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Volumn 13, Issue 19-20, 2008, Pages 894-901

Natural products in drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CASPOFUNGIN; CRYPTOPHYCIN DERIVATIVE; CURACIN A; DAPTOMYCIN; DOLASTATIN 10; ELLIPTINIUM; EVEROLIMUS; GALANTAMINE; HUPERZINE A; IXABEPILONE; MICAFUNGIN; NATURAL PRODUCT; PLATENSIMYCIN; RETAPAMULIN; SALINOSPORAMIDE A; SORAFENIB; TELITHROMYCIN; TIGECYCLINE; TRABECTEDIN; VANCOMYCIN;

EID: 52049109838     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2008.07.004     Document Type: Review
Times cited : (1518)

References (60)
  • 2
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman D.J., and Cragg G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod. 70 (2007) 461-477
    • (2007) J. Nat. Prod. , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 3
    • 44249098800 scopus 로고    scopus 로고
    • Natural products to drugs: natural product-derived compounds in clinical trials
    • Butler M.S. Natural products to drugs: natural product-derived compounds in clinical trials. Nat. Prod. Rep. 25 (2008) 475-516
    • (2008) Nat. Prod. Rep. , vol.25 , pp. 475-516
    • Butler, M.S.1
  • 4
    • 33646056420 scopus 로고    scopus 로고
    • Drug discovery from natural sources
    • Chin Y.-W., et al. Drug discovery from natural sources. AAPS J. 8 (2006) E239-E253
    • (2006) AAPS J. , vol.8
    • Chin, Y.-W.1
  • 5
    • 34249811180 scopus 로고    scopus 로고
    • New aspects of natural products in drug discovery
    • Lam K.S. New aspects of natural products in drug discovery. Trends Microbiol. 15 (2007) 279-289
    • (2007) Trends Microbiol. , vol.15 , pp. 279-289
    • Lam, K.S.1
  • 6
    • 44949134801 scopus 로고    scopus 로고
    • The impact of natural products upon modern drug discovery
    • Ganesan A. The impact of natural products upon modern drug discovery. Curr. Opin. Chem. Biol. 12 (2008) 306-317
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 306-317
    • Ganesan, A.1
  • 7
    • 33644544089 scopus 로고    scopus 로고
    • Empirical antibacterial drug discovery- foundation in natural products
    • Singh S.B., and Barrett J.F. Empirical antibacterial drug discovery- foundation in natural products. Biochem. Pharmacol. 71 (2006) 1006-1015
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1006-1015
    • Singh, S.B.1    Barrett, J.F.2
  • 8
    • 36348987143 scopus 로고    scopus 로고
    • The value of natural products to future pharmaceutical discovery
    • Baker D.D., et al. The value of natural products to future pharmaceutical discovery. Nat. Prod. Rep. 24 (2007) 1225-1244
    • (2007) Nat. Prod. Rep. , vol.24 , pp. 1225-1244
    • Baker, D.D.1
  • 9
    • 34447096207 scopus 로고    scopus 로고
    • Plant natural products: back to the future or into extinction?
    • McChesney J.D. Plant natural products: back to the future or into extinction?. Phytochemistry 68 (2007) 2015-2022
    • (2007) Phytochemistry , vol.68 , pp. 2015-2022
    • McChesney, J.D.1
  • 10
    • 43049183607 scopus 로고    scopus 로고
    • Natural products as a robust source of new drugs and drug leads: past successes and present day issues
    • Rishton G.M. Natural products as a robust source of new drugs and drug leads: past successes and present day issues. Am. J. Cardiol. 101 Suppl. (2008) 43D-49D
    • (2008) Am. J. Cardiol. , vol.101 , Issue.SUPPL
    • Rishton, G.M.1
  • 12
    • 52049123418 scopus 로고    scopus 로고
    • Traditional remedies: latter day medicines
    • Charlish P. Traditional remedies: latter day medicines. Scrip World Pharmaceutical News 3351 (2008) 31-34
    • (2008) Scrip World Pharmaceutical News , vol.3351 , pp. 31-34
    • Charlish, P.1
  • 13
    • 0037208308 scopus 로고    scopus 로고
    • Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry
    • Feher M., and Schmidt J.M. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J. Chem. Inf. Comput. Sci. 43 (2003) 218-227
    • (2003) J. Chem. Inf. Comput. Sci. , vol.43 , pp. 218-227
    • Feher, M.1    Schmidt, J.M.2
  • 14
    • 34547265045 scopus 로고    scopus 로고
    • Properties and architecture of drugs and natural products revisited
    • Grabowski K., and Schneider G. Properties and architecture of drugs and natural products revisited. Curr. Chem. Biol. 1 (2007) 115-127
    • (2007) Curr. Chem. Biol. , vol.1 , pp. 115-127
    • Grabowski, K.1    Schneider, G.2
  • 15
    • 35349020474 scopus 로고    scopus 로고
    • Natural product drug discovery: the times have never been better
    • Galm U., and Shen B. Natural product drug discovery: the times have never been better. Chem. Biol. 14 (2007) 1098-1104
    • (2007) Chem. Biol. , vol.14 , pp. 1098-1104
    • Galm, U.1    Shen, B.2
  • 16
    • 0034237675 scopus 로고    scopus 로고
    • Strategies for discovering drugs from previously unexplored natural products
    • Harvey A.L. Strategies for discovering drugs from previously unexplored natural products. Drug Dis. Today 5 (2000) 294-300
    • (2000) Drug Dis. Today , vol.5 , pp. 294-300
    • Harvey, A.L.1
  • 17
    • 33744537287 scopus 로고    scopus 로고
    • Discovery of novel metabolites from marine actinomycetes
    • Lam K.S. Discovery of novel metabolites from marine actinomycetes. Curr. Opin. Microbiol. 9 (2006) 245-251
    • (2006) Curr. Opin. Microbiol. , vol.9 , pp. 245-251
    • Lam, K.S.1
  • 18
    • 33751100882 scopus 로고    scopus 로고
    • Developing a new resource for drug discovery: marine actinomycete bacteria
    • Fenical W., and Jensen P.R. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat. Chem. Biol. 2 (2006) 666-673
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 666-673
    • Fenical, W.1    Jensen, P.R.2
  • 19
    • 36049009735 scopus 로고    scopus 로고
    • Marine actinobacteria: new opportunities for natural product search and discovery
    • Bull A.T., and Stach J.E. Marine actinobacteria: new opportunities for natural product search and discovery. Trends Microbiol. 15 (2007) 491-499
    • (2007) Trends Microbiol. , vol.15 , pp. 491-499
    • Bull, A.T.1    Stach, J.E.2
  • 20
    • 33947104489 scopus 로고    scopus 로고
    • Bioactive natural products from marine cyanobacteria for drug discovery
    • Tan L.T. Bioactive natural products from marine cyanobacteria for drug discovery. Phytochemistry 68 (2007) 954-979
    • (2007) Phytochemistry , vol.68 , pp. 954-979
    • Tan, L.T.1
  • 21
    • 35348824837 scopus 로고    scopus 로고
    • Natural products as a screening resource
    • Harvey A.L. Natural products as a screening resource. Curr. Opin. Chem. Biol. 11 (2007) 480-484
    • (2007) Curr. Opin. Chem. Biol. , vol.11 , pp. 480-484
    • Harvey, A.L.1
  • 22
    • 34250790717 scopus 로고    scopus 로고
    • Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
    • Cox R.J. Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets. Org. Biomol. Chem. 5 (2007) 2010-2026
    • (2007) Org. Biomol. Chem. , vol.5 , pp. 2010-2026
    • Cox, R.J.1
  • 23
    • 37549071045 scopus 로고    scopus 로고
    • Drug discovery beyond the 'rule-of-five'
    • Zhang M.Q., and Wilkinson B. Drug discovery beyond the 'rule-of-five'. Curr. Opin. Biotechnol. 18 (2007) 478-488
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 478-488
    • Zhang, M.Q.1    Wilkinson, B.2
  • 24
    • 33744537000 scopus 로고    scopus 로고
    • Combinatorial biosynthesis- potential and problems
    • Floss H.G. Combinatorial biosynthesis- potential and problems. J. Biotechnol. 124 (2006) 242-257
    • (2006) J. Biotechnol. , vol.124 , pp. 242-257
    • Floss, H.G.1
  • 25
    • 33751120932 scopus 로고    scopus 로고
    • Production of isoprenoid pharmaceuticals by engineered microbes
    • Chang M.C.Y., and Keasling J.D. Production of isoprenoid pharmaceuticals by engineered microbes. Nat. Chem. Biol. 2 (2006) 674-681
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 674-681
    • Chang, M.C.Y.1    Keasling, J.D.2
  • 26
    • 34249312597 scopus 로고    scopus 로고
    • Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms
    • Chemler J.A., et al. Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms. Org. Lett. 9 (2007) 1855-1858
    • (2007) Org. Lett. , vol.9 , pp. 1855-1858
    • Chemler, J.A.1
  • 27
    • 17844407663 scopus 로고    scopus 로고
    • Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example
    • McAlpine J.B., et al. Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example. J. Nat. Prod. 68 (2005) 493-496
    • (2005) J. Nat. Prod. , vol.68 , pp. 493-496
    • McAlpine, J.B.1
  • 28
    • 34247628549 scopus 로고    scopus 로고
    • Metagenomic approaches to exploit the biotechnological potential of the microbial consortia of marine sponges
    • Kennedy J., et al. Metagenomic approaches to exploit the biotechnological potential of the microbial consortia of marine sponges. Appl. Microbiol. Biotechnol. 75 (2007) 11-20
    • (2007) Appl. Microbiol. Biotechnol. , vol.75 , pp. 11-20
    • Kennedy, J.1
  • 29
    • 41749090471 scopus 로고    scopus 로고
    • Drugs from hidden bugs: their discovery via untapped resources
    • Lefevre F., et al. Drugs from hidden bugs: their discovery via untapped resources. Res. Microbiol. 159 (2008) 153-161
    • (2008) Res. Microbiol. , vol.159 , pp. 153-161
    • Lefevre, F.1
  • 30
    • 34249101623 scopus 로고    scopus 로고
    • Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites
    • Barrios-Llerena M.E., et al. Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites. J. Ind. Microbiol. Biotechnol. 34 (2007) 443-456
    • (2007) J. Ind. Microbiol. Biotechnol. , vol.34 , pp. 443-456
    • Barrios-Llerena, M.E.1
  • 31
    • 0036727242 scopus 로고    scopus 로고
    • Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA
    • Gillespie D.E., et al. Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA. Appl. Environ. Microbiol. 68 (2002) 4301-4306
    • (2002) Appl. Environ. Microbiol. , vol.68 , pp. 4301-4306
    • Gillespie, D.E.1
  • 32
    • 38849174356 scopus 로고    scopus 로고
    • Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products
    • Kennedy J. Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products. Nat. Prod. Rep. 25 (2008) 25-34
    • (2008) Nat. Prod. Rep. , vol.25 , pp. 25-34
    • Kennedy, J.1
  • 33
    • 37549038629 scopus 로고    scopus 로고
    • Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides
    • Kopp F., and Marahiel M.A. Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides. Curr. Opin. Biotechnol. 18 (2007) 513-520
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 513-520
    • Kopp, F.1    Marahiel, M.A.2
  • 34
    • 37549012937 scopus 로고    scopus 로고
    • Cytochromes P450 and drug discovery
    • Lamb D.C., et al. Cytochromes P450 and drug discovery. Curr. Opin. Biotechnol. 18 (2007) 504-512
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 504-512
    • Lamb, D.C.1
  • 35
    • 33750464876 scopus 로고    scopus 로고
    • Small molecule natural products in the discovery of therapeutic agents: the synthesis connection
    • Wilson R.M., and Danishefsky S.J. Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. J. Org. Chem. 71 (2006) 8329-8351
    • (2006) J. Org. Chem. , vol.71 , pp. 8329-8351
    • Wilson, R.M.1    Danishefsky, S.J.2
  • 36
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to potential drugs: an old process or the new hope for drug discovery?
    • Newman D.J. Natural products as leads to potential drugs: an old process or the new hope for drug discovery?. J. Med. Chem. 51 (2008) 2589-2599
    • (2008) J. Med. Chem. , vol.51 , pp. 2589-2599
    • Newman, D.J.1
  • 37
    • 40549118156 scopus 로고    scopus 로고
    • Efficient total synthesis of novel bioactive microbial metabolites
    • Sunazuka T., et al. Efficient total synthesis of novel bioactive microbial metabolites. Acc. Chem. Res. 41 (2008) 302-314
    • (2008) Acc. Chem. Res. , vol.41 , pp. 302-314
    • Sunazuka, T.1
  • 38
    • 2942590399 scopus 로고    scopus 로고
    • Libraries from natural product-like scaffolds
    • Boldi A.M. Libraries from natural product-like scaffolds. Curr. Opin. Chem. Biol. 8 (2004) 281-286
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 281-286
    • Boldi, A.M.1
  • 39
    • 34547232568 scopus 로고    scopus 로고
    • Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries
    • Yao N., et al. Synthesis of flavonoid analogues as scaffolds for natural product-based combinatorial libraries. J. Comb. Chem. 9 (2007) 668-676
    • (2007) J. Comb. Chem. , vol.9 , pp. 668-676
    • Yao, N.1
  • 40
    • 39449121965 scopus 로고    scopus 로고
    • Natural product-likeness score and its application for prioritization of compound libraries
    • Ertl P., et al. Natural product-likeness score and its application for prioritization of compound libraries. J. Chem. Inf. Model. 48 (2008) 68-74
    • (2008) J. Chem. Inf. Model. , vol.48 , pp. 68-74
    • Ertl, P.1
  • 41
    • 38349062303 scopus 로고    scopus 로고
    • Multi-channel counter-current chromatography for high-throughput fractionation of natural products for drug discovery
    • Wu S., et al. Multi-channel counter-current chromatography for high-throughput fractionation of natural products for drug discovery. J. Chromatogr. A 1180 (2007) 99-107
    • (2007) J. Chromatogr. A , vol.1180 , pp. 99-107
    • Wu, S.1
  • 42
    • 42249105044 scopus 로고    scopus 로고
    • Developing a drug-like natural product library
    • Quinn R.J., et al. Developing a drug-like natural product library. J. Nat. Prod. 71 (2008) 464-468
    • (2008) J. Nat. Prod. , vol.71 , pp. 464-468
    • Quinn, R.J.1
  • 43
    • 27844536497 scopus 로고    scopus 로고
    • Novel approaches to plant drug discovery based on high throughput pharmacological screening and genetic manipulation
    • Littleton J., et al. Novel approaches to plant drug discovery based on high throughput pharmacological screening and genetic manipulation. Life Sci. 78 (2005) 467-475
    • (2005) Life Sci. , vol.78 , pp. 467-475
    • Littleton, J.1
  • 44
    • 33947313918 scopus 로고    scopus 로고
    • Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing
    • Singh S.B., et al. Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing. Curr. Opin. Drug Discov. Dev. 10 (2007) 160-166
    • (2007) Curr. Opin. Drug Discov. Dev. , vol.10 , pp. 160-166
    • Singh, S.B.1
  • 45
    • 34250649348 scopus 로고    scopus 로고
    • Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
    • Wang J., et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 7612-7616
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 7612-7616
    • Wang, J.1
  • 46
    • 33746753342 scopus 로고    scopus 로고
    • Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast
    • Parsons A.B., et al. Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell 126 (2006) 611-625
    • (2006) Cell , vol.126 , pp. 611-625
    • Parsons, A.B.1
  • 47
    • 33645865550 scopus 로고    scopus 로고
    • A causal relationship discovery-based approach to identifying active components of herbal medicine
    • Cheng Y., et al. A causal relationship discovery-based approach to identifying active components of herbal medicine. Comput. Biol. Chem. 30 (2006) 148-154
    • (2006) Comput. Biol. Chem. , vol.30 , pp. 148-154
    • Cheng, Y.1
  • 48
    • 44249117823 scopus 로고    scopus 로고
    • Discovering active compounds from mixtures of natural products by data mining approach
    • Wang Y., et al. Discovering active compounds from mixtures of natural products by data mining approach. Med. Biol. Eng. Comput. 46 (2008) 605-611
    • (2008) Med. Biol. Eng. Comput. , vol.46 , pp. 605-611
    • Wang, Y.1
  • 49
    • 34247196059 scopus 로고    scopus 로고
    • Virtual screening of Chinese herbs with Random Forest
    • Ehrman T.M., et al. Virtual screening of Chinese herbs with Random Forest. J. Chem. Inf. Model. 47 (2007) 264-278
    • (2007) J. Chem. Inf. Model. , vol.47 , pp. 264-278
    • Ehrman, T.M.1
  • 50
    • 37249035096 scopus 로고    scopus 로고
    • Phytochemical informatics of traditional Chinese medicine and therapeutic relevance
    • Ehrman T.M., et al. Phytochemical informatics of traditional Chinese medicine and therapeutic relevance. J. Chem. Inf. Model. 47 (2007) 2316-2334
    • (2007) J. Chem. Inf. Model. , vol.47 , pp. 2316-2334
    • Ehrman, T.M.1
  • 51
    • 33845618105 scopus 로고    scopus 로고
    • Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation
    • Chen X., et al. Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation. Brit. J. Pharmacol. 149 (2006) 1092-1103
    • (2006) Brit. J. Pharmacol. , vol.149 , pp. 1092-1103
    • Chen, X.1
  • 52
    • 35348881537 scopus 로고    scopus 로고
    • NCL-3D: a 3D natural compound library for structure-based drug discovery
    • Xu Q., et al. NCL-3D: a 3D natural compound library for structure-based drug discovery. 1st International Conference Bioinform. Biomed. Eng. ICBBE (2007) 367-369
    • (2007) 1st International Conference Bioinform. Biomed. Eng. ICBBE , pp. 367-369
    • Xu, Q.1
  • 53
    • 35548972101 scopus 로고    scopus 로고
    • Reverse pharmacognosy: identifying biological properties for plants by means of their molecule constituents: application to meranzin
    • Do Q.Y., et al. Reverse pharmacognosy: identifying biological properties for plants by means of their molecule constituents: application to meranzin. Planta Med. 73 (2007) 1235-1240
    • (2007) Planta Med. , vol.73 , pp. 1235-1240
    • Do, Q.Y.1
  • 54
    • 28444498830 scopus 로고    scopus 로고
    • Charting biologically relevant chemical space: a structural classification of natural products (SCONP)
    • Koch M.A., et al. Charting biologically relevant chemical space: a structural classification of natural products (SCONP). Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 17272-17277
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 17272-17277
    • Koch, M.A.1
  • 55
    • 33746047675 scopus 로고    scopus 로고
    • Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis
    • Nören-Müller A., et al. Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 10606-10611
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 10606-10611
    • Nören-Müller, A.1
  • 56
    • 10044253102 scopus 로고    scopus 로고
    • Compound library development guided by protein structure similarity clustering and natural product structure
    • Koch M.A., et al. Compound library development guided by protein structure similarity clustering and natural product structure. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 16721-21676
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 16721-21676
    • Koch, M.A.1
  • 57
    • 42249106818 scopus 로고    scopus 로고
    • Synthesis of dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering
    • Scheck M., et al. Synthesis of dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering. Tetrahedron 64 (2008) 4792-4802
    • (2008) Tetrahedron , vol.64 , pp. 4792-4802
    • Scheck, M.1
  • 58
    • 11144298973 scopus 로고    scopus 로고
    • Exploring biology with small organic molecules
    • Stockwell B.R. Exploring biology with small organic molecules. Nature 432 (2004) 846-854
    • (2004) Nature , vol.432 , pp. 846-854
    • Stockwell, B.R.1
  • 59
    • 33645993609 scopus 로고    scopus 로고
    • Gene expression profiling in the discovery, optimization and development of novel drugs: one universal screening platform
    • Bol D., and Ebner R. Gene expression profiling in the discovery, optimization and development of novel drugs: one universal screening platform. Pharmacogenomics 7 (2006) 227-235
    • (2006) Pharmacogenomics , vol.7 , pp. 227-235
    • Bol, D.1    Ebner, R.2
  • 60
    • 40849130043 scopus 로고    scopus 로고
    • Proteomic methods for drug target discovery
    • Sleno L., and Emili A. Proteomic methods for drug target discovery. Curr. Opin. Chem. Biol. 12 (2008) 46-54
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 46-54
    • Sleno, L.1    Emili, A.2


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