메뉴 건너뛰기




Volumn 19, Issue 6, 2018, Pages

Natural products for drug discovery in the 21st century: Innovations for novel drug discovery

Author keywords

Automation; Bioinformatics; Computational softwares; Drug design and development; Global health; Innovation; Natural products; Omics; Precisionmedicine

Indexed keywords

BIOLOGICAL MARKER; NATURAL PRODUCT; PLANT EXTRACT; BIOLOGICAL PRODUCT;

EID: 85047725344     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms19061578     Document Type: Review
Times cited : (840)

References (307)
  • 1
    • 84862996527 scopus 로고    scopus 로고
    • The rise of chemodiversity in plants
    • Weng, J.K.; Philippe, R.N.; Noel, J.P. The rise of chemodiversity in plants. Science 2012, 336, 1667-1670.
    • (2012) Science , vol.336 , pp. 1667-1670
    • Weng, J.K.1    Philippe, R.N.2    Noel, J.P.3
  • 2
    • 0026551822 scopus 로고
    • Medicinal plants in a Middle Paleolithic grave Shanidar IV?
    • Lietava, J. Medicinal plants in a Middle Paleolithic grave Shanidar IV? J. Ethnopharmacol. 1992, 35, 263-266.
    • (1992) J. Ethnopharmacol. , vol.35 , pp. 263-266
    • Lietava, J.1
  • 4
    • 84916633156 scopus 로고    scopus 로고
    • An ancient plant Lawsonia inermis (henna): Determination of in vitro antifungal activity against dermatophytes species
    • Gozubuyuk, G.S.; Aktas, E.; Yigit, N. An ancient plant Lawsonia inermis (henna): Determination of in vitro antifungal activity against dermatophytes species. J. Mycol. Med. 2014, 24, 313-318.
    • (2014) J. Mycol. Med. , vol.24 , pp. 313-318
    • Gozubuyuk, G.S.1    Aktas, E.2    Yigit, N.3
  • 6
    • 78751471119 scopus 로고    scopus 로고
    • Traditional Chinese medicine for treatment of alcoholism: From ancient to modern
    • Liu, Q.; Lawrence, A.J.; Liang, J.H. Traditional Chinese medicine for treatment of alcoholism: From ancient to modern. Am. J. Chin. Med. 2011, 39, 1-13.
    • (2011) Am. J. Chin. Med. , vol.39 , pp. 1-13
    • Liu, Q.1    Lawrence, A.J.2    Liang, J.H.3
  • 7
    • 85041573899 scopus 로고    scopus 로고
    • Indian herbs for the treatment of neurodegenerative disease
    • Mannangatti, P.; Naidu, K.N. Indian herbs for the treatment of neurodegenerative disease. Adv. Neurobiol. 2016, 12, 323-336.
    • (2016) Adv. Neurobiol. , vol.12 , pp. 323-336
    • Mannangatti, P.1    Naidu, K.N.2
  • 10
    • 52049109838 scopus 로고    scopus 로고
    • Natural products in drug discovery
    • Harvey, A.L. Natural products in drug discovery. Drug Discov. Today 2008, 13, 894-901.
    • (2008) Drug Discov. Today , vol.13 , pp. 894-901
    • Harvey, A.L.1
  • 12
    • 84926205808 scopus 로고    scopus 로고
    • The re-emergence of natural products for drug discovery in the genomics era
    • Harvey, A.L.; Edrada-Ebel, R.; Quinn, R.J. The re-emergence of natural products for drug discovery in the genomics era. Nat. Rev. Drug Discov. 2015, 14, 111-129.
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 111-129
    • Harvey, A.L.1    Edrada-Ebel, R.2    Quinn, R.J.3
  • 13
    • 84973460564 scopus 로고    scopus 로고
    • Advances in identification and validation of protein targets of natural products without chemical modification
    • Chang, J.; Kim, Y.; Kwon, H.J. Advances in identification and validation of protein targets of natural products without chemical modification. Nat. Prod. Rep. 2016, 33, 719-730.
    • (2016) Nat. Prod. Rep. , vol.33 , pp. 719-730
    • Chang, J.1    Kim, Y.2    Kwon, H.J.3
  • 14
    • 84969134757 scopus 로고    scopus 로고
    • Comparison of leiomyoma of modern medicine and traditional Persian medicine
    • Tansaz, M.; Tajadini, H. Comparison of leiomyoma of modern medicine and traditional Persian medicine. J. Evid.-Based Complement. Altern. Med. 2016, 21, 160-163.
    • (2016) J. Evid.-Based Complement. Altern. Med. , vol.21 , pp. 160-163
    • Tansaz, M.1    Tajadini, H.2
  • 16
    • 84973868065 scopus 로고    scopus 로고
    • The traditional medicine and modern medicine from natural products
    • Yuan, H.; Ma, Q.; Ye, L.; Piao, G. The traditional medicine and modern medicine from natural products. Molecules 2016, 21, 559.
    • (2016) Molecules , vol.21 , pp. 559
    • Yuan, H.1    Ma, Q.2    Ye, L.3    Piao, G.4
  • 19
    • 84964678029 scopus 로고    scopus 로고
    • Inhibition of cyp2b6 by medicinal plant extracts: Implication for use of efavirenz and nevirapine-based highly active anti-retroviral therapy (HAART) in resource-limited settings
    • Thomford, N.E.; Awortwe, C.; Dzobo, K.; Adu, F.; Chopera, D.; Wonkam, A.; Skelton, M.; Blackhurst, D.; Dandara, C. Inhibition of cyp2b6 by medicinal plant extracts: Implication for use of efavirenz and nevirapine-based highly active anti-retroviral therapy (HAART) in resource-limited settings. Molecules 2016, 21, 211.
    • (2016) Molecules , vol.21 , pp. 211
    • Thomford, N.E.1    Awortwe, C.2    Dzobo, K.3    Adu, F.4    Chopera, D.5    Wonkam, A.6    Skelton, M.7    Blackhurst, D.8    Dandara, C.9
  • 20
    • 84979498494 scopus 로고    scopus 로고
    • In vitro reversible and time-dependent cyp450 inhibition profiles of medicinal herbal plant extracts Newbouldia laevis and Cassia abbreviata: Implications for herb-drug interactions
    • Thomford, N.E.; Dzobo, K.; Chopera, D.; Wonkam, A.; Maroyi, A.; Blackhurst, D.; Dandara, C. In vitro reversible and time-dependent cyp450 inhibition profiles of medicinal herbal plant extracts Newbouldia laevis and Cassia abbreviata: Implications for herb-drug interactions. Molecules 2016, 21, 891.
    • (2016) Molecules , vol.21 , pp. 891
    • Thomford, N.E.1    Dzobo, K.2    Chopera, D.3    Wonkam, A.4    Maroyi, A.5    Blackhurst, D.6    Dandara, C.7
  • 22
    • 84987851371 scopus 로고    scopus 로고
    • African lettuce (Launaea taraxacifolia) displays possible anticancer effects and herb-drug interaction potential by CYP1A2, CYP2C9, and CYP2C19 inhibition
    • Thomford, N.E.; Mkhize, B.; Dzobo, K.; Mpye, K.; Rowe, A.; Parker, M.I.; Wonkam, A.; Skelton, M.; September, A.V.; Dandara, C. African lettuce (Launaea taraxacifolia) displays possible anticancer effects and herb-drug interaction potential by CYP1A2, CYP2C9, and CYP2C19 inhibition. Omics 2016, 20, 528-537.
    • (2016) Omics , vol.20 , pp. 528-537
    • Thomford, N.E.1    Mkhize, B.2    Dzobo, K.3    Mpye, K.4    Rowe, A.5    Parker, M.I.6    Wonkam, A.7    Skelton, M.8    September, A.V.9    Dandara, C.10
  • 23
    • 85035235153 scopus 로고    scopus 로고
    • Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria
    • Ji, S.; Fattahi, A.; Raffel, N.; Hoffmann, I.; Beckmann, M.W.; Dittrich, R.; Schrauder, M. Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria. Eur. J. Med. Res. 2017, 22, 50.
    • (2017) Eur. J. Med. Res. , vol.22 , pp. 50
    • Ji, S.1    Fattahi, A.2    Raffel, N.3    Hoffmann, I.4    Beckmann, M.W.5    Dittrich, R.6    Schrauder, M.7
  • 24
    • 85034084923 scopus 로고    scopus 로고
    • Authentication of eleutherococcus and rhodiola herbal supplement products in the United Kingdom
    • Ruhsam, M.; Hollingsworth, P.M. Authentication of eleutherococcus and rhodiola herbal supplement products in the United Kingdom. J. Pharm. Biomed. Anal. 2017, 149, 403-409.
    • (2017) J. Pharm. Biomed. Anal. , vol.149 , pp. 403-409
    • Ruhsam, M.1    Hollingsworth, P.M.2
  • 25
    • 84922106952 scopus 로고    scopus 로고
    • An analysis of FDA-approved drugs: Natural products and their derivatives
    • Patridge, E.; Gareiss, P.; Kinch, M.S.; Hoyer, D. An analysis of FDA-approved drugs: Natural products and their derivatives. Drug Discov. Today 2016, 21, 204-207.
    • (2016) Drug Discov. Today , vol.21 , pp. 204-207
    • Patridge, E.1    Gareiss, P.2    Kinch, M.S.3    Hoyer, D.4
  • 26
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani, M.C.; Taylor, H.L.; Wall, M.E.; Coggon, P.; McPhail, A.T. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc. 1971, 93, 2325-2327.
    • (1971) J. Am. Chem. Soc. , vol.93 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5
  • 27
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012, 75, 311-335.
    • (2012) J. Nat. Prod. , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 28
    • 80055018013 scopus 로고    scopus 로고
    • Natural products and Pharma 2011: Strategic changes spur new opportunities
    • Carter, G.T. Natural products and Pharma 2011: Strategic changes spur new opportunities. Nat. Prod. Rep. 2011, 28, 1783-1789.
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 1783-1789
    • Carter, G.T.1
  • 29
    • 67650436176 scopus 로고    scopus 로고
    • Drug discovery and natural products: End of an era or an endless frontier?
    • Li, J.W.; Vederas, J.C. Drug discovery and natural products: End of an era or an endless frontier? Science 2009, 325, 161-165.
    • (2009) Science , vol.325 , pp. 161-165
    • Li, J.W.1    Vederas, J.C.2
  • 30
    • 85026659438 scopus 로고    scopus 로고
    • Demystifying traditional herbal medicine with modern approach
    • Li, F.S.; Weng, J.K. Demystifying traditional herbal medicine with modern approach. Nat. Plants 2017, 3, 17109.
    • (2017) Nat. Plants , vol.3 , pp. 17109
    • Li, F.S.1    Weng, J.K.2
  • 31
    • 14744297337 scopus 로고    scopus 로고
    • Combination effects of herbs in a multi-herbal formula: Expression of juzen-taiho-to’s immuno-modulatory activity on the intestinal immune system
    • Kiyohara, H.; Matsumoto, T.; Yamada, H. Combination effects of herbs in a multi-herbal formula: Expression of juzen-taiho-to’s immuno-modulatory activity on the intestinal immune system. Evid.-Based Complement. Altern. Med. 2004, 1, 83-91.
    • (2004) Evid.-Based Complement. Altern. Med. , vol.1 , pp. 83-91
    • Kiyohara, H.1    Matsumoto, T.2    Yamada, H.3
  • 32
    • 85011675537 scopus 로고    scopus 로고
    • Traditional Mediterranean and European herbal medicines
    • Leonti, M.; Verpoorte, R. Traditional Mediterranean and European herbal medicines. J. Ethnopharmacol. 2017, 199, 161-167.
    • (2017) J. Ethnopharmacol. , vol.199 , pp. 161-167
    • Leonti, M.1    Verpoorte, R.2
  • 33
    • 85045445268 scopus 로고    scopus 로고
    • Birth of industry 5.0: Making sense of big data with artificial intelligence, “the internet of things” and next-generation technology policy
    • Ozdemir, V.; Hekim, N. Birth of industry 5.0: Making sense of big data with artificial intelligence, “the internet of things” and next-generation technology policy. Omics 2018, 22, 65-76.
    • (2018) Omics , vol.22 , pp. 65-76
    • Ozdemir, V.1    Hekim, N.2
  • 34
    • 84945278925 scopus 로고    scopus 로고
    • Omics 2.0: An accelerator for global science, systems medicine and responsible innovation
    • Özdemir, V. Omics 2.0: An accelerator for global science, systems medicine and responsible innovation. Omics 2015, 19, 579-580.
    • (2015) Omics , vol.19 , pp. 579-580
    • Özdemir, V.1
  • 36
    • 0037102427 scopus 로고    scopus 로고
    • High-throughput method for the production and analysis of large natural product libraries for drug discovery
    • Eldridge, G.R.; Vervoort, H.C.; Lee, C.M.; Cremin, P.A.; Williams, C.T.; Hart, S.M.; Goering, M.G.; O’Neil-Johnson, M.; Zeng, L. High-throughput method for the production and analysis of large natural product libraries for drug discovery. Anal. Chem. 2002, 74, 3963-3971.
    • (2002) Anal. Chem. , vol.74 , pp. 3963-3971
    • Eldridge, G.R.1    Vervoort, H.C.2    Lee, C.M.3    Cremin, P.A.4    Williams, C.T.5    Hart, S.M.6    Goering, M.G.7    Zeng, L.8
  • 37
    • 79951647147 scopus 로고    scopus 로고
    • Counter-current chromatography for high throughput analysis of natural products
    • Wu, S.; Liang, J. Counter-current chromatography for high throughput analysis of natural products. Comb. Chem. High Throughput Screen. 2010, 13, 932-942.
    • (2010) Comb. Chem. High Throughput Screen. , vol.13 , pp. 932-942
    • Wu, S.1    Liang, J.2
  • 38
    • 46749152580 scopus 로고    scopus 로고
    • Marine natural product libraries for high-throughput screening and rapid drug discovery
    • Bugni, T.S.; Richards, B.; Bhoite, L.; Cimbora, D.; Harper, M.K.; Ireland, C.M. Marine natural product libraries for high-throughput screening and rapid drug discovery. J. Nat. Prod. 2008, 71, 1095-1098.
    • (2008) J. Nat. Prod. , vol.71 , pp. 1095-1098
    • Bugni, T.S.1    Richards, B.2    Bhoite, L.3    Cimbora, D.4    Harper, M.K.5    Ireland, C.M.6
  • 39
    • 38449122425 scopus 로고    scopus 로고
    • High impact technologies for natural products screening
    • Birkhäuser: Basel, Switzerland
    • Koehn, F.E. High impact technologies for natural products screening. In Natural Compounds as Drugs Volume I; Birkhäuser: Basel, Switzerland, 2008; Volume 65, pp. 175-210.
    • (2008) Natural Compounds as Drugs Volume I , vol.65 , pp. 175-210
    • Koehn, F.E.1
  • 40
    • 84870043139 scopus 로고    scopus 로고
    • Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics
    • Wong, W.R.; Oliver, A.G.; Linington, R.G. Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics. Chem. Biol. 2012, 19, 1483-1495.
    • (2012) Chem. Biol. , vol.19 , pp. 1483-1495
    • Wong, W.R.1    Oliver, A.G.2    Linington, R.G.3
  • 41
    • 85014697871 scopus 로고    scopus 로고
    • Semi-bionic extraction of effective ingredient from fishbone by high intensity pulsed electric fields
    • He, G.; Yin, Y.; Yan, X.;Wang, Y. Semi-bionic extraction of effective ingredient from fishbone by high intensity pulsed electric fields. J. Food Process Eng. 2017, 40, e12392.
    • (2017) J. Food Process Eng. , vol.40 , pp. 12392
    • He, G.1    Yin, Y.2    Yan, X.3    Wang, Y.4
  • 42
    • 85042657968 scopus 로고    scopus 로고
    • Development of an analytical method for polycyclic aromatic hydrocarbons in coffee beverages and dark beer using novel high-sensitivity technique of supercritical fluid chromatography/mass spectrometry
    • Yoshioka, T.; Nagatomi, Y.; Harayama, K.; Bamba, T. Development of an analytical method for polycyclic aromatic hydrocarbons in coffee beverages and dark beer using novel high-sensitivity technique of supercritical fluid chromatography/mass spectrometry. J. Biosci. Bioeng. 2018.
    • (2018) J. Biosci. Bioeng.
    • Yoshioka, T.1    Nagatomi, Y.2    Harayama, K.3    Bamba, T.4
  • 43
    • 85041281259 scopus 로고    scopus 로고
    • Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on-line SFE-SFC-MS)
    • Hofstetter, R.; Fassauer, G.M.; Link, A. Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on-line SFE-SFC-MS). J. Chromatogr. B 2018, 1076, 77-83.
    • (2018) J. Chromatogr. B , vol.1076 , pp. 77-83
    • Hofstetter, R.1    Fassauer, G.M.2    Link, A.3
  • 44
    • 85041811904 scopus 로고    scopus 로고
    • Extraction of bioactive compounds against cardiovascular diseases from Lentinula edodes using a sequential extraction method
    • Morales, D.; Piris, A.J.; Ruiz-Rodriguez, A.; Prodanov, M.; Soler-Rivas, C. Extraction of bioactive compounds against cardiovascular diseases from Lentinula edodes using a sequential extraction method. Biotechnol. Prog. 2018.
    • (2018) Biotechnol. Prog.
    • Morales, D.1    Piris, A.J.2    Ruiz-Rodriguez, A.3    Prodanov, M.4    Soler-Rivas, C.5
  • 47
    • 84953253618 scopus 로고    scopus 로고
    • Separation and preparation of 6-gingerol from molecular distillation residue of Yunnan ginger rhizomes by high-speed counter-current chromatography and the antioxidant activity of ginger oils in vitro
    • Gan, Z.; Liang, Z.; Chen, X.;Wen, X.;Wang, Y.; Li, M.; Ni, Y. Separation and preparation of 6-gingerol from molecular distillation residue of Yunnan ginger rhizomes by high-speed counter-current chromatography and the antioxidant activity of ginger oils in vitro. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2016, 1011, 99-107.
    • (2016) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.1011 , pp. 99-107
    • Gan, Z.1    Liang, Z.2    Chen, X.3    Wen, X.4    Wang, Y.5    Li, M.6    Ni, Y.7
  • 49
    • 84891917445 scopus 로고    scopus 로고
    • Membrane technology for the improved separation of bioactive compounds
    • Williams, S.; Oatley, D.; Abdrahman, A.; Butt, T.; Nash, R. Membrane technology for the improved separation of bioactive compounds. Procedia Eng. 2012, 44, 2112-2114.
    • (2012) Procedia Eng. , vol.44 , pp. 2112-2114
    • Williams, S.1    Oatley, D.2    Abdrahman, A.3    Butt, T.4    Nash, R.5
  • 50
    • 85042625229 scopus 로고    scopus 로고
    • Simultaneous determination and qualitative analysis of six types of components in Naoxintong capsule by miniaturized matrix solid-phase dispersion extraction coupled with ultra high-performance liquid chromatography with photodiode array detection and quadrupole time-of-flight mass spectrometry
    • Wang, H.; Jiang, Y.; Ding, M.; Li, J.; Hao, J.; He, J.; Wang, H.; Gao, X.M.; Chang, Y.X. Simultaneous determination and qualitative analysis of six types of components in Naoxintong capsule by miniaturized matrix solid-phase dispersion extraction coupled with ultra high-performance liquid chromatography with photodiode array detection and quadrupole time-of-flight mass spectrometry. J. Sep. Sci. 2018.
    • (2018) J. Sep. Sci.
    • Wang, H.1    Jiang, Y.2    Ding, M.3    Li, J.4    Hao, J.5    He, J.6    Wang, H.7    Gao, X.M.8    Chang, Y.X.9
  • 51
    • 85042688346 scopus 로고    scopus 로고
    • Simultaneous determination of columbianetin-beta-d-glucopyranoside and columbianetin in a biological sample by high-performance liquid chromatography with fluorescence detection and identification of other columbianetin-beta-d-glucopyranoside metabolites by ultra high-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry
    • Zhang, L.; Ge, Y.; Li, J.; Hao, J.; Wang, H.; He, J.; Gao, X.M.; Chang, Y.X. Simultaneous determination of columbianetin-beta-d-glucopyranoside and columbianetin in a biological sample by high-performance liquid chromatography with fluorescence detection and identification of other columbianetin-beta-d-glucopyranoside metabolites by ultra high-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry. J. Pharm. Biomed. Anal. 2018, 153, 221-231.
    • (2018) J. Pharm. Biomed. Anal. , vol.153 , pp. 221-231
    • Zhang, L.1    Ge, Y.2    Li, J.3    Hao, J.4    Wang, H.5    He, J.6    Gao, X.M.7    Chang, Y.X.8
  • 53
    • 85047746525 scopus 로고    scopus 로고
    • Forces of habit: Drugs and the making of the modern world
    • Edwards, G. Forces of habit: Drugs and the making of the modern world. Addiction 2002, 97, 608-609.
    • (2002) Addiction , vol.97 , pp. 608-609
    • Edwards, G.1
  • 54
    • 84896709262 scopus 로고    scopus 로고
    • Phytochemical and biological activities of an anticancer plant medicine: Brucea javanica
    • Zhao, L.; Li, C.; Zhang, Y.;Wen, Q.; Ren, D. Phytochemical and biological activities of an anticancer plant medicine: Brucea javanica. Anti-Cancer Agents Med. Chem. 2014, 14, 440-458.
    • (2014) Anti-Cancer Agents Med. Chem. , vol.14 , pp. 440-458
    • Zhao, L.1    Li, C.2    Zhang, Y.3    Wen, Q.4    Ren, D.5
  • 55
    • 80053976628 scopus 로고    scopus 로고
    • The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
    • Tu, Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat. Med. 2011, 17, 1217-1220.
    • (2011) Nat. Med. , vol.17 , pp. 1217-1220
    • Tu, Y.1
  • 56
    • 84982190036 scopus 로고    scopus 로고
    • Artemisinin-A gift from traditional Chinese medicine to the world (Nobel lecture)
    • Tu, Y. Artemisinin-A gift from traditional Chinese medicine to the world (Nobel lecture). Angew. Chem. Int. Ed. Engl. 2016, 55, 10210-10226.
    • (2016) Angew. Chem. Int. Ed. Engl. , vol.55 , pp. 10210-10226
    • Tu, Y.1
  • 58
    • 28844439369 scopus 로고    scopus 로고
    • Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (dmba)-induced breast cancer in the rat
    • Lai, H.; Singh, N.P. Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (dmba)-induced breast cancer in the rat. Cancer Lett. 2006, 231, 43-48.
    • (2006) Cancer Lett. , vol.231 , pp. 43-48
    • Lai, H.1    Singh, N.P.2
  • 59
    • 84873856866 scopus 로고    scopus 로고
    • Development of artemisinin compounds for cancer treatment
    • Lai, H.C.; Singh, N.P.; Sasaki, T. Development of artemisinin compounds for cancer treatment. Investig. New Drugs 2013, 31, 230-246.
    • (2013) Investig. New Drugs , vol.31 , pp. 230-246
    • Lai, H.C.1    Singh, N.P.2    Sasaki, T.3
  • 60
    • 84864607971 scopus 로고    scopus 로고
    • Return to Rio: Second chance for the planet. Nature 2012, 486, 19.
    • (2012) Nature , vol.46 , pp. 19
  • 61
    • 79958071887 scopus 로고    scopus 로고
    • 2010: A new beginning for biodiversity?
    • Barbault, R. 2010: A new beginning for biodiversity? C.R. Biol. 2011, 334, 483-488.
    • (2011) C.R. Biol. , vol.334 , pp. 483-488
    • Barbault, R.1
  • 62
    • 0039607834 scopus 로고    scopus 로고
    • Intellectual property rights in Costa Rica in the light of the biodiversity convention
    • Salazar, R.; Cabrera, J.A. Intellectual property rights in Costa Rica in the light of the biodiversity convention. J. Ethnopharmacol. 1996, 51, 177-193.
    • (1996) J. Ethnopharmacol. , vol.51 , pp. 177-193
    • Salazar, R.1    Cabrera, J.A.2
  • 64
    • 0036512022 scopus 로고    scopus 로고
    • Pharmaceuticals from natural products: Current trends
    • Seidl, P.R. Pharmaceuticals from natural products: Current trends. Anais da Academia Brasileira de Ciencias 2002, 74, 145-150.
    • (2002) Anais da Academia Brasileira de Ciencias , vol.74 , pp. 145-150
    • Seidl, P.R.1
  • 65
    • 84861921931 scopus 로고    scopus 로고
    • Earth summit: Rio report card
    • Tollefson, J.; Gilbert, N. Earth summit: Rio report card. Nature 2012, 486, 20-23.
    • (2012) Nature , vol.486 , pp. 20-23
    • Tollefson, J.1    Gilbert, N.2
  • 67
    • 84890365322 scopus 로고    scopus 로고
    • The anti-asthma herbal medicine ashmi acutely inhibits airway smooth muscle contraction via prostaglandin e2 activation of ep2/ep4 receptors
    • Srivastava, K.; Sampson, H.A.; Charles, W.; Emala, S.; Li, X.-M. The anti-asthma herbal medicine ashmi acutely inhibits airway smooth muscle contraction via prostaglandin e2 activation of ep2/ep4 receptors. Am. J. Physiol.-Lung Cell. Mol. Physiol. 2013, 305, L1002-L1010.
    • (2013) Am. J. Physiol.-Lung Cell. Mol. Physiol. , vol.305 , pp. L1002-L1010
    • Srivastava, K.1    Sampson, H.A.2    Charles, W.3    Emala, S.4    Li, X.-M.5
  • 68
    • 84893763163 scopus 로고    scopus 로고
    • The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction
    • Yang, N.; Liang, B.; Srivastava, K.; Zeng, J.; Zhan, J.; Brown, L.; Sampson, H.; Goldfarb, J.; Emala, C.; Li, X.M. The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction. Phytochemistry 2013, 95, 259-267.
    • (2013) Phytochemistry , vol.95 , pp. 259-267
    • Yang, N.1    Liang, B.2    Srivastava, K.3    Zeng, J.4    Zhan, J.5    Brown, L.6    Sampson, H.7    Goldfarb, J.8    Emala, C.9    Li, X.M.10
  • 69
    • 84862776615 scopus 로고    scopus 로고
    • Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica
    • Chan, K.; Shaw, D.; Simmonds, M.S.; Leon, C.J.; Xu, Q.; Lu, A.; Sutherland, I.; Ignatova, S.; Zhu, Y.P.; Verpoorte, R.; et al. Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica. J. Ethnopharmacol. 2012, 140, 469-475.
    • (2012) J. Ethnopharmacol. , vol.140 , pp. 469-475
    • Chan, K.1    Shaw, D.2    Simmonds, M.S.3    Leon, C.J.4    Xu, Q.5    Lu, A.6    Sutherland, I.7    Ignatova, S.8    Zhu, Y.P.9    Verpoorte, R.10
  • 70
    • 84925879264 scopus 로고    scopus 로고
    • Investigation of the potential synergistic effect of resveratrol with other phenolic compounds: A case of binary phenolic mixtures
    • Skroza, D.; Generalić Mekinić, I.; Svilović, S.; Šimat, V.; Katalinić, V. Investigation of the potential synergistic effect of resveratrol with other phenolic compounds: A case of binary phenolic mixtures. J. Food Compos. Anal. 2015, 38, 13-18.
    • (2015) J. Food Compos. Anal. , vol.38 , pp. 13-18
    • Skroza, D.1    Generalić Mekinić, I.2    Svilović, S.3    Šimat, V.4    Katalinić, V.5
  • 71
    • 84904600542 scopus 로고    scopus 로고
    • Synergistic effects of ethnomedicinal plants of Apocynaceae family and antibiotics against clinical isolates of Acinetobacter baumannii
    • Chusri, S.; Siriyong, T.; Na-Phatthalung, P.; Voravuthikunchai, S.P. Synergistic effects of ethnomedicinal plants of Apocynaceae family and antibiotics against clinical isolates of Acinetobacter baumannii. Asian Pac. J. Trop. Med. 2014, 7, 456-461.
    • (2014) Asian Pac. J. Trop. Med. , vol.7 , pp. 456-461
    • Chusri, S.1    Siriyong, T.2    Na-Phatthalung, P.3    Voravuthikunchai, S.P.4
  • 72
    • 1842554875 scopus 로고    scopus 로고
    • Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells
    • Sharma, G.; Tyagi, A.K.; Singh, R.P.; Chan, D.C.; Agarwal, R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res. Treat. 2004, 85, 1-12.
    • (2004) Breast Cancer Res. Treat. , vol.85 , pp. 1-12
    • Sharma, G.1    Tyagi, A.K.2    Singh, R.P.3    Chan, D.C.4    Agarwal, R.5
  • 73
    • 84939536885 scopus 로고    scopus 로고
    • Computational approaches to natural product discovery
    • Medema, M.H.; Fischbach, M.A. Computational approaches to natural product discovery. Nat. Chem. Biol. 2015, 11, 639-648.
    • (2015) Nat. Chem. Biol. , vol.11 , pp. 639-648
    • Medema, M.H.1    Fischbach, M.A.2
  • 74
    • 84939541097 scopus 로고    scopus 로고
    • Reinvigorating natural product combinatorial biosynthesis with synthetic biology
    • Kim, E.; Moore, B.S.; Yoon, Y.J. Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nat. Chem. Biol. 2015, 11, 649-659.
    • (2015) Nat. Chem. Biol. , vol.11 , pp. 649-659
    • Kim, E.1    Moore, B.S.2    Yoon, Y.J.3
  • 80
    • 85017628877 scopus 로고    scopus 로고
    • Unidentifiable by morphology: DNA barcoding of plant material in local markets in Iran
    • Ghorbani, A.; Saeedi, Y.; de Boer, H.J. Unidentifiable by morphology: DNA barcoding of plant material in local markets in Iran. PLoS ONE 2017, 12, e0175722.
    • (2017) PLoS ONE , vol.12 , pp. 175722
    • Ghorbani, A.1    Saeedi, Y.2    de Boer, H.J.3
  • 81
    • 84900027227 scopus 로고    scopus 로고
    • Molecular taxonomic tools provide more accurate estimates of species richness at less cost than traditional morphology-based taxonomic practices in a vegetation survey
    • Thompson, K.A.; Newmaster, S.G. Molecular taxonomic tools provide more accurate estimates of species richness at less cost than traditional morphology-based taxonomic practices in a vegetation survey. Biodivers. Conserv. 2014, 23, 1411-1424.
    • (2014) Biodivers. Conserv. , vol.23 , pp. 1411-1424
    • Thompson, K.A.1    Newmaster, S.G.2
  • 82
    • 84897524360 scopus 로고    scopus 로고
    • Authentication of animal signatures in traditional Chinese medicine of Lingyang Qingfei Wan using routine molecular diagnostic assays
    • Cao, M.; Wang, J.; Yao, L.; Xie, S.; Du, J.; Zhao, X. Authentication of animal signatures in traditional Chinese medicine of Lingyang Qingfei Wan using routine molecular diagnostic assays. Mol. Biol. Rep. 2014, 41, 2485-2491.
    • (2014) Mol. Biol. Rep. , vol.41 , pp. 2485-2491
    • Cao, M.1    Wang, J.2    Yao, L.3    Xie, S.4    Du, J.5    Zhao, X.6
  • 83
  • 85
    • 85012095453 scopus 로고    scopus 로고
    • Identification of crude drugs in the Japanese pharmacopoeia using a DNA barcoding system
    • Chen, X.; Xiang, L.; Shi, L.; Li, G.; Yao, H.; Han, J.; Lin, Y.; Song, J.; Chen, S. Identification of crude drugs in the Japanese pharmacopoeia using a DNA barcoding system. Sci. Rep. 2017, 7, 42325.
    • (2017) Sci. Rep. , vol.7 , pp. 42325
    • Chen, X.1    Xiang, L.2    Shi, L.3    Li, G.4    Yao, H.5    Han, J.6    Lin, Y.7    Song, J.8    Chen, S.9
  • 86
    • 84961711370 scopus 로고    scopus 로고
    • Molecular farming in Artemisia annua, a promising approach to improve anti-malarial drug production
    • Pulice, G.; Pelaz, S.; Matías-Hernández, L. Molecular farming in Artemisia annua, a promising approach to improve anti-malarial drug production. Front. Plant Sci. 2016, 7, 329.
    • (2016) Front. Plant Sci. , vol.7 , pp. 329
    • Pulice, G.1    Pelaz, S.2    Matías-Hernández, L.3
  • 87
    • 84941105483 scopus 로고    scopus 로고
    • Genomic profile of the plants with pharmaceutical value
    • Gantait, S.; Debnath, S.; Nasim Ali, M. Genomic profile of the plants with pharmaceutical value. 3 Biotech 2014, 4, 563-578.
    • (2014) 3 Biotech , vol.4 , pp. 563-578
    • Gantait, S.1    Debnath, S.2    Nasim Ali, M.3
  • 88
    • 85016817417 scopus 로고    scopus 로고
    • The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: A general template for research on TCMs
    • Lv, C.; Wu, X.; Wang, X.; Su, J.; Zeng, H.; Zhao, J.; Lin, S.; Liu, R.; Li, H.; Li, X.; et al. The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: A general template for research on TCMs. Sci. Rep. 2017, 7, 352.
    • (2017) Sci. Rep. , vol.7 , pp. 352
    • Lv, C.1    Wu, X.2    Wang, X.3    Su, J.4    Zeng, H.5    Zhao, J.6    Lin, S.7    Liu, R.8    Li, H.9    Li, X.10
  • 89
    • 84923324365 scopus 로고    scopus 로고
    • A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine Berberine
    • Lee, K.-H.; Lo, H.-L.; Tang,W.-C.; Hsiao, H.H.-Y.; Yang, P.-M. A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine Berberine. Sci. Rep. 2014, 4, 6394.
    • (2014) Sci. Rep. , vol.4 , pp. 6394
    • Lee, K.-H.1    Lo, H.-L.2    Tang, W.-C.3    Hsiao, H.H.-Y.4    Yang, P.-M.5
  • 90
    • 85025447710 scopus 로고    scopus 로고
    • DNA microarray-based screening and characterization of traditional Chinese medicine
    • Kiyama, R. DNA microarray-based screening and characterization of traditional Chinese medicine. Microarrays 2017, 6, 4.
    • (2017) Microarrays , vol.6 , pp. 4
    • Kiyama, R.1
  • 91
    • 84954379553 scopus 로고    scopus 로고
    • DNA methylation and healthy human aging
    • Jones, M.J.; Goodman, S.J.; Kobor, M.S. DNA methylation and healthy human aging. Aging Cell 2015, 14, 924-932.
    • (2015) Aging Cell , vol.14 , pp. 924-932
    • Jones, M.J.1    Goodman, S.J.2    Kobor, M.S.3
  • 92
    • 84870552401 scopus 로고    scopus 로고
    • Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules
    • Kelly, T.K.; Liu, Y.; Lay, F.D.; Liang, G.; Berman, B.P.; Jones, P.A. Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Res. 2012, 22, 2497-2506.
    • (2012) Genome Res. , vol.22 , pp. 2497-2506
    • Kelly, T.K.1    Liu, Y.2    Lay, F.D.3    Liang, G.4    Berman, B.P.5    Jones, P.A.6
  • 94
    • 84892175537 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA methylation in bovine placentas
    • Su, J.;Wang, Y.; Xing, X.; Liu, J.; Zhang, Y. Genome-wide analysis of DNA methylation in bovine placentas. BMC Genom. 2014, 15, 12.
    • (2014) BMC Genom. , vol.15 , pp. 12
    • Su, J.1    Wang, Y.2    Xing, X.3    Liu, J.4    Zhang, Y.5
  • 96
    • 84939454981 scopus 로고    scopus 로고
    • Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets
    • Barbosa, S.; Carreira, S.; Bailey, D.; Abaitua, F.; O’Hare, P. Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets. Mol. Biol. Cell 2015, 26, 2939-2954.
    • (2015) Mol. Biol. Cell , vol.26 , pp. 2939-2954
    • Barbosa, S.1    Carreira, S.2    Bailey, D.3    Abaitua, F.4
  • 101
    • 85034266008 scopus 로고    scopus 로고
    • Delineation of the HPV11e6 and HPV18e6 pathways in initiating cellular transformation
    • Mwapagha, L.M.; Tiffin, N.; Parker, M.I. Delineation of the HPV11e6 and HPV18e6 pathways in initiating cellular transformation. Front. Oncol. 2017, 7, 258.
    • (2017) Front. Oncol. , vol.7 , pp. 258
    • Mwapagha, L.M.1    Tiffin, N.2    Parker, M.I.3
  • 102
    • 84862109148 scopus 로고    scopus 로고
    • The cumulative effects of polymorphisms in the DNA mismatch repair genes and tobacco smoking in oesophageal cancer risk
    • Vogelsang, M.; Wang, Y.; Veber, N.; Mwapagha, L.M.; Parker, M.I. The cumulative effects of polymorphisms in the DNA mismatch repair genes and tobacco smoking in oesophageal cancer risk. PLoS ONE 2012, 7, e36962.
    • (2012) PLoS ONE , vol.7 , pp. 36962
    • Vogelsang, M.1    Wang, Y.2    Veber, N.3    Mwapagha, L.M.4    Parker, M.I.5
  • 106
    • 85020184580 scopus 로고    scopus 로고
    • DNA methylation-based chromatin compartments and CHIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis
    • Simmonds, P.; Loomis, E.; Curry, E. DNA methylation-based chromatin compartments and CHIP-seq profiles reveal transcriptional drivers of prostate carcinogenesis. Genome Med. 2017, 9, 54.
    • (2017) Genome Med. , vol.9 , pp. 54
    • Simmonds, P.1    Loomis, E.2    Curry, E.3
  • 107
  • 108
    • 84879105989 scopus 로고    scopus 로고
    • Cracking the encode: From transcription to therapeutics
    • Mehta, G.; Jalan, R.; Mookerjee, R.P. Cracking the encode: From transcription to therapeutics. Hepatology 2013, 57, 2532-2535.
    • (2013) Hepatology , vol.57 , pp. 2532-2535
    • Mehta, G.1    Jalan, R.2    Mookerjee, R.P.3
  • 110
    • 70349959824 scopus 로고    scopus 로고
    • A proteomics approach to discovery of natural products and their biosynthetic pathways
    • Bumpus, S.B.; Evans, B.S.; Thomas, P.M.; Ntai, I.; Kelleher, N.L. A proteomics approach to discovery of natural products and their biosynthetic pathways. Nat. Biotechnol. 2009, 27, 951-956.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 951-956
    • Bumpus, S.B.1    Evans, B.S.2    Thomas, P.M.3    Ntai, I.4    Kelleher, N.L.5
  • 112
    • 0036744503 scopus 로고    scopus 로고
    • Proteome of oriental ginseng Panax ginseng C.A. Meyer and the potential to use it as an identification tool
    • Lum, J.H.; Fung, K.L.; Cheung, P.Y.; Wong, M.S.; Lee, C.H.; Kwok, F.S.; Leung, M.C.; Hui, P.K.; Lo, S.C. Proteome of oriental ginseng Panax ginseng C.A. Meyer and the potential to use it as an identification tool. Proteomics 2002, 2, 1123-1130.
    • (2002) Proteomics , vol.2 , pp. 1123-1130
    • Lum, J.H.1    Fung, K.L.2    Cheung, P.Y.3    Wong, M.S.4    Lee, C.H.5    Kwok, F.S.6    Leung, M.C.7    Hui, P.K.8    Lo, S.C.9
  • 114
    • 79959215895 scopus 로고    scopus 로고
    • Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae
    • Li, Z.H.; Alex, D.; Siu, S.O.; Chu, I.K.; Renn, J.; Winkler, C.; Lou, S.; Tsui, S.K.; Zhao, H.Y.; Yan, W.R.; et al. Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Mol. BioSyst. 2011, 7, 2128-2138.
    • (2011) Mol. BioSyst. , vol.7 , pp. 2128-2138
    • Li, Z.H.1    Alex, D.2    Siu, S.O.3    Chu, I.K.4    Renn, J.5    Winkler, C.6    Lou, S.7    Tsui, S.K.8    Zhao, H.Y.9    Yan, W.R.10
  • 115
    • 84866168913 scopus 로고    scopus 로고
    • From omics to drug metabolism and high content screen of natural product in zebrafish: A new model for discovery of neuroactive compound
    • Hung, M.W.; Zhang, Z.J.; Li, S.; Lei, B.; Yuan, S.; Cui, G.Z.; Man Hoi, P.; Chan, K.; Lee, S.M.Y. From omics to drug metabolism and high content screen of natural product in zebrafish: A new model for discovery of neuroactive compound. Evid.-Based Complement. Altern. Med. 2012, 2012, 605303.
    • (2012) Evid.-Based Complement. Altern. Med. , vol.2012 , pp. 605303
    • Hung, M.W.1    Zhang, Z.J.2    Li, S.3    Lei, B.4    Yuan, S.5    Cui, G.Z.6    Man Hoi, P.7    Chan, K.8    Lee, S.M.Y.9
  • 116
    • 84905049466 scopus 로고    scopus 로고
    • Application of proteomics to determine the mechanism of action of traditional Chinese medicine remedies
    • Lao, Y.; Wang, X.; Xu, N.; Zhang, H.; Xu, H. Application of proteomics to determine the mechanism of action of traditional Chinese medicine remedies. J. Ethnopharmacol. 2014, 155, 1-8.
    • (2014) J. Ethnopharmacol. , vol.155 , pp. 1-8
    • Lao, Y.1    Wang, X.2    Xu, N.3    Zhang, H.4    Xu, H.5
  • 117
    • 84902250745 scopus 로고    scopus 로고
    • Challenges and recent advances in affinity purification of tag-free proteins
    • Guan, D.; Chen, Z. Challenges and recent advances in affinity purification of tag-free proteins. Biotechnol. Lett. 2014, 36, 1391-1406.
    • (2014) Biotechnol. Lett. , vol.36 , pp. 1391-1406
    • Guan, D.1    Chen, Z.2
  • 118
    • 84555195900 scopus 로고    scopus 로고
    • Ligand affinity chromatography, an indispensable method for the purification of soluble cytokine receptors and binding proteins
    • Novick, D.; Rubinstein, M. Ligand affinity chromatography, an indispensable method for the purification of soluble cytokine receptors and binding proteins. Methods Mol. Biol. 2012, 820, 195-214. [PubMed]
    • (2012) Methods Mol. Biol. , vol.820 , pp. 195-214
    • Novick, D.1    Rubinstein, M.2
  • 119
    • 84878286912 scopus 로고    scopus 로고
    • Affinity monolith chromatography: A review of principles and recent analytical applications
    • Pfaunmiller, E.L.; Paulemond, M.L.; Dupper, C.M.; Hage, D.S. Affinity monolith chromatography: A review of principles and recent analytical applications. Anal. Bioanal. Chem. 2013, 405, 2133-2145.
    • (2013) Anal. Bioanal. Chem. , vol.405 , pp. 2133-2145
    • Pfaunmiller, E.L.1    Paulemond, M.L.2    Dupper, C.M.3    Hage, D.S.4
  • 120
    • 82355190829 scopus 로고    scopus 로고
    • Compound immobilization and drug-affinity chromatography
    • Rix, U.; Gridling, M.; Superti-Furga, G. Compound immobilization and drug-affinity chromatography. Methods Mol. Biol. 2012, 803, 25-38. [PubMed]
    • (2012) Methods Mol. Biol. , vol.803 , pp. 25-38
    • Rix, U.1    Gridling, M.2    Superti-Furga, G.3
  • 122
    • 84906049995 scopus 로고    scopus 로고
    • Profiling of drug binding proteins by monolithic affinity chromatography in combination with liquid chromatography-tandem mass spectrometry
    • Zhang, X.; Wang, T.; Zhang, H.; Han, B.; Wang, L.; Kang, J. Profiling of drug binding proteins by monolithic affinity chromatography in combination with liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2014, 1359, 84-90.
    • (2014) J. Chromatogr. A , vol.1359 , pp. 84-90
    • Zhang, X.1    Wang, T.2    Zhang, H.3    Han, B.4    Wang, L.5    Kang, J.6
  • 123
    • 84875458314 scopus 로고    scopus 로고
    • Target identification and mechanism of action in chemical biology and drug discovery
    • Schenone, M.; Dancik, V.; Wagner, B.K.; Clemons, P.A. Target identification and mechanism of action in chemical biology and drug discovery. Nat. Chem. Biol. 2013, 9, 232-240.
    • (2013) Nat. Chem. Biol. , vol.9 , pp. 232-240
    • Schenone, M.1    Dancik, V.2    Wagner, B.K.3    Clemons, P.A.4
  • 124
    • 84878217893 scopus 로고    scopus 로고
    • Methods for the elucidation of protein-small molecule interactions
    • McFedries, A.; Schwaid, A.; Saghatelian, A. Methods for the elucidation of protein-small molecule interactions. Chem. Biol. 2013, 20, 667-673.
    • (2013) Chem. Biol. , vol.20 , pp. 667-673
    • McFedries, A.1    Schwaid, A.2    Saghatelian, A.3
  • 125
    • 69249136243 scopus 로고    scopus 로고
    • Target profiling of small molecules by chemical proteomics
    • Rix, U.; Superti-Furga, G. Target profiling of small molecules by chemical proteomics. Nat. Chem. Biol. 2009, 5, 616-624.
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 616-624
    • Rix, U.1    Superti-Furga, G.2
  • 126
    • 84978129485 scopus 로고    scopus 로고
    • Target identification for biologically active small molecules using chemical biology approaches
    • Lee, H.; Lee, J.W. Target identification for biologically active small molecules using chemical biology approaches. Arch. Pharm. Res. 2016, 39, 1193-1201.
    • (2016) Arch. Pharm. Res. , vol.39 , pp. 1193-1201
    • Lee, H.1    Lee, J.W.2
  • 127
    • 84942513706 scopus 로고    scopus 로고
    • Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry
    • Franken, H.; Mathieson, T.; Childs, D.; Sweetman, G.M.;Werner, T.; Togel, I.; Doce, C.; Gade, S.; Bantscheff, M.; Drewes, G.; et al. Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry. Nat. Protoc. 2015, 10, 1567-1593.
    • (2015) Nat. Protoc. , vol.10 , pp. 1567-1593
    • Franken, H.1    Mathieson, T.2    Childs, D.3    Sweetman, G.M.4    Werner, T.5    Togel, I.6    Doce, C.7    Gade, S.8    Bantscheff, M.9    Drewes, G.10
  • 130
    • 84856392676 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics in preclinical drug discovery
    • Schirle, M.; Bantscheff, M.; Kuster, B. Mass spectrometry-based proteomics in preclinical drug discovery. Chem. Biol. 2012, 19, 72-84.
    • (2012) Chem. Biol. , vol.19 , pp. 72-84
    • Schirle, M.1    Bantscheff, M.2    Kuster, B.3
  • 131
    • 79251511501 scopus 로고    scopus 로고
    • Identification of direct protein targets of small molecules
    • Lomenick, B.; Olsen, R.W.; Huang, J. Identification of direct protein targets of small molecules. ACS Chem. Biol. 2011, 6, 34-46.
    • (2011) ACS Chem. Biol. , vol.6 , pp. 34-46
    • Lomenick, B.1    Olsen, R.W.2    Huang, J.3
  • 132
    • 84979762846 scopus 로고    scopus 로고
    • Target identification strategies in plant chemical biology
    • Dejonghe, W.; Russinova, E. Target identification strategies in plant chemical biology. Front. Plant Sci. 2014, 5, 352.
    • (2014) Front. Plant Sci. , vol.5 , pp. 352
    • Dejonghe, W.1    Russinova, E.2
  • 133
    • 77952722630 scopus 로고    scopus 로고
    • Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements
    • West, G.M.; Tucker, C.L.; Xu, T.; Park, S.K.; Han, X.; Yates, J.R., 3rd; Fitzgerald, M.C. Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. Proc. Natl. Acad. Sci. USA 2010, 107, 9078-9082.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 9078-9082
    • West, G.M.1    Tucker, C.L.2    Xu, T.3    Park, S.K.4    Han, X.5    Yates, J.R.6    Fitzgerald, M.C.7
  • 134
    • 44949229448 scopus 로고    scopus 로고
    • Thermodynamic analysis of protein stability and ligand binding using a chemical modification-and mass spectrometry-based strategy
    • West, G.M.; Tang, L.; Fitzgerald, M.C. Thermodynamic analysis of protein stability and ligand binding using a chemical modification-and mass spectrometry-based strategy. Anal. Chem. 2008, 80, 4175-4185.
    • (2008) Anal. Chem. , vol.80 , pp. 4175-4185
    • West, G.M.1    Tang, L.2    Fitzgerald, M.C.3
  • 135
    • 85028763491 scopus 로고    scopus 로고
    • Targeted mass spectrometry-based approach for protein-ligand binding analyses in complex biological mixtures using a phenacyl bromide modification strategy
    • Jin, L.;Wang, D.; Gooden, D.M.; Ball, C.H.; Fitzgerald, M.C. Targeted mass spectrometry-based approach for protein-ligand binding analyses in complex biological mixtures using a phenacyl bromide modification strategy. Anal. Chem. 2016, 88, 10987-10993.
    • (2016) Anal. Chem. , vol.88 , pp. 10987-10993
    • Jin, L.1    Wang, D.2    Gooden, D.M.3    Ball, C.H.4    Fitzgerald, M.C.5
  • 136
    • 84987715116 scopus 로고    scopus 로고
    • Identification of protein binding partners of small molecules using label-free methods
    • Saxena, C. Identification of protein binding partners of small molecules using label-free methods. Expert Opin. Drug Discov. 2016, 11, 1017-1025.
    • (2016) Expert Opin. Drug Discov. , vol.11 , pp. 1017-1025
    • Saxena, C.1
  • 137
    • 84892665329 scopus 로고    scopus 로고
    • False-positive rate determination of protein target discovery using a covalent modification-and mass spectrometry-based proteomics platform
    • Strickland, E.C.; Geer, M.A.; Hong, J.; Fitzgerald, M.C. False-positive rate determination of protein target discovery using a covalent modification-and mass spectrometry-based proteomics platform. J. Am. Soc. Mass Spectrom. 2014, 25, 132-140.
    • (2014) J. Am. Soc. Mass Spectrom. , vol.25 , pp. 132-140
    • Strickland, E.C.1    Geer, M.A.2    Hong, J.3    Fitzgerald, M.C.4
  • 138
    • 80655131110 scopus 로고    scopus 로고
    • Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach
    • Dearmond, P.D.; Xu, Y.; Strickland, E.C.; Daniels, K.G.; Fitzgerald, M.C. Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach. J. Proteome Res. 2011, 10, 4948-4958.
    • (2011) J. Proteome Res. , vol.10 , pp. 4948-4958
    • Dearmond, P.D.1    Xu, Y.2    Strickland, E.C.3    Daniels, K.G.4    Fitzgerald, M.C.5
  • 139
    • 84904111844 scopus 로고    scopus 로고
    • Stableisotope labeling with amino acids in cell culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions
    • Tran, D.T.; Adhikari, J.; Fitzgerald, M.C. Stableisotope labeling with amino acids in cell culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions. Mol. Cell. Proteom. 2014, 13, 1800-1813.
    • (2014) Mol. Cell. Proteom. , vol.13 , pp. 1800-1813
    • Tran, D.T.1    Adhikari, J.2    Fitzgerald, M.C.3
  • 140
    • 79551663189 scopus 로고    scopus 로고
    • Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics
    • Geiger, T.; Wisniewski, J.R.; Cox, J.; Zanivan, S.; Kruger, M.; Ishihama, Y.; Mann, M. Use of stable isotope labeling by amino acids in cell culture as a spike-in standard in quantitative proteomics. Nat. Protoc. 2011, 6, 147-157.
    • (2011) Nat. Protoc. , vol.6 , pp. 147-157
    • Geiger, T.1    Wisniewski, J.R.2    Cox, J.3    Zanivan, S.4    Kruger, M.5    Ishihama, Y.6    Mann, M.7
  • 141
    • 84907423820 scopus 로고    scopus 로고
    • Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics
    • Hoedt, E.; Zhang, G.; Neubert, T.A. Stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomics. Adv. Exp. Med. Biol. 2014, 806, 93-106. [PubMed]
    • (2014) Adv. Exp. Med. Biol. , vol.806 , pp. 93-106
    • Hoedt, E.1    Zhang, G.2    Neubert, T.A.3
  • 143
    • 34247396011 scopus 로고    scopus 로고
    • A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)
    • Ong, S.E.; Mann, M. A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC). Nat. Protoc. 2006, 1, 2650-2660.
    • (2006) Nat. Protoc. , vol.1 , pp. 2650-2660
    • Ong, S.E.1    Mann, M.2
  • 144
    • 84938208316 scopus 로고    scopus 로고
    • Quantitative analysis of differential protein expression in cervical carcinoma cells after zeylenone treatment by stable isotope labeling with amino acids in cell culture
    • Zhang, L.; Jin, J.; Zhang, L.; Hu, R.; Gao, L.; Huo, X.; Liu, D.; Ma, X.;Wang, C.; Han, J.; et al. Quantitative analysis of differential protein expression in cervical carcinoma cells after zeylenone treatment by stable isotope labeling with amino acids in cell culture. J. Proteom. 2015, 126, 279-287.
    • (2015) J. Proteom. , vol.126 , pp. 279-287
    • Zhang, L.1    Jin, J.2    Zhang, L.3    Hu, R.4    Gao, L.5    Huo, X.6    Liu, D.7    Ma, X.8    Wang, C.9    Han, J.10
  • 146
    • 84960199094 scopus 로고    scopus 로고
    • Identifying compound efficacy targets in phenotypic drug discovery
    • Schirle, M.; Jenkins, J.L. Identifying compound efficacy targets in phenotypic drug discovery. Drug Discov. Today 2016, 21, 82-89.
    • (2016) Drug Discov. Today , vol.21 , pp. 82-89
    • Schirle, M.1    Jenkins, J.L.2
  • 147
    • 84954528369 scopus 로고    scopus 로고
    • Target identification of compounds from a cell viability phenotypic screen using a bead/lysate-based affinity capture platform
    • Tang, H.; Duggan, S.; Richardson, P.L.; Marin, V.; Warder, S.E.; McLoughlin, S.M. Target identification of compounds from a cell viability phenotypic screen using a bead/lysate-based affinity capture platform. J. Biomol. Screen. 2016, 21, 201-211.
    • (2016) J. Biomol. Screen. , vol.21 , pp. 201-211
    • Tang, H.1    Duggan, S.2    Richardson, P.L.3    Marin, V.4    Warder, S.E.5    McLoughlin, S.M.6
  • 152
    • 85021212038 scopus 로고    scopus 로고
    • Thermal proteome profiling: Unbiased assessment of protein state through heat-induced stability changes
    • Mateus, A.; Maatta, T.A.; Savitski, M.M. Thermal proteome profiling: Unbiased assessment of protein state through heat-induced stability changes. Proteome Sci. 2016, 15, 13.
    • (2016) Proteome Sci. , vol.15 , pp. 13
    • Mateus, A.1    Maatta, T.A.2    Savitski, M.M.3
  • 154
    • 84941992624 scopus 로고    scopus 로고
    • Target deconvolution of bioactive small molecules: The heart of chemical biology and drug discovery
    • Jung, H.J.; Kwon, H.J. Target deconvolution of bioactive small molecules: The heart of chemical biology and drug discovery. Arch. Pharm. Res. 2015, 38, 1627-1641.
    • (2015) Arch. Pharm. Res. , vol.38 , pp. 1627-1641
    • Jung, H.J.1    Kwon, H.J.2
  • 157
    • 84904768201 scopus 로고    scopus 로고
    • Drugtargetseqr: A genomics-and CRISPR-Cas9-based method to analyze drug targets
    • Kasap, C.; Elemento, O.; Kapoor, T.M. Drugtargetseqr: A genomics-and CRISPR-Cas9-based method to analyze drug targets. Nat. Chem. Biol. 2014, 10, 626-628.
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 626-628
    • Kasap, C.1    Elemento, O.2    Kapoor, T.M.3
  • 158
    • 85013798316 scopus 로고    scopus 로고
    • Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis
    • Ipsaro, J.J.; Shen, C.; Arai, E.; Xu, Y.; Kinney, J.B.; Joshua-Tor, L.; Vakoc, C.R.; Shi, J. Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis. PLoS ONE 2017, 12, e0172177.
    • (2017) PLoS ONE , vol.12 , pp. 0172177
    • Ipsaro, J.J.1    Shen, C.2    Arai, E.3    Xu, Y.4    Kinney, J.B.5    Joshua-Tor, L.6    Vakoc, C.R.7    Shi, J.8
  • 161
    • 85011665391 scopus 로고    scopus 로고
    • Metabolomics: An emerging but powerful tool for precision medicine
    • Clish, C.B. Metabolomics: An emerging but powerful tool for precision medicine. Cold Spring Harb. Mol. Case Stud. 2015, 1, a000588.
    • (2015) Cold Spring Harb. Mol. Case Stud. , vol.1 , pp. a000588
    • Clish, C.B.1
  • 162
    • 54549091125 scopus 로고    scopus 로고
    • Systems biology: Metabonomics
    • Nicholson, J.K.; Lindon, J.C. Systems biology: Metabonomics. Nature 2008, 455, 7216.
    • (2008) Nature , vol.455 , pp. 7216
    • Nicholson, J.K.1    Lindon, J.C.2
  • 164
    • 0015635456 scopus 로고
    • Genetic manipulation: Now is the time to consider controls
    • Siminovitch, L. Genetic manipulation: Now is the time to consider controls. Sci. Forum 1973, 6, 7-11.
    • (1973) Sci. Forum , vol.6 , pp. 7-11
    • Siminovitch, L.1
  • 165
    • 0642305408 scopus 로고    scopus 로고
    • Metabolic engineering: Advances in modeling and intervention in health and disease
    • Yarmush, M.L.; Banta, S. Metabolic engineering: Advances in modeling and intervention in health and disease. Ann. Rev. Biomed. Eng. 2003, 5, 349-381.
    • (2003) Ann. Rev. Biomed. Eng. , vol.5 , pp. 349-381
    • Yarmush, M.L.1    Banta, S.2
  • 166
    • 84922011080 scopus 로고    scopus 로고
    • UPLC-MS/MS determination of ephedrine, methylephedrine, amygdalin and glycyrrhizic acid in beagle plasma and its application to a pharmacokinetic study after oral administration of Ma Huang Tang
    • Yan, T.; Fu, Q.;Wang, J.; Ma, S. UPLC-MS/MS determination of ephedrine, methylephedrine, amygdalin and glycyrrhizic acid in beagle plasma and its application to a pharmacokinetic study after oral administration of Ma Huang Tang. Drug. Test. Anal. 2015, 7, 158-163.
    • (2015) Drug. Test. Anal. , vol.7 , pp. 158-163
    • Yan, T.1    Fu, Q.2    Wang, J.3    Ma, S.4
  • 167
    • 85030086527 scopus 로고    scopus 로고
    • Bush mint (Hyptis suaveolens) and spreading hogweed (Boerhavia diffusa) medicinal plant extracts differentially affect activities of CYP1A2, CYP2D6 and CYP3A4 enzymes
    • Ekow Thomford, N.; Dzobo, K.; Adu, F.; Chirikure, S.;Wonkam, A.; Dandara, C. Bush mint (Hyptis suaveolens) and spreading hogweed (Boerhavia diffusa) medicinal plant extracts differentially affect activities of CYP1A2, CYP2D6 and CYP3A4 enzymes. J. Ethnopharmacol. 2018, 211, 58-69.
    • (2018) J. Ethnopharmacol. , vol.211 , pp. 58-69
    • Ekow Thomford, N.1    Dzobo, K.2    Adu, F.3    Chirikure, S.4    Wonkam, A.5    Dandara, C.6
  • 168
    • 43249119417 scopus 로고    scopus 로고
    • Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research
    • Xie, G.; Plumb, R.; Su, M.; Xu, Z.; Zhao, A.; Qiu, M.; Long, X.; Liu, Z.; Jia,W. Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research. J. Sep. Sci. 2008, 31, 1015-1026.
    • (2008) J. Sep. Sci. , vol.31 , pp. 1015-1026
    • Xie, G.1    Plumb, R.2    Su, M.3    Xu, Z.4    Zhao, A.5    Qiu, M.6    Long, X.7    Liu, Z.8    Jia, W.9
  • 169
    • 84893016096 scopus 로고    scopus 로고
    • Metabolomic approach for discrimination of processed ginseng genus (Panax ginseng and Panax quinquefolius) using UPLC-QTOF MS
    • Park, H.-W.; In, G.; Kim, J.-H.; Cho, B.-G.; Han, G.-H.; Chang, I.-M. Metabolomic approach for discrimination of processed ginseng genus (Panax ginseng and Panax quinquefolius) using UPLC-QTOF MS. J. Ginseng Res. 2014, 38, 59-65.
    • (2014) J. Ginseng Res. , vol.38 , pp. 59-65
    • Park, H.-W.1    In, G.2    Kim, J.-H.3    Cho, B.-G.4    Han, G.-H.5    Chang, I.-M.6
  • 170
    • 85037661214 scopus 로고    scopus 로고
    • Comparison of deep learning with multiple machine learning methods and metrics using diverse drug discovery data sets
    • Korotcov, A.; Tkachenko, V.; Russo, D.P.; Ekins, S. Comparison of deep learning with multiple machine learning methods and metrics using diverse drug discovery data sets. Mol. Pharm. 2017, 14, 4462-4475.
    • (2017) Mol. Pharm. , vol.14 , pp. 4462-4475
    • Korotcov, A.1    Tkachenko, V.2    Russo, D.P.3    Ekins, S.4
  • 171
    • 3242888975 scopus 로고    scopus 로고
    • Integrating virtual screening in lead discovery
    • Oprea, T.I.; Matter, H. Integrating virtual screening in lead discovery. Curr. Opin. Chem. Biol. 2004, 8, 349-358.
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 349-358
    • Oprea, T.I.1    Matter, H.2
  • 174
    • 84927724806 scopus 로고    scopus 로고
    • Systematic evaluation of connectivity map for disease indications
    • Cheng, J.; Yang, L.; Kumar, V.; Agarwal, P. Systematic evaluation of connectivity map for disease indications. Genome Med. 2014, 6, 95.
    • (2014) Genome Med. , vol.6 , pp. 95
    • Cheng, J.1    Yang, L.2    Kumar, V.3    Agarwal, P.4
  • 175
    • 33845876254 scopus 로고    scopus 로고
    • The connectivity map: A new tool for biomedical research
    • Lamb, J. The connectivity map: A new tool for biomedical research. Nat. Rev. Cancer 2007, 7, 54-60.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 54-60
    • Lamb, J.1
  • 179
    • 84929666468 scopus 로고    scopus 로고
    • Druggable cancer secretome: Neoplasm-associated traits
    • Narayanan, R. Druggable cancer secretome: Neoplasm-associated traits. Cancer Genom. Proteom. 2015, 12, 119-131.
    • (2015) Cancer Genom. Proteom. , vol.12 , pp. 119-131
    • Narayanan, R.1
  • 180
    • 84856415793 scopus 로고    scopus 로고
    • Genetic and proteomic approaches to identify cancer drug targets
    • Roti, G.; Stegmaier, K. Genetic and proteomic approaches to identify cancer drug targets. Br. J. Cancer 2012, 106, 254-261.
    • (2012) Br. J. Cancer , vol.106 , pp. 254-261
    • Roti, G.1    Stegmaier, K.2
  • 181
    • 0034748195 scopus 로고    scopus 로고
    • Proteomic approaches within the NCI early detection research network for the discovery and identification of cancer biomarkers
    • Verma, M.; Wright, G.L., Jr.; Hanash, S.M.; Gopal-Srivastava, R.; Srivastava, S. Proteomic approaches within the NCI early detection research network for the discovery and identification of cancer biomarkers. Ann. N. Y. Acad. Sci. 2001, 945, 103-115.
    • (2001) Ann. N. Y. Acad. Sci. , vol.945 , pp. 103-115
    • Verma, M.1    Wright, G.L.2    Hanash, S.M.3    Gopal-Srivastava, R.4    Srivastava, S.5
  • 182
    • 85032933645 scopus 로고    scopus 로고
    • Chemical space: Big data challenge for molecular diversity
    • Awale, M.; Visini, R.; Probst, D.; Arus-Pous, J.; Reymond, J.L. Chemical space: Big data challenge for molecular diversity. Chimia 2017, 71, 661-666.
    • (2017) Chimia , vol.71 , pp. 661-666
    • Awale, M.1    Visini, R.2    Probst, D.3    Arus-Pous, J.4    Reymond, J.L.5
  • 183
    • 85041566290 scopus 로고    scopus 로고
    • The influence of big (clinical) data and genomics on precision medicine and drug development
    • Denny, J.C.; Van Driest, S.L.;Wei,W.Q.; Roden, D.M. The influence of big (clinical) data and genomics on precision medicine and drug development. Clin. Pharmacol. Ther. 2018, 103, 409-418.
    • (2018) Clin. Pharmacol. Ther. , vol.103 , pp. 409-418
    • Denny, J.C.1    Van Driest, S.L.2    Wei, W.Q.3    Roden, D.M.4
  • 188
    • 84877930051 scopus 로고    scopus 로고
    • Mapping small molecule binding data to structural domains
    • Kruger, F.A.; Rostom, R.; Overington, J.P. Mapping small molecule binding data to structural domains. BMC Bioinform. 2012, 13, S11.
    • (2012) BMC Bioinform. , vol.13 , pp. S11
    • Kruger, F.A.1    Rostom, R.2    Overington, J.P.3
  • 189
    • 0035895496 scopus 로고    scopus 로고
    • Computational biology. Bioinformatics-Trying to swim in a sea of data
    • Roos, D.S. Computational biology. Bioinformatics-Trying to swim in a sea of data. Science 2001, 291, 1260-1261.
    • (2001) Science , vol.291 , pp. 1260-1261
    • Roos, D.S.1
  • 190
    • 42249106492 scopus 로고    scopus 로고
    • Discovery strategies in a pharmaceutical setting: The application of computational techniques
    • Jennings, A.; Tennant, M. Discovery strategies in a pharmaceutical setting: The application of computational techniques. Expert Opin. Drug Discov. 2006, 1, 709-721.
    • (2006) Expert Opin. Drug Discov. , vol.1 , pp. 709-721
    • Jennings, A.1    Tennant, M.2
  • 191
    • 42149176184 scopus 로고    scopus 로고
    • Identifying targets for drug discovery using bioinformatics
    • Chen, Y.P.; Chen, F. Identifying targets for drug discovery using bioinformatics. Expert Opin. Ther. Targets 2008, 12, 383-389.
    • (2008) Expert Opin. Ther. Targets , vol.12 , pp. 383-389
    • Chen, Y.P.1    Chen, F.2
  • 194
    • 80051943962 scopus 로고    scopus 로고
    • Nonclinical support of pediatric drug development in a global context: An industry perspective
    • Cappon, G.D. Nonclinical support of pediatric drug development in a global context: An industry perspective. Birth Defects Res. Part B Dev. Reprod. Toxicol. 2011, 92, 269-272.
    • (2011) Birth Defects Res. Part B Dev. Reprod. Toxicol. , vol.92 , pp. 269-272
    • Cappon, G.D.1
  • 195
    • 80052404956 scopus 로고    scopus 로고
    • Challenges and opportunities in developing novel drugs for TB
    • Kaneko, T.; Cooper, C.; Mdluli, K. Challenges and opportunities in developing novel drugs for TB. Future Med. Chem. 2011, 3, 1373-1400.
    • (2011) Future Med. Chem. , vol.3 , pp. 1373-1400
    • Kaneko, T.1    Cooper, C.2    Mdluli, K.3
  • 197
    • 84937638665 scopus 로고    scopus 로고
    • Determining drug efficacy parameters for mathematical models of influenza
    • Beggs, N.F.; Dobrovolny, H.M. Determining drug efficacy parameters for mathematical models of influenza. J. Biol. Dyn. 2015, 9, 332-346.
    • (2015) J. Biol. Dyn. , vol.9 , pp. 332-346
    • Beggs, N.F.1    Dobrovolny, H.M.2
  • 198
    • 84979608669 scopus 로고    scopus 로고
    • Context-specific functional module based drug efficacy prediction
    • Hwang,W.; Choi, J.; Kwon, M.; Lee, D. Context-specific functional module based drug efficacy prediction. BMC Bioinform. 2016, 17 (Suppl. 6).
    • (2016) BMC Bioinform. , vol.17
    • Hwang, W.1    Choi, J.2    Kwon, M.3    Lee, D.4
  • 201
    • 84936946795 scopus 로고    scopus 로고
    • Impact of insufficient drug efficacy of antiparkinson agents on patient’s quality of life: A cross-sectional study
    • Tsugawa, J.; Onozawa, R.; Fukae, J.; Mishima, T.; Fujioka, S.; Tsuboi, Y. Impact of insufficient drug efficacy of antiparkinson agents on patient’s quality of life: A cross-sectional study. BMC Neurol. 2015, 15, 105.
    • (2015) BMC Neurol. , vol.15 , pp. 105
    • Tsugawa, J.1    Onozawa, R.2    Fukae, J.3    Mishima, T.4    Fujioka, S.5    Tsuboi, Y.6
  • 202
    • 84960417268 scopus 로고    scopus 로고
    • From smallpox to big data: The next 100 years of epidemiologic methods
    • Gange, S.J.; Golub, E.T. From smallpox to big data: The next 100 years of epidemiologic methods. Am. J. Epidemiol. 2016, 183, 423-426.
    • (2016) Am. J. Epidemiol. , vol.183 , pp. 423-426
    • Gange, S.J.1    Golub, E.T.2
  • 203
    • 84959522410 scopus 로고    scopus 로고
    • Exploiting big data for critical care research
    • Docherty, A.B.; Lone, N.I. Exploiting big data for critical care research. Curr. Opin. Crit. Care 2015, 21, 467-472.
    • (2015) Curr. Opin. Crit. Care , vol.21 , pp. 467-472
    • Docherty, A.B.1    Lone, N.I.2
  • 205
    • 84948185748 scopus 로고    scopus 로고
    • Big data and analytics in healthcare
    • Tan, S.S.; Gao, G.; Koch, S. Big data and analytics in healthcare. Methods Inf. Med. 2015, 54, 546-547.
    • (2015) Methods Inf. Med. , vol.54 , pp. 546-547
    • Tan, S.S.1    Gao, G.2    Koch, S.3
  • 206
    • 84946616074 scopus 로고    scopus 로고
    • Using ‘big data’ to validate claims made in the pharmaceutical approval process
    • Wasser, T.; Haynes, K.; Barron, J.; Cziraky, M. Using ‘big data’ to validate claims made in the pharmaceutical approval process. J. Med. Econ. 2015, 18, 1013-1019.
    • (2015) J. Med. Econ. , vol.18 , pp. 1013-1019
    • Wasser, T.1    Haynes, K.2    Barron, J.3    Cziraky, M.4
  • 210
    • 0037421630 scopus 로고    scopus 로고
    • Lab automation and robotics: Automation on the move
    • Chapman, T. Lab automation and robotics: Automation on the move. Nature 2003, 421, 661-666.
    • (2003) Nature , vol.421 , pp. 661-666
    • Chapman, T.1
  • 213
    • 84964692636 scopus 로고    scopus 로고
    • Improving drug design: An update on recent applications of efficiency metrics, strategies for replacing problematic elements, and compounds in non-traditional drug space
    • Meanwell, N.A. Improving drug design: An update on recent applications of efficiency metrics, strategies for replacing problematic elements, and compounds in non-traditional drug space. Chem. Res. Toxicol. 2016, 29, 564-616.
    • (2016) Chem. Res. Toxicol. , vol.29 , pp. 564-616
    • Meanwell, N.A.1
  • 214
    • 85017505688 scopus 로고    scopus 로고
    • An integrated microfluidic processor for DNA-encoded combinatorial library functional screening
    • MacConnell, A.B.; Price, A.K.; Paegel, B.M. An integrated microfluidic processor for DNA-encoded combinatorial library functional screening. ACS Comb. Sci. 2017, 19, 181-192.
    • (2017) ACS Comb. Sci. , vol.19 , pp. 181-192
    • MacConnell, A.B.1    Price, A.K.2    Paegel, B.M.3
  • 217
    • 85042067622 scopus 로고    scopus 로고
    • De novo design of bioactive small molecules by artificial intelligence
    • Merk, D.; Friedrich, L.; Grisoni, F.; Schneider, G. De novo design of bioactive small molecules by artificial intelligence. Mol. Inform. 2018.
    • (2018) Mol. Inform.
    • Merk, D.1    Friedrich, L.2    Grisoni, F.3    Schneider, G.4
  • 218
    • 85028803040 scopus 로고    scopus 로고
    • From machine learning to deep learning: Progress in machine intelligence for rational drug discovery
    • Zhang, L.; Tan, J.; Han, D.; Zhu, H. From machine learning to deep learning: Progress in machine intelligence for rational drug discovery. Drug Discov. Today 2017, 22, 1680-1685.
    • (2017) Drug Discov. Today , vol.22 , pp. 1680-1685
    • Zhang, L.1    Tan, J.2    Han, D.3    Zhu, H.4
  • 219
    • 34249846647 scopus 로고    scopus 로고
    • Artificial intelligence approaches for rational drug design and discovery
    • Duch, W.; Swaminathan, K.; Meller, J. Artificial intelligence approaches for rational drug design and discovery. Curr. Pharm. Des. 2007, 13, 1497-1508.
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 1497-1508
    • Duch, W.1    Swaminathan, K.2    Meller, J.3
  • 220
    • 84926408953 scopus 로고    scopus 로고
    • Organs-on-chips at the frontiers of drug discovery
    • Esch, E.W.; Bahinski, A.; Huh, D. Organs-on-chips at the frontiers of drug discovery. Nat. Rev. Drug Discov. 2015, 14, 248-260.
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 248-260
    • Esch, E.W.1    Bahinski, A.2    Huh, D.3
  • 221
    • 84965181368 scopus 로고    scopus 로고
    • Drug discovery goes three-dimensional: Goodbye to flat high-throughput screening?
    • Eglen, R.M.; Randle, D.H. Drug discovery goes three-dimensional: Goodbye to flat high-throughput screening? Assay Drug Dev. Technol. 2015, 13, 262-265.
    • (2015) Assay Drug Dev. Technol. , vol.13 , pp. 262-265
    • Eglen, R.M.1    Randle, D.H.2
  • 222
    • 85034221481 scopus 로고    scopus 로고
    • David bowie and the art of slow innovation: A fast-second winner strategy for biotechnology and precision medicine global development
    • Ozdemir, V.; Patrinos, G.P. David bowie and the art of slow innovation: A fast-second winner strategy for biotechnology and precision medicine global development. Omics 2017, 21, 633-637.
    • (2017) Omics , vol.21 , pp. 633-637
    • Ozdemir, V.1    Patrinos, G.P.2
  • 223
    • 0036015844 scopus 로고    scopus 로고
    • Teaching target-oriented and diversity-oriented organic synthesis at Harvard University
    • Burke, M.D.; Lalic, G. Teaching target-oriented and diversity-oriented organic synthesis at Harvard University. Chem. Biol. 2002, 9, 535-541.
    • (2002) Chem. Biol. , vol.9 , pp. 535-541
    • Burke, M.D.1    Lalic, G.2
  • 224
    • 0034678033 scopus 로고    scopus 로고
    • Target-oriented and diversity-oriented organic synthesis in drug discovery
    • Schreiber, S.L. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 2000, 287, 1964-1969.
    • (2000) Science , vol.287 , pp. 1964-1969
    • Schreiber, S.L.1
  • 225
    • 84929103526 scopus 로고    scopus 로고
    • Design and synthesis of analogues of natural products
    • Maier, M.E. Design and synthesis of analogues of natural products. Org. Biomol. Chem. 2015, 13, 5302-5343.
    • (2015) Org. Biomol. Chem. , vol.13 , pp. 5302-5343
    • Maier, M.E.1
  • 226
    • 79955568244 scopus 로고    scopus 로고
    • Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway
    • Basu, S.; Ellinger, B.; Rizzo, S.; Deraeve, C.; Schurmann, M.; Preut, H.; Arndt, H.D.; Waldmann, H. Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway. Proc. Natl. Acad. Sci. USA 2011, 108, 6805-6810.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 6805-6810
    • Basu, S.1    Ellinger, B.2    Rizzo, S.3    Deraeve, C.4    Schurmann, M.5    Preut, H.6    Arndt, H.D.7    Waldmann, H.8
  • 229
  • 230
  • 232
    • 78049448019 scopus 로고    scopus 로고
    • Generative models for chemical structures
    • White, D.; Wilson, R.C. Generative models for chemical structures. J. Chem. Inf. Model. 2010, 50, 1257-1274.
    • (2010) J. Chem. Inf. Model. , vol.50 , pp. 1257-1274
    • White, D.1    Wilson, R.C.2
  • 234
    • 85044842229 scopus 로고    scopus 로고
    • Deep learning for drug design: An artificial intelligence paradigm for drug discovery in the big data era
    • Jing, Y.; Bian, Y.; Hu, Z.;Wang, L.; Xie, X.S. Deep learning for drug design: An artificial intelligence paradigm for drug discovery in the big data era. AAPS J. 2018, 20, 58.
    • (2018) AAPS J. , vol.20 , pp. 58
    • Jing, Y.1    Bian, Y.2    Hu, Z.3    Wang, L.4    Xie, X.S.5
  • 235
    • 84891793035 scopus 로고    scopus 로고
    • Combining on-chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPCR ligands
    • Reutlinger, M.; Rodrigues, T.; Schneider, P.; Schneider, G. Combining on-chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPCR ligands. Angew. Chem. Int. Ed. Engl. 2014, 53, 582-585.
    • (2014) Angew. Chem. Int. Ed. Engl. , vol.53 , pp. 582-585
    • Reutlinger, M.1    Rodrigues, T.2    Schneider, P.3    Schneider, G.4
  • 236
    • 85041303900 scopus 로고    scopus 로고
    • Automating drug discovery
    • Schneider, G. Automating drug discovery. Nat. Rev. Drug Discov. 2018, 17, 97-113.
    • (2018) Nat. Rev. Drug Discov. , vol.17 , pp. 97-113
    • Schneider, G.1
  • 238
    • 84953776512 scopus 로고    scopus 로고
    • Spotting and designing promiscuous ligands for drug discovery
    • Schneider, P.; Rothlisberger, M.; Reker, D.; Schneider, G. Spotting and designing promiscuous ligands for drug discovery. Chem. Commun. 2016, 52, 1135-1138.
    • (2016) Chem. Commun. , vol.52 , pp. 1135-1138
    • Schneider, P.1    Rothlisberger, M.2    Reker, D.3    Schneider, G.4
  • 239
    • 84923538660 scopus 로고    scopus 로고
    • Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field
    • Wang, L.; Wu, Y.; Deng, Y.; Kim, B.; Pierce, L.; Krilov, G.; Lupyan, D.; Robinson, S.; Dahlgren, M.K.; Greenwood, J.; et al. Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field. J. Am. Chem. Soc. 2015, 137, 2695-2703.
    • (2015) J. Am. Chem. Soc. , vol.137 , pp. 2695-2703
    • Wang, L.1    Wu, Y.2    Deng, Y.3    Kim, B.4    Pierce, L.5    Krilov, G.6    Lupyan, D.7    Robinson, S.8    Dahlgren, M.K.9    Greenwood, J.10
  • 241
    • 33646529146 scopus 로고    scopus 로고
    • Automated medicinal chemistry
    • Koppitz, M.; Eis, K. Automated medicinal chemistry. Drug Discov. Today 2006, 11, 561-568.
    • (2006) Drug Discov. Today , vol.11 , pp. 561-568
    • Koppitz, M.1    Eis, K.2
  • 242
    • 84896272686 scopus 로고    scopus 로고
    • An automated synthesis-purification-sample-management platform for the accelerated generation of pharmaceutical candidates
    • Sutherland, J.D.; Tu, N.P.; Nemcek, T.A.; Searle, P.A.; Hochlowski, J.E.; Djuric, S.W.; Pan, J.Y. An automated synthesis-purification-sample-management platform for the accelerated generation of pharmaceutical candidates. J. Lab. Autom. 2014, 19, 176-182.
    • (2014) J. Lab. Autom. , vol.19 , pp. 176-182
    • Sutherland, J.D.1    Tu, N.P.2    Nemcek, T.A.3    Searle, P.A.4    Hochlowski, J.E.5    Djuric, S.W.6    Pan, J.Y.7
  • 243
    • 84883258908 scopus 로고    scopus 로고
    • A remote-controlled adaptive medchem lab: An innovative approach to enable drug discovery in the 21st century
    • Godfrey, A.G.; Masquelin, T.; Hemmerle, H. A remote-controlled adaptive medchem lab: An innovative approach to enable drug discovery in the 21st century. Drug Discov. Today 2013, 18, 795-802.
    • (2013) Drug Discov. Today , vol.18 , pp. 795-802
    • Godfrey, A.G.1    Masquelin, T.2    Hemmerle, H.3
  • 244
    • 84979643825 scopus 로고    scopus 로고
    • The proximal lilly collection: Mapping, exploring and exploiting feasible chemical space
    • Nicolaou, C.A.; Watson, I.A.; Hu, H.; Wang, J. The proximal lilly collection: Mapping, exploring and exploiting feasible chemical space. J. Chem. Inf. Model. 2016, 56, 1253-1266.
    • (2016) J. Chem. Inf. Model. , vol.56 , pp. 1253-1266
    • Nicolaou, C.A.1    Watson, I.A.2    Hu, H.3    Wang, J.4
  • 246
    • 84887928802 scopus 로고    scopus 로고
    • Preparative microfluidic electrosynthesis of drug metabolites
    • Stalder, R.; Roth, G.P. Preparative microfluidic electrosynthesis of drug metabolites. ACS Med. Chem. Lett. 2013, 4, 1119-1123.
    • (2013) ACS Med. Chem. Lett. , vol.4 , pp. 1119-1123
    • Stalder, R.1    Roth, G.P.2
  • 247
    • 84990966860 scopus 로고    scopus 로고
    • Accessing drug metabolites via transition-metal catalyzed c-h oxidation: The liver as synthetic inspiration
    • Genovino, J.; Sames, D.; Hamann, L.G.; Toure, B.B. Accessing drug metabolites via transition-metal catalyzed c-h oxidation: The liver as synthetic inspiration. Angew. Chem. Int. Ed. Engl. 2016, 55, 14218-14238.
    • (2016) Angew. Chem. Int. Ed. Engl. , vol.55 , pp. 14218-14238
    • Genovino, J.1    Sames, D.2    Hamann, L.G.3    Toure, B.B.4
  • 248
    • 35948998871 scopus 로고    scopus 로고
    • Continuous processes for the production of pharmaceutical intermediates and active pharmaceutical ingredients
    • LaPorte, T.L.; Wang, C. Continuous processes for the production of pharmaceutical intermediates and active pharmaceutical ingredients. Curr. Opin. Drug Discov. Dev. 2007, 10, 738-745.
    • (2007) Curr. Opin. Drug Discov. Dev. , vol.10 , pp. 738-745
    • LaPorte, T.L.1    Wang, C.2
  • 249
    • 70350764840 scopus 로고    scopus 로고
    • Microstructured reactors as tools for the intensification of pharmaceutical reactions and processes
    • Chin, P.; Barney, W.S.; Pindzola, B.A. Microstructured reactors as tools for the intensification of pharmaceutical reactions and processes. Curr. Opin. Drug Discov. Dev. 2009, 12, 848-861.
    • (2009) Curr. Opin. Drug Discov. Dev. , vol.12 , pp. 848-861
    • Chin, P.1    Barney, W.S.2    Pindzola, B.A.3
  • 250
    • 21444450169 scopus 로고    scopus 로고
    • The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines
    • Saaby, S.; Knudsen, K.R.; Ladlow, M.; Ley, S.V. The use of a continuous flow-reactor employing a mixed hydrogen-liquid flow stream for the efficient reduction of imines to amines. Chem. Commun. 2005, 2909-2911.
    • (2005) Chem. Commun. , pp. 2909-2911
    • Saaby, S.1    Knudsen, K.R.2    Ladlow, M.3    Ley, S.V.4
  • 251
    • 84923083164 scopus 로고    scopus 로고
    • Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor
    • Brzozowski, M.; O’Brien, M.; Ley, S.V.; Polyzos, A. Flow chemistry: Intelligent processing of gas-liquid transformations using a tube-in-tube reactor. Acc. Chem. Res. 2015, 48, 349-362.
    • (2015) Acc. Chem. Res. , vol.48 , pp. 349-362
    • Brzozowski, M.1    Ley, S.V.2    Polyzos, A.3
  • 253
    • 84875428584 scopus 로고    scopus 로고
    • Implementing enzyme-linked immunosorbent assays on a microfluidic chip to quantify intracellular molecules in single cells
    • Eyer, K.; Stratz, S.; Kuhn, P.; Kuster, S.K.; Dittrich, P.S. Implementing enzyme-linked immunosorbent assays on a microfluidic chip to quantify intracellular molecules in single cells. Anal. Chem. 2013, 85, 3280-3287.
    • (2013) Anal. Chem. , vol.85 , pp. 3280-3287
    • Eyer, K.1    Stratz, S.2    Kuhn, P.3    Kuster, S.K.4    Dittrich, P.S.5
  • 254
    • 77949632782 scopus 로고    scopus 로고
    • Frontiers in cancer nanomedicine: Directing mass transport through biological barriers
    • Ferrari, M. Frontiers in cancer nanomedicine: Directing mass transport through biological barriers. Trends Biotechnol. 2010, 28, 181-188.
    • (2010) Trends Biotechnol. , vol.28 , pp. 181-188
    • Ferrari, M.1
  • 255
    • 85017474227 scopus 로고    scopus 로고
    • Cancer-on-a-chip systems at the frontier of nanomedicine
    • Zhang, Y.S.; Zhang, Y.N.; Zhang, W. Cancer-on-a-chip systems at the frontier of nanomedicine. Drug Discov. Today 2017, 22, 1392-1399.
    • (2017) Drug Discov. Today , vol.22 , pp. 1392-1399
    • Zhang, Y.S.1    Zhang, Y.N.2    Zhang, W.3
  • 256
    • 84894273782 scopus 로고    scopus 로고
    • Making a big thing of a small cell-recent advances in single cell analysis
    • Galler, K.; Brautigam, K.; Grosse, C.; Popp, J.; Neugebauer, U. Making a big thing of a small cell-recent advances in single cell analysis. Analyst 2014, 139, 1237-1273.
    • (2014) Analyst , vol.139 , pp. 1237-1273
    • Galler, K.1    Brautigam, K.2    Grosse, C.3    Popp, J.4    Neugebauer, U.5
  • 258
    • 84942194863 scopus 로고    scopus 로고
    • Incorporating virtual reactions into a logic-based ligand-based virtual screening method to discover new leads
    • Reynolds, C.R.; Muggleton, S.H.; Sternberg, M.J. Incorporating virtual reactions into a logic-based ligand-based virtual screening method to discover new leads. Mol. Inform. 2015, 34, 615-625.
    • (2015) Mol. Inform. , vol.34 , pp. 615-625
    • Reynolds, C.R.1    Muggleton, S.H.2    Sternberg, M.J.3
  • 261
    • 84877721615 scopus 로고    scopus 로고
    • Europe bets on drug discovery
    • Baker, M. Europe bets on drug discovery. Nature 2013, 494, 20.
    • (2013) Nature , vol.494 , pp. 20
    • Baker, M.1
  • 264
    • 84866436445 scopus 로고    scopus 로고
    • Artificial neural networks: Theoretical background and pharmaceutical applications: A review
    • Wesolowski, M.; Suchacz, B. Artificial neural networks: Theoretical background and pharmaceutical applications: A review. J. AOAC Int. 2012, 95, 652-668.
    • (2012) J. AOAC Int. , vol.95 , pp. 652-668
    • Wesolowski, M.1    Suchacz, B.2
  • 266
    • 18944391092 scopus 로고    scopus 로고
    • Biological networks and analysis of experimental data in drug discovery
    • Nikolsky, Y.; Nikolskaya, T.; Bugrim, A. Biological networks and analysis of experimental data in drug discovery. Drug Discov. Today 2005, 10, 653-662.
    • (2005) Drug Discov. Today , vol.10 , pp. 653-662
    • Nikolsky, Y.1    Nikolskaya, T.2    Bugrim, A.3
  • 268
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski, C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44, 235-249.
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 269
    • 0141726877 scopus 로고    scopus 로고
    • A ‘rule of three’ for fragment-based lead discovery?
    • Congreve, M.; Carr, R.; Murray, C.; Jhoti, H. A ‘rule of three’ for fragment-based lead discovery? Drug Discov. Today 2003, 8, 876-877.
    • (2003) Drug Discov. Today , vol.8 , pp. 876-877
    • Congreve, M.1    Carr, R.2    Murray, C.3    Jhoti, H.4
  • 270
    • 84868026890 scopus 로고    scopus 로고
    • Dissecting fragment-based lead discovery at the von Hippel-Lindau protein: Hypoxia inducible factor 1alpha protein-protein interface
    • Van Molle, I.; Thomann, A.; Buckley, D.L.; So, E.C.; Lang, S.; Crews, C.M.; Ciulli, A. Dissecting fragment-based lead discovery at the von Hippel-Lindau protein: Hypoxia inducible factor 1alpha protein-protein interface. Chem. Biol. 2012, 19, 1300-1312.
    • (2012) Chem. Biol. , vol.19 , pp. 1300-1312
    • Van Molle, I.1    Thomann, A.2    Buckley, D.L.3    So, E.C.4    Lang, S.5    Crews, C.M.6    Ciulli, A.7
  • 271
    • 84866945774 scopus 로고    scopus 로고
    • Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening
    • Zuegg, J.; Cooper, M.A. Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening. Curr. Top. Med. Chem. 2012, 12, 1500-1513.
    • (2012) Curr. Top. Med. Chem. , vol.12 , pp. 1500-1513
    • Zuegg, J.1    Cooper, M.A.2
  • 273
    • 52649134945 scopus 로고    scopus 로고
    • Scaffold diversity of natural products: Inspiration for combinatorial library design
    • Grabowski, K.; Baringhaus, K.H.; Schneider, G. Scaffold diversity of natural products: Inspiration for combinatorial library design. Nat. Prod. Rep. 2008, 25, 892-904.
    • (2008) Nat. Prod. Rep. , vol.25 , pp. 892-904
    • Grabowski, K.1    Baringhaus, K.H.2    Schneider, G.3
  • 274
    • 84923376898 scopus 로고    scopus 로고
    • Nanomolar inhibitors of the transcription factor STAT5b with high selectivity over STAT5a
    • Elumalai, N.; Berg, A.; Natarajan, K.; Scharow, A.; Berg, T. Nanomolar inhibitors of the transcription factor STAT5b with high selectivity over STAT5a. Angew. Chem. Int. Ed. Engl. 2015, 54, 4758-4763.
    • (2015) Angew. Chem. Int. Ed. Engl. , vol.54 , pp. 4758-4763
    • Elumalai, N.1    Berg, A.2    Natarajan, K.3    Scharow, A.4    Berg, T.5
  • 275
    • 77955705492 scopus 로고    scopus 로고
    • Bioactivity-guided navigation of chemical space
    • Bon, R.S.; Waldmann, H. Bioactivity-guided navigation of chemical space. Acc. Chem. Res. 2010, 43, 1103-1114.
    • (2010) Acc. Chem. Res. , vol.43 , pp. 1103-1114
    • Bon, R.S.1    Waldmann, H.2
  • 279
    • 0033737778 scopus 로고    scopus 로고
    • Pass: Prediction of activity spectra for biologically active substances
    • Lagunin, A.; Stepanchikova, A.; Filimonov, D.; Poroikov, V. Pass: Prediction of activity spectra for biologically active substances. Bioinformatics 2000, 16, 747-748.
    • (2000) Bioinformatics , vol.16 , pp. 747-748
    • Lagunin, A.1    Stepanchikova, A.2    Filimonov, D.3    Poroikov, V.4
  • 280
    • 0037241423 scopus 로고    scopus 로고
    • Prediction of biological activity spectra for substances: Evaluation on the diverse sets of drug-like structures
    • Stepanchikova, A.V.; Lagunin, A.A.; Filimonov, D.A.; Poroikov, V.V. Prediction of biological activity spectra for substances: Evaluation on the diverse sets of drug-like structures. Curr. Med. Chem. 2003, 10, 225-233.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 225-233
    • Stepanchikova, A.V.1    Lagunin, A.A.2    Filimonov, D.A.3    Poroikov, V.V.4
  • 281
    • 84896525962 scopus 로고    scopus 로고
    • Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus
    • Reker, D.; Rodrigues, T.; Schneider, P.; Schneider, G. Identifying the macromolecular targets of de novo-designed chemical entities through self-organizing map consensus. Proc. Natl. Acad. Sci. USA 2014, 111, 4067-4072.
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 4067-4072
    • Reker, D.1    Rodrigues, T.2    Schneider, P.3    Schneider, G.4
  • 282
    • 84907506421 scopus 로고    scopus 로고
    • Coping with polypharmacology by computational medicinal chemistry
    • Schneider, G.; Reker, D.; Rodrigues, T.; Schneider, P. Coping with polypharmacology by computational medicinal chemistry. Chimia 2014, 68, 648-653.
    • (2014) Chimia , vol.68 , pp. 648-653
    • Schneider, G.1    Reker, D.2    Rodrigues, T.3    Schneider, P.4
  • 284
    • 77149155968 scopus 로고    scopus 로고
    • Trends in risks associated with new drug development:Success rates for investigational drugs
    • DiMasi, J.A.; Feldman, L.; Seckler, A.; Wilson, A. Trends in risks associated with new drug development:Success rates for investigational drugs. Clin. Pharmacol. Ther. 2010, 87, 272-277.
    • (2010) Clin. Pharmacol. Ther. , vol.87 , pp. 272-277
    • DiMasi, J.A.1    Feldman, L.2    Seckler, A.3    Wilson, A.4
  • 290
    • 84870563542 scopus 로고    scopus 로고
    • Methods for building QSARs
    • Devillers, J. Methods for building QSARs. Methods Mol. Biol. 2013, 930, 3-27. [PubMed]
    • (2013) Methods Mol. Biol. , vol.930 , pp. 3-27
    • Devillers, J.1
  • 291
    • 84902259948 scopus 로고    scopus 로고
    • Building on a solid foundation: SAR and QSAR as a fundamental strategy to reduce animal testing
    • Sullivan, K.M.; Manuppello, J.R.; Willett, C.E. Building on a solid foundation: SAR and QSAR as a fundamental strategy to reduce animal testing. SAR QSAR Environ. Res. 2014, 25, 357-365.
    • (2014) SAR QSAR Environ. Res. , vol.25 , pp. 357-365
    • Sullivan, K.M.1    Manuppello, J.R.2    Willett, C.E.3
  • 293
    • 84934915265 scopus 로고    scopus 로고
    • Predicting the binding modes and sites of metabolism of xenobiotics
    • Mukherjee, G.; Lal Gupta, P.; Jayaram, B. Predicting the binding modes and sites of metabolism of xenobiotics. Mol. BioSyst. 2015, 11, 1914-1924.
    • (2015) Mol. BioSyst. , vol.11 , pp. 1914-1924
    • Mukherjee, G.1    Lal Gupta, P.2    Jayaram, B.3
  • 294
    • 84938953300 scopus 로고    scopus 로고
    • Idrug-target: Predicting the interactions between drug compounds and target proteins in cellular networking via benchmark dataset optimization approach
    • Xiao, X.; Min, J.L.; Lin, W.Z.; Liu, Z.; Cheng, X.; Chou, K.C. Idrug-target: Predicting the interactions between drug compounds and target proteins in cellular networking via benchmark dataset optimization approach. J. Biomol. Struct. Dyn. 2015, 33, 2221-2233.
    • (2015) J. Biomol. Struct. Dyn. , vol.33 , pp. 2221-2233
    • Xiao, X.1    Min, J.L.2    Lin, W.Z.3    Liu, Z.4    Cheng, X.5    Chou, K.C.6
  • 295
    • 84946416532 scopus 로고    scopus 로고
    • Predicting drug side effects by multi-label learning and ensemble learning
    • Zhang, W.; Liu, F.; Luo, L.; Zhang, J. Predicting drug side effects by multi-label learning and ensemble learning. BMC Bioinform. 2015, 16, 365.
    • (2015) BMC Bioinform. , vol.16 , pp. 365
    • Zhang, W.1    Liu, F.2    Luo, L.3    Zhang, J.4
  • 296
    • 84875192633 scopus 로고    scopus 로고
    • Synergistic activity of bortezomib and hdaci in preclinical models of b-cell precursor acute lymphoblastic leukemia via modulation of p53, pi3k/akt, and nf-kappab
    • Bastian, L.; Hof, J.; Pfau, M.; Fichtner, I.; Eckert, C.; Henze, G.; Prada, J.; von Stackelberg, A.; Seeger, K.; Shalapour, S. Synergistic activity of bortezomib and hdaci in preclinical models of b-cell precursor acute lymphoblastic leukemia via modulation of p53, pi3k/akt, and nf-kappab. Clin. Cancer Res. 2013, 19, 1445-1457.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1445-1457
    • Bastian, L.1    Hof, J.2    Pfau, M.3    Fichtner, I.4    Eckert, C.5    Henze, G.6    Prada, J.7    Von Stackelberg, A.8    Seeger, K.9    Shalapour, S.10
  • 297
    • 39149087969 scopus 로고    scopus 로고
    • Anti-cd19 and anti-cd22 monoclonal antibodies increase the effectiveness of chemotherapy in pre-b acute lymphoblastic leukemia cell lines
    • Stanciu-Herrera, C.; Morgan, C.; Herrera, L. Anti-cd19 and anti-cd22 monoclonal antibodies increase the effectiveness of chemotherapy in pre-b acute lymphoblastic leukemia cell lines. Leukemia Res. 2008, 32, 625-632.
    • (2008) Leukemia Res. , vol.32 , pp. 625-632
    • Stanciu-Herrera, C.1    Morgan, C.2    Herrera, L.3
  • 298
    • 85005996201 scopus 로고    scopus 로고
    • Cancer stem cell hypothesis for therapeutic innovation in clinical oncology? Taking the root out, not chopping the leaf
    • Dzobo, K.; Senthebane, D.A.; Rowe, A.; Thomford, N.E.; Mwapagha, L.M.; Al-Awwad, N.; Dandara, C.; Parker, M.I. Cancer stem cell hypothesis for therapeutic innovation in clinical oncology? Taking the root out, not chopping the leaf. Omics 2016, 20, 681-691.
    • (2016) Omics , vol.20 , pp. 681-691
    • Dzobo, K.1    Senthebane, D.A.2    Rowe, A.3    Thomford, N.E.4    Mwapagha, L.M.5    Al-Awwad, N.6    Dandara, C.7    Parker, M.I.8
  • 299
    • 85047728923 scopus 로고    scopus 로고
    • Not everyone fits the mold: Intratumor and intertumor heterogeneity and innovative cancer drug design and development
    • Dzobo, K.; Senthebane, D.A.; Thomford, N.E.; Rowe, A.; Dandara, C.; Parker, M.I. Not everyone fits the mold: Intratumor and intertumor heterogeneity and innovative cancer drug design and development. Omics 2018, 22, 17-34.
    • (2018) Omics , vol.22 , pp. 17-34
    • Dzobo, K.1    Senthebane, D.A.2    Thomford, N.E.3    Rowe, A.4    Dandara, C.5    Parker, M.I.6
  • 303
    • 84903885321 scopus 로고    scopus 로고
    • Incidence of central nervous system metastases in patients with HER2-positive metastatic breast cancer treated with pertuzumab, trastuzumab, and docetaxel: Results from the randomized phase iii study cleopatra
    • Swain, S.M.; Baselga, J.; Miles, D.; Im, Y.H.; Quah, C.; Lee, L.F.; Cortes, J. Incidence of central nervous system metastases in patients with HER2-positive metastatic breast cancer treated with pertuzumab, trastuzumab, and docetaxel: Results from the randomized phase iii study cleopatra. Ann. Oncol. 2014, 25, 1116-1121.
    • (2014) Ann. Oncol. , vol.25 , pp. 1116-1121
    • Swain, S.M.1    Baselga, J.2    Miles, D.3    Im, Y.H.4    Quah, C.5    Lee, L.F.6    Cortes, J.7
  • 304
    • 84876970810 scopus 로고    scopus 로고
    • Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (cleopatra study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
    • Swain, S.M.; Kim, S.B.; Cortes, J.; Ro, J.; Semiglazov, V.; Campone, M.; Ciruelos, E.; Ferrero, J.M.; Schneeweiss, A.; Knott, A.; et al. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (cleopatra study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 2013, 14, 461-471.
    • (2013) Lancet Oncol. , vol.14 , pp. 461-471
    • Swain, S.M.1    Kim, S.B.2    Cortes, J.3    Ro, J.4    Semiglazov, V.5    Campone, M.6    Ciruelos, E.7    Ferrero, J.M.8    Schneeweiss, A.9    Knott, A.10
  • 305
    • 84969163133 scopus 로고    scopus 로고
    • The national academies collection: Reports funded by national institutes of health
    • National Academies Press (US), National Academy of Sciences: Washington, DC, USA
    • National Academy of Sciences (US). The national academies collection: Reports funded by national institutes of health. In Toward PrecisionMedicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease; National Academies Press (US), National Academy of Sciences: Washington, DC, USA, 2011.
    • (2011) Toward PrecisionMedicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease
  • 306
    • 61349117380 scopus 로고    scopus 로고
    • Integrating genomics across drug discovery and development
    • Debouck, C. Integrating genomics across drug discovery and development. Toxicol. Lett. 2009, 186, 9-12.
    • (2009) Toxicol. Lett. , vol.186 , pp. 9-12
    • Debouck, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.