Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy

Analytical Chemistry

Volumn 80, Issue 11, 2008, Pages 4175-4185

  West, Graham M ^a   Tang, Liangjie ^a   Fitzgerald, Michael C ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOMOLECULES; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL OXYGEN DEMAND; CHEMICAL STABILITY; COMPLEXATION; DESORPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN; HYDROGEN PEROXIDE; LIGANDS; MASS SPECTROMETERS; MASS SPECTROMETRY; MECHANICS; OXIDATION; PROTEINS; PULSED LASER DEPOSITION; RATE CONSTANTS; REACTION RATES; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; SYSTEM STABILITY; THERMOANALYSIS; THERMODYNAMICS;

(SKEW) FREE ENERGY; DENATURANT CONCENTRATION; ELECTROSPRAY (ES); LIGAND BINDING; MATRIX-ASSISTED LASER DESORPTION/IONIZATION (MALDI) MASS SPECTROMETRY; OXIDATION REACTIONS; OXIDATION TIME; PROTEIN STABILITY; PROTEIN-LIGAND COMPLEXES;

THERMODYNAMIC STABILITY;

BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE II; CARZENIDE; CYCLOPHILIN A; CYCLOSPORIN A; HYDROGEN PEROXIDE; RIBONUCLEASE A; UBIQUITIN;

ACCURACY; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); DISSOCIATION CONSTANT; ELECTROSPRAY MASS SPECTROMETRY; LIGAND BINDING; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEASUREMENT; OXIDATION; PROTEIN FOLDING; PROTEIN STABILITY; THERMODYNAMICS;

ANIMALS; CATTLE; ENZYME STABILITY; KINETICS; LIGANDS; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEINS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THERMODYNAMICS;

EID: 44949229448     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac702610a     Document Type: Article

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