, 8502-8506 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8502-8506
-
-
Donahue, B.A.1
Yin, S.2
Taylor, J.S.3
Reines, D.4
Hanawalt, P.C.5
-
75
-
-
0033588105
-
Structural characterization of RNA polymerase II complexes arrested by a cyclobutane pyrimidine dimer in the transcribed strand of template DNA
-
Tornaletti, S., Reines, D. & Hanawalt, P. C. Structural characterization of RNA polymerase II complexes arrested by a cyclobutane pyrimidine dimer in the transcribed strand of template DNA. J. Biol. Chem. 274, 24124-24130 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24124-24130
-
-
Tornaletti, S.1
Reines, D.2
Hanawalt, P.C.3
-
76
-
-
0018163396
-
Gene and transcription mapping by radiation effects
-
Sauerbier, W. & Hercules, K. Gene and transcription mapping by radiation effects. Annu. Rev. Genet. 12, 329-363 (1978).
-
(1978)
Annu. Rev. Genet.
, vol.12
, pp. 329-363
-
-
Sauerbier, W.1
Hercules, K.2
-
77
-
-
0033032157
-
Recovery of RNA synthesis from the DHFR gene following UV-irradiation precedes the removal of photolesions from the transcribed strand
-
Ljungman, M. Recovery of RNA synthesis from the DHFR gene following UV-irradiation precedes the removal of photolesions from the transcribed strand. Carcinogenesis 20, 395-399 (1999).
-
(1999)
Carcinogenesis
, vol.20
, pp. 395-399
-
-
Ljungman, M.1
-
78
-
-
0023781396
-
Differential repair of DNA damage in the human metallothionein gene family
-
Leadon, S. & Snowden, M. Differential repair of DNA damage in the human metallothionein gene family. Mol. Cell. Biol. 8, 5331-5338 (1988).
-
(1988)
Mol. Cell. Biol.
, vol.8
, pp. 5331-5338
-
-
Leadon, S.1
Snowden, M.2
-
79
-
-
0037196071
-
Translesion synthesis by RNA polymerases: Occurrence and biological implications for transcriptional mutagenesis
-
Doetsch, P. W. Translesion synthesis by RNA polymerases: occurrence and biological implications for transcriptional mutagenesis. Mutat. Res. 510, 131-140 (2002).
-
(2002)
Mutat. Res.
, vol.510
, pp. 131-140
-
-
Doetsch, P.W.1
-
80
-
-
0027749417
-
Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells
-
van Hoffen, A. et al. Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells. Nucleic Acids Res. 21, 5890-5895 (1993).
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 5890-5895
-
-
Van Hoffen, A.1
-
81
-
-
0027379353
-
Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome
-
Leadon, S. A. & Cooper, P. K. Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome. Proc. Natl Acad. Sci. USA 90, 10499-10503 (1993).
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10499-10503
-
-
Leadon, S.A.1
Cooper, P.K.2
-
82
-
-
0029887819
-
Transcription-coupled repair deficiency and mutations in human mismatch repair genes
-
Mellon, I., Rajpal, D. K., Koi, M., Boland, C. R. & Champe, G. N. Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science 272, 557-560 (1996).
-
(1996)
Science
, vol.272
, pp. 557-560
-
-
Mellon, I.1
Rajpal, D.K.2
Koi, M.3
Boland, C.R.4
Champe, G.N.5
-
83
-
-
0034634570
-
XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription
-
Nakatsu, Y. et al. XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. J. Biol. Chem. 275, 34931-34937 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34931-34937
-
-
Nakatsu, Y.1
-
84
-
-
0033603440
-
BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair
-
Abbott, D. W. et al. BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair. J. Biol. Chem. 274, 18808-18812 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18808-18812
-
-
Abbott, D.W.1
-
85
-
-
0034307185
-
BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells
-
Le Page, F. et al. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. Cancer Res. 60, 5548-5552 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 5548-5552
-
-
Le Page, F.1
-
86
-
-
0036732039
-
Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells
-
Furuta, T. et al. Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells. Cancer Res. 62, 4899-4902 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 4899-4902
-
-
Furuta, T.1
-
87
-
-
0034054019
-
Nucleotide excision repair and human syndromes
-
de Boer, J. & Hoeijmakers, J. H. J. Nucleotide excision repair and human syndromes. Carcinogenesis 21, 453-460 (2000).
-
(2000)
Carcinogenesis
, vol.21
, pp. 453-460
-
-
De Boer, J.1
Hoeijmakers, J.H.J.2
-
88
-
-
0035137181
-
Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice
-
Lu, Y. et al. Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice. Mol. Cell. Biol. 21, 1810-1818 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1810-1818
-
-
Lu, Y.1
-
89
-
-
17944374027
-
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
-
Takebayashi, Y. et al. Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nature Med. 7, 961-966 (2001).
-
(2001)
Nature Med.
, vol.7
, pp. 961-966
-
-
Takebayashi, Y.1
-
90
-
-
0037027835
-
Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways
-
Jaspers, N. G. J. et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair 1, 1027-1038 (2002).
-
(2002)
DNA Repair
, vol.1
, pp. 1027-1038
-
-
Jaspers, N.G.J.1
-
91
-
-
0029947168
-
The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription
-
Ljungman, M. & Hanawalt, P. C. The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription. Carcinogenesis 17, 31-35 (1996).
-
(1996)
Carcinogenesis
, vol.17
, pp. 31-35
-
-
Ljungman, M.1
Hanawalt, P.C.2
-
92
-
-
0032570562
-
Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II - Implications for transcription-coupled DNA repair
-
Ratner, J. N., Balasubramanian, B., Corden, J., Warren, S. L. & Bregman, D. B. Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II - implications for transcription-coupled DNA repair. J. Biol. Chem. 273, 5184-5189 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5184-5189
-
-
Ratner, J.N.1
Balasubramanian, B.2
Corden, J.3
Warren, S.L.4
Bregman, D.B.5
-
93
-
-
0029859295
-
UV-induced ubiquitination of RNA polymerase II: A novel modification deficient in cockayne syndrome cells
-
Bregman, D. B. et al. UV-induced ubiquitination of RNA polymerase II: A novel modification deficient in cockayne syndrome cells. Proc. Natl Acad. Sci. USA 93, 11586-11590 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 11586-11590
-
-
Bregman, D.B.1
-
94
-
-
0035820074
-
UV light-induced degradation of RNA polymerase II is dependent on the Cockayne's syndrome A and B proteins but not p53 or MLH1
-
McKay, B. C. et al. UV light-induced degradation of RNA polymerase II is dependent on the Cockayne's syndrome A and B proteins but not p53 or MLH1. Mutat. Res. 485, 93-105 (2001).
-
(2001)
Mutat. Res.
, vol.485
, pp. 93-105
-
-
McKay, B.C.1
-
95
-
-
0037007036
-
Transcription-coupled and DNA damage dependent ubiquitination of RNA polymerase II in vitro
-
Lee, K. B., Wang, D., Lippard, S. J. & Sharp, P. A. Transcription-coupled and DNA damage dependent ubiquitination of RNA polymerase II in vitro. Proc. Natl Acad. Sci. USA 99, 4239-4244 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 4239-4244
-
-
Lee, K.B.1
Wang, D.2
Lippard, S.J.3
Sharp, P.A.4
-
96
-
-
0242311016
-
RNA polymerase II stalled on a DNA template during transcription elongation is ubiquitinated and the ubiquitination facilitates displacement of the elongation complex
-
Yang, L. Y., Jiang, H. & Rangel, K. M. RNA polymerase II stalled on a DNA template during transcription elongation is ubiquitinated and the ubiquitination facilitates displacement of the elongation complex. Int. J. Oncol. 22, 683-689 (2003).
-
(2003)
Int. J. Oncol.
, vol.22
, pp. 683-689
-
-
Yang, L.Y.1
Jiang, H.2
Rangel, K.M.3
-
97
-
-
1942437536
-
Physical and functional association of RNA polymerase II and the proteasome
-
Gillette, T. G., Gonzalez, F., Delahodde, A., Johnston, S. A. & Kodadek, T. Physical and functional association of RNA polymerase II and the proteasome. Proc. Natl Acad. Sci. USA 101, 5904-5909 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 5904-5909
-
-
Gillette, T.G.1
Gonzalez, F.2
Delahodde, A.3
Johnston, S.A.4
Kodadek, T.5
-
98
-
-
0033607291
-
Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
-
Iwai, K. et al. Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc. Natl Acad. Sci. USA 96, 12436-12441 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 12436-12441
-
-
Iwai, K.1
-
99
-
-
0344838401
-
Von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
-
Kuznetsova, A. V. et al. von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc. Natl Acad. Sci. USA 100, 2706-2711 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 2706-2711
-
-
Kuznetsova, A.V.1
-
100
-
-
0034735902
-
The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis
-
Schoenfeld, A. R. et al. The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis. Oncogene 19, 5851-5857 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 5851-5857
-
-
Schoenfeld, A.R.1
-
101
-
-
0035807072
-
Ultraviolet radiation alters the phosphorylation of RNA polymerase II large subunit and accelerates its proteasome-dependent degradation
-
Luo, Z. H., Zheng, J. H., Lu, Y. & Bregman, D. B. Ultraviolet radiation alters the phosphorylation of RNA polymerase II large subunit and accelerates its proteasome-dependent degradation. Mutat. Res. 486, 259-274 (2001).
-
(2001)
Mutat. Res.
, vol.486
, pp. 259-274
-
-
Luo, Z.H.1
Zheng, J.H.2
Lu, Y.3
Bregman, D.B.4
-
102
-
-
0037509859
-
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
-
Groisman, R. et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113, 357-367 (2003).
-
(2003)
Cell
, vol.113
, pp. 357-367
-
-
Groisman, R.1
-
103
-
-
0030965157
-
BRCA1 is a component of the RNA polymerase II holoenzyme
-
Scully, R. et al. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl Acad. Sci. USA 94, 5605-5610 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 5605-5610
-
-
Scully, R.1
-
104
-
-
0036682183
-
The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme
-
Chiba, N. & Parvin, J. D. The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. Cancer Res. 62, 4222-4228 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 4222-4228
-
-
Chiba, N.1
Parvin, J.D.2
-
105
-
-
0346732323
-
BRCA1 associates with processive RNA polymerase II
-
Krum, S. A., Miranda, G. A., Lin, C. & Lane, T. F. BRCA1 associates with processive RNA polymerase II. J. Biol. Cnem. 278, 52012-52020 (2003).
-
(2003)
J. Biol. Cnem.
, vol.278
, pp. 52012-52020
-
-
Krum, S.A.1
Miranda, G.A.2
Lin, C.3
Lane, T.F.4
-
106
-
-
0034283878
-
Linking DNA damage and neurodegeneration
-
Rolig, R. L. & McKinnon, P. J. Linking DNA damage and neurodegeneration. Trends Neurosci. 23, 417-424 (2000).
-
(2000)
Trends Neurosci.
, vol.23
, pp. 417-424
-
-
Rolig, R.L.1
McKinnon, P.J.2
-
107
-
-
0037470542
-
Aging and genome maintenance: Lessons from the mouse?
-
Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H. & Vijg, J. Aging and genome maintenance: lessons from the mouse? Science 299, 1355-1359 (2003).
-
(2003)
Science
, vol.299
, pp. 1355-1359
-
-
Hasty, P.1
Campisi, J.2
Hoeijmakers, J.3
Van Steeg, H.4
Vijg, J.5
-
108
-
-
0032803070
-
The Werner syndrome protein is involved in RNA polymerase II transcription
-
Balajee, A. S. et al. The Werner syndrome protein is involved in RNA polymerase II transcription. Mol. Biol. Cell 10, 2655-2668 (1999).
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 2655-2668
-
-
Balajee, A.S.1
-
109
-
-
0033579343
-
Requirement of yeast SGS1 and SRS2 genes for replication and transcription
-
Lee, S. K., Johnson, R. E., Yu, S. L., Prakash, L. & Prakash, S. Requirement of yeast SGS1 and SRS2 genes for replication and transcription. Science 286, 2339-2342 (1999).
-
(1999)
Science
, vol.286
, pp. 2339-2342
-
-
Lee, S.K.1
Johnson, R.E.2
Yu, S.L.3
Prakash, L.4
Prakash, S.5
-
110
-
-
0035034884
-
Premature aging and predisposition to cancers caused by mutations in RecQ family helicases
-
Furuichi, Y. Premature aging and predisposition to cancers caused by mutations in RecQ family helicases. Ann. NY Acad. Sci. 928, 121-131 (2001).
-
(2001)
Ann. N.Y. Acad. Sci.
, vol.928
, pp. 121-131
-
-
Furuichi, Y.1
-
111
-
-
0037673950
-
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
-
Eriksson, M. et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423, 293-298 (2003).
-
(2003)
Nature
, vol.423
, pp. 293-298
-
-
Eriksson, M.1
-
112
-
-
0037673940
-
A progeroid syndrome in mice is caused by defects in A-type lamins
-
Mounkes, L. C., Kozlov, S., Hernandez, L., Sullivan, T. & Stewart, C. L. A progeroid syndrome in mice is caused by defects in A-type lamins. Nature 423, 298-301 (2003).
-
(2003)
Nature
, vol.423
, pp. 298-301
-
-
Mounkes, L.C.1
Kozlov, S.2
Hernandez, L.3
Sullivan, T.4
Stewart, C.L.5
-
113
-
-
0037128211
-
Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription
-
Spann, T. P., Goldman, A. E., Wang, C., Huang, S. & Goldman, R. D. Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J. Cell Biol. 156, 603-608 (2002).
-
(2002)
J. Cell Biol.
, vol.156
, pp. 603-608
-
-
Spann, T.P.1
Goldman, A.E.2
Wang, C.3
Huang, S.4
Goldman, R.D.5
-
114
-
-
0037049554
-
Lamin A/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription
-
Kumaran, R. I., Muralikrishna, B. & Parnaik, V. K. Lamin A/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription. J. Cell Biol. 159, 783-793 (2002).
-
(2002)
J. Cell Biol.
, vol.159
, pp. 783-793
-
-
Kumaran, R.I.1
Muralikrishna, B.2
Parnaik, V.K.3
-
115
-
-
0032827888
-
Deletion of Ku86 causes early onset of senescence in mice
-
Vogel, H., Lim, D. S., Karsenty, G., Finegold, M. & Hasty, P. Deletion of Ku86 causes early onset of senescence in mice. Proc. Natl Acad. Sci. USA 96, 10770-10775 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.S.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
116
-
-
0035805545
-
Distinct roles for Ku protein in transcriptional reinitiation and DNA repair
-
Woodard, R. L., Lee, K. J., Huang, J. & Dynan, W. S. Distinct roles for Ku protein in transcriptional reinitiation and DNA repair. J. Biol. Chem. 276, 15423-15433 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 15423-15433
-
-
Woodard, R.L.1
Lee, K.J.2
Huang, J.3
Dynan, W.S.4
-
117
-
-
0036839642
-
Subnuclear localization of Ku protein: Functional association with RNA polymerase II elongation sites
-
Mo, X. M. & Dynan, W. S. Subnuclear localization of Ku protein: Functional association with RNA polymerase II elongation sites. Mol. Cell. Biol. 22, 8088-8099 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 8088-8099
-
-
Mo, X.M.1
Dynan, W.S.2
-
118
-
-
0037413699
-
Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription
-
Bertinato, J., Tomlinson, J. J., Schild-Poulter, C. & Hache, R. J. G. Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription. Gene 302, 53-64 (2003).
-
(2003)
Gene
, vol.302
, pp. 53-64
-
-
Bertinato, J.1
Tomlinson, J.J.2
Schild-Poulter, C.3
Hache, R.J.G.4
-
119
-
-
0342547005
-
Effects of transcription and translation inhibitors on a human gastric carcinoma cell line- Potential role of Bcl-X-s in apoptosis triggered by these inhibitors
-
Chang, T. C. et al. Effects of transcription and translation inhibitors on a human gastric carcinoma cell line- Potential role of Bcl-X-s in apoptosis triggered by these inhibitors. Biochem. Pharmacol. 53, 969-977 (1997).
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 969-977
-
-
Chang, T.C.1
-
120
-
-
0033059183
-
Dose-dependent effects of DNA-damaging agents on p53-mediated cell cycle arrest
-
Chang, D., Chen, F., Zhang, F. F., McKay, B. C. & Ljungman, M. Dose-dependent effects of DNA-damaging agents on p53-mediated cell cycle arrest. Cell Growth Differ. 10, 155-162 (1999).
-
(1999)
Cell Growth Differ.
, vol.10
, pp. 155-162
-
-
Chang, D.1
Chen, F.2
Zhang, F.F.3
McKay, B.C.4
Ljungman, M.5
-
121
-
-
0035200324
-
Transcriptional consequences of topoisomerase inhibition
-
Collins, I., Weber, A. & Levens, D. Transcriptional consequences of topoisomerase inhibition. Mol. Cell. Biol. 21, 8437-8451 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 8437-8451
-
-
Collins, I.1
Weber, A.2
Levens, D.3
-
122
-
-
0027173884
-
Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA
-
Squires, S., Ryan, A. J., Strutt, H. L. & Johnson, R. T. Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA. Cancer Res. 53, 2012-2019 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 2012-2019
-
-
Squires, S.1
Ryan, A.J.2
Strutt, H.L.3
Johnson, R.T.4
-
123
-
-
0028657658
-
Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells
-
Geoffroy, F. J., Allegra, C. J., Sinha, B. & Grem, J. L. Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells. Oncol. Res. 6, 581-591 (1994).
-
(1994)
Oncol. Res.
, vol.6
, pp. 581-591
-
-
Geoffroy, F.J.1
Allegra, C.J.2
Sinha, B.3
Grem, J.L.4
-
124
-
-
12644291915
-
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation
-
Pritchard, D. M., Watson, A. J. M., Potten, C. S., Jackman, A. L. & Hickman, J. A. Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation. Proc. Natl Acad. Sci. USA 94, 1795-1799 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 1795-1799
-
-
Pritchard, D.M.1
Watson, A.J.M.2
Potten, C.S.3
Jackman, A.L.4
Hickman, J.A.5
-
125
-
-
0033902940
-
Inhibition of RNA transcription: A biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine
-
Huang, P., Sandoval, A., Van Den Neste, E., Keating, M. J. & Plunkett, W. Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine. Leukemia 14, 1405-1413 (2000).
-
(2000)
Leukemia
, vol.14
, pp. 1405-1413
-
-
Huang, P.1
Sandoval, A.2
Van Den Neste, E.3
Keating, M.J.4
Plunkett, W.5
-
126
-
-
0037058678
-
In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)
-
McClue, S. J. et al. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). Int. J. Cancer 102, 463-468 (2002).
-
(2002)
Int. J. Cancer
, vol.102
, pp. 463-468
-
-
McClue, S.J.1
-
127
-
-
0041324624
-
Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms
-
Senderowicz, A. M. Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms. Cancer Chemother. Pharmacol. 52, 61-73 (2003).
-
(2003)
Cancer Chemother. Pharmacol.
, vol.52
, pp. 61-73
-
-
Senderowicz, A.M.1
-
128
-
-
0034812298
-
The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382
-
Ljungman, M. & Paulsen, M. T. The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382. Mol. Pharm. 60, 785-789 (2001).
-
(2001)
Mol. Pharm.
, vol.60
, pp. 785-789
-
-
Ljungman, M.1
Paulsen, M.T.2
-
129
-
-
0002557555
-
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
-
Lam, L. T. et al. Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biol. 2, 1-11 (2001).
-
(2001)
Genome Biol.
, vol.2
, pp. 1-11
-
-
Lam, L.T.1
-
130
-
-
0036850211
-
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1
-
Gojo, I., Zhang, B. & Fenton, R. G. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin. Cancer Res. 8, 3527-3538 (2002).
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3527-3538
-
-
Gojo, I.1
Zhang, B.2
Fenton, R.G.3
-
131
-
-
0034682468
-
Activation of p53 in cervical carcinoma cells by small molecules
-
Hietanen, S., Lain, S., Krausz, E., Blattner, C. & Lane, D. P. Activation of p53 in cervical carcinoma cells by small molecules. Proc. Natl Acad. Sci. USA 97, 8501-8506 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8501-8506
-
-
Hietanen, S.1
Lain, S.2
Krausz, E.3
Blattner, C.4
Lane, D.P.5
-
132
-
-
0034632675
-
Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways
-
Blaydes, J. P. et al. Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways. Oncogene 19, 3829-3839 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3829-3839
-
-
Blaydes, J.P.1
-
133
-
-
0038519961
-
Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo
-
Maggiorella, L. et al. Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo. Cancer Res. 63, 2513-2517 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 2513-2517
-
-
Maggiorella, L.1
-
134
-
-
0037726822
-
Improving cancer therapy by nongenotoxic activation of p53
-
Lain, S. & Lane, D. Improving cancer therapy by nongenotoxic activation of p53. Eur. J. Cancer 39, 1053-1060 (2003).
-
(2003)
Eur. J. Cancer
, vol.39
, pp. 1053-1060
-
-
Lain, S.1
Lane, D.2
-
135
-
-
0043025622
-
Exploiting the p53 pathway for cancer diagnosis and therapy
-
Woods, Y. L. & Lane, D. P. Exploiting the p53 pathway for cancer diagnosis and therapy. Hematol. J. 4, 233-247 (2003).
-
(2003)
Hematol. J.
, vol.4
, pp. 233-247
-
-
Woods, Y.L.1
Lane, D.P.2
-
136
-
-
0343938848
-
Accumulating active p53 in the nucleus by inhibition of nuclear export: A novel strategy to promote the p53 tumor suppressor function
-
Lain, S., Xirodimas, D. & Lane, D. P. Accumulating active p53 in the nucleus by inhibition of nuclear export: A novel strategy to promote the p53 tumor suppressor function. Exp. Cell Res. 253, 315-324 (1999).
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 315-324
-
-
Lain, S.1
Xirodimas, D.2
Lane, D.P.3
-
137
-
-
0032813181
-
Exploiting the p53 pathway for cancer diagnosis and therapy
-
Lane, D. P. Exploiting the p53 pathway for cancer diagnosis and therapy. Br. J. Cancer 80, 1-5 (1999).
-
(1999)
Br. J. Cancer
, vol.80
, pp. 1-5
-
-
Lane, D.P.1
-
138
-
-
0036219608
-
Therapeutic exploitation of the p53 pathway
-
Lane, D. P. & Lain, S. Therapeutic exploitation of the p53 pathway. Trends Mol. Med. 8, S38-S42 (2002).
-
(2002)
Trends Mol. Med.
, vol.8
-
-
Lane, D.P.1
Lain, S.2
-
139
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003).
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
140
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R. T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
141
-
-
2942572923
-
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells
-
Brumbaugh, K. M. et al. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol. Cell 14, 585-598 (2004).
-
(2004)
Mol. Cell
, vol.14
, pp. 585-598
-
-
Brumbaugh, K.M.1
-
142
-
-
0037169354
-
Cancer susceptibility and the functions of BRCA1 and BRCA2
-
Venkitaraman, A. R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108, 171-182 (2002).
-
(2002)
Cell
, vol.108
, pp. 171-182
-
-
Venkitaraman, A.R.1
-
143
-
-
0035032649
-
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
-
Xu, B., Kim, S. T. & Kastan, M. B. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21, 3445-3450 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3445-3450
-
-
Xu, B.1
Kim, S.T.2
Kastan, M.B.3
-
144
-
-
0033637170
-
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
-
Tibbetts, R. S. et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14, 2989-3002 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 2989-3002
-
-
Tibbetts, R.S.1
-
145
-
-
0035907395
-
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
-
Gatei, M. et al. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J. Biol. Chem. 276, 17276-17280 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 17276-17280
-
-
Gatei, M.1
-
146
-
-
0033865957
-
Roles of BRCA1 and its interacting proteins
-
Deng, C. X. & Brodie, S. G. Roles of BRCA1 and its interacting proteins. Bioessays 22, 728-737 2000).
-
(2000)
Bioessays
, vol.22
, pp. 728-737
-
-
Deng, C.X.1
Brodie, S.G.2
-
147
-
-
0034707053
-
In search of the tumour-suppressor functions of BRCA1 and BRCA2
-
Scully, R. & Livingston, D. M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429-432 (2000).
-
(2000)
Nature
, vol.408
, pp. 429-432
-
-
Scully, R.1
Livingston, D.M.2
|