-
1
-
-
42649111665
-
Progress and prospects in rat genetics: a community view
-
Aitman T.J., Critser J.K., Cupper E., Dominiczak A., Fernandez-Suarez X., Flint J., Gauguier D., Geurts A.M., Gould M., Harris P.C., Holmdahl R., Hubner N., Izsvák Z., Jacob H.J., Kuramoto T., Kwitek A.E., Marrone A., Mashimo T., Moreno C., Mullins J., Mullins L., Olsson T., Pravenec M., Riley L., Saar K., Serikawa T., Shull J.D., Szpirer C., Twigger S.N., Voigt B., and Worley K. Progress and prospects in rat genetics: a community view. Nat. Genet. 40 (2008) 516-522
-
(2008)
Nat. Genet.
, vol.40
, pp. 516-522
-
-
Aitman, T.J.1
Critser, J.K.2
Cupper, E.3
Dominiczak, A.4
Fernandez-Suarez, X.5
Flint, J.6
Gauguier, D.7
Geurts, A.M.8
Gould, M.9
Harris, P.C.10
Holmdahl, R.11
Hubner, N.12
Izsvák, Z.13
Jacob, H.J.14
Kuramoto, T.15
Kwitek, A.E.16
Marrone, A.17
Mashimo, T.18
Moreno, C.19
Mullins, J.20
Mullins, L.21
Olsson, T.22
Pravenec, M.23
Riley, L.24
Saar, K.25
Serikawa, T.26
Shull, J.D.27
Szpirer, C.28
Twigger, S.N.29
Voigt, B.30
Worley, K.31
more..
-
2
-
-
38349160711
-
The biomarkers consortium: on the critical path of drug discovery
-
Altar C.A. The biomarkers consortium: on the critical path of drug discovery. Clin. Pharmacol. Ther. 83 (2008) 361-364
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 361-364
-
-
Altar, C.A.1
-
5
-
-
41449117945
-
RNAi technologies: a screen whose time has arrived
-
Blow N. RNAi technologies: a screen whose time has arrived. Nat. Methods 5 (2008) 361-368
-
(2008)
Nat. Methods
, vol.5
, pp. 361-368
-
-
Blow, N.1
-
6
-
-
38749114620
-
Structural genomics: inside a protein structure initiative center
-
Blow N. Structural genomics: inside a protein structure initiative center. Nat. Methods 5 (2008) 203-207
-
(2008)
Nat. Methods
, vol.5
, pp. 203-207
-
-
Blow, N.1
-
7
-
-
84934444321
-
Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology
-
Buck W.R., Waring J.F., and Blomme E.A. Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology. Methods Mol. Biol. 460 (2008) 23-44
-
(2008)
Methods Mol. Biol.
, vol.460
, pp. 23-44
-
-
Buck, W.R.1
Waring, J.F.2
Blomme, E.A.3
-
8
-
-
33645959506
-
Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies
-
Burczynski M.E., and Dorner A.J. Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies. Pharmacogenomics 7 (2006) 187-202
-
(2006)
Pharmacogenomics
, vol.7
, pp. 187-202
-
-
Burczynski, M.E.1
Dorner, A.J.2
-
9
-
-
36749009126
-
Blood gene expression signatures predict exposure levels
-
Bushel P.R., Heinloth A.N., Huang L., Chou J.W., Boorman G.A., Malarkey D.E., Houle C.D., Ward S.M., Wilson R.E., Fannin R.D., Russo M.W., Watkins P.B., Tennant R.W., and Paules R.S. Blood gene expression signatures predict exposure levels. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 18211-18216
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 18211-18216
-
-
Bushel, P.R.1
Heinloth, A.N.2
Huang, L.3
Chou, J.W.4
Boorman, G.A.5
Malarkey, D.E.6
Houle, C.D.7
Ward, S.M.8
Wilson, R.E.9
Fannin, R.D.10
Russo, M.W.11
Watkins, P.B.12
Tennant, R.W.13
Paules, R.S.14
-
10
-
-
38749114995
-
Oncogenes and cancer
-
Croce. Oncogenes and cancer. N. Engl. J. Med. 358 (2008) 502-511
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 502-511
-
-
Croce1
-
11
-
-
42449142396
-
Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: two novel biomarkers of Alzheimer's disease in human plasma
-
Cutler P., Akuffo E.L., Bodnar W.M., Briggs D.M., Davis J.B., Debouck C.M., Fox S.M., Gibson R.A., Gormley D.A., Holbrook J.D., Hunter A.J., Kinsey E.E., Prinjha R., Richardson J.C., Roses A.D., Smith M.A., Tsokanas N., Willé D.R., Wu W., Yates J.W., and Gloger I.S. Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: two novel biomarkers of Alzheimer's disease in human plasma. Proteomics Clin. Appl. 2 (2008) 467-477
-
(2008)
Proteomics Clin. Appl.
, vol.2
, pp. 467-477
-
-
Cutler, P.1
Akuffo, E.L.2
Bodnar, W.M.3
Briggs, D.M.4
Davis, J.B.5
Debouck, C.M.6
Fox, S.M.7
Gibson, R.A.8
Gormley, D.A.9
Holbrook, J.D.10
Hunter, A.J.11
Kinsey, E.E.12
Prinjha, R.13
Richardson, J.C.14
Roses, A.D.15
Smith, M.A.16
Tsokanas, N.17
Willé, D.R.18
Wu, W.19
Yates, J.W.20
Gloger, I.S.21
more..
-
12
-
-
0242363668
-
Looking backward to move forward: early detection of neurodegenerative disorders
-
DeKosky S.T., and Marek K. Looking backward to move forward: early detection of neurodegenerative disorders. Science 302 (2003) 830-834
-
(2003)
Science
, vol.302
, pp. 830-834
-
-
DeKosky, S.T.1
Marek, K.2
-
13
-
-
37149025669
-
Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies
-
Ellinger-Ziegelbauer H., Gmuender H., Bandenburg A., and Ahr H.J. Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies. Mutat. Res. 637 (2008) 23-39
-
(2008)
Mutat. Res.
, vol.637
, pp. 23-39
-
-
Ellinger-Ziegelbauer, H.1
Gmuender, H.2
Bandenburg, A.3
Ahr, H.J.4
-
14
-
-
39049094335
-
Virtual screening and its integration with modern drug design technologies
-
Guido R.V., Oliva G., and Andricopulo A.D. Virtual screening and its integration with modern drug design technologies. Curr. Med. Chem. 15 (2008) 37-46
-
(2008)
Curr. Med. Chem.
, vol.15
, pp. 37-46
-
-
Guido, R.V.1
Oliva, G.2
Andricopulo, A.D.3
-
15
-
-
41649100689
-
Mining the plasma proteome for cancer biomarkers
-
Hanash S.M., Pitteri S.J., and Faca V.M. Mining the plasma proteome for cancer biomarkers. Nature 452 (2008) 571-579
-
(2008)
Nature
, vol.452
, pp. 571-579
-
-
Hanash, S.M.1
Pitteri, S.J.2
Faca, V.M.3
-
16
-
-
0036597864
-
The SNP consortium: summary of a private consortium effort to develop an applied map of the human genome
-
Holden A.L. The SNP consortium: summary of a private consortium effort to develop an applied map of the human genome. Biotechniques 32 (2002) S22-S26
-
(2002)
Biotechniques
, vol.32
-
-
Holden, A.L.1
-
17
-
-
43349090926
-
miRNAs: effectors of environmental influences on gene expression and disease
-
Hudder A., and Novak R.F. miRNAs: effectors of environmental influences on gene expression and disease. Toxicol. Sci. 103 (2008) 228-240
-
(2008)
Toxicol. Sci.
, vol.103
, pp. 228-240
-
-
Hudder, A.1
Novak, R.F.2
-
18
-
-
79959524146
-
A haplotype map of the human genome
-
International HapMap Consortium. A haplotype map of the human genome. Nature 437 (2005) 1299-1320
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
International HapMap Consortium1
-
19
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
International Human Genome Sequencing Consortium1
-
21
-
-
37349116252
-
The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
-
Khoury M.J., Gwinn M., Yoon P.W., Dowling N., Moore C.A., and Bradley L. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?. Genet. Med. 9 (2007) 665-674
-
(2007)
Genet. Med.
, vol.9
, pp. 665-674
-
-
Khoury, M.J.1
Gwinn, M.2
Yoon, P.W.3
Dowling, N.4
Moore, C.A.5
Bradley, L.6
-
22
-
-
38349090575
-
The state of innovation in drug development
-
Kola I. The state of innovation in drug development. Clin. Pharmacol. Ther. 83 (2008) 227-230
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 227-230
-
-
Kola, I.1
-
23
-
-
33846600867
-
Paving the critical path: how can clinical pharmacology help achieve the vision?
-
Lesko L.J. Paving the critical path: how can clinical pharmacology help achieve the vision?. Clin. Pharmacol. Ther. 81 (2007) 170-177
-
(2007)
Clin. Pharmacol. Ther.
, vol.81
, pp. 170-177
-
-
Lesko, L.J.1
-
24
-
-
33846950455
-
Systems biology approach to integrative comparative genomics
-
Lin J., and Qian J. Systems biology approach to integrative comparative genomics. Expert Rev. Proteomics 4 (2007) 107-119
-
(2007)
Expert Rev. Proteomics
, vol.4
, pp. 107-119
-
-
Lin, J.1
Qian, J.2
-
25
-
-
34548616496
-
Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia
-
Lum P.Y., He Y.D., Slatter J.G., Waring J.F., Zelinsky N., Cavet G., Dai X., Fong O., Gum R., Jin L., Adamson G.E., Roberts C.J., Olsen D.B., Hazuda D.J., and Ulrich R.G. Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia. Genomics 90 (2007) 464-473
-
(2007)
Genomics
, vol.90
, pp. 464-473
-
-
Lum, P.Y.1
He, Y.D.2
Slatter, J.G.3
Waring, J.F.4
Zelinsky, N.5
Cavet, G.6
Dai, X.7
Fong, O.8
Gum, R.9
Jin, L.10
Adamson, G.E.11
Roberts, C.J.12
Olsen, D.B.13
Hazuda, D.J.14
Ulrich, R.G.15
-
26
-
-
43049146524
-
A HapMap harvest of insights into the genetics of common disease
-
Manolio T.A., Brooks L.D., and Collins F.S. A HapMap harvest of insights into the genetics of common disease. J. Clin. Invest. 118 (2008) 1590-1605
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1590-1605
-
-
Manolio, T.A.1
Brooks, L.D.2
Collins, F.S.3
-
27
-
-
34548324267
-
The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials
-
Marchetti S., and Schellens J.H. The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials. Br. J. Cancer 97 (2007) 577-581
-
(2007)
Br. J. Cancer
, vol.97
, pp. 577-581
-
-
Marchetti, S.1
Schellens, J.H.2
-
28
-
-
55049103071
-
Human proteinpedia as a resource for clinical proteomics
-
Mathivanan S., and Pandey A. Human proteinpedia as a resource for clinical proteomics. Mol. Cell. Proteomics 7 (2008) 2038-2047
-
(2008)
Mol. Cell. Proteomics
, vol.7
, pp. 2038-2047
-
-
Mathivanan, S.1
Pandey, A.2
-
29
-
-
33745795732
-
The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks
-
Mattingly C.J., Rosenstein M.C., Davis A.P., Colby G.T., Forrest Jr. J.N., and Boyer J.L. The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks. Toxicol. Sci. 92 (2006) 587-595
-
(2006)
Toxicol. Sci.
, vol.92
, pp. 587-595
-
-
Mattingly, C.J.1
Rosenstein, M.C.2
Davis, A.P.3
Colby, G.T.4
Forrest Jr., J.N.5
Boyer, J.L.6
-
30
-
-
47149084410
-
Calling on a million minds for community annotation in WikiProteins
-
Mons B., Ashburner M., Chichester C., van Mulligen E., Weeber M., den Dunnen J., van Ommen G.-J., Musen M., Cockerill M., Hermjakob H., Mons A., Packer A., Pacheco R., Lewis S., Berkeley A., Melton W., Barris N., Wales J., Meijssen G., Moeller E., Roes P.J., Borner K., and Bairoch A. Calling on a million minds for community annotation in WikiProteins. Genome Biol. 9 (2008) R89.1-R89.15
-
(2008)
Genome Biol.
, vol.9
-
-
Mons, B.1
Ashburner, M.2
Chichester, C.3
van Mulligen, E.4
Weeber, M.5
den Dunnen, J.6
van Ommen, G.-J.7
Musen, M.8
Cockerill, M.9
Hermjakob, H.10
Mons, A.11
Packer, A.12
Pacheco, R.13
Lewis, S.14
Berkeley, A.15
Melton, W.16
Barris, N.17
Wales, J.18
Meijssen, G.19
Moeller, E.20
Roes, P.J.21
Borner, K.22
Bairoch, A.23
more..
-
31
-
-
34447555782
-
Mining gene expression profiles: expression signatures as cancer phenotypes
-
Nevins J.R., and Potti A. Mining gene expression profiles: expression signatures as cancer phenotypes. Nat. Rev. Genet. 8 (2007) 601-609
-
(2007)
Nat. Rev. Genet.
, vol.8
, pp. 601-609
-
-
Nevins, J.R.1
Potti, A.2
-
33
-
-
43749090221
-
Genomic medicine and developing countries: creating a room of their own
-
Seguin B., Hardy B.-J., Singer P.A., and Daar A.S. Genomic medicine and developing countries: creating a room of their own. Nat. Rev. Genet. 9 (2008) 487-493
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 487-493
-
-
Seguin, B.1
Hardy, B.-J.2
Singer, P.A.3
Daar, A.S.4
-
34
-
-
46249130709
-
The beginning of the end for microarrays?
-
Shendure J. The beginning of the end for microarrays?. Nat. Methods 5 (2008) 585-587
-
(2008)
Nat. Methods
, vol.5
, pp. 585-587
-
-
Shendure, J.1
-
35
-
-
36849029833
-
Systems biology and the host response to viral infection
-
Tan S.-L., Ganji G., Paeper B., Proll S., and Katze M. Systems biology and the host response to viral infection. Nat. Biotechnol. 25 (2007) 1383-1389
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1383-1389
-
-
Tan, S.-L.1
Ganji, G.2
Paeper, B.3
Proll, S.4
Katze, M.5
-
36
-
-
39149109286
-
Integrated approaches to uncovering transcription regulatory networks in mammalian cells
-
Tan K., Tegner J., and Ravasi T. Integrated approaches to uncovering transcription regulatory networks in mammalian cells. Genomics 91 (2008) 219-231
-
(2008)
Genomics
, vol.91
, pp. 219-231
-
-
Tan, K.1
Tegner, J.2
Ravasi, T.3
-
37
-
-
41649114164
-
Enabling personalized cancer medicine through analysis of gene-expression patterns
-
Van't Veer L.J., and Bernards R. Enabling personalized cancer medicine through analysis of gene-expression patterns. Nature 452 (2008) 564-570
-
(2008)
Nature
, vol.452
, pp. 564-570
-
-
Van't Veer, L.J.1
Bernards, R.2
-
38
-
-
38549162759
-
CEBSchemical effects in biological systems: a public data repository integrating study design and toxicity data with microarray and proteomics data
-
Waters M., Stasiewicz S., Merrick B.A., Tomer K., Bushel P., Paules R., Stegman N., Nehls G., Yost K.J., Johnson C.H., Gustafson S.F., Xirasagar S., Xiao N., Huang C.-C., Boyer P., Chan D.D., Pan Q., Gong H., Taylor J., Choi D., Rashid A., Ahmed A., Howle R., Selkirk J., Tennant R., and Fostel J. CEBSchemical effects in biological systems: a public data repository integrating study design and toxicity data with microarray and proteomics data. Nucleic Acids Res. 36 (2008) D892-D900
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Waters, M.1
Stasiewicz, S.2
Merrick, B.A.3
Tomer, K.4
Bushel, P.5
Paules, R.6
Stegman, N.7
Nehls, G.8
Yost, K.J.9
Johnson, C.H.10
Gustafson, S.F.11
Xirasagar, S.12
Xiao, N.13
Huang, C.-C.14
Boyer, P.15
Chan, D.D.16
Pan, Q.17
Gong, H.18
Taylor, J.19
Choi, D.20
Rashid, A.21
Ahmed, A.22
Howle, R.23
Selkirk, J.24
Tennant, R.25
Fostel, J.26
more..
-
39
-
-
41649110649
-
Imaging in the era of molecular oncology
-
Weissleder R., and Pittet M.J. Imaging in the era of molecular oncology. Nature 452 (2008) 580-589
-
(2008)
Nature
, vol.452
, pp. 580-589
-
-
Weissleder, R.1
Pittet, M.J.2
-
40
-
-
35748961114
-
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges
-
Wilke R.A., Lin D.W., Roden D.M., Watkins P.B., Flockhart D., Zineh I., Giacomini K.M., and Krauss R.M. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat. Rev. Drug Discov. 6 (2007) 904-916
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 904-916
-
-
Wilke, R.A.1
Lin, D.W.2
Roden, D.M.3
Watkins, P.B.4
Flockhart, D.5
Zineh, I.6
Giacomini, K.M.7
Krauss, R.M.8
-
41
-
-
0031792950
-
Orphan G-protein-coupled receptors: the next generation of drug targets?
-
Wilson S., Bergsma D.J., Chambers J.K., Muir A.I., Fantom K.G., Ellis C., Murdock P.R., Herrity N.C., and Stadel J.M. Orphan G-protein-coupled receptors: the next generation of drug targets?. Br. J. Pharmacol. 125 (1998) 1387-1392
-
(1998)
Br. J. Pharmacol.
, vol.125
, pp. 1387-1392
-
-
Wilson, S.1
Bergsma, D.J.2
Chambers, J.K.3
Muir, A.I.4
Fantom, K.G.5
Ellis, C.6
Murdock, P.R.7
Herrity, N.C.8
Stadel, J.M.9
-
42
-
-
39649084919
-
The FDA critical path initiative and its influence on new drug development
-
Woodcock J., and Woosley R. The FDA critical path initiative and its influence on new drug development. Annu. Rev. Med. 59 (2008) 1-12
-
(2008)
Annu. Rev. Med.
, vol.59
, pp. 1-12
-
-
Woodcock, J.1
Woosley, R.2
-
43
-
-
0037267313
-
Knockouts model the 100 best-selling drugs-will they model the next 100?
-
Zambrowicz B.P., and Sands A.T. Knockouts model the 100 best-selling drugs-will they model the next 100?. Nat. Rev. Drug Discov. 2 (2003) 38-51
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 38-51
-
-
Zambrowicz, B.P.1
Sands, A.T.2
|