Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells

Breast Cancer Research and Treatment

Volumn 85, Issue 1, 2004, Pages 1-12

  Sharma, Girish ^a   Tyagi, Anil K ^a   Singh, Rana P ^a   Chan, Daniel C F ^a,b   Agarwal, Rajesh ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Apoptosis; Breast cancer; Cell cycle; Doxorubicin; Grape seed extract

Indexed keywords

7 AMINODACTINOMYCIN; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; DIMETHYL SULFOXIDE; DOXORUBICIN; ESTROGEN RECEPTOR; GRAPE SEED EXTRACT; PLANT EXTRACT; POLYPHENOL; PROCYANIDIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CELL CYCLE; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG POTENTIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DEATH; CELL DIVISION; CELL LINE, TUMOR; DOXORUBICIN; DRUG SYNERGISM; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS; RECEPTORS, ESTROGEN; SEEDS; VITIS;

EID: 1842554875     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:BREA.0000020991.55659.59     Document Type: Article

References (35)

1. Jemal A, Thomas A, Murray T, Thun M: Cancer statistics, 2002. CA Cancer J Clin 52: 23-47, 2002
2. Fournier DB, Erdman Jr JW, Gordon GB: Soy, its components, and cancer prevention: a review of the in vitro, animal, and human data. Cancer Epidemiol Biomarkers Prev 7: 1055-1065, 1998
3. Agarwal R, Mukhtar H: Chemoprevention of photocarcinogenesis. Photochem Photobiol 63: 440-444, 1996
4. Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE: Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 47: 293-303, 2001
5. Lippman SM, Lee JJ, Sabichi AL: Cancer chemoprevention: progress and promise. J Natl Cancer Inst 90: 1514-1528, 1998
6. Kelloff GJ: Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res 78: 199-334, 2000
7. Hill MJ: Nutrition and human cancer. Ann NY Acad Sci 833: 68-78, 1997
8. Wargovich MJ: Nutrition and cancer: the herbal revolution. Curr Opin Clin Nutr Metab Care 2: 421-424, 1999
9. Dragsted LO: Natural antioxidants in chemoprevention. Arch Toxicol Suppl 20: 209-226, 1998
10. Mukhtar H, Agarwal R: Skin cancer chemoprevention. J Invest Dermatol Symp Proc 1: 209-214, 1996
11. Singleton VL: Tannins and the qualities of wines. In: Laks PE, Hemingway RW (eds) Plant Polyphenols. Plenum Press, New York, 1992, pp 859-880
12. Bartolome B, Hernandez T, Bengoechea ML, Quesada C, Gomez-Cordoves C, Estrella I: Determination of some structural features of procyanidins and related compounds by photodiode-array detection. J Chromatogr A 723: 19-26, 1996
13. Escribano-Bailon MT, Gutierrez-Fernandez Y, Rivas-Gonzalo JC, Santos-Buelga C: Characterization of procyanidins of Vitis vinifera variety Tinta del Paris grape seeds. J Agric Food Chem 40: 1794-1799, 1992
14. Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ: Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Gen Pharmacol 30: 771-776, 1998
15. Maffei Facina R, Carini M, Aldini G, Berti F, Rossoni G, Bombardelli E, Morazzoni P: Procyanidins from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injuri: antioxidant intervention and/or iron and copper sequestering ability. Planta Med 62: 495-502, 1996
16. Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, Stohs SJ: Oxygen free radical scavenging abilities of vitamin C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95: 179-189, 1997
17. Packer L, Rimbach G, Virgili F: Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27: 704-724, 1999
18. Halpern MJ, Dahlgren AL, Laakso I, Seppanen-Laakso T, Dahlgren J, McAnulty PA: Red-wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26: 171-180, 1998
19. Soleas GJ, Diamandis EP, Goldberg DM: Wine as a biological fluid: history, production, and role in disease prevention. J Clin Lab Anal 11:287-313, 1997
20. Ye X, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss HG, Stohs SJ, Bagchi D: The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol Cell Biochem 196: 99-108, 1999
21. Min mouse. Proc Am Assoc Cancer Res Annu Meet 39: Abstract 20, 1998
22. Bomser JA, Singletary KW, Wallig MA, Smith MA: Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds. Cancer Lett 135: 151-157, 1999
23. Zhao J, Wang J, Chen Y, Agarwal R: Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidins B5-3′-gallate as the most effective antioxidant constituent. Carcinogenesis 20: 1737-1745, 1999
24. Zheng T, Boyle P, Willett WC, Hu H, Dan J, Evstifeeva TV, Niu S, MacMahon BA: A case-control study of oral cancer in Beijing. People's Republic of China. Associations with nutrient intakes, foods and food groups. Eur J Cancer Biol Oral Oncol 29B: 45-55, 1993
25. Hortobagyi GN: Chemotherapy of breast cancer: a historical perspective. Semin Oncol S17: 1-4, 1997
26. Chou TC, Talalay P: Analysis of combined drug effects: a new look at a very old problem. Trends Pharmacol Sci 4: 450-454, 1983
27. Philpott NJ, Turner AJ, Scopes J, Westby M, Marsh JC, Gordon-Smith EC, Dalgleish AG, Gibson FM: The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood 87: 2244-2251, 1996
28. Chen ST, Pan TL, Tsai YC, Huang CM: Proteomics reveals protein profile changes in doxorubicin-treated MCF-7 human breast cancer cells. Cancer Lett 181: 95-107, 2002
29. Von Hoff DD, Layard MW, Basa P, Davis Jr HL, Von Hoff AL, Rozencweig M, Muggia FM: Risk factors for doxorubicin-induced congestive heart failure. Ann Int Med 91: 710-717, 1979
30. Raghavan D, Koczwara B, Javle M: Evolving strategies of cytotoxic chemotherapy for advanced prostate cancer. Eur J Cancer 33: 566-574, 1997
31. Hortobagyi GN: Progress in systemic chemotherapy of primary breast cancer: an overview. J Natl Cancer Inst Monogr 72-79, 2001
32. Tyagi AK, Singh RP, Agarwal C, Chan DCF, Agarwal R: Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest and apoptosis. Clin Cancer Res 8: 3512-3519, 2002
33. Agarwal C, Sharma Y, Agarwal R: Anticarcinogenic effect of a polyphenolic fraction isolated from grape seeds in human prostrate carcinoma DU145 cells: modulation of mitogenic signaling and cell-cycle regulators and induction of G1 arrest and apoptosis. Mol Carcinog 28: 129-138, 2000
34. Agarwal C, Sharma Y, Zhao J, Agarwal R: A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation. Clin Cancer Res 6: 2921-2930, 2000
35. Singh RP, Dhanalakshmi S, Agarwal R: Phytochemicals as cell cycle modulators: a less toxic approach in halting human cancers. Cell Cycle 1: 156-161, 2002