Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 20, 2010, Pages 9078-9082

  West, Graham M ^a   Tucker, Chandra L ^a   Xu, Tao ^b   Park, Sung Kyu ^b   Han, Xuemei ^b   Yates III, John R ^b   Fitzgerald, Michael C ^a  

^a DUKE UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cyclosporine; Ligand binding; Liquid chromatography mass spectrometry; Protein folding; Thermodynamics

Indexed keywords

CYCLOPHILIN A; CYCLOSPORIN A; GLUCOSE; URIDINE DIPHOSPHATE GLUCOSE 4 EPIMERASE;

ARTICLE; CELL LYSATE; DRUG BINDING; GLUCOSE METABOLISM; HUMAN; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STABILITY; PROTEOMICS; QUANTITATIVE ANALYSIS; THERMODYNAMICS;

CHROMATOGRAPHY, LIQUID; COMPLEX MIXTURES; CYCLOSPORINE; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; PROTEIN FOLDING; PROTEINS; PROTEOMICS; THERMODYNAMICS; UDPGLUCOSE 4-EPIMERASE; YEASTS;

EID: 77952722630     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1000148107     Document Type: Article

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