Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

Cell

Volumn 168, Issue 1-2, 2017, Pages 86-100.e15

  Li, Jin ^a   Casteels, Tamara ^a   Huber, Kilian V M ^a   Lardeau, Charles Hugues ^a   Klughammer, Johanna ^a   Farlik, Matthias ^a   Sdelci, Sara ^a   Májek, Peter ^a   Pauler, Florian M ^a   Penz, Thomas ^a   Stukalov, Alexey ^a   Gridling, Manuela ^a   Parapatics, Katja ^a   Colinge, Jacques ^a   Bennett, Keiryn L ^a   Bock, Christoph ^a,j,k   Superti Furga, Giulio ^a,j   Kubicek, Stefan ^a   Frogne, Thomas ^b   Ingvorsen, Camilla ^b   Honoré, Christian ^b   Hecksher Sørensen, Jacob ^b   Courtney, Monica ^c   Vieira, Andhira ^c   Avolio, Fabio ^c   Collombat, Patrick ^c   Schmitner, Nicole ^d   Kimmel, Robin A ^d   Meyer, Dirk ^d   Romanov, Roman A ^e,l   Harkany, Tibor ^e,l   Sturtzel, Caterina ^f   Distel, Martin ^f   Briand, François ^g   Sulpice, Thierry ^g   Baburin, Igor ^h   Hering, Steffen ^h   Barbieux, Charlotte ⁱ   Berishvili, Ekaterine ^i,m   Spittler, Andreas ^j   more..

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITÉ CÔTE D'AZUR   (France)

^d UNIVERSITY OF INNSBRUCK   (Austria)

^e Medical University of Vienna   (Austria)

^f CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^g Prologue Biotech   (France)

^h UNIVERSITY OF VIENNA   (Austria)

ⁱ GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^j MEDICAL UNIVERSITY OF VIENNA   (Austria)

^k MAX PLANCK INSTITUTE FOR INFORMATICS   (Germany)

^l KAROLINSKA INSTITUTE   (Sweden)

^m ILIA STATE UNIVERSITY   (Georgia)

more..

Author keywords

artemisinins; ARX translocation; chemical biology; diabetes; GABA receptor signaling; gephyrin; insulin secretion; pancreatic endocrine transdifferentiation; regenerative medicine; cell

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ARTEMISININ DERIVATIVE; GEPHYRIN; INSULIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARX; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; ARTEMETHER; ARX PROTEIN, HUMAN; CARRIER PROTEIN; HOMEODOMAIN PROTEIN; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; GLUCAGON RELEASE; GLUCOSE HOMEOSTASIS; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; CELL CULTURE; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 1; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; HUMAN; METABOLISM; PANCREAS ISLET; PATHOLOGY; PROTEIN STABILITY; RAT; SINGLE CELL ANALYSIS; ZEBRA FISH;

ANIMALS; ARTEMISININS; CARRIER PROTEINS; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION PROFILING; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MEMBRANE PROTEINS; MICE; PROTEIN STABILITY; RATS; RECEPTORS, GABA-A; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; TRANSCRIPTION FACTORS; ZEBRAFISH;

EID: 85007346465     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.11.010     Document Type: Article

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