Accessing Drug Metabolites via Transition-Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration

Angewandte Chemie - International Edition

Volumn 55, Issue 46, 2016, Pages 14218-14238

  Genovino, Julien ^a   Sames, Dalibor ^b   Hamann, Lawrence G ^c   Touré, B Barry ^c  

^a PFIZER INC   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

biotransformation; chemotransformation; C H functionalization; drug discovery; drug metabolites

Indexed keywords

BIOCONVERSION; BIOMOLECULES; OXIDATION; TRANSITION METALS;

BIOTRANSFORMATION; CHEMOTRANSFORMATION; DRUG DISCOVERY; DRUG METABOLITES; FUNCTIONALIZATIONS;

METABOLITES;

BIOLOGICAL PRODUCT; CARBON; DRUG; HYDROGEN; TRANSITION ELEMENT;

CATALYSIS; CHEMISTRY; ELECTROCHEMICAL ANALYSIS; METABOLISM; MICROFLUIDIC ANALYSIS; OXIDATION REDUCTION REACTION;

BIOLOGICAL PRODUCTS; CARBON; CATALYSIS; ELECTROCHEMICAL TECHNIQUES; HYDROGEN; MICROFLUIDIC ANALYTICAL TECHNIQUES; OXIDATION-REDUCTION; PHARMACEUTICAL PREPARATIONS; TRANSITION ELEMENTS;

EID: 84990966860     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201602644     Document Type: Review

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