SCOPUS 정보 검색 플랫폼

Angewandte Chemie - International Edition

Volumn 53, Issue 2, 2014, Pages 582-585

Combining on-chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPCR ligands

(4) Reutlinger, Michael a Rodrigues, Tiago a Schneider, Petra a,b Schneider, Gisbert a,b

a ETH ZURICH (Switzerland)

b InSilicom GmbH (Switzerland)

Author keywords

combinatorial chemistry; computer chemistry; drug design; microfluidics; multicomponent reactions

Indexed keywords

COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; COMBINATORIAL SYNTHESIS; COMPUTER CHEMISTRY; DRUG DESIGN; MULTI-COMPONENT REACTIONS; RECEPTOR ANTAGONISTS; THREE COMPONENT REACTIONS;

ASSOCIATION REACTIONS; BIOASSAY; BIOCHIPS; FORECASTING; LIGANDS; SYNTHESIS (CHEMICAL);

MICROFLUIDICS;

ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; G PROTEIN COUPLED RECEPTOR; IMIDAZOLE DERIVATIVE; LIGAND; PYRIDINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPUTER CHEMISTRY; DRUG DESIGN; METHODOLOGY; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; MULTICOMPONENT REACTIONS; PREDICTIVE VALUE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COMBINATORIAL CHEMISTRY; COMPUTER CHEMISTRY; DRUG DESIGN; MICROFLUIDICS; MULTICOMPONENT REACTIONS;

ADENOSINE A1 RECEPTOR ANTAGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; IMIDAZOLES; LIGANDS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, MOLECULAR; PREDICTIVE VALUE OF TESTS; PYRIDINES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891793035 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201307786 Document Type: Article

Times cited : (61)

References (36)

1
- 79952131874
- R. Macarron, M. N. Banks, D. Bojanic, D. J. Burns, D. A. Cirovic, T. Garyantes, D. V. S. Green, R. P. Hertzberg, W. P. Janzen, J. W. Paslay, U. Schopfer, G. S. Sittampalam, Nat. Rev. Drug Discovery 2011, 10, 188-195
- (2011) Nat. Rev. Drug Discovery , vol.10 , pp. 188-195
- MacArron, R.¹ Banks, M.N.² Bojanic, D.³ Burns, D.J.⁴ Cirovic, D.A.⁵ Garyantes, T.⁶ Green, D.V.S.⁷ Hertzberg, R.P.⁸ Janzen, W.P.⁹ Paslay, J.W.¹⁰ Schopfer, U.¹¹ Sittampalam, G.S.¹²

2
- 84883809894
- M. C. Bryan, C. D. Hein, H. Gao, X. Xia, H. Eastwood, B. A. Bruenner, S. W. Louie, E. M. Doherty, ACS Comb. Sci. 2013, 15, 503-511.
- (2013) ACS Comb. Sci. , vol.15 , pp. 503-511
- Bryan, M.C.¹ Hein, C.D.² Gao, H.³ Xia, X.⁴ Eastwood, H.⁵ Bruenner, B.A.⁶ Louie, S.W.⁷ Doherty, E.M.⁸

3
- 0003076580
- I. Ugi, Angew. Chem. 1962, 74, 9-22
- (1962) Angew. Chem. , vol.74 , pp. 9-22
- Ugi, I.¹

4
- 84995181383
- Angew. Chem. Int. Ed. Engl. 1962, 1, 8-21.
- (1962) Angew. Chem. Int. Ed. Engl. , vol.1 , pp. 8-21

5
- 78650176366
- B. Beck, S. Srivastava, K. Khoury, E. Herdtweck, A. Dömling, Mol. Diversity 2010, 14, 479-491.
- (2010) Mol. Diversity , vol.14 , pp. 479-491
- Beck, B.¹ Srivastava, S.² Khoury, K.³ Herdtweck, E.⁴ Dömling, A.⁵

6
- 58149355283
- C. Kalinski, H. Lemoine, J. Schmidt, C. Burdack, J. Kolb, M. Umkehrer, G. Ross, Synthesis 2008, 4007-4011.
- (2008) Synthesis , pp. 4007-4011
- Kalinski, C.¹ Lemoine, H.² Schmidt, J.³ Burdack, C.⁴ Kolb, J.⁵ Umkehrer, M.⁶ Ross, G.⁷

7
- 0013103264
- H. Bienaymé, K. Bouzid, Angew. Chem. 1998, 110, 2349-2352
- (1998) Angew. Chem. , vol.110 , pp. 2349-2352
- Bienaymé, H.¹ Bouzid, K.²

8
- 0031661388
- Angew. Chem. Int. Ed. 1998, 37, 2234-2237.
- (1998) Angew. Chem. Int. Ed. , vol.37 , pp. 2234-2237

9
- 84874101052
- M. Reutlinger, C. P. Koch, D. Reker, N. Todoroff, P. Schneider, T. Rodrigues, G. Schneider, Mol. Inf. 2013, 32, 133-138.
- (2013) Mol. Inf. , vol.32 , pp. 133-138
- Reutlinger, M.¹ Koch, C.P.² Reker, D.³ Todoroff, N.⁴ Schneider, P.⁵ Rodrigues, T.⁶ Schneider, G.⁷

10
- 84857361838
- M. Hieke, C. B. Rödl, J. M. Wisniewska, E. Buscatõ, H. Stark, M. Schubert-Zsilavecz, D. Steinhilber, B. Hofmann, E. Proschak, Bioorg. Med. Chem. Lett. 2012, 22, 1969-1975.
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 1969-1975
- Hieke, M.¹ Rödl, C.B.² Wisniewska, J.M.³ Buscatõ, E.⁴ Stark, H.⁵ Schubert-Zsilavecz, M.⁶ Steinhilber, D.⁷ Hofmann, B.⁸ Proschak, E.⁹

11
- 83255176722
- S. Meister, D. M. Plouffe, K. L. Kuhen, G. M. C. Bonamy, T. Wu, S. W. Barnes, S. E. Bopp, R. Borboa, A. T. Bright, J. Che, S. Cohen, N. V. Dharia, K. Gagaring, M. Gettayacamin, P. Gordon, T. Groessl, N. Kato, M. C. S. Lee, C. W. McNamara, D. A. Fidock, A. Nagle, T.-g. Nam, W. Richmond, J. Roland, M. Rottmann, B. Zhou, P. Froissard, R. J. Glynne, D. Mazier, A. Chatterjee, T. T. Diagana, E. A. Winzeler, Science 2011, 334, 1372-1377
- (2011) Science , vol.334 , pp. 1372-1377
- Meister, S.¹ Plouffe, D.M.² Kuhen, K.L.³ Bonamy, G.M.C.⁴ Wu, T.⁵ Barnes, S.W.⁶ Bopp, S.E.⁷ Borboa, R.⁸ Bright, A.T.⁹ Che, J.¹⁰ Cohen, S.¹¹ Dharia, N.V.¹² Gagaring, K.¹³ Gettayacamin, M.¹⁴ Gordon, P.¹⁵ Groessl, T.¹⁶ Kato, N.¹⁷ Lee, M.C.S.¹⁸ McNamara, C.W.¹⁹ Fidock, D.A.²⁰ more..

12
- 79960645150
- T. Wu, A. Nagle, K. Kuhen, K. Gagaring, R. Borboa, C. Francek, Z. Chen, D. Plouffe, A. Goh, S. B. Lakshminarayana, J. Wu, H. Q. Ang, P. Zeng, M. L. Kang, W. Tan, M. Tan, N. Ye, X. Lin, C. Caldwell, J. Ek, S. Skolnik, F. Liu, J. Wang, J. Chang, C. Li, T. Hollenbeck, T. Tuntland, J. Isbell, C. Fischli, R. Brun, M. Rottmann, V. Dartois, T. Keller, T. Diagana, E. Winzeler, R. Glynne, D. C. Tully, A. K. Chatterjee, J. Med. Chem. 2011, 54, 5116-5130
- (2011) J. Med. Chem. , vol.54 , pp. 5116-5130
- Wu, T.¹ Nagle, A.² Kuhen, K.³ Gagaring, K.⁴ Borboa, R.⁵ Francek, C.⁶ Chen, Z.⁷ Plouffe, D.⁸ Goh, A.⁹ Lakshminarayana, S.B.¹⁰ Wu, J.¹¹ Ang, H.Q.¹² Zeng, P.¹³ Kang, M.L.¹⁴ Tan, W.¹⁵ Tan, M.¹⁶ Ye, N.¹⁷ Lin, X.¹⁸ Caldwell, C.¹⁹ Ek, J.²⁰ more..

13
- 79960651733
- A. T. Baviskar, C. Madaan, R. Preet, P. Mohapatra, V. Jain, A. Agarwal, S. K. Guchhait, C. N. Kundu, U. C. Banerjee, P. V. Bharatam, J. Med. Chem. 2011, 54, 5013-5030
- (2011) J. Med. Chem. , vol.54 , pp. 5013-5030
- Baviskar, A.T.¹ Madaan, C.² Preet, R.³ Mohapatra, P.⁴ Jain, V.⁵ Agarwal, A.⁶ Guchhait, S.K.⁷ Kundu, C.N.⁸ Banerjee, U.C.⁹ Bharatam, P.V.¹⁰

14
- 83955163766
- J. M. Wisniewska, C. B. Rödl, A. S. Kahnt, E. Buscato, S. Ulrich, Y. Tanrikulu, J. Achenbach, F. Rörsch, S. Grösch, G. Schneider, J. Cinatl, Jr., E. Proschak, D. Steinhilber, B. Hofmann, Biochem. Pharmacol. 2012, 83, 228-240
- (2012) Biochem. Pharmacol. , vol.83 , pp. 228-240
- Wisniewska, J.M.¹ Rödl, C.B.² Kahnt, A.S.³ Buscato, E.⁴ Ulrich, S.⁵ Tanrikulu, Y.⁶ Achenbach, J.⁷ Rörsch, F.⁸ Grösch, S.⁹ Schneider, G.¹⁰ Cinatl Jr., J.¹¹ Proschak, E.¹² Steinhilber, D.¹³ Hofmann, B.¹⁴

15
- 84891816339
- S. Nordhoff, H. Deppe, U. Abel, A. Feurer, I. Ott, G. Metz, EP1974729 A1, 2008
- S. Nordhoff, H. Deppe, U. Abel, A. Feurer, I. Ott, G. Metz, EP1974729 A1, 2008

16
- 0024239320
- B. E. Evans, K. E. Rittle, M. G. Bock, R. M. DiPardo, R. M. Freidinger, W. L. Whitter, G. F. Lundell, D. F. Veber, P. S. Anderson, R. S. L. Chang, V. J. Lotti, D. J. Cerino, T. B. Chen, P. J. Kling, K. A. Kunkel, J. P. Springer, J. Hirshfield, J. Med. Chem. 1988, 31, 2235-2246.
- (1988) J. Med. Chem. , vol.31 , pp. 2235-2246
- Evans, B.E.¹ Rittle, K.E.² Bock, M.G.³ Dipardo, R.M.⁴ Freidinger, R.M.⁵ Whitter, W.L.⁶ Lundell, G.F.⁷ Veber, D.F.⁸ Anderson, P.S.⁹ Chang, R.S.L.¹⁰ Lotti, V.J.¹¹ Cerino, D.J.¹² Chen, T.B.¹³ Kling, P.J.¹⁴ Kunkel, K.A.¹⁵ Springer, J.P.¹⁶ Hirshfield, J.¹⁷

17
- 84862192766
- A. Gaulton, L. J. Bellis, A. P. Bento, J. Chambers, M. Davies, A. Hersey, Y. Light, S. McGlinchey, D. Michalovich, B. Al-Lazikani, J. P. Overington, Nucleic Acids Res. 2011, 40, D 1100 -D 1107.
- (2011) Nucleic Acids Res. , vol.40
- Gaulton, A.¹ Bellis, L.J.² Bento, A.P.³ Chambers, J.⁴ Davies, M.⁵ Hersey, A.⁶ Light, Y.⁷ McGlinchey, S.⁸ Michalovich, D.⁹ Al-Lazikani, B.¹⁰ Overington, J.P.¹¹

18
- 84862510972
- E. Lounkine, M. J. Keiser, S. Whitebread, D. Mikhailov, J. Hamon, J. L. Jenkins, P. Lavan, E. Weber, A. K. Doak, S. Côté, B. K. Shoichet, L. Urban, Nature 2012, 486, 361-367
- (2012) Nature , vol.486 , pp. 361-367
- Lounkine, E.¹ Keiser, M.J.² Whitebread, S.³ Mikhailov, D.⁴ Hamon, J.⁵ Jenkins, J.L.⁶ Lavan, P.⁷ Weber, E.⁸ Doak, A.K.⁹ Côté, S.¹⁰ Shoichet, B.K.¹¹ Urban, L.¹²

19
- 84870987376
- J. Besnard, G. F. Ruda, V. Setola, K. Abecassis, R. M. Rodriguiz, X. P. Huang, S. Norval, M. F. Sassano, A. I. Shin, L. A. Webster, F. R. Simeons, L. Stojanovski, A. Prat, N. G. Seidah, D. B. Constam, G. R. Bickerton, K. D. Read, W. C. Wetsel, I. H. Gilbert, B. L. Roth, A. L. Hopkins, Nature 2012, 492, 215-220.
- (2012) Nature , vol.492 , pp. 215-220
- Besnard, J.¹ Ruda, G.F.² Setola, V.³ Abecassis, K.⁴ Rodriguiz, R.M.⁵ Huang, X.P.⁶ Norval, S.⁷ Sassano, M.F.⁸ Shin, A.I.⁹ Webster, L.A.¹⁰ Simeons, F.R.¹¹ Stojanovski, L.¹² Prat, A.¹³ Seidah, N.G.¹⁴ Constam, D.B.¹⁵ Bickerton, G.R.¹⁶ Read, K.D.¹⁷ Wetsel, W.C.¹⁸ Gilbert, I.H.¹⁹ Roth, B.L.²⁰ Hopkins, A.L.²¹ more..

20
- 84891752998
- Wiley, New York
- A. A. Antolín, J. Mestres, Therapeutic Targets, Wiley, New York, pp. 309-326
- Therapeutic Targets , pp. 309-326
- Antolín, A.A.¹ Mestres, J.²

21
- 84879794647
- Y. Hu, J. Bajorath, AAPS J. 2013, 15, 808-815.
- (2013) AAPS J. , vol.15 , pp. 808-815
- Hu, Y.¹ Bajorath, J.²

22
- 77956964002
- A. Tropsha, Mol. Inf. 2010, 29, 476-488
- (2010) Mol. Inf. , vol.29 , pp. 476-488
- Tropsha, A.¹

23
- 41349093326
- A. Nicholls, J. Comput.-Aided Mol. Des. 2008, 22, 239-255
- (2008) J. Comput.-Aided Mol. Des. , vol.22 , pp. 239-255
- Nicholls, A.¹

24
- 79957985250
- K. Roy, I. Mitra, Comb. Chem. High Throughput Screening 2011, 14, 450-474.
- (2011) Comb. Chem. High Throughput Screening , vol.14 , pp. 450-474
- Roy, K.¹ Mitra, I.²

25
- 84860359784
- M. M. Hann, G. M. Keserü, Nat. Rev. Drug Discovery 2012, 11, 355-365
- (2012) Nat. Rev. Drug Discovery , vol.11 , pp. 355-365
- Hann, M.M.¹ Keserü, G.M.²

26
- 84856201851
- G. R. Bickerton, G. V. Paolini, J. Besnard, S. Muresan, A. L. Hopkins, Nat. Chem. 2012, 4, 90-98.
- (2012) Nat. Chem. , vol.4 , pp. 90-98
- Bickerton, G.R.¹ Paolini, G.V.² Besnard, J.³ Muresan, S.⁴ Hopkins, A.L.⁵

27
- 84876099601
- P. N. Nge, C. I. Rogers, A. T. Woolley, Chem. Rev. 2013, 113, 2550-2583
- (2013) Chem. Rev. , vol.113 , pp. 2550-2583
- Nge, P.N.¹ Rogers, C.I.² Woolley, A.T.³

28
- 77958559522
- D. Lombardi, P. S. Dittrich, Expert Opin. Drug Discovery 2010, 5, 1081-1094
- (2010) Expert Opin. Drug Discovery , vol.5 , pp. 1081-1094
- Lombardi, D.¹ Dittrich, P.S.²

29
- 77952531806
- T. Tsukahara, K. Mawatari, T. Kitamori, Chem. Soc. Rev. 2010, 39, 1000-1013.
- (2010) Chem. Soc. Rev. , vol.39 , pp. 1000-1013
- Tsukahara, T.¹ Mawatari, K.² Kitamori, T.³

30
- 25444448065
- The MIT Press, Cambridge
- C. E. Rasmussen, C. K. I. Williams, Gaussian Processes for Machine Learning, The MIT Press, Cambridge, 2006
- (2006) Gaussian Processes for Machine Learning
- Rasmussen, C.E.¹ Williams, C.K.I.²

31
- 75749099299
- M. Rupp, T. Schroeter, R. Steri, H. Zettl, E. Proschak, K. Hansen, O. Rau, O. Schwarz, L. Müller-Kuhrt, M. Schubert-Zsilavecz, K. R. Müller, G. Schneider, ChemMedChem 2010, 5, 191-194.
- (2010) ChemMedChem , vol.5 , pp. 191-194
- Rupp, M.¹ Schroeter, T.² Steri, R.³ Zettl, H.⁴ Proschak, E.⁵ Hansen, K.⁶ Rau, O.⁷ Schwarz, O.⁸ Müller-Kuhrt, L.⁹ Schubert-Zsilavecz, M.¹⁰ Müller, K.R.¹¹ Schneider, G.¹²

32
- 80052949059
- Springer, Berlin
- M. R. Berthold, N. Cebron, F. Dill, T. Gabriel, T. Koetter, T. Meinl, P. Ohl, C. Sieb, K. Thiel, B. Wiswedel, Studies in Classification, Data Analysis, and Knowledge Organization (GfKL), Springer, Berlin, 2007, pp. 319-326.
- (2007) Studies in Classification, Data Analysis, and Knowledge Organization (GfKL) , pp. 319-326
- Berthold, M.R.¹ Cebron, N.² Dill, F.³ Gabriel, T.⁴ Koetter, T.⁵ Meinl, T.⁶ Ohl, P.⁷ Sieb, C.⁸ Thiel, K.⁹ Wiswedel, B.¹⁰

33
- 77952772341
- D. Rogers, M. Hahn, J. Chem. Inf. Model. 2010, 50, 742-754.
- (2010) J. Chem. Inf. Model. , vol.50 , pp. 742-754
- Rogers, D.¹ Hahn, M.²

34
- 34247272948
- J. F. Truchon, C. I. Bayly, J. Chem. Inf. Model. 2007, 47, 488-508.
- (2007) J. Chem. Inf. Model. , vol.47 , pp. 488-508
- Truchon, J.F.¹ Bayly, C.I.²

35
- 34548742854
- J. H. Chen, E. Linstead, S. J. Swamidass, D. Wang, P. Baldi, Bioinformatics 2007, 23, 2348-2351.
- (2007) Bioinformatics , vol.23 , pp. 2348-2351
- Chen, J.H.¹ Linstead, E.² Swamidass, S.J.³ Wang, D.⁴ Baldi, P.⁵

36
- 84891792127
- Chemical Abstracts Service, SciFinder Columbus, OH, U.S.A.
- Chemical Abstracts Service, SciFinder, https://scifinder.cas.org/, Columbus, OH, U.S.A.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.