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Volumn 14, Issue 6, 2015, Pages 924-932

DNA methylation and healthy human aging

Author keywords

Aging; DNA methylation; Epigenetics; Human; Review

Indexed keywords

AGING; DNA METHYLATION; DYNAMICS; EPIGENETICS; GENE INTERACTION; GENOME; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; PRIORITY JOURNAL; REVIEW; CPG ISLAND; GENETIC EPIGENESIS; GENETICS; HUMAN GENOME; METABOLISM; TELOMERE SHORTENING;

EID: 84954379553     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12349     Document Type: Review
Times cited : (633)

References (94)
  • 1
    • 79953180072 scopus 로고    scopus 로고
    • Parental ages and levels of DNA methylation in the newborn are correlated
    • Adkins RM, Thomas F, Tylavsky FA, Krushkal J (2011) Parental ages and levels of DNA methylation in the newborn are correlated. BMC Med. Genet. 12, 47.
    • (2011) BMC Med. Genet. , vol.12 , pp. 47
    • Adkins, R.M.1    Thomas, F.2    Tylavsky, F.A.3    Krushkal, J.4
  • 3
    • 0030591769 scopus 로고    scopus 로고
    • Differential methylation of human LINE-1 retrotransposons in malignant cells
    • Alves G, Tatro A, Fanning T (1996) Differential methylation of human LINE-1 retrotransposons in malignant cells. Gene 176, 39-44.
    • (1996) Gene , vol.176 , pp. 39-44
    • Alves, G.1    Tatro, A.2    Fanning, T.3
  • 4
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - biological and translational implications
    • Baylin SB, Jones PA (2011) A decade of exploring the cancer epigenome - biological and translational implications. Nat. Rev. Cancer 11, 726-734.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 7
    • 84875129831 scopus 로고    scopus 로고
    • DNA methylation dynamics in health and disease
    • Bergman Y, Cedar H (2013) DNA methylation dynamics in health and disease. Nat. Struct. Mol. Biol. 20, 274-281.
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 274-281
    • Bergman, Y.1    Cedar, H.2
  • 8
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A (2007) Perceptions of epigenetics. Nature 447, 396-398.
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1
  • 9
    • 3242663659 scopus 로고    scopus 로고
    • An integrated epigenetic and genetic approach to common human disease
    • Bjornsson HT, Fallin MD, Feinberg AP (2004) An integrated epigenetic and genetic approach to common human disease. Trends Genet. 20, 350-358.
    • (2004) Trends Genet. , vol.20 , pp. 350-358
    • Bjornsson, H.T.1    Fallin, M.D.2    Feinberg, A.P.3
  • 16
    • 70450169678 scopus 로고    scopus 로고
    • Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns
    • Byun H-M, Siegmund KD, Pan F, Weisenberger DJ, Kanel G, Laird PW, Yang AS (2009) Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum. Mol. Genet. 18, 4808-4817.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 4808-4817
    • Byun, H.-M.1    Siegmund, K.D.2    Pan, F.3    Weisenberger, D.J.4    Kanel, G.5    Laird, P.W.6    Yang, A.S.7
  • 17
    • 84969319212 scopus 로고
    • Are somatic-cells inherently deficient in methylation metabolism - a proposed mechanism for DNA methylation loss, senescence and aging
    • Cooney CA (1993) Are somatic-cells inherently deficient in methylation metabolism - a proposed mechanism for DNA methylation loss, senescence and aging. J. Cell. Biochem. 17D, 164-164.
    • (1993) J. Cell. Biochem. , vol.17D , pp. 164-164
    • Cooney, C.A.1
  • 20
    • 84883727941 scopus 로고    scopus 로고
    • Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
    • Day K, Waite LL, Thalacker-Mercer A, West A, Bamman MM, Brooks JD, Myers RM, Absher D (2013) Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biol. 14, R102.
    • (2013) Genome Biol. , vol.14 , pp. R102
    • Day, K.1    Waite, L.L.2    Thalacker-Mercer, A.3    West, A.4    Bamman, M.M.5    Brooks, J.D.6    Myers, R.M.7    Absher, D.8
  • 22
    • 0024552485 scopus 로고
    • Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA
    • Drinkwater RD, Blake TJ, Morley AA, Turner DR (1989) Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA. Mutat. Res. 219, 29-37.
    • (1989) Mutat. Res. , vol.219 , pp. 29-37
    • Drinkwater, R.D.1    Blake, T.J.2    Morley, A.A.3    Turner, D.R.4
  • 23
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429, 457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 27
    • 84855956247 scopus 로고    scopus 로고
    • Epigenetics and the environment: emerging patterns and implications
    • Feil R, Fraga MF (2012) Epigenetics and the environment: emerging patterns and implications. Nat. Rev. Genet. 13, 97-109.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 97-109
    • Feil, R.1    Fraga, M.F.2
  • 28
    • 84894088246 scopus 로고    scopus 로고
    • Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites
    • Florath I, Butterbach K, Müller H, Bewerunge-Hudler M, Brenner H (2014) Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites. Hum. Mol. Genet. 23, 1186-1201.
    • (2014) Hum. Mol. Genet. , vol.23 , pp. 1186-1201
    • Florath, I.1    Butterbach, K.2    Müller, H.3    Bewerunge-Hudler, M.4    Brenner, H.5
  • 29
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: the targets and the marks
    • Fraga MF, Esteller M (2007) Epigenetics and aging: the targets and the marks. Trends Genet. 23, 413-418.
    • (2007) Trends Genet. , vol.23 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 36
    • 84875700729 scopus 로고    scopus 로고
    • A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression
    • Guintivano J, Aryee MJ, Kaminsky ZA (2013) A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression. Epigenetics 8, 290-302.
    • (2013) Epigenetics , vol.8 , pp. 290-302
    • Guintivano, J.1    Aryee, M.J.2    Kaminsky, Z.A.3
  • 41
    • 84886111619 scopus 로고    scopus 로고
    • DNA methylation age of human tissues and cell types
    • Horvath S (2013) DNA methylation age of human tissues and cell types. Genome Biol. 14, R115.
    • (2013) Genome Biol. , vol.14 , pp. R115
    • Horvath, S.1
  • 45
    • 67349255210 scopus 로고    scopus 로고
    • CpG islands-'a rough guide'
    • Illingworth RS, Bird AP (2009) CpG islands-'a rough guide'. FEBS Lett. 583, 1713-1720.
    • (2009) FEBS Lett. , vol.583 , pp. 1713-1720
    • Illingworth, R.S.1    Bird, A.P.2
  • 46
    • 84893192328 scopus 로고    scopus 로고
    • Accounting for cellular heterogeneity is critical in epigenome-wide association studies
    • Jaffe AE, Irizarry RA (2014) Accounting for cellular heterogeneity is critical in epigenome-wide association studies. Genome Biol. 15, R31.
    • (2014) Genome Biol. , vol.15 , pp. R31
    • Jaffe, A.E.1    Irizarry, R.A.2
  • 47
    • 84884906522 scopus 로고    scopus 로고
    • Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels
    • Jenkins TG, Aston KI, Cairns BR, Carrell DT (2013) Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil. Steril. 100, 945-951.
    • (2013) Fertil. Steril. , vol.100 , pp. 945-951
    • Jenkins, T.G.1    Aston, K.I.2    Cairns, B.R.3    Carrell, D.T.4
  • 49
    • 84879537717 scopus 로고    scopus 로고
    • Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan
    • Johansson A, Enroth S, Gyllensten U (2013) Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan. PLoS ONE 8, e67378.
    • (2013) PLoS ONE , vol.8 , pp. e67378
    • Johansson, A.1    Enroth, S.2    Gyllensten, U.3
  • 50
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: islands, start sites, gene bodies and beyond
    • Jones PA (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet. 13, 484-492.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 54
    • 0027474543 scopus 로고
    • DNA methylation in the Alu sequences of diploid and haploid primary human cells
    • Kochanek S, Renz D, Doerfler W (1993) DNA methylation in the Alu sequences of diploid and haploid primary human cells. EMBO J. 12, 1141-1151.
    • (1993) EMBO J. , vol.12 , pp. 1141-1151
    • Kochanek, S.1    Renz, D.2    Doerfler, W.3
  • 57
    • 84861144097 scopus 로고    scopus 로고
    • Potential forensic application of DNA methylation profiling to body fluid identification
    • Lee HY, Park MJ, Choi A, An JH, Yang WI, Shin K-J (2012) Potential forensic application of DNA methylation profiling to body fluid identification. Int. J. Legal Med. 126, 55-62.
    • (2012) Int. J. Legal Med. , vol.126 , pp. 55-62
    • Lee, H.Y.1    Park, M.J.2    Choi, A.3    An, J.H.4    Yang, W.I.5    Shin, K.-J.6
  • 63
    • 23044446596 scopus 로고    scopus 로고
    • Epigenetic drift in aging identical twins
    • Martin GM (2005) Epigenetic drift in aging identical twins. Proc. Natl. Acad. Sci. USA 102, 10413-10414.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 10413-10414
    • Martin, G.M.1
  • 64
    • 80052555415 scopus 로고    scopus 로고
    • Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans
    • Martino DJ, Tulic MK, Gordon L, Hodder M, Richman TR, Metcalfe J, Prescott SL, Saffery R (2011) Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans. Epigenetics 6, 1085-1094.
    • (2011) Epigenetics , vol.6 , pp. 1085-1094
    • Martino, D.J.1    Tulic, M.K.2    Gordon, L.3    Hodder, M.4    Richman, T.R.5    Metcalfe, J.6    Prescott, S.L.7    Saffery, R.8
  • 65
    • 84878004354 scopus 로고    scopus 로고
    • Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance
    • Martino D, Loke YJ, Gordon L, Ollikainen M, Cruickshank MN, Saffery R, Craig JM (2013) Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance. Genome Biol. 14, R42.
    • (2013) Genome Biol. , vol.14 , pp. R42
    • Martino, D.1    Loke, Y.J.2    Gordon, L.3    Ollikainen, M.4    Cruickshank, M.N.5    Saffery, R.6    Craig, J.M.7
  • 67
    • 76749090671 scopus 로고    scopus 로고
    • Epigenetics and the biological definition of gene x environment interactions
    • Meaney MJ (2010) Epigenetics and the biological definition of gene x environment interactions. Child Dev. 81, 41-79.
    • (2010) Child Dev. , vol.81 , pp. 41-79
    • Meaney, M.J.1
  • 68
    • 84881083007 scopus 로고    scopus 로고
    • Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits
    • Moen EL, Zhang X, Mu W, Delaney SM, Wing C, McQuade J, Myers J, Godley LA, Dolan ME, Zhang W (2013) Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits. Genetics 194, 987-996.
    • (2013) Genetics , vol.194 , pp. 987-996
    • Moen, E.L.1    Zhang, X.2    Mu, W.3    Delaney, S.M.4    Wing, C.5    McQuade, J.6    Myers, J.7    Godley, L.A.8    Dolan, M.E.9    Zhang, W.10
  • 73
    • 84892495521 scopus 로고    scopus 로고
    • Novel region discovery method for Infinium 450K DNA methylation data reveals changes associated with aging in muscle and neuronal pathways
    • Ong M-L, Holbrook JD (2014) Novel region discovery method for Infinium 450K DNA methylation data reveals changes associated with aging in muscle and neuronal pathways. Aging Cell 13, 142-155.
    • (2014) Aging Cell , vol.13 , pp. 142-155
    • Ong, M.-L.1    Holbrook, J.D.2
  • 74
    • 34247473478 scopus 로고    scopus 로고
    • The epigenetic basis of twin discordance in age-related diseases
    • Poulsen P, Esteller M, Vaag A, Fraga MF (2007) The epigenetic basis of twin discordance in age-related diseases. Pediatr. Res. 61, 38R-42R.
    • (2007) Pediatr. Res. , vol.61 , pp. 38R-42R
    • Poulsen, P.1    Esteller, M.2    Vaag, A.3    Fraga, M.F.4
  • 76
    • 79960556965 scopus 로고    scopus 로고
    • Epigenome-wide association studies for common human diseases
    • Rakyan VK, Down TA, Balding DJ, Beck S (2011) Epigenome-wide association studies for common human diseases. Nat. Rev. Genet. 12, 529-541.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 529-541
    • Rakyan, V.K.1    Down, T.A.2    Balding, D.J.3    Beck, S.4
  • 77
    • 31944432339 scopus 로고    scopus 로고
    • A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters
    • Saxonov S, Berg P, Brutlag DL (2006) A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc. Natl. Acad. Sci. USA 103, 1412-1417.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 1412-1417
    • Saxonov, S.1    Berg, P.2    Brutlag, D.L.3
  • 86
    • 84884784742 scopus 로고    scopus 로고
    • Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
    • Teschendorff AE, West J, Beck S (2013) Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Hum. Mol. Genet. 22, 7-15.
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 7-15
    • Teschendorff, A.E.1    West, J.2    Beck, S.3
  • 88
    • 84897489039 scopus 로고    scopus 로고
    • The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts
    • Wagner JR, Busche S, Ge B, Kwan T, Pastinen T, Blanchette M (2014) The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts. Genome Biol. 15, R37.
    • (2014) Genome Biol. , vol.15 , pp. R37
    • Wagner, J.R.1    Busche, S.2    Ge, B.3    Kwan, T.4    Pastinen, T.5    Blanchette, M.6
  • 90
    • 34047116826 scopus 로고    scopus 로고
    • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    • Weber M, Hellmann I, Stadler MB, Ramos L, Pääbo S, Rebhan M, Schübeler D (2007) Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat. Genet. 39, 457-466.
    • (2007) Nat. Genet. , vol.39 , pp. 457-466
    • Weber, M.1    Hellmann, I.2    Stadler, M.B.3    Ramos, L.4    Pääbo, S.5    Rebhan, M.6    Schübeler, D.7
  • 92
    • 67649407892 scopus 로고    scopus 로고
    • CD28(-) T cells: their role in the age-associated decline of immune function
    • Weng N-P, Akbar AN, Goronzy J (2009) CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol. 30, 306-312.
    • (2009) Trends Immunol. , vol.30 , pp. 306-312
    • Weng, N.-P.1    Akbar, A.N.2    Goronzy, J.3
  • 93


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