메뉴 건너뛰기




Volumn 4, Issue 9, 2004, Pages 727-737

Transcription - Guarding the genome by sensing DNA damage

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CISPLATIN; DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE III; DOXORUBICIN; FLAVOPIRIDOL; FLUOROURACIL; PROTEIN P53; RNA POLYMERASE II; ROSCOVITINE;

EID: 4544259868     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1435     Document Type: Review
Times cited : (222)

References (147)
  • 1
    • 0023663101 scopus 로고
    • Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene
    • Mellon, I., Spivak, G. & Hanawalt, P. C. Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell 51, 241-249 (1987).
    • (1987) Cell , vol.51 , pp. 241-249
    • Mellon, I.1    Spivak, G.2    Hanawalt, P.C.3
  • 2
    • 0027370604 scopus 로고
    • Lack of Transcription-coupled repair in mammalian ribosomal RNA genes
    • Christians, F. C. & Hanawalt, P. C. Lack of Transcription-coupled repair in mammalian ribosomal RNA genes. Biochemistry 32, 10512-10518 (1993).
    • (1993) Biochemistry , vol.32 , pp. 10512-10518
    • Christians, F.C.1    Hanawalt, P.C.2
  • 3
    • 0031014596 scopus 로고    scopus 로고
    • Lack of gene- and strand-specific DNA repair in RNA polymerase III-transcribed human tRNA genes
    • Dammann, R. & Pfeifer, G. P. Lack of gene- and strand-specific DNA repair in RNA polymerase III-transcribed human tRNA genes. Mol. Cell. Biol. 17, 219-229 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 219-229
    • Dammann, R.1    Pfeifer, G.P.2
  • 4
    • 0037376173 scopus 로고    scopus 로고
    • Divide and conquer: Nucleotide excision repair battles cancer and ageing
    • Mitchell, J. R., Hoeijmakers, J. H. & Niedernhofer, L. J. Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr. Opin. Cell Biol. 15, 232-240 (2003).
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 232-240
    • Mitchell, J.R.1    Hoeijmakers, J.H.2    Niedernhofer, L.J.3
  • 5
    • 0029785723 scopus 로고    scopus 로고
    • Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis
    • Ljungman, M. & Zhang, F. Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis. Oncogene 13, 823-831 (1996).
    • (1996) Oncogene , vol.13 , pp. 823-831
    • Ljungman, M.1    Zhang, F.2
  • 6
    • 0031416213 scopus 로고    scopus 로고
    • Transcription abnormalities potentiate apoptosis of normal human fibroblasts
    • Andera, L. & Wasylyk, B. Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Mol. Med. 3, 852-863 (1997).
    • (1997) Mol. Med. , vol.3 , pp. 852-863
    • Andera, L.1    Wasylyk, B.2
  • 7
    • 0033590624 scopus 로고    scopus 로고
    • Inhibition of RNA polymerase II as a trigger for the p53 response
    • Ljungman, M., Zhang, F. F., Chen, F., Rainbow, A. J. & McKay, B. C. Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene 18, 583-592 (1999).
    • (1999) Oncogene , vol.18 , pp. 583-592
    • Ljungman, M.1    Zhang, F.F.2    Chen, F.3    Rainbow, A.J.4    McKay, B.C.5
  • 8
    • 12944300387 scopus 로고    scopus 로고
    • Differential role of transcription-coupled repair in UVB-induced G(2) arrest and apoptosis in mouse epidermis
    • van Oosten, M. et al. Differential role of transcription-coupled repair in UVB-induced G(2) arrest and apoptosis in mouse epidermis. Proc. Natl Acad. Sci. USA 97, 11268-11273 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11268-11273
    • Van Oosten, M.1
  • 9
    • 0035725421 scopus 로고    scopus 로고
    • The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes
    • Brash, D. E. et al. The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes. J. Invest. Derm. 117, 1234-1240 (2001).
    • (2001) J. Invest. Derm. , vol.117 , pp. 1234-1240
    • Brash, D.E.1
  • 10
    • 0035723355 scopus 로고    scopus 로고
    • Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes
    • Queille, S., Drougard, C., Sarasin, A. & Daya-Grosjean, L. Effects of XPD mutations on ultraviolet-induced apoptosis in relation to skin cancer-proneness in repair-deficient syndromes. J. Invest. Derm. 117, 1162-1170 (2001).
    • (2001) J. Invest. Derm. , vol.117 , pp. 1162-1170
    • Queille, S.1    Drougard, C.2    Sarasin, A.3    Daya-Grosjean, L.4
  • 11
    • 0035845852 scopus 로고    scopus 로고
    • P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts
    • McKay, B. C., Becerril, C. & Ljungman, M. P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts. Oncogene 20, 6805-6808 (2001).
    • (2001) Oncogene , vol.20 , pp. 6805-6808
    • McKay, B.C.1    Becerril, C.2    Ljungman, M.3
  • 12
    • 0041345730 scopus 로고    scopus 로고
    • Blockage of transcription as a trigger for p53 accumulation by 2-acetylaminofluorene DNA-adducts
    • van Gijssel, H. E., Mullenders, L. H., van Oosterwijk, M. F. & Meerman, J. H. Blockage of transcription as a trigger for p53 accumulation by 2-acetylaminofluorene DNA-adducts. Life Sci. 73, 1759-1771 (2003).
    • (2003) Life Sci. , vol.73 , pp. 1759-1771
    • Van Gijssel, H.E.1    Mullenders, L.H.2    Van Oosterwijk, M.F.3    Meerman, J.H.4
  • 13
    • 0042916149 scopus 로고    scopus 로고
    • Smoking, DNA repair capacity and risk of nonsmall cell lung cancer
    • Shen, H. et al. Smoking, DNA repair capacity and risk of nonsmall cell lung cancer. Int. J. Cancer 107, 84-88 (2003).
    • (2003) Int. J. Cancer , vol.107 , pp. 84-88
    • Shen, H.1
  • 14
    • 0036801661 scopus 로고    scopus 로고
    • Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer
    • Park, J. Y. et al. Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. Cancer Epidemiol. Biomarkers Prev. 11, 993-997 (2002).
    • (2002) Cancer Epidemiol. Biomarkers Prev. , vol.11 , pp. 993-997
    • Park, J.Y.1
  • 15
    • 0034332586 scopus 로고    scopus 로고
    • Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: A molecular epidemiologic study
    • Wei, Q. et al. Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. J. Natl Cancer Inst. 92, 1764-1772 (2000).
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1764-1772
    • Wei, Q.1
  • 16
    • 0029832418 scopus 로고    scopus 로고
    • Reduced DNA repair capacity in lung cancer patients
    • Wei, Q. Y., Cheng, L., Hong, W. K. & Spitz, M. R. Reduced DNA repair capacity in lung cancer patients. Cancer Res. 56, 4103-4107 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 4103-4107
    • Wei, Q.Y.1    Cheng, L.2    Hong, W.K.3    Spitz, M.R.4
  • 17
    • 4544388821 scopus 로고    scopus 로고
    • Reduced DNA repair of benzo(a)pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients
    • in the press
    • Shi, Q. et al. Reduced DNA repair of benzo(a)pyrene diol epoxide-induced adducts and common XPD polymorphisms in breast cancer patients. Carcinogenesis (in the press).
    • Carcinogenesis
    • Shi, Q.1
  • 18
    • 1642400578 scopus 로고    scopus 로고
    • DNA repair and breast carcinoma susceptibility in women
    • Ramos, J. M. et al. DNA repair and breast carcinoma susceptibility in women. Cancer 100, 1352-1357 (2004).
    • (2004) Cancer , vol.100 , pp. 1352-1357
    • Ramos, J.M.1
  • 19
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane, D. p53, guardian of the genome. Nature 358, 15-16 (1992).
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.1
  • 20
    • 0034039040 scopus 로고    scopus 로고
    • Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
    • Ljungman, M. Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress. Neoplasia 2, 208-225 (2000).
    • (2000) Neoplasia , vol.2 , pp. 208-225
    • Ljungman, M.1
  • 21
    • 0028030791 scopus 로고
    • UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle
    • Yamaizumi, M. & Sugano, T. UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene 9, 2775-2784 (1994).
    • (1994) Oncogene , vol.9 , pp. 2775-2784
    • Yamaizumi, M.1    Sugano, T.2
  • 22
    • 0031426286 scopus 로고    scopus 로고
    • Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes
    • Dumaz, N. et al. Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes. Mol. Carcinogen. 20, 340-347 (1997).
    • (1997) Mol. Carcinogen. , vol.20 , pp. 340-347
    • Dumaz, N.1
  • 23
    • 0032490853 scopus 로고    scopus 로고
    • WAF1 and bax expression: Implications for DNA repair, UV sensitivity and the induction of apoptosis
    • WAF1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis. Oncogene 17, 545-555 (1998).
    • (1998) Oncogene , vol.17 , pp. 545-555
    • McKay, B.C.1    Ljungman, M.2    Rainbow, A.J.3
  • 24
    • 0032482435 scopus 로고    scopus 로고
    • Photoproducts in transcriptionally active DNA induce signal transduction to delay U. V.-responsive genes for collagenase and metallothionein
    • Blattner, C., Bender, K., Herrlich, P. & Rahmsdorf, H. Photoproducts in transcriptionally active DNA induce signal transduction to delay U. V.-responsive genes for collagenase and metallothionein. Oncogene 16, 2827-2834 (1998).
    • (1998) Oncogene , vol.16 , pp. 2827-2834
    • Blattner, C.1    Bender, K.2    Herrlich, P.3    Rahmsdorf, H.4
  • 26
    • 0037123638 scopus 로고    scopus 로고
    • Premature aging in mice deficient in DNA repair and transcription
    • de Boer, J. et al. Premature aging in mice deficient in DNA repair and transcription. Science 296, 1276-1279 (2002).
    • (2002) Science , vol.296 , pp. 1276-1279
    • De Boer, J.1
  • 27
    • 0032085182 scopus 로고    scopus 로고
    • A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy
    • de Boer, J. et al. A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. Mol. Cell 1, 981-990 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 981-990
    • De Boer, J.1
  • 28
    • 0033565649 scopus 로고    scopus 로고
    • Mouse model for the DNA repair/basal transcription disorder trichotiodystrophy reveals cancer predisposition
    • de Boer, J. et al. Mouse model for the DNA repair/basal transcription disorder trichotiodystrophy reveals cancer predisposition. Cancer Res. 59, 3489-3494 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 3489-3494
    • De Boer, J.1
  • 29
    • 0034659755 scopus 로고    scopus 로고
    • Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression
    • Garssen, J. et al. Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression. J. Immunol. 164, 6199-6205 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 6199-6205
    • Garssen, J.1
  • 30
    • 0035921573 scopus 로고    scopus 로고
    • Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation
    • Ljungman, M., O'Hagan, H. M. & Paulsen, M. T. Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation. Oncogene 20, 5964-5971 (2001).
    • (2001) Oncogene , vol.20 , pp. 5964-5971
    • Ljungman, M.1    O'Hagan, H.M.2    Paulsen, M.T.3
  • 31
    • 0034993222 scopus 로고    scopus 로고
    • Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress
    • Klibanov, S. A., O'Hagan, H. M. & Ljungman, M. Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress. J. Cell Sci. 114, 1867-1873 (2001).
    • (2001) J. Cell Sci. , vol.114 , pp. 1867-1873
    • Klibanov, S.A.1    O'Hagan, H.M.2    Ljungman, M.3
  • 32
    • 1642481261 scopus 로고    scopus 로고
    • Phosphorylation and nuclear accumulation are distinct events contributing to the activation of p53
    • O'Hagan, H. M. & Ljungman, M. Phosphorylation and nuclear accumulation are distinct events contributing to the activation of p53. Mutat. Res. 546, 7-15 (2004).
    • (2004) Mutat. Res. , vol.546 , pp. 7-15
    • O'Hagan, H.M.1    Ljungman, M.2
  • 33
    • 0030612360 scopus 로고    scopus 로고
    • MDM2-arbiter of p53's destruction
    • Lane, D. P. & Hall, P. A. MDM2-arbiter of p53's destruction. Trends Biochem. Sci. 22, 372-374 (1997).
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 372-374
    • Lane, D.P.1    Hall, P.A.2
  • 34
    • 0031724593 scopus 로고    scopus 로고
    • Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
    • Freedman, D. A. & Levine, A. J. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 18, 7288-7293 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7288-7293
    • Freedman, D.A.1    Levine, A.J.2
  • 35
    • 0034282102 scopus 로고    scopus 로고
    • An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
    • Boyd, S. D., Tsai, K. Y. & Jacks, T. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nature Cell Biol. 2, 563-568 (2000).
    • (2000) Nature Cell Biol. , vol.2 , pp. 563-568
    • Boyd, S.D.1    Tsai, K.Y.2    Jacks, T.3
  • 36
    • 0034282220 scopus 로고    scopus 로고
    • The MDM2 RING-finger domain is required to promote p53 nuclear export
    • Geyer, R. K., Yu, Z. K. & Maki, C. G. The MDM2 RING-finger domain is required to promote p53 nuclear export. Nature Cell Biol. 2, 569-573 (2000).
    • (2000) Nature Cell Biol. , vol.2 , pp. 569-573
    • Geyer, R.K.1    Yu, Z.K.2    Maki, C.G.3
  • 37
    • 0035196861 scopus 로고    scopus 로고
    • Identification of p53 sequence elements that are required for MDM2-mediated nuclear export
    • Gu, J. J., Nie, L. H., Wiederschain, D. & Yuan, Z. M. Identification of p53 sequence elements that are required for MDM2-mediated nuclear export. Mol. Cell. Biol. 21, 8533-8546 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8533-8546
    • Gu, J.J.1    Nie, L.H.2    Wiederschain, D.3    Yuan, Z.M.4
  • 39
    • 0032939925 scopus 로고    scopus 로고
    • Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
    • Blattner, C., Sparks, A. & Lane, D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol. Cell. Biol. 19, 3704-3713 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3704-3713
    • Blattner, C.1    Sparks, A.2    Lane, D.3
  • 40
    • 0034003005 scopus 로고    scopus 로고
    • Stress signals utilize multiple pathways to stabilize p53
    • Ashcroft, M., Taya, Y. & Vousden, K. H. Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20, 3224-3233 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3224-3233
    • Ashcroft, M.1    Taya, Y.2    Vousden, K.H.3
  • 41
    • 0034682243 scopus 로고    scopus 로고
    • Proneness to UV-induced apoptosis in human fibroblasts defective in transcription coupled repair is associated with the lack of Mdm2 transactivation
    • Conforti, G., Nardo, T., D'Incalci, M. & Stefanini, M. Proneness to UV-induced apoptosis in human fibroblasts defective in transcription coupled repair is associated with the lack of Mdm2 transactivation. Oncogene 19, 2714-2720 (2000).
    • (2000) Oncogene , vol.19 , pp. 2714-2720
    • Conforti, G.1    Nardo, T.2    D'Incalci, M.3    Stefanini, M.4
  • 42
    • 0036044958 scopus 로고    scopus 로고
    • Inhibition of transcription results in accumulation of wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity
    • Blagosklonny, M., Demidenko, Z. & Fojo, T. Inhibition of transcription results in accumulation of wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity. Cell Cycle 1, 67-74 (2002).
    • (2002) Cell Cycle , vol.1 , pp. 67-74
    • Blagosklonny, M.1    Demidenko, Z.2    Fojo, T.3
  • 43
    • 3843086271 scopus 로고    scopus 로고
    • Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2
    • O'Hagan, H. M. & Ljungman, M. Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2. Oncogene 23, 5505-5512 (2004).
    • (2004) Oncogene , vol.23 , pp. 5505-5512
    • O'Hagan, H.M.1    Ljungman, M.2
  • 44
    • 0030666852 scopus 로고    scopus 로고
    • Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis
    • Koumenis, C. & Giaccia, A. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Mol. Cell. Biol. 17, 7306-7316 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7306-7316
    • Koumenis, C.1    Giaccia, A.2
  • 45
    • 0033554609 scopus 로고    scopus 로고
    • RNA synthesis block by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells
    • Poele, R. H. T., Dkorokov, A. L. & Joel, S. P. RNA synthesis block by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene 18, 5765-5772 (1999).
    • (1999) Oncogene , vol.18 , pp. 5765-5772
    • Poele, R.H.T.1    Dkorokov, A.L.2    Joel, S.P.3
  • 46
    • 0344011603 scopus 로고    scopus 로고
    • Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other streases
    • Rubbi, C. P. & Milner, J. Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other streases. EMBO J. 22, 6068-6077 (2003).
    • (2003) EMBO J. , vol.22 , pp. 6068-6077
    • Rubbi, C.P.1    Milner, J.2
  • 48
    • 0034915032 scopus 로고    scopus 로고
    • Control of p53 Ubiquitination and nuclear export by MDM2 and ARF
    • Zhang, Y. & Xiong, Y. Control of p53 Ubiquitination and nuclear export by MDM2 and ARF. Cell Growth Diff. 12, 175-186 (2001).
    • (2001) Cell Growth Diff. , vol.12 , pp. 175-186
    • Zhang, Y.1    Xiong, Y.2
  • 49
    • 0023735773 scopus 로고
    • Nucleolar changes after microinjection of antibodies to RNA polymerase I into the nucleus of mammalian cells
    • Benavente, R., Reimer, G., Rose, K. M., Hugle-Dorr, B. & Scheer, U. Nucleolar changes after microinjection of antibodies to RNA polymerase I into the nucleus of mammalian cells. Chromosoma 97, 115-123 (1988).
    • (1988) Chromosoma , vol.97 , pp. 115-123
    • Benavente, R.1    Reimer, G.2    Rose, K.M.3    Hugle-Dorr, B.4    Scheer, U.5
  • 50
    • 0030005052 scopus 로고    scopus 로고
    • Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains
    • Haaf, T. & Ward, D. C. Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains. Exp. Cell Res. 224, 163-173 (1996).
    • (1996) Exp. Cell Res. , vol.224 , pp. 163-173
    • Haaf, T.1    Ward, D.C.2
  • 51
    • 2942744364 scopus 로고    scopus 로고
    • Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs
    • O'Hagan, H. M. & Ljungman, M. Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs. Exp. Cell Res. 297, 548-559 (2004).
    • (2004) Exp. Cell Res. , vol.297 , pp. 548-559
    • O'Hagan, H.M.1    Ljungman, M.2
  • 52
    • 0033559256 scopus 로고    scopus 로고
    • A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
    • Stommel, J. M. et al. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18, 1660-1672 (1999).
    • (1999) EMBO J. , vol.18 , pp. 1660-1672
    • Stommel, J.M.1
  • 53
    • 0035827335 scopus 로고    scopus 로고
    • A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
    • Zhang, Y. P. & Xiong, Y. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science 292, 1910-1915 (2001).
    • (2001) Science , vol.292 , pp. 1910-1915
    • Zhang, Y.P.1    Xiong, Y.2
  • 54
    • 3042664521 scopus 로고    scopus 로고
    • Binding of RNA to p53 regulates its oligomerization and DNA-binding activity
    • Yoshida, Y. et al. Binding of RNA to p53 regulates its oligomerization and DNA-binding activity. Oncogene 23, 4371-4379 (2004).
    • (2004) Oncogene , vol.23 , pp. 4371-4379
    • Yoshida, Y.1
  • 55
    • 2342471907 scopus 로고    scopus 로고
    • Regulation of ultraviolet light-induced gene expression by gene size
    • McKay, B. C. et al. Regulation of ultraviolet light-induced gene expression by gene size. Proc. Natl Acad. Sci. USA 101, 6582-6586 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6582-6586
    • McKay, B.C.1
  • 56
    • 0037019177 scopus 로고    scopus 로고
    • Lack of functional pRb results in attenuated recovery of mRNA synthesis and increased apoptosis following UV radiation in human breast cancer cells
    • Billecke, C. A. et al. Lack of functional pRb results in attenuated recovery of mRNA synthesis and increased apoptosis following UV radiation in human breast cancer cells. Oncogene 21, 4481-4489 (2002).
    • (2002) Oncogene , vol.21 , pp. 4481-4489
    • Billecke, C.A.1
  • 57
    • 0033836606 scopus 로고    scopus 로고
    • The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis
    • McKay, B. C., Chen, F., Perumalswami, C. R., Zhang, F. F. & Ljungman, M. The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis. Mol. Biol. Cell 11, 2543-2551 (2000).
    • (2000) Mol. Biol. Cell , vol.11 , pp. 2543-2551
    • McKay, B.C.1    Chen, F.2    Perumalswami, C.R.3    Zhang, F.F.4    Ljungman, M.5
  • 58
    • 0033170538 scopus 로고    scopus 로고
    • Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet light
    • McKay, B. & Ljungman, M. Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet light. Neoplasia 1, 276-284 (1999).
    • (1999) Neoplasia , vol.1 , pp. 276-284
    • McKay, B.1    Ljungman, M.2
  • 59
    • 0142029128 scopus 로고    scopus 로고
    • Inhibition of p53, p21 and Bax by pifithrin-α does not affect UV induced apoptotic response in CS-B cells
    • Proietti De Santis, L. et al. Inhibition of p53, p21 and Bax by pifithrin-α does not affect UV induced apoptotic response in CS-B cells. DNA Repair 2, 891-900 (2003).
    • (2003) DNA Repair , vol.2 , pp. 891-900
    • Proietti De Santis, L.1
  • 60
    • 0036646113 scopus 로고    scopus 로고
    • UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53
    • Chouinard, N., Valerie, K., Rouabhia, M. & Huot, J. UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53. Biochem. J. 365, 133-145 (2002).
    • (2002) Biochem. J. , vol.365 , pp. 133-145
    • Chouinard, N.1    Valerie, K.2    Rouabhia, M.3    Huot, J.4
  • 61
    • 0036772564 scopus 로고    scopus 로고
    • Ultraviolet light-induced apoptosis is associated with S-phase in primary human fibroblasts
    • McKay, B., Beceml, C., Spronck, J. & Ljungman, M. Ultraviolet light-induced apoptosis is associated with S-phase in primary human fibroblasts. DNA Repair 1, 811-820 (2002).
    • (2002) DNA Repair , vol.1 , pp. 811-820
    • McKay, B.1    Beceml, C.2    Spronck, J.3    Ljungman, M.4
  • 62
    • 0036844340 scopus 로고    scopus 로고
    • Recombinational repair and restart of damaged replication forks
    • McGlynn, P. & Lloyd, R. G. Recombinational repair and restart of damaged replication forks. Nature Rev. Mol. Cell Biol. 3, 859-870 (2002).
    • (2002) Nature Rev. Mol. Cell Biol. , vol.3 , pp. 859-870
    • McGlynn, P.1    Lloyd, R.G.2
  • 63
    • 0032474904 scopus 로고    scopus 로고
    • p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage
    • Bissonnette, N. & Hunting, D. J. p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage. Oncogene 16, 3461-3469 (1998).
    • (1998) Oncogene , vol.16 , pp. 3461-3469
    • Bissonnette, N.1    Hunting, D.J.2
  • 64
    • 0037369235 scopus 로고    scopus 로고
    • Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis
    • Porter, L. A., Cukier, I. H. & Lee, J. M. Nuclear localization of cyclin B1 regulates DNA damage-induced apoptosis. Blood 101, 1928-1933 (2003).
    • (2003) Blood , vol.101 , pp. 1928-1933
    • Porter, L.A.1    Cukier, I.H.2    Lee, J.M.3
  • 65
    • 0032516880 scopus 로고    scopus 로고
    • Effects of nonbulky DNA base damages on Escherichia coli RNA polymerase-mediated elongation and promoter clearance
    • Viswanathan, A. & Doetsch, P. W. Effects of nonbulky DNA base damages on Escherichia coli RNA polymerase-mediated elongation and promoter clearance. J. Biol. Chem. 273, 21276-21281 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 21276-21281
    • Viswanathan, A.1    Doetsch, P.W.2
  • 66
    • 0035977062 scopus 로고    scopus 로고
    • Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II
    • Tornaletti, S., Maeda, L. S., Lloyd, D. R., Reines, D. & Hanawalt, P. C. Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II. J. Biol. Chem. 276, 45367-45371 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 45367-45371
    • Tornaletti, S.1    Maeda, L.S.2    Lloyd, D.R.3    Reines, D.4    Hanawalt, P.C.5
  • 67
    • 1842685197 scopus 로고    scopus 로고
    • Effect of 8-oxoguanine on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II
    • Tornaletti, S., Maeda, L. S., Kolodner, R. D. & Hanawalt, P. C. Effect of 8-oxoguanine on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II. DNA Repair (Amst) 3, 483-494 (2004).
    • (2004) DNA Repair (Amst) , vol.3 , pp. 483-494
    • Tornaletti, S.1    Maeda, L.S.2    Kolodner, R.D.3    Hanawalt, P.C.4
  • 68
    • 0034646516 scopus 로고    scopus 로고
    • Transcription-coupled repair of 8-oxoGuanine: Requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome
    • Le Page, F. et al. Transcription-coupled repair of 8-oxoGuanine: Requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome. Cell 101, 159-171 (2000).
    • (2000) Cell , vol.101 , pp. 159-171
    • Le Page, F.1
  • 69
    • 0041928171 scopus 로고    scopus 로고
    • Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates
    • Yanamadala, S. & Ljungman, M. Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates. Mol. Cancer Res. 1, 747-754 (2003).
    • (2003) Mol. Cancer Res. , vol.1 , pp. 747-754
    • Yanamadala, S.1    Ljungman, M.2
  • 70
    • 0029665878 scopus 로고    scopus 로고
    • 4-methylthymine, or the cisplatin-d(GpG) adduct
    • 4-methylthymine, or the cisplatin-d(GpG) adduct. Proc. Natl Acad. Sci. USA 93, 6443-6447 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 6443-6447
    • Duckett, D.R.1
  • 71
    • 0035161816 scopus 로고    scopus 로고
    • Functional interactions and signaling properties of mammalian DNA mismatch repair proteins
    • Bellacosa, A. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell Death Differ. 8, 1076-1092 (2001).
    • (2001) Cell Death Differ. , vol.8 , pp. 1076-1092
    • Bellacosa, A.1
  • 72
    • 0033607055 scopus 로고    scopus 로고
    • hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
    • Duckett, D. R., Bronstein, S. M., Taya, Y. & Modrich, P. hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage. Proc. Natl Acad. Sci. USA 96, 12384-12388 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12384-12388
    • Duckett, D.R.1    Bronstein, S.M.2    Taya, Y.3    Modrich, P.4
  • 73
    • 0032851842 scopus 로고    scopus 로고
    • Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
    • Hickman, M. J. & Samson, L. D. Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc. Natl Acad. Sci. USA 96, 10764-10769 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10764-10769
    • Hickman, M.J.1    Samson, L.D.2
  • 74
    • 0028106162 scopus 로고
    • Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template
    • Donahue, B. A., Yin, S., Taylor, J. S., Reines, D. & Hanawalt, P. C. Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template. Proc. Natl Acad. Sci. USA 91, 8502-8506 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8502-8506
    • Donahue, B.A.1    Yin, S.2    Taylor, J.S.3    Reines, D.4    Hanawalt, P.C.5
  • 75
    • 0033588105 scopus 로고    scopus 로고
    • Structural characterization of RNA polymerase II complexes arrested by a cyclobutane pyrimidine dimer in the transcribed strand of template DNA
    • Tornaletti, S., Reines, D. & Hanawalt, P. C. Structural characterization of RNA polymerase II complexes arrested by a cyclobutane pyrimidine dimer in the transcribed strand of template DNA. J. Biol. Chem. 274, 24124-24130 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 24124-24130
    • Tornaletti, S.1    Reines, D.2    Hanawalt, P.C.3
  • 76
    • 0018163396 scopus 로고
    • Gene and transcription mapping by radiation effects
    • Sauerbier, W. & Hercules, K. Gene and transcription mapping by radiation effects. Annu. Rev. Genet. 12, 329-363 (1978).
    • (1978) Annu. Rev. Genet. , vol.12 , pp. 329-363
    • Sauerbier, W.1    Hercules, K.2
  • 77
    • 0033032157 scopus 로고    scopus 로고
    • Recovery of RNA synthesis from the DHFR gene following UV-irradiation precedes the removal of photolesions from the transcribed strand
    • Ljungman, M. Recovery of RNA synthesis from the DHFR gene following UV-irradiation precedes the removal of photolesions from the transcribed strand. Carcinogenesis 20, 395-399 (1999).
    • (1999) Carcinogenesis , vol.20 , pp. 395-399
    • Ljungman, M.1
  • 78
    • 0023781396 scopus 로고
    • Differential repair of DNA damage in the human metallothionein gene family
    • Leadon, S. & Snowden, M. Differential repair of DNA damage in the human metallothionein gene family. Mol. Cell. Biol. 8, 5331-5338 (1988).
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 5331-5338
    • Leadon, S.1    Snowden, M.2
  • 79
    • 0037196071 scopus 로고    scopus 로고
    • Translesion synthesis by RNA polymerases: Occurrence and biological implications for transcriptional mutagenesis
    • Doetsch, P. W. Translesion synthesis by RNA polymerases: occurrence and biological implications for transcriptional mutagenesis. Mutat. Res. 510, 131-140 (2002).
    • (2002) Mutat. Res. , vol.510 , pp. 131-140
    • Doetsch, P.W.1
  • 80
    • 0027749417 scopus 로고
    • Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells
    • van Hoffen, A. et al. Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells. Nucleic Acids Res. 21, 5890-5895 (1993).
    • (1993) Nucleic Acids Res. , vol.21 , pp. 5890-5895
    • Van Hoffen, A.1
  • 81
    • 0027379353 scopus 로고
    • Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome
    • Leadon, S. A. & Cooper, P. K. Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome. Proc. Natl Acad. Sci. USA 90, 10499-10503 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10499-10503
    • Leadon, S.A.1    Cooper, P.K.2
  • 82
    • 0029887819 scopus 로고    scopus 로고
    • Transcription-coupled repair deficiency and mutations in human mismatch repair genes
    • Mellon, I., Rajpal, D. K., Koi, M., Boland, C. R. & Champe, G. N. Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science 272, 557-560 (1996).
    • (1996) Science , vol.272 , pp. 557-560
    • Mellon, I.1    Rajpal, D.K.2    Koi, M.3    Boland, C.R.4    Champe, G.N.5
  • 83
    • 0034634570 scopus 로고    scopus 로고
    • XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription
    • Nakatsu, Y. et al. XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. J. Biol. Chem. 275, 34931-34937 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 34931-34937
    • Nakatsu, Y.1
  • 84
    • 0033603440 scopus 로고    scopus 로고
    • BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair
    • Abbott, D. W. et al. BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair. J. Biol. Chem. 274, 18808-18812 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 18808-18812
    • Abbott, D.W.1
  • 85
    • 0034307185 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells
    • Le Page, F. et al. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. Cancer Res. 60, 5548-5552 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 5548-5552
    • Le Page, F.1
  • 86
    • 0036732039 scopus 로고    scopus 로고
    • Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells
    • Furuta, T. et al. Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells. Cancer Res. 62, 4899-4902 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4899-4902
    • Furuta, T.1
  • 87
    • 0034054019 scopus 로고    scopus 로고
    • Nucleotide excision repair and human syndromes
    • de Boer, J. & Hoeijmakers, J. H. J. Nucleotide excision repair and human syndromes. Carcinogenesis 21, 453-460 (2000).
    • (2000) Carcinogenesis , vol.21 , pp. 453-460
    • De Boer, J.1    Hoeijmakers, J.H.J.2
  • 88
    • 0035137181 scopus 로고    scopus 로고
    • Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice
    • Lu, Y. et al. Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice. Mol. Cell. Biol. 21, 1810-1818 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1810-1818
    • Lu, Y.1
  • 89
    • 17944374027 scopus 로고    scopus 로고
    • Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
    • Takebayashi, Y. et al. Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nature Med. 7, 961-966 (2001).
    • (2001) Nature Med. , vol.7 , pp. 961-966
    • Takebayashi, Y.1
  • 90
    • 0037027835 scopus 로고    scopus 로고
    • Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways
    • Jaspers, N. G. J. et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair 1, 1027-1038 (2002).
    • (2002) DNA Repair , vol.1 , pp. 1027-1038
    • Jaspers, N.G.J.1
  • 91
    • 0029947168 scopus 로고    scopus 로고
    • The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription
    • Ljungman, M. & Hanawalt, P. C. The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription. Carcinogenesis 17, 31-35 (1996).
    • (1996) Carcinogenesis , vol.17 , pp. 31-35
    • Ljungman, M.1    Hanawalt, P.C.2
  • 92
    • 0032570562 scopus 로고    scopus 로고
    • Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II - Implications for transcription-coupled DNA repair
    • Ratner, J. N., Balasubramanian, B., Corden, J., Warren, S. L. & Bregman, D. B. Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II - implications for transcription-coupled DNA repair. J. Biol. Chem. 273, 5184-5189 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 5184-5189
    • Ratner, J.N.1    Balasubramanian, B.2    Corden, J.3    Warren, S.L.4    Bregman, D.B.5
  • 93
    • 0029859295 scopus 로고    scopus 로고
    • UV-induced ubiquitination of RNA polymerase II: A novel modification deficient in cockayne syndrome cells
    • Bregman, D. B. et al. UV-induced ubiquitination of RNA polymerase II: A novel modification deficient in cockayne syndrome cells. Proc. Natl Acad. Sci. USA 93, 11586-11590 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11586-11590
    • Bregman, D.B.1
  • 94
    • 0035820074 scopus 로고    scopus 로고
    • UV light-induced degradation of RNA polymerase II is dependent on the Cockayne's syndrome A and B proteins but not p53 or MLH1
    • McKay, B. C. et al. UV light-induced degradation of RNA polymerase II is dependent on the Cockayne's syndrome A and B proteins but not p53 or MLH1. Mutat. Res. 485, 93-105 (2001).
    • (2001) Mutat. Res. , vol.485 , pp. 93-105
    • McKay, B.C.1
  • 95
    • 0037007036 scopus 로고    scopus 로고
    • Transcription-coupled and DNA damage dependent ubiquitination of RNA polymerase II in vitro
    • Lee, K. B., Wang, D., Lippard, S. J. & Sharp, P. A. Transcription-coupled and DNA damage dependent ubiquitination of RNA polymerase II in vitro. Proc. Natl Acad. Sci. USA 99, 4239-4244 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 4239-4244
    • Lee, K.B.1    Wang, D.2    Lippard, S.J.3    Sharp, P.A.4
  • 96
    • 0242311016 scopus 로고    scopus 로고
    • RNA polymerase II stalled on a DNA template during transcription elongation is ubiquitinated and the ubiquitination facilitates displacement of the elongation complex
    • Yang, L. Y., Jiang, H. & Rangel, K. M. RNA polymerase II stalled on a DNA template during transcription elongation is ubiquitinated and the ubiquitination facilitates displacement of the elongation complex. Int. J. Oncol. 22, 683-689 (2003).
    • (2003) Int. J. Oncol. , vol.22 , pp. 683-689
    • Yang, L.Y.1    Jiang, H.2    Rangel, K.M.3
  • 98
    • 0033607291 scopus 로고    scopus 로고
    • Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
    • Iwai, K. et al. Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc. Natl Acad. Sci. USA 96, 12436-12441 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12436-12441
    • Iwai, K.1
  • 99
    • 0344838401 scopus 로고    scopus 로고
    • Von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
    • Kuznetsova, A. V. et al. von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc. Natl Acad. Sci. USA 100, 2706-2711 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2706-2711
    • Kuznetsova, A.V.1
  • 100
    • 0034735902 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis
    • Schoenfeld, A. R. et al. The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis. Oncogene 19, 5851-5857 (2000).
    • (2000) Oncogene , vol.19 , pp. 5851-5857
    • Schoenfeld, A.R.1
  • 101
    • 0035807072 scopus 로고    scopus 로고
    • Ultraviolet radiation alters the phosphorylation of RNA polymerase II large subunit and accelerates its proteasome-dependent degradation
    • Luo, Z. H., Zheng, J. H., Lu, Y. & Bregman, D. B. Ultraviolet radiation alters the phosphorylation of RNA polymerase II large subunit and accelerates its proteasome-dependent degradation. Mutat. Res. 486, 259-274 (2001).
    • (2001) Mutat. Res. , vol.486 , pp. 259-274
    • Luo, Z.H.1    Zheng, J.H.2    Lu, Y.3    Bregman, D.B.4
  • 102
    • 0037509859 scopus 로고    scopus 로고
    • The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
    • Groisman, R. et al. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113, 357-367 (2003).
    • (2003) Cell , vol.113 , pp. 357-367
    • Groisman, R.1
  • 103
    • 0030965157 scopus 로고    scopus 로고
    • BRCA1 is a component of the RNA polymerase II holoenzyme
    • Scully, R. et al. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl Acad. Sci. USA 94, 5605-5610 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5605-5610
    • Scully, R.1
  • 104
    • 0036682183 scopus 로고    scopus 로고
    • The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme
    • Chiba, N. & Parvin, J. D. The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. Cancer Res. 62, 4222-4228 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4222-4228
    • Chiba, N.1    Parvin, J.D.2
  • 105
    • 0346732323 scopus 로고    scopus 로고
    • BRCA1 associates with processive RNA polymerase II
    • Krum, S. A., Miranda, G. A., Lin, C. & Lane, T. F. BRCA1 associates with processive RNA polymerase II. J. Biol. Cnem. 278, 52012-52020 (2003).
    • (2003) J. Biol. Cnem. , vol.278 , pp. 52012-52020
    • Krum, S.A.1    Miranda, G.A.2    Lin, C.3    Lane, T.F.4
  • 106
    • 0034283878 scopus 로고    scopus 로고
    • Linking DNA damage and neurodegeneration
    • Rolig, R. L. & McKinnon, P. J. Linking DNA damage and neurodegeneration. Trends Neurosci. 23, 417-424 (2000).
    • (2000) Trends Neurosci. , vol.23 , pp. 417-424
    • Rolig, R.L.1    McKinnon, P.J.2
  • 107
    • 0037470542 scopus 로고    scopus 로고
    • Aging and genome maintenance: Lessons from the mouse?
    • Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H. & Vijg, J. Aging and genome maintenance: lessons from the mouse? Science 299, 1355-1359 (2003).
    • (2003) Science , vol.299 , pp. 1355-1359
    • Hasty, P.1    Campisi, J.2    Hoeijmakers, J.3    Van Steeg, H.4    Vijg, J.5
  • 108
    • 0032803070 scopus 로고    scopus 로고
    • The Werner syndrome protein is involved in RNA polymerase II transcription
    • Balajee, A. S. et al. The Werner syndrome protein is involved in RNA polymerase II transcription. Mol. Biol. Cell 10, 2655-2668 (1999).
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2655-2668
    • Balajee, A.S.1
  • 109
    • 0033579343 scopus 로고    scopus 로고
    • Requirement of yeast SGS1 and SRS2 genes for replication and transcription
    • Lee, S. K., Johnson, R. E., Yu, S. L., Prakash, L. & Prakash, S. Requirement of yeast SGS1 and SRS2 genes for replication and transcription. Science 286, 2339-2342 (1999).
    • (1999) Science , vol.286 , pp. 2339-2342
    • Lee, S.K.1    Johnson, R.E.2    Yu, S.L.3    Prakash, L.4    Prakash, S.5
  • 110
    • 0035034884 scopus 로고    scopus 로고
    • Premature aging and predisposition to cancers caused by mutations in RecQ family helicases
    • Furuichi, Y. Premature aging and predisposition to cancers caused by mutations in RecQ family helicases. Ann. NY Acad. Sci. 928, 121-131 (2001).
    • (2001) Ann. N.Y. Acad. Sci. , vol.928 , pp. 121-131
    • Furuichi, Y.1
  • 111
    • 0037673950 scopus 로고    scopus 로고
    • Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
    • Eriksson, M. et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423, 293-298 (2003).
    • (2003) Nature , vol.423 , pp. 293-298
    • Eriksson, M.1
  • 112
    • 0037673940 scopus 로고    scopus 로고
    • A progeroid syndrome in mice is caused by defects in A-type lamins
    • Mounkes, L. C., Kozlov, S., Hernandez, L., Sullivan, T. & Stewart, C. L. A progeroid syndrome in mice is caused by defects in A-type lamins. Nature 423, 298-301 (2003).
    • (2003) Nature , vol.423 , pp. 298-301
    • Mounkes, L.C.1    Kozlov, S.2    Hernandez, L.3    Sullivan, T.4    Stewart, C.L.5
  • 113
    • 0037128211 scopus 로고    scopus 로고
    • Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription
    • Spann, T. P., Goldman, A. E., Wang, C., Huang, S. & Goldman, R. D. Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J. Cell Biol. 156, 603-608 (2002).
    • (2002) J. Cell Biol. , vol.156 , pp. 603-608
    • Spann, T.P.1    Goldman, A.E.2    Wang, C.3    Huang, S.4    Goldman, R.D.5
  • 114
    • 0037049554 scopus 로고    scopus 로고
    • Lamin A/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription
    • Kumaran, R. I., Muralikrishna, B. & Parnaik, V. K. Lamin A/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription. J. Cell Biol. 159, 783-793 (2002).
    • (2002) J. Cell Biol. , vol.159 , pp. 783-793
    • Kumaran, R.I.1    Muralikrishna, B.2    Parnaik, V.K.3
  • 116
    • 0035805545 scopus 로고    scopus 로고
    • Distinct roles for Ku protein in transcriptional reinitiation and DNA repair
    • Woodard, R. L., Lee, K. J., Huang, J. & Dynan, W. S. Distinct roles for Ku protein in transcriptional reinitiation and DNA repair. J. Biol. Chem. 276, 15423-15433 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 15423-15433
    • Woodard, R.L.1    Lee, K.J.2    Huang, J.3    Dynan, W.S.4
  • 117
    • 0036839642 scopus 로고    scopus 로고
    • Subnuclear localization of Ku protein: Functional association with RNA polymerase II elongation sites
    • Mo, X. M. & Dynan, W. S. Subnuclear localization of Ku protein: Functional association with RNA polymerase II elongation sites. Mol. Cell. Biol. 22, 8088-8099 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8088-8099
    • Mo, X.M.1    Dynan, W.S.2
  • 118
    • 0037413699 scopus 로고    scopus 로고
    • Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription
    • Bertinato, J., Tomlinson, J. J., Schild-Poulter, C. & Hache, R. J. G. Evidence implicating Ku antigen as a structural factor in RNA polymerase II-mediated transcription. Gene 302, 53-64 (2003).
    • (2003) Gene , vol.302 , pp. 53-64
    • Bertinato, J.1    Tomlinson, J.J.2    Schild-Poulter, C.3    Hache, R.J.G.4
  • 119
    • 0342547005 scopus 로고    scopus 로고
    • Effects of transcription and translation inhibitors on a human gastric carcinoma cell line- Potential role of Bcl-X-s in apoptosis triggered by these inhibitors
    • Chang, T. C. et al. Effects of transcription and translation inhibitors on a human gastric carcinoma cell line- Potential role of Bcl-X-s in apoptosis triggered by these inhibitors. Biochem. Pharmacol. 53, 969-977 (1997).
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 969-977
    • Chang, T.C.1
  • 120
    • 0033059183 scopus 로고    scopus 로고
    • Dose-dependent effects of DNA-damaging agents on p53-mediated cell cycle arrest
    • Chang, D., Chen, F., Zhang, F. F., McKay, B. C. & Ljungman, M. Dose-dependent effects of DNA-damaging agents on p53-mediated cell cycle arrest. Cell Growth Differ. 10, 155-162 (1999).
    • (1999) Cell Growth Differ. , vol.10 , pp. 155-162
    • Chang, D.1    Chen, F.2    Zhang, F.F.3    McKay, B.C.4    Ljungman, M.5
  • 121
    • 0035200324 scopus 로고    scopus 로고
    • Transcriptional consequences of topoisomerase inhibition
    • Collins, I., Weber, A. & Levens, D. Transcriptional consequences of topoisomerase inhibition. Mol. Cell. Biol. 21, 8437-8451 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8437-8451
    • Collins, I.1    Weber, A.2    Levens, D.3
  • 122
    • 0027173884 scopus 로고
    • Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA
    • Squires, S., Ryan, A. J., Strutt, H. L. & Johnson, R. T. Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA. Cancer Res. 53, 2012-2019 (1993).
    • (1993) Cancer Res. , vol.53 , pp. 2012-2019
    • Squires, S.1    Ryan, A.J.2    Strutt, H.L.3    Johnson, R.T.4
  • 123
    • 0028657658 scopus 로고
    • Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells
    • Geoffroy, F. J., Allegra, C. J., Sinha, B. & Grem, J. L. Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells. Oncol. Res. 6, 581-591 (1994).
    • (1994) Oncol. Res. , vol.6 , pp. 581-591
    • Geoffroy, F.J.1    Allegra, C.J.2    Sinha, B.3    Grem, J.L.4
  • 124
    • 12644291915 scopus 로고    scopus 로고
    • Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation
    • Pritchard, D. M., Watson, A. J. M., Potten, C. S., Jackman, A. L. & Hickman, J. A. Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: Evidence for the involvement of RNA perturbation. Proc. Natl Acad. Sci. USA 94, 1795-1799 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1795-1799
    • Pritchard, D.M.1    Watson, A.J.M.2    Potten, C.S.3    Jackman, A.L.4    Hickman, J.A.5
  • 125
    • 0033902940 scopus 로고    scopus 로고
    • Inhibition of RNA transcription: A biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine
    • Huang, P., Sandoval, A., Van Den Neste, E., Keating, M. J. & Plunkett, W. Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine. Leukemia 14, 1405-1413 (2000).
    • (2000) Leukemia , vol.14 , pp. 1405-1413
    • Huang, P.1    Sandoval, A.2    Van Den Neste, E.3    Keating, M.J.4    Plunkett, W.5
  • 126
    • 0037058678 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)
    • McClue, S. J. et al. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). Int. J. Cancer 102, 463-468 (2002).
    • (2002) Int. J. Cancer , vol.102 , pp. 463-468
    • McClue, S.J.1
  • 127
    • 0041324624 scopus 로고    scopus 로고
    • Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms
    • Senderowicz, A. M. Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms. Cancer Chemother. Pharmacol. 52, 61-73 (2003).
    • (2003) Cancer Chemother. Pharmacol. , vol.52 , pp. 61-73
    • Senderowicz, A.M.1
  • 128
    • 0034812298 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382
    • Ljungman, M. & Paulsen, M. T. The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382. Mol. Pharm. 60, 785-789 (2001).
    • (2001) Mol. Pharm. , vol.60 , pp. 785-789
    • Ljungman, M.1    Paulsen, M.T.2
  • 129
    • 0002557555 scopus 로고    scopus 로고
    • Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
    • Lam, L. T. et al. Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biol. 2, 1-11 (2001).
    • (2001) Genome Biol. , vol.2 , pp. 1-11
    • Lam, L.T.1
  • 130
    • 0036850211 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1
    • Gojo, I., Zhang, B. & Fenton, R. G. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin. Cancer Res. 8, 3527-3538 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3527-3538
    • Gojo, I.1    Zhang, B.2    Fenton, R.G.3
  • 132
    • 0034632675 scopus 로고    scopus 로고
    • Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways
    • Blaydes, J. P. et al. Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways. Oncogene 19, 3829-3839 (2000).
    • (2000) Oncogene , vol.19 , pp. 3829-3839
    • Blaydes, J.P.1
  • 133
    • 0038519961 scopus 로고    scopus 로고
    • Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo
    • Maggiorella, L. et al. Enhancement of radiation response by roscovitine in human breast carcinoma in vitro and in vivo. Cancer Res. 63, 2513-2517 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2513-2517
    • Maggiorella, L.1
  • 134
    • 0037726822 scopus 로고    scopus 로고
    • Improving cancer therapy by nongenotoxic activation of p53
    • Lain, S. & Lane, D. Improving cancer therapy by nongenotoxic activation of p53. Eur. J. Cancer 39, 1053-1060 (2003).
    • (2003) Eur. J. Cancer , vol.39 , pp. 1053-1060
    • Lain, S.1    Lane, D.2
  • 135
    • 0043025622 scopus 로고    scopus 로고
    • Exploiting the p53 pathway for cancer diagnosis and therapy
    • Woods, Y. L. & Lane, D. P. Exploiting the p53 pathway for cancer diagnosis and therapy. Hematol. J. 4, 233-247 (2003).
    • (2003) Hematol. J. , vol.4 , pp. 233-247
    • Woods, Y.L.1    Lane, D.P.2
  • 136
    • 0343938848 scopus 로고    scopus 로고
    • Accumulating active p53 in the nucleus by inhibition of nuclear export: A novel strategy to promote the p53 tumor suppressor function
    • Lain, S., Xirodimas, D. & Lane, D. P. Accumulating active p53 in the nucleus by inhibition of nuclear export: A novel strategy to promote the p53 tumor suppressor function. Exp. Cell Res. 253, 315-324 (1999).
    • (1999) Exp. Cell Res. , vol.253 , pp. 315-324
    • Lain, S.1    Xirodimas, D.2    Lane, D.P.3
  • 137
    • 0032813181 scopus 로고    scopus 로고
    • Exploiting the p53 pathway for cancer diagnosis and therapy
    • Lane, D. P. Exploiting the p53 pathway for cancer diagnosis and therapy. Br. J. Cancer 80, 1-5 (1999).
    • (1999) Br. J. Cancer , vol.80 , pp. 1-5
    • Lane, D.P.1
  • 138
    • 0036219608 scopus 로고    scopus 로고
    • Therapeutic exploitation of the p53 pathway
    • Lane, D. P. & Lain, S. Therapeutic exploitation of the p53 pathway. Trends Mol. Med. 8, S38-S42 (2002).
    • (2002) Trends Mol. Med. , vol.8
    • Lane, D.P.1    Lain, S.2
  • 139
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003).
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 140
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R. T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 141
    • 2942572923 scopus 로고    scopus 로고
    • The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells
    • Brumbaugh, K. M. et al. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol. Cell 14, 585-598 (2004).
    • (2004) Mol. Cell , vol.14 , pp. 585-598
    • Brumbaugh, K.M.1
  • 142
    • 0037169354 scopus 로고    scopus 로고
    • Cancer susceptibility and the functions of BRCA1 and BRCA2
    • Venkitaraman, A. R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108, 171-182 (2002).
    • (2002) Cell , vol.108 , pp. 171-182
    • Venkitaraman, A.R.1
  • 143
    • 0035032649 scopus 로고    scopus 로고
    • Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
    • Xu, B., Kim, S. T. & Kastan, M. B. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21, 3445-3450 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3445-3450
    • Xu, B.1    Kim, S.T.2    Kastan, M.B.3
  • 144
    • 0033637170 scopus 로고    scopus 로고
    • Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
    • Tibbetts, R. S. et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14, 2989-3002 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2989-3002
    • Tibbetts, R.S.1
  • 145
    • 0035907395 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
    • Gatei, M. et al. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J. Biol. Chem. 276, 17276-17280 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 17276-17280
    • Gatei, M.1
  • 146
    • 0033865957 scopus 로고    scopus 로고
    • Roles of BRCA1 and its interacting proteins
    • Deng, C. X. & Brodie, S. G. Roles of BRCA1 and its interacting proteins. Bioessays 22, 728-737 2000).
    • (2000) Bioessays , vol.22 , pp. 728-737
    • Deng, C.X.1    Brodie, S.G.2
  • 147
    • 0034707053 scopus 로고    scopus 로고
    • In search of the tumour-suppressor functions of BRCA1 and BRCA2
    • Scully, R. & Livingston, D. M. In search of the tumour-suppressor functions of BRCA1 and BRCA2. Nature 408, 429-432 (2000).
    • (2000) Nature , vol.408 , pp. 429-432
    • Scully, R.1    Livingston, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.