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Angewandte Chemie - International Edition

Volumn 54, Issue 12, 2015, Pages 3787-3791

Englerin a is a potent and selective activator of TRPC4 and TRPC5 calcium channels

(15) Akbulut, Yasemin a,b Gaunt, Hannah J c Muraki, Katsuhiko d Ludlow, Melanie J c Amer, Mohamed S c,e Bruns, Alexander c Vasudev, Naveen S c Radtke, Lea f Willot, Matthieu f Hahn, Sven f Seitz, Tobias f Ziegler, Slava a Christmann, Mathias f Beech, David J c Waldmann, Herbert a,b

a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY (Germany)

b TU DORTMUND UNIVERSITY (Germany)

c UNIVERSITY OF LEEDS (United Kingdom)

d AICHI GAKUIN UNIVERSITY (Japan)

e MENOUFIA UNIVERSITY (Egypt)

f FREIE UNIVERSITÄT BERLIN (Germany)

Author keywords

antitumor agents; calcium ions; ion channels; natural products

Indexed keywords

CELL MEMBRANES; CELLS; CHEMICAL ACTIVATION; DISEASES; DRUG PRODUCTS; IONS;

ANTI-TUMOR AGENTS; CALCIUM CHANNELS; CALCIUM IONS; DRUG DISCOVERY; ION CHANNEL; NATURAL PRODUCTS; RENAL CELL CANCERS; TRANSIENT RECEPTOR POTENTIALS;

CALCIUM;

CALCIUM; ENGLERIN A; SESQUITERPENE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC4 ION CHANNEL; TRPC5 PROTEIN, HUMAN;

AGONISTS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HT 29 CELL LINE; HUMAN; METABOLISM; STEREOISOMERISM; TUMOR CELL LINE;

CALCIUM; CELL LINE, TUMOR; CELL SURVIVAL; HEK293 CELLS; HT29 CELLS; HUMANS; SESQUITERPENES, GUAIANE; STEREOISOMERISM; TRPC CATION CHANNELS;

EID: 84924429487 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201411511 Document Type: Article

Times cited : (157)

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