Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry

Nature Protocols

Volumn 10, Issue 10, 2015, Pages 1567-1593

  Franken, Holger ^a   Mathieson, Toby ^a   Childs, Dorothee ^a,b   Sweetman, Gavain M A ^a,b   Werner, Thilo ^a   Tögel, Ina ^a   Doce, Carola ^a   Gade, Stephan ^a   Bantscheff, Marcus ^a   Drewes, Gerard ^a   Reinhard, Friedrich B M ^a   Huber, Wolfgang ^a   Savitski, Mikhail M ^a  

^a GLAXOSMITHKLINE   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DASATINIB; PANOBINOSTAT; PROTEOME;

ARTICLE; BINDING AFFINITY; BIOINFORMATICS; DATA ANALYSIS; DRUG TARGETING; LIGAND BINDING; MASS SPECTROMETRY; MELTING POINT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN STABILITY; PROTEOMICS; TEMPERATURE; THERMOSTABILITY; DRUG DELIVERY SYSTEM; GENETICS; HUMAN; K562 CELL LINE; PROCEDURES; PROTEIN MICROARRAY;

DRUG DELIVERY SYSTEMS; HUMANS; K562 CELLS; MASS SPECTROMETRY; PROTEIN ARRAY ANALYSIS; PROTEIN STABILITY; PROTEOME; TEMPERATURE;

EID: 84942513706     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2015.101     Document Type: Article

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