-
1
-
-
0034677966
-
Drug discovery: A historical perspective
-
Drews J. Drug discovery: a historical perspective. Science 2000;287:1960-4
-
(2000)
Science
, vol.287
, pp. 1960-1964
-
-
Drews, J.1
-
2
-
-
42249093117
-
System biology: A new hope for drug discovery
-
Henney AM. System biology: a new hope for drug discovery. Expert Opin Drug Discov 2006;1:653-61
-
(2006)
Expert Opin Drug Discov
, vol.1
, pp. 653-661
-
-
Henney, A.M.1
-
3
-
-
8844263008
-
Docking and scoring in virtual screening for drug discovery: Methods and applications
-
Kitchen DB, Decornez H, FURR Jr, et al. Docking and scoring in virtual screening for drug discovery: methods and applications. Nature 2004;3:935-49
-
(2004)
Nature
, vol.3
, pp. 935-949
-
-
Kitchen, D.B.1
Decornez, H.2
FURR Jr3
-
4
-
-
11144341956
-
Chemical space and biology
-
Dobson CM. Chemical space and biology. Nature 2004;432:824-8
-
(2004)
Nature
, vol.432
, pp. 824-828
-
-
Dobson, C.M.1
-
5
-
-
33847401924
-
High-throughput electronic biology: Mining information for drug discovery
-
Loging W, Harland L, Bryn WJ. High-throughput electronic biology: mining information for drug discovery. Nature 2007;6:220-30
-
(2007)
Nature
, vol.6
, pp. 220-230
-
-
Loging, W.1
Harland, L.2
Bryn, W.J.3
-
6
-
-
0036606269
-
Bioinformatics and information technology: Reshaping the drug discovery process
-
Augen J. Bioinformatics and information technology: reshaping the drug discovery process. Drug Discov Today 2002;7:39-40
-
(2002)
Drug Discov Today
, vol.7
, pp. 39-40
-
-
Augen, J.1
-
7
-
-
84895362887
-
-
Chen YPP, editor, New York Springer;
-
Chen YPP, editor. Bioinformatics Technologies. New York Springer; 2005
-
(2005)
Bioinformatics Technologies
-
-
-
8
-
-
42249106492
-
Discovery strategies in a pharmaceutical setting: The application of computational techniques
-
Jennings A, Tennant M. Discovery strategies in a pharmaceutical setting: the application of computational techniques. Expert Opin Drug Discov 2006;1:709-21
-
(2006)
Expert Opin Drug Discov
, vol.1
, pp. 709-721
-
-
Jennings, A.1
Tennant, M.2
-
9
-
-
0035895496
-
Computational biology: Bioinformatics-trying to swim in a sea of data
-
Roos DS. Computational biology: bioinformatics-trying to swim in a sea of data. Science 2001;291:1260-1
-
(2001)
Science
, vol.291
, pp. 1260-1261
-
-
Roos, D.S.1
-
10
-
-
1642357706
-
The many roles of computation in drug discovery
-
Jorgensen WL. The many roles of computation in drug discovery. Science 2004;303:1813-7
-
(2004)
Science
, vol.303
, pp. 1813-1817
-
-
Jorgensen, W.L.1
-
11
-
-
42249101507
-
Bioinformatics in the drug discovery process
-
Pollock S, Safer H. Bioinformatics in the drug discovery process. Ann Rep Med Chem 2001;1-9
-
(2001)
Ann Rep Med Chem
, pp. 1-9
-
-
Pollock, S.1
Safer, H.2
-
12
-
-
0035742528
-
Continuing evolution of the drug discovery process in the pharmaceutical industry
-
Ratti E, Trist D. Continuing evolution of the drug discovery process in the pharmaceutical industry. Pure Appl Chem 2001;73:67-75
-
(2001)
Pure Appl Chem
, vol.73
, pp. 67-75
-
-
Ratti, E.1
Trist, D.2
-
13
-
-
36549048029
-
An update on using protein microarrays in drug discovery
-
Kumble KD. An update on using protein microarrays in drug discovery. Expert Opin Drug Discov 2007;2:1477-6
-
(2007)
Expert Opin Drug Discov
, vol.2
, pp. 1477-1486
-
-
Kumble, K.D.1
-
14
-
-
35348890191
-
Mouse genetics in drug target discovery and validation: No simple answers to complex problems
-
Russ AP, Grosse J. Mouse genetics in drug target discovery and validation: no simple answers to complex problems. Expert Opin Drug Discov 2007;2:1379-87
-
(2007)
Expert Opin Drug Discov
, vol.2
, pp. 1379-1387
-
-
Russ, A.P.1
Grosse, J.2
-
15
-
-
33646351764
-
Structural biology and bioinformatics in drug design: Opportunities and challenges for target identification and lead discovery
-
Blundell TL, Sibanda BL, Montalvao RW, et al. Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Phil Trans R Soc B 2006;361:413-423
-
(2006)
Phil Trans R Soc B
, vol.361
, pp. 413-423
-
-
Blundell, T.L.1
Sibanda, B.L.2
Montalvao, R.W.3
-
16
-
-
29544441696
-
Strategies to move beyond target validation
-
Habeman AB. Strategies to move beyond target validation. Genet Eng News 2005;25:36
-
(2005)
Genet Eng News
, vol.25
, pp. 36
-
-
Habeman, A.B.1
-
17
-
-
35748983210
-
Target deconvolution strategies in drug discovery
-
Terstappen GC, schilupen C, Raggiaschi R, et al. Target deconvolution strategies in drug discovery. Nature 2007;6:891-903
-
(2007)
Nature
, vol.6
, pp. 891-903
-
-
Terstappen, G.C.1
schilupen, C.2
Raggiaschi, R.3
-
19
-
-
0037365194
-
Support vector machines far active learning in the drug discovery process
-
Warmuth MK, Liao J, Ratsch G, et al. Support vector machines far active learning in the drug discovery process. J Chem Inf Sci 2003;43:667-73
-
(2003)
J Chem Inf Sci
, vol.43
, pp. 667-673
-
-
Warmuth, M.K.1
Liao, J.2
Ratsch, G.3
-
20
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
Schreiber SL. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 2000;287:1964-8
-
(2000)
Science
, vol.287
, pp. 1964-1968
-
-
Schreiber, S.L.1
-
21
-
-
0034677755
-
Mechanism-based target identifiation and drug discovery in cancer research
-
Gibbs JR. Mechanism-based target identifiation and drug discovery in cancer research. Science 2000;287:1969-73
-
(2000)
Science
, vol.287
, pp. 1969-1973
-
-
Gibbs, J.R.1
-
22
-
-
0033762577
-
Genomics: The babel of bioinformatics
-
Attwood TK. Genomics: the babel of bioinformatics. Science 2000;290:471-3
-
(2000)
Science
, vol.290
, pp. 471-473
-
-
Attwood, T.K.1
-
23
-
-
0037245821
-
Simple rules underlying gene expression profiles of more than six subtypes of acute lymphoblastic leukemia (ALL) patients
-
Li J, Liu H, Downing Jr, et al. Simple rules underlying gene expression profiles of more than six subtypes of acute lymphoblastic leukemia (ALL) patients. Bioinformatics 2003;19:71-8
-
(2003)
Bioinformatics
, vol.19
, pp. 71-78
-
-
Li, J.1
Liu, H.2
Downing Jr3
-
24
-
-
0002034653
-
Efficient mining of emerging patterns: Discovering trends and differences
-
Gond G, Li J. Efficient mining of emerging patterns: discovering trends and differences. Proc Int Conf Knowledge Discov Data Arch 1999:43-52
-
(1999)
Proc Int Conf Knowledge Discov Data Arch
, pp. 43-52
-
-
Gond, G.1
Li, J.2
-
25
-
-
33846687846
-
An evaluation of contemporary hidden markov model gene finders with a predicted exon taxonomy
-
Knapp K, Chen YPP. An evaluation of contemporary hidden markov model gene finders with a predicted exon taxonomy. Nucleic Acids Res 2007;35:317-24
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 317-324
-
-
Knapp, K.1
Chen, Y.P.P.2
-
26
-
-
17244378534
-
A rapid method for detection of putative RNAi target genes in genomic data
-
Horesh Y, Amir A, Michaeli S. A rapid method for detection of putative RNAi target genes in genomic data. Bioinformatics 2003;19:1173-80
-
(2003)
Bioinformatics
, vol.19
, pp. 1173-1180
-
-
Horesh, Y.1
Amir, A.2
Michaeli, S.3
-
27
-
-
12144259760
-
Exploring potential target genes of signaling pathways by predicting conserved transcription factor binding sites
-
Dieterich C, Herwig R, Vingron M. Exploring potential target genes of signaling pathways by predicting conserved transcription factor binding sites. Bioinformatics 2003;19:1150-6
-
(2003)
Bioinformatics
, vol.19
, pp. 1150-1156
-
-
Dieterich, C.1
Herwig, R.2
Vingron, M.3
-
28
-
-
38449123027
-
Microarray data classification using automatic SVM kernel selection
-
Nahar J, Ali S, Chen YPP. Microarray data classification using automatic SVM kernel selection. DNA Cell Biol 2007;10:707-12
-
(2007)
DNA Cell Biol
, vol.10
, pp. 707-712
-
-
Nahar, J.1
Ali, S.2
Chen, Y.P.P.3
-
30
-
-
33846923330
-
A pHMM-ANN based discriminative approach to promoter identification in prokaryote genomic contexts
-
Mann S, Li J, Chen YPP. A pHMM-ANN based discriminative approach to promoter identification in prokaryote genomic contexts. Nucleic Acids Res 2007;35:e121-7
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Mann, S.1
Li, J.2
Chen, Y.P.P.3
-
31
-
-
32144447413
-
Pathway recognition and augmentation by computational analysis of microarray expression data
-
Novak BA, Jam AN. Pathway recognition and augmentation by computational analysis of microarray expression data. Bioinformatics 2006;22:233-41
-
(2006)
Bioinformatics
, vol.22
, pp. 233-241
-
-
Novak, B.A.1
Jam, A.N.2
-
34
-
-
33645811515
-
Structural bioinformatics of DNA: A web-based tool for the analysis of molecular dynamics results and structure prediction
-
Dixit SB, Beveridge DL. Structural bioinformatics of DNA: a web-based tool for the analysis of molecular dynamics results and structure prediction. Bioinformatics 2006;22:1007-9
-
(2006)
Bioinformatics
, vol.22
, pp. 1007-1009
-
-
Dixit, S.B.1
Beveridge, D.L.2
-
35
-
-
0036083294
-
Extraction of knowledge on protein-protein interaction by association rule discovery
-
Oyama T, Kitano K, Satou K, et al. Extraction of knowledge on protein-protein interaction by association rule discovery. Bioinformatics 2002;18:705-14
-
(2002)
Bioinformatics
, vol.18
, pp. 705-714
-
-
Oyama, T.1
Kitano, K.2
Satou, K.3
-
36
-
-
33749138226
-
-
Chen Q, Chen YPP. Mining frequent patterns for AMP-activated protein kinase regulation on skeletal muscle. BMC Bioinform 2007;7:394. Published online 30 August 2006, doi:10.1186/1471-2105-7-394.
-
Chen Q, Chen YPP. Mining frequent patterns for AMP-activated protein kinase regulation on skeletal muscle. BMC Bioinform 2007;7:394. Published online 30 August 2006, doi:10.1186/1471-2105-7-394.
-
-
-
-
37
-
-
34249849395
-
Discovery of microRNA-mRNA modules via population-based probabilistic learning
-
Joung JG, Hwang KB, Nam JW, et al. Discovery of microRNA-mRNA modules via population-based probabilistic learning. Bioinformatics 2007;23:1141-7
-
(2007)
Bioinformatics
, vol.23
, pp. 1141-1147
-
-
Joung, J.G.1
Hwang, K.B.2
Nam, J.W.3
-
38
-
-
36448982458
-
Naïve bayes for microRNA target predictions - machine learning for microRNA targets
-
Yousef M, Jung S, Kossenkov AV, et al. Naïve bayes for microRNA target predictions - machine learning for microRNA targets. Bioinformatics 2007;23:2987-92
-
(2007)
Bioinformatics
, vol.23
, pp. 2987-2992
-
-
Yousef, M.1
Jung, S.2
Kossenkov, A.V.3
-
39
-
-
23244457783
-
Studies define role of microRNA in cancer
-
Hede K. Studies define role of microRNA in cancer. J Natl Cancer Inst 2005;97:1114-5
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1114-1115
-
-
Hede, K.1
-
40
-
-
34547463506
-
Let-7 expression defines two differentiation stages of cancer
-
Shell S, Park SM, Radjabi AR, et al. Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci USA 2007;27:11400-5
-
(2007)
Proc Natl Acad Sci USA
, vol.27
, pp. 11400-11405
-
-
Shell, S.1
Park, S.M.2
Radjabi, A.R.3
-
41
-
-
42249091838
-
Cancer classification with microRNA expression patterns found by an information theory approach
-
Zheng Y, Kwoh CK. Cancer classification with microRNA expression patterns found by an information theory approach. J Comput 2006;1:30-9
-
(2006)
J Comput
, vol.1
, pp. 30-39
-
-
Zheng, Y.1
Kwoh, C.K.2
-
42
-
-
17444415742
-
TargetFinder: A software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA
-
Bo XC, Wang SQ. TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA. Bioinformatcis 2005;21:1401-2
-
(2005)
Bioinformatcis
, vol.21
, pp. 1401-1402
-
-
Bo, X.C.1
Wang, S.Q.2
-
43
-
-
17444426131
-
VitaPad: Visualization tools for the analysis of pathway data
-
Holford M, Li N, Nadkarni P, et al. VitaPad: visualization tools for the analysis of pathway data. Bioinformatics 2005;21:1596-602
-
(2005)
Bioinformatics
, vol.21
, pp. 1596-1602
-
-
Holford, M.1
Li, N.2
Nadkarni, P.3
-
44
-
-
0037944233
-
Pathways database system: An integrated system for biological pathways
-
Krishnamurthy L, Nadeau J, Ozsoyoglu G, et al. Pathways database system: an integrated system for biological pathways. Bioinformatics 2003;19:930-7
-
(2003)
Bioinformatics
, vol.19
, pp. 930-937
-
-
Krishnamurthy, L.1
Nadeau, J.2
Ozsoyoglu, G.3
-
45
-
-
34547840198
-
An efficient method for the detection and elimination of systematic error in high-throughput screening
-
Makarenkov V, Zentilli P, Kevorkov D, et al. An efficient method for the detection and elimination of systematic error in high-throughput screening. Bioinformatics 2007;23:1648-57
-
(2007)
Bioinformatics
, vol.23
, pp. 1648-1657
-
-
Makarenkov, V.1
Zentilli, P.2
Kevorkov, D.3
-
46
-
-
15844427599
-
Improving conformational searches by geometric screening
-
Zhang M, White RA, Wang LQ. Improving conformational searches by geometric screening. Bioinformatics 2005;21:624-30
-
(2005)
Bioinformatics
, vol.21
, pp. 624-630
-
-
Zhang, M.1
White, R.A.2
Wang, L.Q.3
-
47
-
-
33745621325
-
HTS-Corrector: Software for the statistical analysis and correction of experimental high-throughput screening data
-
Makarehkov V, Kevorkov D, Zentilli P. HTS-Corrector: software for the statistical analysis and correction of experimental high-throughput screening data. Bioinformatics 2006;22:1408-9
-
(2006)
Bioinformatics
, vol.22
, pp. 1408-1409
-
-
Makarehkov, V.1
Kevorkov, D.2
Zentilli, P.3
-
49
-
-
34147192127
-
Biskit - a software platform for structural bioinformatics
-
Grunberg R, Nilges M, Leckner J. Biskit - a software platform for structural bioinformatics. Bioinformatics 2007;23:769-70
-
(2007)
Bioinformatics
, vol.23
, pp. 769-770
-
-
Grunberg, R.1
Nilges, M.2
Leckner, J.3
-
50
-
-
42249099578
-
-
Available from
-
Available from: http://www.ebi.ac.uk/embl/index.html
-
-
-
-
51
-
-
42249112009
-
-
Available from
-
Available from: http://www.Ncbi.nlm.nih.gov/Genbank
-
-
-
-
52
-
-
42249106777
-
-
Available from
-
Available from: http://www.ddbj.nig.ac.jp/Welcome-e.html
-
-
-
-
53
-
-
0034069495
-
Gene ontology: Tool for the unification of biology
-
Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology Nat Genet 2000;25:25-9
-
(2000)
Nat Genet
, vol.25
, pp. 25-29
-
-
Ashburner, M.1
Ball, C.A.2
Blake, J.A.3
-
54
-
-
17844370543
-
Advances in knowledge management for pharmaceutical research and development
-
Pfizer TBS. Advances in knowledge management for pharmaceutical research and development. Curr Opin Drug Discov Dev 2005;8:316-22
-
(2005)
Curr Opin Drug Discov Dev
, vol.8
, pp. 316-322
-
-
Pfizer, T.B.S.1
-
55
-
-
39049178060
-
BioDash: A semantic web dashboard for drug development
-
Neumann EK, Quan D. BioDash: a semantic web dashboard for drug development. Pac Symp Biocomput 2006;11:176-87
-
(2006)
Pac Symp Biocomput
, vol.11
, pp. 176-187
-
-
Neumann, E.K.1
Quan, D.2
-
56
-
-
42249086746
-
-
Available from
-
Available from: http://www.targetscan.org/
-
-
-
-
57
-
-
1642276425
-
Drug discovery
-
Kennedy D. Drug discovery. Science 2004;303:1729
-
(2004)
Science
, vol.303
, pp. 1729
-
-
Kennedy, D.1
|