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Volumn 14, Issue 4, 2015, Pages 248-260

Organs-on-chips at the frontiers of drug discovery

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Indexed keywords

DIMETICONE;

EID: 84926408953     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4539     Document Type: Review
Times cited : (939)

References (106)
  • 2
    • 77649234756 scopus 로고    scopus 로고
    • How to improve r&d productivity: The pharmaceutical industry's grand challenge
    • Paul S. M., et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nature Rev. Drug Discov. 9, 203-214 (2010
    • (2010) Nature Rev. Drug Discov , vol.9 , pp. 203-214
    • Paul, S.M.1
  • 3
    • 79952160304 scopus 로고    scopus 로고
    • Advances in the preclinical testing of cancer therapeutic hypotheses
    • Caponigro G. & Sellers W. R. Advances in the preclinical testing of cancer therapeutic hypotheses. Nature Rev. Drug Discov. 10, 179-187 (2011
    • (2011) Nature Rev. Drug Discov , vol.10 , pp. 179-187
    • Caponigro, G.1    Sellers, W.R.2
  • 4
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I. & Landis J. Can the pharmaceutical industry reduce attrition rates?. Nature Rev. Drug Discov. 3, 711-715 (2004
    • (2004) Nature Rev. Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 5
    • 84870774465 scopus 로고    scopus 로고
    • Reducing safety-related drug attrition: The use of in vitro pharmacological profiling
    • Bowes J., et al. Reducing safety-related drug attrition: the use of in vitro pharmacological profiling. Nature Rev. Drug Discov. 11, 909-922 (2012
    • (2012) Nature Rev. Drug Discov , vol.11 , pp. 909-922
    • Bowes, J.1
  • 6
    • 84867027478 scopus 로고    scopus 로고
    • The determination and interpretation of the therapeutic index in drug development
    • Muller P. Y. & Milton M. N. The determination and interpretation of the therapeutic index in drug development. Nature Rev. Drug Discov. 11, 751-761 (2012
    • (2012) Nature Rev. Drug Discov , vol.11 , pp. 751-761
    • Muller, P.Y.1    Milton, M.N.2
  • 7
    • 0034578083 scopus 로고    scopus 로고
    • Microengineering of cellular interactions
    • Folch A. & Toner M. Microengineering of cellular interactions. Annu. Rev. Biomed. Eng. 2, 227-256 (2000
    • (2000) Annu. Rev. Biomed. Eng , vol.2 , pp. 227-256
    • Folch, A.1    Toner, M.2
  • 10
    • 84910136913 scopus 로고    scopus 로고
    • Three-dimensional organotypic culture: Experimental models of mammalian biology and disease
    • Shamir E. R. & Ewald A. J. Three-dimensional organotypic culture: experimental models of mammalian biology and disease. Nature Rev. Mol. Cell Biol. 15, 647-664 (2014
    • (2014) Nature Rev. Mol. Cell Biol , vol.15 , pp. 647-664
    • Shamir, E.R.1    Ewald, A.J.2
  • 11
    • 81355146382 scopus 로고    scopus 로고
    • From 3D cell culture to organs-on chips
    • Huh D., Hamilton G. A. & Ingber D. E. From 3D cell culture to organs-on chips. Trends Cell Biol. 21, 745-754 (2011
    • (2011) Trends Cell Biol , vol.21 , pp. 745-754
    • Huh, D.1    Hamilton, G.A.2    Ingber, D.E.3
  • 13
    • 77954038080 scopus 로고    scopus 로고
    • Reconstituting organ-level lung functions on a chip
    • Huh D., et al. Reconstituting organ-level lung functions on a chip. Science 328, 1662-1668 (2010
    • (2010) Science , vol.328 , pp. 1662-1668
    • Huh, D.1
  • 14
    • 80053384629 scopus 로고    scopus 로고
    • Microfluidic cell culture models for tissue engineering
    • Inamdar N. K. & Borenstein J. T. Microfluidic cell culture models for tissue engineering. Curr. Opin. Biotechnol. 22, 681-689 (2011
    • (2011) Curr. Opin. Biotechnol , vol.22 , pp. 681-689
    • Inamdar, N.K.1    Borenstein, J.T.2
  • 15
    • 84869126274 scopus 로고    scopus 로고
    • A human disease model of drug toxicity-induced pulmonary edema in a lung on a chip microdevice
    • 159ra147
    • Huh D., et al. A human disease model of drug toxicity-induced pulmonary edema in a lung on a chip microdevice. Sci. Transl. Med. 4, 159ra147 (2012
    • (2012) Sci. Transl. Med , vol.4
    • Huh, D.1
  • 16
    • 38049011979 scopus 로고    scopus 로고
    • Microscale culture of human liver cells for drug development
    • Khetani S. R. & Bhatia S. N. Microscale culture of human liver cells for drug development. Nature Biotech. 26, 120-126 (2007
    • (2007) Nature Biotech , vol.26 , pp. 120-126
    • Khetani, S.R.1    Bhatia, S.N.2
  • 17
    • 0032721936 scopus 로고    scopus 로고
    • Effect of cell-cell interactions in preservation of cellular phenotype: Cocultivation of hepatocytes and nonparenchymal cells
    • Bhatia S. N., Balis U. J., Yarmush M. L. & Toner M. Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J. 13, 1883-1900 (1999
    • (1999) Faseb J. , vol.13 , pp. 1883-1900
    • Bhatia, S.N.1    Balis, U.J.2    Yarmush, M.L.3    Toner, M.4
  • 18
    • 84862186471 scopus 로고    scopus 로고
    • Microengineered physiological biomimicry: Organs-on chips
    • Huh D., Torisawa Y. S., Hamilton G. A., Kim H. J. & Ingber D. E. Microengineered physiological biomimicry: organs-on chips. Lab Chip 12, 2156-2164 (2012
    • (2012) Lab Chip , vol.12 , pp. 2156-2164
    • Huh, D.1    Torisawa, Y.S.2    Hamilton, G.A.3    Kim, H.J.4    Ingber, D.E.5
  • 20
  • 21
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3D tissue physiology in vitro
    • Griffith L. G. & Swartz M. A. Capturing complex 3D tissue physiology in vitro. Nature Rev. Mol. Cell Biol. 7, 211-224 (2006
    • (2006) Nature Rev. Mol. Cell Biol , vol.7 , pp. 211-224
    • Griffith, L.G.1    Swartz, M.A.2
  • 23
    • 33747117373 scopus 로고    scopus 로고
    • The origins and the future of microfluidics
    • Whitesides G. M. The origins and the future of microfluidics. Nature 442, 368-373 (2006
    • (2006) Nature , vol.442 , pp. 368-373
    • Whitesides, G.M.1
  • 24
    • 84896284039 scopus 로고    scopus 로고
    • The present and future role of microfluidics in biomedical research
    • Sackmann E. K., Fulton A. L. & Beebe D. J. The present and future role of microfluidics in biomedical research. Nature 507, 181-189 (2014
    • (2014) Nature , vol.507 , pp. 181-189
    • Sackmann, E.K.1    Fulton, A.L.2    Beebe, D.J.3
  • 25
    • 84905754409 scopus 로고    scopus 로고
    • Microfluidic organs-on chips
    • Bhatia S. N. & Ingber D. E. Microfluidic organs-on chips. Nature Biotech. 32, 760-772 (2014
    • (2014) Nature Biotech , vol.32 , pp. 760-772
    • Bhatia, S.N.1    Ingber, D.E.2
  • 26
    • 0033771951 scopus 로고    scopus 로고
    • Concordance of the toxicity of pharmaceuticals in humans and in animals
    • Olson H., et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharm. 32, 56-67 (2000
    • (2000) Regul. Toxicol. Pharm , vol.32 , pp. 56-67
    • Olson, H.1
  • 27
    • 84892960440 scopus 로고    scopus 로고
    • Lost in translation: Animal models and clinical trials in cancer treatment
    • Mak I. W., Evaniew N. & Ghert M. Lost in translation: animal models and clinical trials in cancer treatment. Am. J. Transl. Res. 6, 114-118 (2014
    • (2014) Am. J. Transl. Res , vol.6 , pp. 114-118
    • Mak, I.W.1    Evaniew, N.2    Ghert, M.3
  • 28
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • Seok J., et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl Acad. Sci. USA 110, 3507-3512 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 3507-3512
    • Seok, J.1
  • 29
    • 84881240391 scopus 로고    scopus 로고
    • Threats to validity in the design and conduct of preclinical efficacy studies: A systematic review of guidelines for in vivo animal experiments
    • Henderson V. C., Kimmelman J., Fergusson D., Grimshaw J. M. & Hackam D. G. Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Med. 10, e1001489 (2013
    • (2013) Plos Med , vol.10 , pp. e1001489
    • Henderson, V.C.1    Kimmelman, J.2    Fergusson, D.3    Grimshaw, J.M.4    Hackam, D.G.5
  • 30
    • 84876900215 scopus 로고    scopus 로고
    • Chapter 17: Bioimage informatics for systems pharmacology
    • Li F., Yin Z., Jin G., Zhao H. & Wong S. T. Chapter 17: bioimage informatics for systems pharmacology. PLoS Comput. Biol. 9, e1003043 (2013
    • (2013) Plos Comput. Biol , vol.9 , pp. e1003043
    • Li, F.1    Yin, Z.2    Jin, G.3    Zhao, H.4    Wong, S.T.5
  • 31
    • 84897017613 scopus 로고    scopus 로고
    • Organs-on a chip: A new tool for drug discovery
    • Polini A., et al. Organs-on a chip: a new tool for drug discovery. Expert Opin. Drug Dis. 9, 335-352 (2014
    • (2014) Expert Opin. Drug Dis , vol.9 , pp. 335-352
    • Polini, A.1
  • 32
    • 66849138510 scopus 로고    scopus 로고
    • Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells
    • Song J. W., et al. Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS ONE 4, e5756 (2009
    • (2009) Plos One , vol.4 , pp. e5756
    • Song, J.W.1
  • 33
    • 84891742591 scopus 로고    scopus 로고
    • A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone
    • Bersini S., et al. A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. Biomaterials 35, 2454-2461 (2014
    • (2014) Biomaterials , vol.35 , pp. 2454-2461
    • Bersini, S.1
  • 34
    • 84870895812 scopus 로고    scopus 로고
    • Cross talk between cancer and immune cells: Exploring complex dynamics in a microfluidic environment
    • Businaro L., et al. Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment. Lab Chip 13, 229-239 (2013
    • (2013) Lab Chip , vol.13 , pp. 229-239
    • Businaro, L.1
  • 35
    • 84879986080 scopus 로고    scopus 로고
    • Astrocyte-neuron co culture on microchips based on the model of sod mutation to mimic als
    • Kunze A., et al. Astrocyte-neuron co culture on microchips based on the model of SOD mutation to mimic ALS. Integr. Biol. (Camb.) 5, 964-975 (2013
    • (2013) Integr. Biol. (Camb , vol.5 , pp. 964-975
    • Kunze, A.1
  • 36
    • 84902087268 scopus 로고    scopus 로고
    • Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart on chip technologies
    • Wang G., et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart on chip technologies. Nature Med. 20, 616-623 (2014
    • (2014) Nature Med , vol.20 , pp. 616-623
    • Wang, G.1
  • 37
    • 84873309547 scopus 로고    scopus 로고
    • Screening therapeutic EMT blocking agents in a three-dimensional microenvironment
    • Aref A. R., et al. Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr. Biol. (Camb.) 5, 381-389 (2013
    • (2013) Integr. Biol. (Camb , vol.5 , pp. 381-389
    • Aref, A.R.1
  • 38
    • 84889039734 scopus 로고    scopus 로고
    • Disease-on a chip: Mimicry of tumor growth in mammary ducts
    • Vidi P. A., et al. Disease-on a chip: mimicry of tumor growth in mammary ducts. Lab Chip 14, 172-177 (2014
    • (2014) Lab Chip , vol.14 , pp. 172-177
    • Vidi, P.A.1
  • 39
    • 64749086511 scopus 로고    scopus 로고
    • A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers
    • Tatosian D. A. & Shuler M. L. A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers. Biotechnol. Bioeng. 103, 187-198 (2009
    • (2009) Biotechnol. Bioeng , vol.103 , pp. 187-198
    • Tatosian, D.A.1    Shuler, M.L.2
  • 40
    • 84901823942 scopus 로고    scopus 로고
    • Bone marrow-on a chip replicates hematopoietic niche physiology in vitro
    • Torisawa Y. S., et al. Bone marrow-on a chip replicates hematopoietic niche physiology in vitro. Nature Methods 11, 663-669 (2014
    • (2014) Nature Methods , vol.11 , pp. 663-669
    • Torisawa, Y.S.1
  • 41
    • 77950383999 scopus 로고    scopus 로고
    • Building and manipulating neural pathways with microfluidics
    • Berdichevsky Y., Staley K. J. & Yarmush M. L. Building and manipulating neural pathways with microfluidics. Lab Chip 10, 999-1004 (2010
    • (2010) Lab Chip , vol.10 , pp. 999-1004
    • Berdichevsky, Y.1    Staley, K.J.2    Yarmush, M.L.3
  • 42
    • 84876504162 scopus 로고    scopus 로고
    • Metabolomics-on a chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips
    • Snouber L. C., et al. Metabolomics-on a chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. Toxicol. Sci. 132, 8-20 (2013
    • (2013) Toxicol. Sci , vol.132 , pp. 8-20
    • Snouber, L.C.1
  • 43
    • 82555202753 scopus 로고    scopus 로고
    • Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection
    • Mao S., Gao D., Liu W., Wei H. & Lin J. M. Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection. Lab Chip 12, 219-226 (2012
    • (2012) Lab Chip , vol.12 , pp. 219-226
    • Mao, S.1    Gao, D.2    Liu, W.3    Wei, H.4    Lin, J.M.5
  • 44
    • 84871719607 scopus 로고    scopus 로고
    • Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co culture biochip
    • Choucha-Snouber L., et al. Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co culture biochip. Biotechnol. Bioeng. 110, 597-608 (2013
    • (2013) Biotechnol. Bioeng , vol.110 , pp. 597-608
    • Choucha-Snouber, L.1
  • 45
    • 84882240631 scopus 로고    scopus 로고
    • Microfluidic heart on a chip for higher throughput pharmacological studies
    • Agarwal A., Goss J. A., Cho A., McCain M. L. & Parker K. K. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab Chip 13, 3599-3608 (2013
    • (2013) Lab Chip , vol.13 , pp. 3599-3608
    • Agarwal, A.1    Goss, J.A.2    Cho, A.3    McCain, M.L.4    Parker, K.K.5
  • 46
    • 84857964726 scopus 로고    scopus 로고
    • Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
    • Grosberg A., Alford P. W., McCain M. L. & Parker K. K. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab Chip 11, 4165-4173 (2011
    • (2011) Lab Chip , vol.11 , pp. 4165-4173
    • Grosberg, A.1    Alford, P.W.2    McCain, M.L.3    Parker, K.K.4
  • 48
    • 84889636946 scopus 로고    scopus 로고
    • Design and formulation of functional pluripotent stem cell-derived cardiac microtissues
    • Thavandiran N., et al. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc. Natl Acad. Sci. USA 110, E4698-E4707 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. E4698-E4707
    • Thavandiran, N.1
  • 49
    • 84905440393 scopus 로고    scopus 로고
    • Approaching the in vitro clinical trial: Engineering organs on chips
    • Capulli A. K., et al. Approaching the in vitro clinical trial: engineering organs on chips. Lab Chip 14, 3181-3186 (2014
    • (2014) Lab Chip , vol.14 , pp. 3181-3186
    • Capulli, A.K.1
  • 50
    • 84869141720 scopus 로고    scopus 로고
    • An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
    • 159ra148
    • Thorneloe K. S., et al. An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci. Transl. Med. 4, 159ra148 (2012
    • (2012) Sci. Transl. Med , vol.4
    • Thorneloe, K.S.1
  • 51
    • 34547656228 scopus 로고    scopus 로고
    • The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates
    • Kramer J. A., Sagartz J. E. & Morris D. L. The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nature Rev. Drug Discov. 6, 636-649 (2007
    • (2007) Nature Rev. Drug Discov , vol.6 , pp. 636-649
    • Kramer, J.A.1    Sagartz, J.E.2    Morris, D.L.3
  • 52
    • 84862181007 scopus 로고    scopus 로고
    • Organotypic liver culture models: Meeting current challenges in toxicity testing
    • LeCluyse E. L., Witek R. P., Andersen M. E. & Powers M. J. Organotypic liver culture models: meeting current challenges in toxicity testing. Crit. Rev. Toxicol. 42, 501-548 (2012
    • (2012) Crit. Rev. Toxicol , vol.42 , pp. 501-548
    • Lecluyse, E.L.1    Witek, R.P.2    Andersen, M.E.3    Powers, M.J.4
  • 53
    • 84872168458 scopus 로고    scopus 로고
    • Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips
    • Baudoin R., et al. Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips. Xenobiotica 43, 140-152 (2013
    • (2013) Xenobiotica , vol.43 , pp. 140-152
    • Baudoin, R.1
  • 54
    • 67749115964 scopus 로고    scopus 로고
    • Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human
    • Chao P., Maguire T., Novik E., Cheng K. C. & Yarmush M. Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human. Biochem. Pharmacol. 78, 625-632 (2009
    • (2009) Biochem. Pharmacol , vol.78 , pp. 625-632
    • Chao, P.1    Maguire, T.2    Novik, E.3    Cheng, K.C.4    Yarmush, M.5
  • 55
    • 84862207235 scopus 로고    scopus 로고
    • Human gut on a chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
    • Kim H. J., Huh D., Hamilton G. & Ingber D. E. Human gut on a chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip 12, 2165-2174 (2012
    • (2012) Lab Chip , vol.12 , pp. 2165-2174
    • Kim, H.J.1    Huh, D.2    Hamilton, G.3    Ingber, D.E.4
  • 56
    • 84882627623 scopus 로고    scopus 로고
    • Gut on a chip microenvironment induces human intestinal cells to undergo villus differentiation
    • Kim H. J. & Ingber D. E. Gut on a chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr. Biol. (Camb.) 5, 1130-1140 (2013
    • (2013) Integr. Biol. (Camb , vol.5 , pp. 1130-1140
    • Kim, H.J.1    Ingber, D.E.2
  • 57
    • 84875830288 scopus 로고    scopus 로고
    • Characterization of drug permeability in Caco 2 monolayers by mass spectrometry on a membrane-based microfluidic device
    • Gao D., Liu H., Lin J. M., Wang Y. & Jiang Y. Characterization of drug permeability in Caco 2 monolayers by mass spectrometry on a membrane-based microfluidic device. Lab Chip 13, 978-985 (2013
    • (2013) Lab Chip , vol.13 , pp. 978-985
    • Gao, D.1    Liu, H.2    Lin, J.M.3    Wang, Y.4    Jiang, Y.5
  • 58
    • 84887098518 scopus 로고    scopus 로고
    • Organ on a chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening
    • Lee J. B. & Sung J. H. Organ on a chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening. Biotechnol. J. 8, 1258-1266 (2013
    • (2013) Biotechnol. J. , vol.8 , pp. 1258-1266
    • Lee, J.B.1    Sung, J.H.2
  • 59
    • 84874894377 scopus 로고    scopus 로고
    • Microfabricated mammalian organ systems and their integration into models of whole animals and humans
    • Sung J. H., et al. Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip 13, 1201-1212 (2013
    • (2013) Lab Chip , vol.13 , pp. 1201-1212
    • Sung, J.H.1
  • 60
    • 78650330307 scopus 로고    scopus 로고
    • Micro total bioassay system for ingested substances: Assessment of intestinal absorption hepatic metabolism and bioactivity
    • Imura Y., Sato K. & Yoshimura E. Micro total bioassay system for ingested substances: assessment of intestinal absorption hepatic metabolism and bioactivity. Anal. Chem. 82, 9983-9988 (2010
    • (2010) Anal. Chem , vol.82 , pp. 9983-9988
    • Imura, Y.1    Sato, K.2    Yoshimura, E.3
  • 61
    • 84862247532 scopus 로고    scopus 로고
    • Micro total bioassay system for oral drugs: Evaluation of gastrointestinal degradation intestinal absorption hepatic metabolism and bioactivity
    • Imura Y., Yoshimura E. & Sato K. Micro total bioassay system for oral drugs: evaluation of gastrointestinal degradation intestinal absorption hepatic metabolism and bioactivity. Anal. Sci. 28, 197-199 (2012
    • (2012) Anal. Sci , vol.28 , pp. 197-199
    • Imura, Y.1    Yoshimura, E.2    Sato, K.3
  • 62
    • 84873379284 scopus 로고    scopus 로고
    • Microcirculation system with a dialysis part for bioassays evaluating anticancer activity and retention
    • Imura Y., Yoshimura E. & Sato K. Microcirculation system with a dialysis part for bioassays evaluating anticancer activity and retention. Anal. Chem. 85, 1683-1688 (2013
    • (2013) Anal. Chem , vol.85 , pp. 1683-1688
    • Imura, Y.1    Yoshimura, E.2    Sato, K.3
  • 63
    • 84882245384 scopus 로고    scopus 로고
    • Scaling and systems biology for integrating multiple organs-on a chip
    • Wikswo J. P., et al. Scaling and systems biology for integrating multiple organs-on a chip. Lab Chip 13, 3496-3511 (2013
    • (2013) Lab Chip , vol.13 , pp. 3496-3511
    • Wikswo, J.P.1
  • 64
    • 65649133932 scopus 로고    scopus 로고
    • A micro cell culture analog (μCCA) with 3D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs
    • Sung J. H. & Shuler M. L. A micro cell culture analog (μCCA) with 3D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab Chip 9, 1385-1394 (2009
    • (2009) Lab Chip , vol.9 , pp. 1385-1394
    • Sung, J.H.1    Shuler, M.L.2
  • 65
    • 75749153235 scopus 로고    scopus 로고
    • A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
    • Sung J. H., Kam C. & Shuler M. L. A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip 10, 446-455 (2010
    • (2010) Lab Chip , vol.10 , pp. 446-455
    • Sung, J.H.1    Kam, C.2    Shuler, M.L.3
  • 66
    • 84886953565 scopus 로고    scopus 로고
    • Phenotypic screens as a renewed approach for drug discovery
    • Zheng W., Thorne N. & McKew J. C. Phenotypic screens as a renewed approach for drug discovery. Drug Discov. Today 18, 1067-1073 (2013
    • (2013) Drug Discov. Today , vol.18 , pp. 1067-1073
    • Zheng, W.1    Thorne, N.2    McKew, J.C.3
  • 67
    • 84861490509 scopus 로고    scopus 로고
    • Modern phenotypic drug discovery is a viable neoclassic pharma strategy
    • Lee J. A., Uhlik M. T., Moxham C. M., Tomandl D. & Sall D. J. Modern phenotypic drug discovery is a viable neoclassic pharma strategy. J. Med. Chem. 55, 4527-4538 (2012
    • (2012) J. Med. Chem , vol.55 , pp. 4527-4538
    • Lee, J.A.1    Uhlik, M.T.2    Moxham, C.M.3    Tomandl, D.4    Sall, D.J.5
  • 69
    • 33644685442 scopus 로고    scopus 로고
    • The major role of clinicians in the discovery of off-label drug therapies
    • Demonaco H. J., Ali A. & Hippel E. The major role of clinicians in the discovery of off-label drug therapies. Pharmacotherapy 26, 323-332 (2006
    • (2006) Pharmacotherapy , vol.26 , pp. 323-332
    • Demonaco, H.J.1    Ali, A.2    Hippel, E.3
  • 71
    • 84879694397 scopus 로고    scopus 로고
    • A three-dimensional microfluidic tumor cell migration assay to screen the effect of anti-migratory drugs and interstitial flow
    • Kalchman J., et al. A three-dimensional microfluidic tumor cell migration assay to screen the effect of anti-migratory drugs and interstitial flow. Microfluid. Nanofluid. 14, 969-981 (2013
    • (2013) Microfluid. Nanofluid , vol.14 , pp. 969-981
    • Kalchman, J.1
  • 72
    • 84859326107 scopus 로고    scopus 로고
    • Rare diseases and orphan drugs
    • Melnikova I. Rare diseases and orphan drugs. Nature Rev. Drug Discov. 11, 267-268 (2012
    • (2012) Nature Rev. Drug Discov , vol.11 , pp. 267-268
    • Melnikova, I.1
  • 73
    • 84882249388 scopus 로고    scopus 로고
    • Three-dimensional co cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device
    • van Der Meer A. D., Orlova V. V., ten Dijke P., van Den Berg A. & Mummery C. L. Three-dimensional co cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device. Lab Chip 13, 3562-3568 (2013
    • (2013) Lab Chip , vol.13 , pp. 3562-3568
    • Van Der Meer, A.D.1    Orlova, V.V.2    Ten Dijke, P.3    Van Den Berg, A.4    Mummery, C.L.5
  • 74
    • 80054743209 scopus 로고    scopus 로고
    • An update on ethnic differences in drug metabolism and toxicity from anti-cancer drugs
    • Phan V. H., et al. An update on ethnic differences in drug metabolism and toxicity from anti-cancer drugs. Expert Opin. Drug Metab. Toxicol. 7, 1395-1410 (2011
    • (2011) Expert Opin. Drug Metab. Toxicol , vol.7 , pp. 1395-1410
    • Phan, V.H.1
  • 76
    • 84862811634 scopus 로고    scopus 로고
    • Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system
    • Ma L., et al. Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system. Biomaterials 33, 4353-4361 (2012
    • (2012) Biomaterials , vol.33 , pp. 4353-4361
    • Ma, L.1
  • 77
    • 84870770120 scopus 로고    scopus 로고
    • Human genetic variation of CYP450 superfamily: Analysis of functional diversity in worldwide populations
    • Polimanti R., Piacentini S., Manfellotto D. & Fuciarelli M. Human genetic variation of CYP450 superfamily: analysis of functional diversity in worldwide populations. Pharmacogenomics 13, 1951-1960 (2012
    • (2012) Pharmacogenomics , vol.13 , pp. 1951-1960
    • Polimanti, R.1    Piacentini, S.2    Manfellotto, D.3    Fuciarelli, M.4
  • 78
    • 84862777541 scopus 로고    scopus 로고
    • A murine lung cancer co clinical trial identifies genetic modifiers of therapeutic response
    • Chen Z., et al. A murine lung cancer co clinical trial identifies genetic modifiers of therapeutic response. Nature 483, 613-617 (2012
    • (2012) Nature , vol.483 , pp. 613-617
    • Chen, Z.1
  • 79
    • 34249820576 scopus 로고    scopus 로고
    • Multifunctional nanocarriers
    • Torchilin V. P. Multifunctional nanocarriers. Adv. Drug Deliv. Rev. 58, 1532-1555 (2006
    • (2006) Adv. Drug Deliv. Rev , vol.58 , pp. 1532-1555
    • Torchilin, V.P.1
  • 80
    • 67651233657 scopus 로고    scopus 로고
    • Gold nanoparticles in nanomedicine: Preparations imaging diagnostics therapies and toxicity
    • Boisselier E. & Astruc D. Gold nanoparticles in nanomedicine: preparations imaging diagnostics therapies and toxicity. Chem. Soc. Rev. 38, 1759-1782 (2009
    • (2009) Chem. Soc. Rev , vol.38 , pp. 1759-1782
    • Boisselier, E.1    Astruc, D.2
  • 81
    • 84892921738 scopus 로고    scopus 로고
    • Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis
    • Kim Y., et al. Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis. Proc. Natl Acad. Sci. USA 111, 1078-1083 (2014
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 1078-1083
    • Kim, Y.1
  • 82
    • 84875833460 scopus 로고    scopus 로고
    • Sym-bbb: A microfluidic blood brain barrier model
    • Prabhakarpandian B., et al. SyM-BBB: a microfluidic blood brain barrier model. Lab Chip 13,1093-1101 (2013
    • (2013) Lab Chip , vol.13 , pp. 1093-1101
    • Prabhakarpandian, B.1
  • 83
    • 84872610509 scopus 로고    scopus 로고
    • Bbb on chip: Microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
    • Griep L. M., et al. BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function. Biomed. Microdevices 15, 145-150 (2013
    • (2013) Biomed. Microdevices , vol.15 , pp. 145-150
    • Griep, L.M.1
  • 84
    • 84875775289 scopus 로고    scopus 로고
    • A modular approach to create a neurovascular unit on a chip
    • Achyuta A. K. H., et al. A modular approach to create a neurovascular unit on a chip. Lab Chip 13, 542-553 (2013
    • (2013) Lab Chip , vol.13 , pp. 542-553
    • Achyuta, A.K.H.1
  • 85
    • 84860366574 scopus 로고    scopus 로고
    • Characterization of a microfluidic in vitro model of the blood-brain barrier (mu BBB
    • Booth R. & Kim H. Characterization of a microfluidic in vitro model of the blood-brain barrier (mu BBB). Lab Chip 12, 1784-1792 (2012
    • (2012) Lab Chip , vol.12 , pp. 1784-1792
    • Booth, R.1    Kim, H.2
  • 86
    • 84887003262 scopus 로고    scopus 로고
    • Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape stability blood circulation time and bioactivity in vivo
    • Nelson C. E., et al. Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape stability blood circulation time and bioactivity in vivo. ACS Nano 7, 8870-8880 (2013
    • (2013) ACS Nano , vol.7 , pp. 8870-8880
    • Nelson, C.E.1
  • 87
    • 18744376054 scopus 로고    scopus 로고
    • An extracellular matrix microarray for probing cellular differentiation
    • Flaim C. J., Chien S. & Bhatia S. N. An extracellular matrix microarray for probing cellular differentiation. Nature Methods 2, 119-125 (2005
    • (2005) Nature Methods , vol.2 , pp. 119-125
    • Flaim, C.J.1    Chien, S.2    Bhatia, S.N.3
  • 88
    • 84857944649 scopus 로고    scopus 로고
    • Engineers are from PDMS-land biologists are from polystyrenia
    • Berthier E., Young E. W. & Beebe D. Engineers are from PDMS-land biologists are from polystyrenia. Lab Chip 12, 1224-1237 (2012
    • (2012) Lab Chip , vol.12 , pp. 1224-1237
    • Berthier, E.1    Young, E.W.2    Beebe, D.3
  • 89
    • 69249203894 scopus 로고    scopus 로고
    • Surface molecular property modifications for poly (dimethylsiloxane) (pdms) based microfluidic devices
    • Wong I. & Ho C. M. Surface molecular property modifications for poly (dimethylsiloxane) (PDMS) based microfluidic devices. Microfluid. Nanofluid. 7, 291-306 (2009
    • (2009) Microfluid. Nanofluid , vol.7 , pp. 291-306
    • Wong, I.1    Ho, C.M.2
  • 90
    • 84883305025 scopus 로고    scopus 로고
    • Clear castable polyurethane elastomer for fabrication of microfluidic devices
    • Domansky K., et al. Clear castable polyurethane elastomer for fabrication of microfluidic devices. Lab Chip 13, 3956-3964 (2013
    • (2013) Lab Chip , vol.13 , pp. 3956-3964
    • Domansky, K.1
  • 91
    • 84860439214 scopus 로고    scopus 로고
    • Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models
    • van Midwoud P. M., Janse A., Merema M. T., Groothuis G. M. & Verpoorte E. Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models. Anal. Chem. 84, 3938-3944 (2012
    • (2012) Anal. Chem , vol.84 , pp. 3938-3944
    • Van Midwoud, P.M.1    Janse, A.2    Merema, M.T.3    Groothuis, G.M.4    Verpoorte, E.5
  • 92
    • 80052213154 scopus 로고    scopus 로고
    • Engineered approaches to the stem cell microenvironment for cardiac tissue regeneration
    • Ghafar-Zadeh E., Waldeisen J. R. & Lee L. P. Engineered approaches to the stem cell microenvironment for cardiac tissue regeneration. Lab Chip 11, 3031-3048 (2011
    • (2011) Lab Chip , vol.11 , pp. 3031-3048
    • Ghafar-Zadeh, E.1    Waldeisen, J.R.2    Lee, L.P.3
  • 93
    • 84891367451 scopus 로고    scopus 로고
    • Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development
    • Mathur A., et al. Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development. Stem Cell Res. Ther. 4 (Suppl. 1), S14 (2013
    • (2013) Stem Cell Res. Ther , vol.4 , pp. S14
    • Mathur, A.1
  • 95
    • 84872301011 scopus 로고    scopus 로고
    • Multi-cell type human liver microtissues for hepatotoxicity testing
    • Messner S., Agarkova I., Moritz W. & Kelm J. Multi-cell type human liver microtissues for hepatotoxicity testing. Arch. Toxicol. 87, 209-213 (2013
    • (2013) Arch. Toxicol , vol.87 , pp. 209-213
    • Messner, S.1    Agarkova, I.2    Moritz, W.3    Kelm, J.4
  • 96
    • 84875048928 scopus 로고    scopus 로고
    • Bioengineered 3D human kidney tissue a platform for the determination of nephrotoxicity
    • DesRochers T. M., Suter L., Roth A. & Kaplan D. L. Bioengineered 3D human kidney tissue a platform for the determination of nephrotoxicity. PLoS ONE 8, e59219 (2013
    • (2013) Plos One , vol.8 , pp. e59219
    • Desrochers, T.M.1    Suter, L.2    Roth, A.3    Kaplan, D.L.4
  • 97
    • 42549106741 scopus 로고    scopus 로고
    • Automated cell culture in high density tubeless microfluidic device arrays
    • Meyvantsson I., Warrick J. W., Hayes S., Skoien A. & Beebe D. J. Automated cell culture in high density tubeless microfluidic device arrays. Lab Chip 8, 717-724 (2008
    • (2008) Lab Chip , vol.8 , pp. 717-724
    • Meyvantsson, I.1    Warrick, J.W.2    Hayes, S.3    Skoien, A.4    Beebe, D.J.5
  • 98
    • 84902073326 scopus 로고    scopus 로고
    • Mapping the human toxome by systems toxicology
    • Bouhifd M., et al. Mapping the human toxome by systems toxicology. Basic Clin. Pharmacol. Toxicol. 115, 24-31 (2014
    • (2014) Basic Clin. Pharmacol. Toxicol , vol.115 , pp. 24-31
    • Bouhifd, M.1
  • 99
    • 84905438349 scopus 로고    scopus 로고
    • US Food and Drug Administration Center for Drug Evaluation and Research & Center for Biologics Evaluation and Research US FDA
    • US Food and Drug Administration Center for Drug Evaluation and Research & Center for Biologics Evaluation and Research. Guidance for Industry: Product Development Under the Animal Rule (US FDA 2014
    • (2014) Guidance for Industry: Product Development under the Animal Rule
  • 100
    • 79960527448 scopus 로고    scopus 로고
    • The role of body on a chip devices in drug and toxicity studies
    • Esch M., King T. & Shuler M. The role of body on a chip devices in drug and toxicity studies. Annu. Rev. Biomed. Eng. 13, 55-72 (2011
    • (2011) Annu. Rev. Biomed. Eng , vol.13 , pp. 55-72
    • Esch, M.1    King, T.2    Shuler, M.3
  • 101
    • 84882247304 scopus 로고    scopus 로고
    • The future of the patient-specific body on a chip
    • Williamson A., Singh S., Fernekorn U. & Schober A. The future of the patient-specific body on a chip. Lab Chip 13, 3471-3480 (2013
    • (2013) Lab Chip , vol.13 , pp. 3471-3480
    • Williamson, A.1    Singh, S.2    Fernekorn, U.3    Schober, A.4
  • 102
    • 84891363144 scopus 로고    scopus 로고
    • The national institutes of health microphysiological systems program focuses on a critical challenge in the drug discovery pipeline
    • Sutherland M. L., Fabre K. M. & Tagle D. A. The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline. Stem Cell Res. Ther. 4 (Suppl. 1), I1 (2013
    • (2013) Stem Cell Res. Ther , vol.4 , pp. I1
    • Sutherland, M.L.1    Fabre, K.M.2    Tagle, D.A.3
  • 104
    • 84899125649 scopus 로고    scopus 로고
    • Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems
    • Jeon J. S., et al. Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems. Integr. Biol. (Camb.) 6, 555-563 (2014
    • (2014) Integr. Biol. (Camb , vol.6 , pp. 555-563
    • Jeon, J.S.1
  • 105
    • 84892372328 scopus 로고    scopus 로고
    • A bioengineered array of 3D microvessels for vascular permeability assay
    • Lee H., Kim S., Chung M., Kim J. H. & Jeon N. L. A bioengineered array of 3D microvessels for vascular permeability assay. Microvasc. Res. 91, 90-98 (2014
    • (2014) Microvasc. Res , vol.91 , pp. 90-98
    • Lee, H.1    Kim, S.2    Chung, M.3    Kim, J.H.4    Jeon, N.L.5
  • 106
    • 35848959463 scopus 로고    scopus 로고
    • Engineering tumors with 3D scaffolds
    • Fischbach C., et al. Engineering tumors with 3D scaffolds. Nature Methods 4, 855-860 (2007
    • (2007) Nature Methods , vol.4 , pp. 855-860
    • Fischbach, C.1


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