-
1
-
-
0028899181
-
Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo
-
Andersen, S. L., Ager, A., McGreevy, P., Schuster, B. G., Wesche, D., Kuschner, R., Ohrt, C., Ellis, W., Rossan, R. and Berman, J. (1995). Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo. American Journal of Tropical Medicine and Hygiene 52, 159-161
-
(1995)
American Journal of Tropical Medicine and Hygiene
, vol.52
, pp. 159-161
-
-
Andersen, S.L.1
Ager, A.2
McGreevy, P.3
Schuster, B.G.4
Wesche, D.5
Kuschner, R.6
Ohrt, C.7
Ellis, W.8
Rossan, R.9
Berman, J.10
-
2
-
-
84872948866
-
Novel diaryl ureas with efficacy in a mouse model of malaria
-
doi:10.1016/j.bmcl.2012.12.022
-
Anderson, J.W., Sarantakis, D., Terpinski, J., Kumar, T. R., Tsai, H. C., Kuo, M., Ager, A. L., Jacobs, W. R., Jr., Schiehser, G. A., Ekins, S., Sacchettini, J. C., Jacobus, D. P., Fidock, D. A. and Freundlich, J. S. (2013). Novel diaryl ureas with efficacy in a mouse model of malaria. Bioorganic and Medicinal Chemistry Letters 23, 1022-1025. doi:10.1016/j.bmcl.2012.12.022
-
(2013)
Bioorganic and Medicinal Chemistry Letters
, vol.23
, pp. 1022-1025
-
-
Anderson, J.W.1
Sarantakis, D.2
Terpinski, J.3
Kumar, T.R.4
Tsai, H.C.5
Kuo, M.6
Ager, A.L.7
Jacobs Jr., W.R.8
Schiehser, G.A.9
Ekins, S.10
Sacchettini, J.C.11
Jacobus, D.P.12
Fidock, D.A.13
Freundlich, J.S.14
-
3
-
-
84879234683
-
Humanised models of infection in the evaluation of anti-malarial drugs
-
doi:10.1016/j.ddtec.2012.07.003
-
Angulo-Barturen, I. and Ferrer, S. (2012). Humanised models of infection in the evaluation of anti-malarial drugs. Drug Discovery Today: Technologies. doi:10.1016/j.ddtec.2012.07.003
-
(2012)
Drug Discovery Today: Technologies
-
-
Angulo-Barturen, I.1
Ferrer, S.2
-
4
-
-
48249090848
-
A murine model of falciparum-malaria by in vivo selection of competent strains in nonmyelodepleted mice engrafted with human erythrocytes
-
doi:10.1371/journal.pone.0002252
-
Angulo-Barturen, I., Jiménez-Díaz, M. B., Mulet, T., Rullas, J., Herreros, E., Ferrer, S., Jiménez, E., Mendoza, A., Regadera, J., Rosenthal, P. J., Bathurst, I., Pompliano, D. L., Gómez de las Heras, F. and Gargallo-Viola, D. (2008). A murine model of falciparum-malaria by in vivo selection of competent strains in nonmyelodepleted mice engrafted with human erythrocytes. PLoS ONE 3, e2252. doi:10.1371/journal.pone.0002252
-
(2008)
PLoS ONE
, vol.3
-
-
Angulo-Barturen, I.1
Jiménez-Díaz, M.B.2
Mulet, T.3
Rullas, J.4
Herreros, E.5
Ferrer, S.6
Jiménez, E.7
Mendoza, A.8
Regadera, J.9
Rosenthal, P.J.10
Bathurst, I.11
Pompliano, D.L.12
Gómez De Las Heras, F.13
Gargallo-Viola, D.14
-
5
-
-
80053384602
-
High-Throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood
-
doi: 10.1016/j.ijpara.2011.07.010
-
Apte, S. H., Groves, P. L., Roddick, J. S., V, P. d. H. and Doolan, D. L. (2011). High-Throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood. International Journal for Parasitology 41, 1285-1294 doi: 10.1016/j.ijpara.2011.07.010
-
(2011)
International Journal for Parasitology
, vol.41
, pp. 1285-1294
-
-
Apte, S.H.1
Groves, P.L.2
Roddick, J.S.V.P.D.H.3
Doolan, D.L.4
-
6
-
-
79953328117
-
Further improvements of the P falciparum humanized mouse model
-
doi:10.1371/journal. pone.0018045
-
Arnold, L., Tyagi, R. K., Meija, P., Swetman, C., Gleeson, J., Perignon, J. L. and Druilhe, P. (2011). Further improvements of the P. falciparum humanized mouse model. PLoS ONE, 6. doi:10.1371/journal. pone.0018045
-
(2011)
PLoS ONE
, pp. 6
-
-
Arnold, L.1
Tyagi, R.K.2
Meija, P.3
Swetman, C.4
Gleeson, J.5
Perignon, J.L.6
Druilhe, P.7
-
7
-
-
34547730702
-
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/-mice
-
doi: 10.1038/nbt1326
-
Azuma, H., Paulk, N., Ranade, A., Dorrell, C., Al-Dhalimy, M., Ellis, E., Strom, S., Kay, M. A., Finegold, M. and Grompe, M. (2007). Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/-mice. Nature Biotechnology 25, 903-910 doi: 10.1038/nbt1326
-
(2007)
Nature Biotechnology
, vol.25
, pp. 903-910
-
-
Azuma, H.1
Paulk, N.2
Ranade, A.3
Dorrell, C.4
Al-Dhalimy, M.5
Ellis, E.6
Strom, S.7
Kay, M.A.8
Finegold, M.9
Grompe, M.10
-
8
-
-
33846582342
-
High-Throughput Plasmodium falciparum growth assay for malaria drug discovery
-
doi: 10.1128/ AAC.01144-06
-
Baniecki, M. L., Wirth, D. F. and Clardy, J. (2007). High-Throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrobial Agents and Chemotherapy 51, 716-723 doi: 10.1128/ AAC.01144-06
-
(2007)
Antimicrobial Agents and Chemotherapy
, vol.51
, pp. 716-723
-
-
Baniecki, M.L.1
Wirth, D.F.2
Clardy, J.3
-
9
-
-
79956314434
-
Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum
-
doi:10.1128/AAC.01714-10
-
Barker, R. H., Jr., Urgaonkar, S., Mazitschek, R., Celatka, C., Skerlj, R., Cortese, J. F., Tyndall, E., Liu, H., Cromwell, M., Sidhu, A. B., Guerrero-Bravo, J. E., Crespo-Llado, K. N., Serrano, A. E., Lin, J.W., Janse, C. J., Khan, S. M., Duraisingh, M., Coleman, B. I., Angulo-Barturen, I., Jiménez-Díaz, M. B., Magán, N., Gómez, V., Ferrer, S., Martínez, M. S., Wittlin, S., Papastogiannidis, P., O'Shea, T., Klinger, J. D., Bree, M., Lee, E., Levine, M., Wiegand, R. C., Muñoz, B., Wirth, D. F., Clardy, J., Bathurst, I. and Sybertz, E. (2011). Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 55, 2612-2622. doi:10.1128/AAC.01714-10
-
(2011)
Antimicrobial Agents and Chemotherapy
, vol.55
, pp. 2612-2622
-
-
Barker Jr., R.H.1
Urgaonkar, S.2
Mazitschek, R.3
Celatka, C.4
Skerlj, R.5
Cortese, J.F.6
Tyndall, E.7
Liu, H.8
Cromwell, M.9
Sidhu, A.B.10
Guerrero-Bravo, J.E.11
Crespo-Llado, K.N.12
Serrano, A.E.13
Lin, J.W.14
Janse, C.J.15
Khan, S.M.16
Duraisingh, M.17
Coleman, B.I.18
Angulo-Barturen, I.19
Jiménez-Díaz, M.B.20
Magán, N.21
Gómez, V.22
Ferrer, S.23
Martínez, M.S.24
Wittlin, S.25
Papastogiannidis, P.26
O'Shea, T.27
Klinger, J.D.28
Bree, M.29
Lee, E.30
Levine, M.31
Wiegand, R.C.32
Muñoz, B.33
Wirth, D.F.34
Clardy, J.35
Bathurst, I.36
Sybertz, E.37
more..
-
10
-
-
36749024475
-
Pharmacodynamics of doxycycline in a murine malaria model
-
doi:10.1128/ AAC.00529-07
-
Batty, K. T., Law, A. S., Stirling, V. and Moore, B. R. (2007). Pharmacodynamics of doxycycline in a murine malaria model. Antimicrobial Agents and Chemotherapy 51, 4477-4479. doi:10.1128/ AAC.00529-07
-
(2007)
Antimicrobial Agents and Chemotherapy
, vol.51
, pp. 4477-4479
-
-
Batty, K.T.1
Law, A.S.2
Stirling, V.3
Moore, B.R.4
-
11
-
-
34447563727
-
An in silico 3D pharmacophore model of chalcones useful in the design of novel antimalarial agents
-
Bhattacharjee, A. K., Nichols, D. A., Gerena, L., Roncal, N. and Gutteridge, C. E. (2007). An in silico 3D pharmacophore model of chalcones useful in the design of novel antimalarial agents. Medicinal Chemistry 3, 317-326
-
(2007)
Medicinal Chemistry
, vol.3
, pp. 317-326
-
-
Bhattacharjee, A.K.1
Nichols, D.A.2
Gerena, L.3
Roncal, N.4
Gutteridge, C.E.5
-
12
-
-
84861429203
-
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria
-
doi:10.1073/pnas.1205651109
-
Biagini, G. A., Fisher, N., Shone, A. E., Mubaraki, M. A., Srivastava, A., Hill, A., Antoine, T., Warman, A. J., Davies, J., Pidathala, C., Amewu, R. K., Leung, S. C., Sharma, R., Gibbons, P., Hong, D.W., Pacorel, B., Lawrenson, A. S., Charoensutthivarakul, S., Taylor, L., Berger, O., Mbekeani, A., Stocks, P. A., Nixon, G. L., Chadwick, J., Hemingway, J., Delves, M. J., Sinden, R. E., Zeeman, A. M., Kocken, C. H., Berry, N. G., O'Neill, P. M. and Ward, S. A. (2012). Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. Proceedings of the National Academy of Sciences, USA 109, 8298-8303. doi:10.1073/pnas.1205651109
-
(2012)
Proceedings of the National Academy of Sciences USA
, vol.109
, pp. 8298-8303
-
-
Biagini, G.A.1
Fisher, N.2
Shone, A.E.3
Mubaraki, M.A.4
Srivastava, A.5
Hill, A.6
Antoine, T.7
Warman, A.J.8
Davies, J.9
Pidathala, C.10
Amewu, R.K.11
Leung, S.C.12
Sharma, R.13
Gibbons, P.14
Hong, D.W.15
Pacorel, B.16
Lawrenson, A.S.17
Charoensutthivarakul, S.18
Taylor, L.19
Berger, O.20
Mbekeani, A.21
Stocks, P.A.22
Nixon, G.L.23
Chadwick, J.24
Hemingway, J.25
Delves, M.J.26
Sinden, R.E.27
Zeeman, A.M.28
Kocken, C.H.29
Berry, N.G.30
O'Neill, P.M.31
Ward, S.A.32
more..
-
13
-
-
77958511348
-
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model
-
doi:10.1074/jbc.M110.162081
-
Booker, M. L., Bastos, C. M., Kramer, M. L., Barker, R. H., Jr., Skerlj, R., Sidhu, A. B., Deng, X., Celatka, C., Cortese, J. F., Guerrero Bravo, J. E., Crespo Llado, K. N., Serrano, A. E., Angulo-Barturen, I., Jiménez- Díaz, M. B., Viera, S., Garuti, H., Wittlin, S., Papastogiannidis, P., Lin, J.W., Janse, C. J., Khan, S. M., Duraisingh, M., Coleman, B., Goldsmith, E. J., Phillips, M. A., Muñoz, B., Wirth, D. F., Klinger, J. D., Wiegand, R. and Sybertza, E. (2010). Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. Journal of Biological Chemistry 285, 33054-33064. doi:10.1074/jbc.M110.162081
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 33054-33064
-
-
Booker, M.L.1
Bastos, C.M.2
Kramer, M.L.3
Barker Jr., R.H.4
Skerlj, R.5
Sidhu, A.B.6
Deng, X.7
Celatka, C.8
Cortese, J.F.9
Guerrero Bravo, J.E.10
Crespo Llado, K.N.11
Serrano, A.E.12
Angulo-Barturen, I.13
Jiménez-Díaz, M.B.14
Viera, S.15
Garuti, H.16
Wittlin, S.17
Papastogiannidis, P.18
Lin, J.W.19
Janse, C.J.20
Khan, S.M.21
Duraisingh, M.22
Coleman, B.23
Goldsmith, E.J.24
Phillips, M.A.25
Muñoz, B.26
Wirth, D.F.27
Klinger, J.D.28
Wiegand, R.29
Sybertza, E.30
more..
-
14
-
-
84864955346
-
Identification of a new chemical class of antimalarials
-
doi:10.1093/infdis/jis418
-
Brunner, R., Aissaoui, H., Boss, C., Bozdech, Z., Brun, R., Corminboeuf, O., Delahaye, S., Fischli, C., Heidmann, B., Kaiser, M., Kamber, J., Meyer, S., Papastogiannidis, P., Siegrist, R., Voss, T., Welford, R., Wittlin, S. and Binkert, C. (2012). Identification of a new chemical class of antimalarials. Journal of Infectious Diseases 206, 735-743. doi:10.1093/infdis/jis418
-
(2012)
Journal of Infectious Diseases
, vol.206
, pp. 735-743
-
-
Brunner, R.1
Aissaoui, H.2
Boss, C.3
Bozdech, Z.4
Brun, R.5
Corminboeuf, O.6
Delahaye, S.7
Fischli, C.8
Heidmann, B.9
Kaiser, M.10
Kamber, J.11
Meyer, S.12
Papastogiannidis, P.13
Siegrist, R.14
Voss, T.15
Welford, R.16
Wittlin, S.17
Binkert, C.18
-
15
-
-
80052405122
-
Challenges in antimalarial drug discovery
-
doi:10.4155/fmc.11.91
-
Burrows, J. N., Leroy, D., Lotharius, J. and Waterson, D. (2011). Challenges in antimalarial drug discovery. Future Medicinal Chemistry 3, 1401-1412. doi:10.4155/fmc.11.91
-
(2011)
Future Medicinal Chemistry
, vol.3
, pp. 1401-1412
-
-
Burrows, J.N.1
Leroy, D.2
Lotharius, J.3
Waterson, D.4
-
16
-
-
53649104458
-
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
-
doi:10.1038/nature07327
-
Carlton, J. M., Adams, J. H., Silva, J. C., Bidwell, S. L., Lorenzi, H., Caler, E., Crabtree, J., Angiuoli, S. V., Merino, E. F., Amedeo, P., Cheng, Q., Coulson, R. M. R., Crabb, B. S., del Portillo, H. A., Essien, K., Feldblyum, T. V., Fernandez-Becerra, C., Gilson, P. R., Gueye, A. H., Guo, X., Kang/'a, S., Kooij, T.W. A., Korsinczky, M., Meyer, E. V. S., Nene, V., Paulsen, I., White, O., Ralph, S. A., Ren, Q., Sargeant, T. J., Salzberg, S. L., Stoeckert, C. J., Sullivan, S. A., Yamamoto, M. M., Hoffman, S. L., Wortman, J. R., Gardner, M. J., Galinski, M. R., Barnwell, J.W. and Fraser-Liggett, C. M. (2008). Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature 455, 757-763. doi:10.1038/nature07327
-
(2008)
Nature
, vol.455
, pp. 757-763
-
-
Carlton, J.M.1
Adams, J.H.2
Silva, J.C.3
Bidwell, S.L.4
Lorenzi, H.5
Caler, E.6
Crabtree, J.7
Angiuoli, S.V.8
Merino, E.F.9
Amedeo, P.10
Cheng, Q.11
Coulson, R.M.R.12
Crabb, B.S.13
Del Portillo, H.A.14
Essien, K.15
Feldblyum, T.V.16
Fernandez-Becerra, C.17
Gilson, P.R.18
Gueye, A.H.19
Guo, X.20
Kanga, S.21
Kooij, T.W.A.22
Korsinczky, M.23
Meyer, E.V.S.24
Nene, V.25
Paulsen, I.26
White, O.27
Ralph, S.A.28
Ren, Q.29
Sargeant, T.J.30
Salzberg, S.L.31
Stoeckert, C.J.32
Sullivan, S.A.33
Yamamoto, M.M.34
Hoffman, S.L.35
Wortman, J.R.36
Gardner, M.J.37
Galinski, M.R.38
Barnwell, J.W.39
Fraser-Liggett, C.M.40
more..
-
17
-
-
79952732772
-
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
-
doi:10.1073/ pnas.1015762108
-
Charman, S. A., Arbe-Barnes, S., Bathurst, I. C., Brund, R., Campbell, M., Charman, W. N., Chiu, F. C. K., Chollet, J., Craft, J. C., Creek, D. J., Don, Y., Matile, H., Maurer, M., Morizzi, J., Nguyen, T., Papastogiannidis, P., Scheurer, C., Shackleford, D. M., Sriraghavan, K., Stingelin, L., Tang, Y., Urwyler, H., Wang, X., White, K. L., Wittlin, S., Zhou, L. and Vennerstrom, J. L. (2011). Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proceedings of the National Academy of Sciences, USA 108, 4400-4405. doi:10.1073/ pnas.1015762108
-
(2011)
Proceedings of the National Academy of Sciences USA
, vol.108
, pp. 4400-4405
-
-
Charman, S.A.1
Arbe-Barnes, S.2
Bathurst, I.C.3
Brund, R.4
Campbell, M.5
Charman, W.N.6
Chiu, F.C.K.7
Chollet, J.8
Craft, J.C.9
Creek, D.J.10
Don, Y.11
Matile, H.12
Maurer, M.13
Morizzi, J.14
Nguyen, T.15
Papastogiannidis, P.16
Scheurer, C.17
Shackleford, D.M.18
Sriraghavan, K.19
Stingelin, L.20
Tang, Y.21
Urwyler, H.22
Wang, X.23
White, K.L.24
Wittlin, S.25
Zhou, L.26
Vennerstrom, J.L.27
more..
-
18
-
-
84857734006
-
Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials
-
doi:10.2174/156802612799362977
-
Chatterjee, A. K. and Yeung, B. K. S. (2012). Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials. Current Topics in Medicinal Chemistry 12, 473-483. doi:10.2174/156802612799362977
-
(2012)
Current Topics in Medicinal Chemistry
, vol.12
, pp. 473-483
-
-
Chatterjee, A.K.1
Yeung, B.K.S.2
-
19
-
-
33746381549
-
A clinical drug library screen identifies astemizole as an antimalarial agent
-
doi:10.1038/nchembio806
-
Chong, C. R., Chen, X., Shi, L., Liu, J. O. and Sullivan, D. J., Jr. (2006). A clinical drug library screen identifies astemizole as an antimalarial agent. Nature Chemical Biology 2, 415-416. doi:10.1038/nchembio806
-
(2006)
Nature Chemical Biology
, vol.2
, pp. 415-416
-
-
Chong, C.R.1
Chen, X.2
Shi, L.3
Liu, J.O.4
Sullivan Jr., D.J.5
-
20
-
-
0004286128
-
-
Washington, DC
-
Coatney, G. R., Collins, W. E., McWarren, W. and Contacos, P. G. (1971). The Primate Malarias, US Government Printing Office, Washington, D.C.
-
(1971)
The Primate Malarias US Government Printing Office
-
-
Coatney, G.R.1
Collins, W.E.2
McWarren, W.3
Contacos, P.G.4
-
21
-
-
4544304641
-
Transmission of the M strain of Plasmodium cynomolgi to man
-
Coatney, G. R., Elder, H. A., Contacos, P. G., Getz, M. E., Greenland, R., Rossan, R. N. and Schmidt, L. H. (1961). Transmission of the M strain of Plasmodium cynomolgi to man. American Journal of Tropical Medicine and Hygiene 10, 673-678
-
(1961)
American Journal of Tropical Medicine and Hygiene
, vol.10
, pp. 673-678
-
-
Coatney, G.R.1
Elder, H.A.2
Contacos, P.G.3
Getz, M.E.4
Greenland, R.5
Rossan, R.N.6
Schmidt, L.H.7
-
22
-
-
0036047984
-
Nonhuman primate models I. Nonhuman primate host-parasite combinations
-
Collins,W. E. (2002a). Nonhuman primate models. I. Nonhuman primate host-parasite combinations. Methods in Molecular Medicine 72, 77-84
-
(2002)
Methods in Molecular Medicine
, vol.72
, pp. 77-84
-
-
Collins, W.E.1
-
23
-
-
0036052705
-
Nonhuman primate models II Infection of Saimiri and Aotus monkeys with Plasmodium vivax
-
Collins,W. E. (2002b). Nonhuman primate models. II. Infection of Saimiri and Aotus monkeys with Plasmodium vivax. Methods in Molecular Medicine 72, 85-92
-
(2002)
Methods in Molecular Medicine
, vol.72
, pp. 85-92
-
-
Collins, W.E.1
-
24
-
-
56249098367
-
Selection of a trioxaquine as an antimalarial drug candidate
-
doi:10.1073/pnas.0804338105
-
Coslédan, F., Fraisse, L., Pellet, A., Guillou, F., Mordmuller, B., Kremsner, P. G., Moreno, A., Mazier, D., Maffrand, J. P. and Meunier, B. (2008). Selection of a trioxaquine as an antimalarial drug candidate. Proceedings of the National Academy of Sciences, USA 105, 17579-17584. doi:10.1073/pnas.0804338105
-
(2008)
Proceedings of the National Academy of Sciences, USA
, vol.105
, pp. 17579-17584
-
-
Coslédan, F.1
Fraisse, L.2
Pellet, A.3
Guillou, F.4
Mordmuller, B.5
Kremsner, P.G.6
Moreno, A.7
Mazier, D.8
Maffrand, J.P.9
Meunier, B.10
-
25
-
-
79961223551
-
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential
-
doi:10.1021/jm200592f.
-
Coteron, J. M., Marco, M., Esquivias, J., Deng, X., White, K. L., White, J., Koltun, M., El Mazouni, F., Kokkonda, S., Katneni, K., Bhamidipati, R., Shackleford, D. M., Angulo-Barturen, I., Ferrer, S. B., Jiménez- Díaz, M. B., Gamo, F. J., Goldsmith, E. J., Charman,W. N., Bathurst, I., Floyd, D., Matthews, D., Burrows, J. N., Rathod, P. K., Charman, S. A. and Phillips, M. A. (2011). Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. Journal of Medicinal Chemistry 54, 5540-5561. doi:10.1021/jm200592f.
-
(2011)
Journal of Medicinal Chemistry
, vol.54
, pp. 5540-5561
-
-
Coteron, J.M.1
Marco, M.2
Esquivias, J.3
Deng, X.4
White, K.L.5
White, J.6
Koltun, M.7
El Mazouni, F.8
Kokkonda, S.9
Katneni, K.10
Bhamidipati, R.11
Shackleford, D.M.12
Angulo-Barturen, I.13
Ferrer, S.B.14
Jiménez-Díaz, M.B.15
Gamo, F.J.16
Goldsmith, E.J.17
Charman, W.N.18
Bathurst, I.19
Floyd, D.20
Matthews, D.21
Burrows, J.N.22
Rathod, P.K.23
Charman, S.A.24
Phillips, M.A.25
more..
-
26
-
-
84891889319
-
Primaquine and tafenoquine in the Plasmodium cynomolgi causal prophylactic malaria model
-
doi: 10.1016/j.pt.2009.12.005
-
DiTusa, C. A., Gettayacamin, M., Kozar, M. P., Lin, A. J., Fracisco, S. D., Ohrt, C. and Magill, A. (2010). Primaquine and tafenoquine in the Plasmodium cynomolgi causal prophylactic malaria model. American Journal of Tropical Medicine and Hygiene 83, 81 doi: 10.1016/j.pt.2009.12.005
-
(2010)
American Journal of Tropical Medicine and Hygiene
, vol.83
, pp. 81
-
-
DiTusa, C.A.1
Gettayacamin, M.2
Kozar, M.P.3
Lin, A.J.4
Fracisco, S.D.5
Ohrt, C.6
Magill, A.7
-
27
-
-
84861314596
-
Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model
-
doi:10.1371/journal.pone.0037171
-
Ferrer, P., Tripathi, A. K., Clark, M. A., Hand, C. C., Rienhoff, H.Y., Jr. and Sullivan, D. J., Jr. (2012). Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model. PLoS ONE 7, e37171. doi:10.1371/journal.pone.0037171
-
(2012)
PLoS ONE
, vol.7
-
-
Ferrer, P.1
Tripathi, A.K.2
Clark, M.A.3
Hand, C.C.4
Rienhoff Jr., H.Y.5
Sullivanti Jr., J.6
-
28
-
-
3042550882
-
Antimalarial drug discovery: Efficacy models for compound screening
-
doi:10.1038/nrd1416
-
Fidock, D. A., Rosenthal, P. J., Croft, S. L., Brun, R. and Nwaka, S. (2004). Antimalarial drug discovery: Efficacy models for compound screening. Nature Reviews Drug Discovery 3, 509-520. doi:10.1038/nrd1416
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, pp. 509-520
-
-
Fidock, D.A.1
Rosenthal, P.J.2
Croft, S.L.3
Brun, R.4
Nwaka, S.5
-
29
-
-
63149182785
-
Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: Strategic considerations
-
doi: 10.1016/j.drudis.2008.12.011
-
Gabrielsson, J., Dolgos, H., Gillberg, P-G. r., Bredberg, U., Benthem, B. and Duker, G. R. (2009). Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: Strategic considerations. Drug Discovery Today 14, 358-372 doi: 10.1016/j.drudis.2008.12. 011
-
(2009)
Drug Discovery Today
, vol.14
, pp. 358-372
-
-
Gabrielsson, J.1
Dolgos, H.2
Gillberg, P.-G.R.3
Bredberg, U.4
Benthem, B.5
Duker, G.R.6
-
30
-
-
57649149608
-
Plasmodium vivax: Who cares?
-
doi:10.1186/1475-2875-7-S1-S9
-
Galinski, M. and Barnwell, J. (2008). Plasmodium vivax: Who cares? Malaria Journal 7, S9. doi:10.1186/1475-2875-7-S1-S9
-
(2008)
Malaria Journal
, vol.7
-
-
Galinski, M.1
Barnwell, J.2
-
31
-
-
77952704258
-
Thousands of chemical starting points for antimalarial lead identification
-
doi:10.1038/ nature09107
-
Gamo, F. J., Sanz, L. M., Vidal, J., de Cózar, C., Alvarez, E., Lavandera, J. L., Vanderwall, D. E., Green, D. V., Kumar, V., Hasan, S., Brown, J. R., Peishoff, C. E., Cardon, L. R. and García-Bustos, J. F. (2010). Thousands of chemical starting points for antimalarial lead identification. Nature 465, 305-310. doi:10.1038/ nature09107
-
(2010)
Nature
, vol.465
, pp. 305-310
-
-
Gamo, F.J.1
Sanz, L.M.2
Vidal, J.3
De Cózar, C.4
Alvarez, E.5
Lavandera, J.L.6
Vanderwall, D.E.7
Green, D.V.8
Kumar, V.9
Hasan, S.10
Brown, J.R.11
Peishoff, C.E.12
Cardon, L.R.13
García-Bustos, J.F.14
-
32
-
-
0037015614
-
Genome sequence of the human malaria parasite Plasmodium falciparum
-
doi:10.1038/ nature01097
-
Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., Carlton, J. M., Pain, A., Nelson, K. E., Bowman, S., Paulsen, I. T., James, K., Eisen, J. A., Rutherford, K., Salzberg, S. L., Craig, A., Kyes, S., Chan, M-S., Nene, V., Shallom, S. J., Suh, B., Peterson, J., Angiuoli, S., Pertea, M., Allen, J., Selengut, J., Haft, D., Mather, M.W., Vaidya, A. B., Martin, D. M. A., Fairlamb, A. H., Fraunholz, M. J., Roos, D. S., Ralph, S. A., McFadden, G. I., Cummings, L. M., Subramanian, G. M., Mungall, C., Venter, J. C., Carucci, D. J., Hoffman, S. L., Newbold, C., Davis, R.W., Fraser, C. M. and Barrell, B. (2002). Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498-511. doi:10.1038/ nature01097
-
(2002)
Nature
, vol.419
, pp. 498-511
-
-
Gardner, M.J.1
Hall, N.2
Fung, E.3
White, O.4
Berriman, M.5
Hyman, R.W.6
Carlton, J.M.7
Pain, A.8
Nelson, K.E.9
Bowman, S.10
Paulsen, I.T.11
James, K.12
Eisen, J.A.13
Rutherford, K.14
Salzberg, S.L.15
Craig, A.16
Kyes, S.17
Chan, M.-S.18
Nene, V.19
Shallom, S.J.20
Suh, B.21
Peterson, J.22
Angiuoli, S.23
Pertea, M.24
Allen, J.25
Selengut, J.26
Haft, D.27
Mather, M.W.28
Vaidya, A.B.29
Martin, D.M.A.30
Fairlamb, A.H.31
Fraunholz, M.J.32
Roos, D.S.33
Ralph, S.A.34
McFadden, G.I.35
Cummings, L.M.36
Subramanian, G.M.37
Mungall, C.38
Venter, J.C.39
Carucci, D.J.40
Hoffman, S.L.41
Newbold, C.42
Davis, R.W.43
Fraser, C.M.44
Barrell, B.45
more..
-
33
-
-
79551667504
-
In silico ADME models: A general assessment of their utility in drug discovery applications
-
doi:10.2174/ 156802611794480927
-
Gleeson, M. P., Hersey, A. and Hannongbua, S. (2011). In silico ADME models: A general assessment of their utility in drug discovery applications. Current Topics in Medicinal Chemistry 11, 358-381. doi:10.2174/ 156802611794480927
-
(2011)
Current Topics in Medicinal Chemistry
, vol.11
, pp. 358-381
-
-
Gleeson, M.P.1
Hersey, A.2
Hannongbua, S.3
-
34
-
-
77952718950
-
Chemical genetics of Plasmodium falciparum
-
doi:10.1038/ nature09099
-
Guiguemde,W. A., Shelat, A. A., Bouck, D., Duffy, S., Crowther, G. J., Davis, P. H., Smithson, D. C., Connelly, M., Clark, J., Zhu, F., Jiménez-Díaz, M. B., Martínez, M. S., Wilson, E. B., Tripathi, A. K., Gut, J., Sharlow, E. R., Bathurst, I., El Mazouni, F., Fowble, J.W., Forquer, I., McGinley, P. L., Castro, S., Angulo-Barturen, I., Ferrer, S., Rosenthal, P. J., Derisi, J. L., Sullivan, D. J., Lazo, J. S., Roos, D. S., Riscoe, M. K., Phillips, M. A., Rathod, P. K., Van Voorhis, W. C., Avery, V. M. and Guy, R. K. (2010). Chemical genetics of Plasmodium falciparum. Nature 465, 311-315. doi:10.1038/ nature09099
-
(2010)
Nature
, vol.465
, pp. 311-315
-
-
Guiguemde, W.A.1
Shelat, A.A.2
Bouck, D.3
Duffy, S.4
Crowther, G.J.5
Davis, P.H.6
Smithson, D.C.7
Connelly, M.8
Clark, J.9
Zhu, F.10
Jiménez-Díaz, M.B.11
Martínez, M.S.12
Wilson, E.B.13
Tripathi, A.K.14
Gut, J.15
Sharlow, E.R.16
Bathurst, I.17
El Mazouni, F.18
Fowble, J.W.19
Forquer, I.20
McGinley, P.L.21
Castro, S.22
Angulo-Barturen, I.23
Ferrer, S.24
Rosenthal, P.J.25
Derisi, J.L.26
Sullivan, D.J.27
Lazo, J.S.28
Roos, D.S.29
Riscoe, M.K.30
Phillips, M.A.31
Rathod, P.K.32
Van Voorhis, W.C.33
Avery, V.M.34
Guy, R.K.35
more..
-
35
-
-
84856367163
-
Global phenotypic screening for antimalarials
-
doi:10.1016/j. chembiol.2012.01.004
-
Guiguemde, W. A., Shelat, A. A., García-Bustos, J. F., Diagana, T. T., Gamo, F. J. and Guy, R. K. (2012). Global phenotypic screening for antimalarials. Chemistry and Biology 19, 116-129. doi:10.1016/j. chembiol.2012.01.004
-
(2012)
Chemistry and Biology
, vol.19
, pp. 116-129
-
-
Guiguemde, W.A.1
Shelat, A.A.2
García-Bustos, J.F.3
Diagana, T.T.4
Gamo, F.J.5
Guy, R.K.6
-
36
-
-
84455170032
-
Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria
-
doi:10.1128/ AAC.05006-11
-
Guo, J., Guiguemde, A.W., Bentura-Marciano, A., Clark, J., Haynes, R. K., Chan, W. C., Wong, H. N., Hunt, N. H., Guy, R. K. and Golenser, J. (2012). Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria. Antimicrobial Agents and Chemotherapy 56, 163-173. doi:10.1128/ AAC.05006-11
-
(2012)
Antimicrobial Agents and Chemotherapy
, vol.56
, pp. 163-173
-
-
Guo, J.1
Guiguemde, A.W.2
Bentura-Marciano, A.3
Clark, J.4
Haynes, R.K.5
Chan, W.C.6
Wong, H.N.7
Hunt, N.H.8
Guy, R.K.9
Golenser, J.10
-
37
-
-
9144273190
-
Discovery of a bulky 2-Tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity
-
doi:10.1021/jm0304562
-
Jain, M., Vangapandu, S., Sachdeva, S., Singh, S., Singh, P. P., Jena, G. B., Tikoo, K., Ramarao, P., Kaul, C. L. and Jain, R. (2004). Discovery of a bulky 2-Tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity. Journal of Medicinal Chemistry 47, 285-287. doi:10.1021/jm0304562
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, pp. 285-287
-
-
Jain, M.1
Vangapandu, S.2
Sachdeva, S.3
Singh, S.4
Singh, P.P.5
Jena, G.B.6
Tikoo, K.7
Ramarao, P.8
Kaul, C.L.9
Jain, R.10
-
38
-
-
65349180180
-
Quantitative measurement of plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence
-
doi:10.1002/cyto a20647
-
Jiménez-Díaz, M. B., Mulet, T., Gómez, V., Viera, S., Alvarez, A., Garuti, H., Vázquez, Y., Fernández, A., Ibañez, J., Jiménez, M., Gargallo-Viola, D. and Angulo-Barturen, I. (2009a). Quantitative measurement of plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence. Cytometry Part A 75, 225-235. doi:10.1002/cyto. a.20647
-
(2009)
Cytometry Part A
, vol.75
, pp. 225-235
-
-
Jiménez-Díaz, M.B.1
Mulet, T.2
Gómez, V.3
Viera, S.4
Alvarez, A.5
Garuti, H.6
Vázquez, Y.7
Fernández, A.8
Ibañez, J.9
Jiménez, M.10
Gargallo-Viola, D.11
Angulo-Barturen, I.12
-
39
-
-
70349313478
-
Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL-2Rgnull mice engrafted with human erythrocytes
-
doi: 10.1128/AAC.00519-09
-
Jiménez-Díaz, M. B., Mulet, T., Viera, S., Gómez, V., Garuti, H., Ibañez, J., Alvarez-Doval, A., Shultz, L. D., Martínez, A., Gargallo-Viola, D. and Angulo-Barturen, I. (2009b). Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL-2Rgnull mice engrafted with human erythrocytes. Antimicrobial Agents and Chemotherapy 53, 4533-4536 doi: 10.1128/AAC.00519-09
-
(2009)
Antimicrobial Agents and Chemotherapy
, vol.53
, pp. 4533-4536
-
-
Jiménez-Díaz, M.B.1
Mulet, T.2
Viera, S.3
Gómez, V.4
Garuti, H.5
Ibañez, J.6
Alvarez-Doval, A.7
Shultz, L.D.8
Martínez, A.9
Gargallo-Viola, D.10
Angulo-Barturen, I.11
-
40
-
-
84891840314
-
A new paradigm to accelerate drug discovery of new antimalarials using in vivo screening
-
In press
-
Jiménez-Díaz, M. B., Viera, S., Ibáñez, J., Mulet, T., Magán-Marchal, N., Garuti, H., Gómez, V., Cortés-Gil, L., Martínez, A., Ferrer, S., Fraile, M. T., Calderón, F., Fernández, E., Shultz, L. D., Leroy, D., Wilson, D. M., García-Bustos, J. F., Gamo, F. J. and Angulo-Barturen, I. (2013). A new paradigm to accelerate drug discovery of new antimalarials using in vivo screening. PLoS ONE. In press
-
(2013)
PLoS ONE
-
-
Jiménez-Díaz, M.B.1
Viera, S.2
Ibáñez, J.3
Mulet, T.4
Magán-Marchal, N.5
Garuti, H.6
Gómez, V.7
Cortés-Gil, L.8
Martínez, A.9
Ferrer, S.10
Fraile, M.T.11
Calderón, F.12
Fernández, E.13
Shultz, L.D.14
Leroy, D.15
Wilson, D.M.16
García-Bustos, J.F.17
Gamo, F.J.18
Angulo-Barturen, I.19
-
41
-
-
72449122816
-
Measurement and prediction of oral absorption
-
doi:10.1002/cbdv.200900054
-
Keldenich, J. (2009). Measurement and prediction of oral absorption. Chemistry and Biodiversity 6, 2000-2013. doi:10.1002/cbdv.200900054
-
(2009)
Chemistry and Biodiversity
, vol.6
, pp. 2000-2013
-
-
Keldenich, J.1
-
42
-
-
67349189204
-
Discovery of dual function acridones as a new antimalarial chemotype
-
doi:10.1038/nature07937
-
Kelly, J. X., Smilkstein, M. J., Brun, R., Wittlin, S., Cooper, R. A., Lane, K. D., Janowsky, A., Johnson, R. A., Dodean, R. A., Winter, R., Hinrichs, D. J. and Riscoe, M. K. (2009). Discovery of dual function acridones as a new antimalarial chemotype. Nature 459, 270-273. doi:10.1038/nature07937
-
(2009)
Nature
, vol.459
, pp. 270-273
-
-
Kelly, J.X.1
Smilkstein, M.J.2
Brun, R.3
Wittlin, S.4
Cooper, R.A.5
Lane, K.D.6
Janowsky, A.7
Johnson, R.A.8
Dodean, R.A.9
Winter, R.10
Hinrichs, D.J.11
Riscoe, M.K.12
-
43
-
-
65649098733
-
Synthesis and antimalarial activities of cyclen 4-Aminoquinoline analogs
-
doi: 10.1128/AAC.01304-08
-
Khan, M. O. F., Levi, M. S., Tekwani, B. L., Khan, S. I., Kimura, E. and Borne, R. F. (2009). Synthesis and antimalarial activities of cyclen 4-Aminoquinoline analogs. Antimicrobial Agents and Chemotherapy 53, 1320-1324 doi: 10.1128/AAC.01304-08
-
(2009)
Antimicrobial Agents and Chemotherapy
, vol.53
, pp. 1320-1324
-
-
Khan, M.O.F.1
Levi, M.S.2
Tekwani, B.L.3
Khan, S.I.4
Kimura, E.5
Borne, R.F.6
-
45
-
-
59749089036
-
Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria
-
doi: 10.1128/ AAC.00576-08
-
Kocken, C. H. M., Remarque, E. J., Dubbeld, M. A., Wein, S., Van Der Wel, A., Verburgh, R. J., Vial, H. J. and Thomas, A.W. (2009). Statistical model to evaluate in vivo activities of antimalarial drugs in a Plasmodium cynomolgi-macaque model for Plasmodium vivax malaria. Antimicrobial Agents and Chemotherapy 53, 421-427 doi: 10.1128/ AAC.00576-08
-
(2009)
Antimicrobial Agents and Chemotherapy
, vol.53
, pp. 421-427
-
-
Kocken, C.H.M.1
Remarque, E.J.2
Dubbeld, M.A.3
Wein, S.4
Van Der Wel, A.5
Verburgh, R.J.6
Vial, H.J.7
Thomas, A.W.8
-
46
-
-
0001278854
-
Animal models: Rodents
-
(ed. Sherman, I.W. ASM Press, Washington, D.C.
-
Landau, I. and Gautret, P. (1998). Animal models: Rodents. In Malaria: Parasite b, Pathogenesis and Protection (ed. Sherman, I.W.), pp. 401-417. ASM Press, Washington, D.C.
-
(1998)
Malaria: Parasite b, Pathogenesis and Protection
, pp. 401-417
-
-
Landau, I.1
Gautret, P.2
-
47
-
-
84891876746
-
Lead optimization and pre-clinical studies of imidazolidinedione derivatives as malaria prophylactic agents
-
Lin, A., Kozar, M. P., O'Neil, M. T., Melendez, V., Saunders, D. and Magill, A. J. (2009). Lead optimization and pre-clinical studies of imidazolidinedione derivatives as malaria prophylactic agents. Tropical Medicine and International Health 14, 120
-
(2009)
Tropical Medicine and International Health
, vol.14
, pp. 120
-
-
Lin, A.1
Kozar, M.P.2
O'Neil, M.T.3
Melendez, V.4
Saunders, D.5
Magill, A.J.6
-
48
-
-
84863834611
-
Lead optimization of antimalarial propafenone analogues
-
doi:10.1021/jm300286a.
-
Lowes, D., Pradhan, A., Iyer, L. V., Parman, T., Gow, J., Zhu, F., Furimsky, A., Lemoff, A., Guiguemde, W. A., Sigal, M., Clark, J. A., Wilson, E., Tang, L., Connelly, M. C., DeRisi, J. L., Kyle, D. E., Mirsalis, J. and Guy, R. K. (2012). Lead optimization of antimalarial propafenone analogues. Journal of Medicinal Chemistry 55, 6087-6093. doi:10.1021/jm300286a.
-
(2012)
Journal of Medicinal Chemistry
, vol.55
, pp. 6087-6093
-
-
Lowes, D.1
Pradhan, A.2
Iyer, L.V.3
Parman, T.4
Gow, J.5
Zhu, F.6
Furimsky, A.7
Lemoff, A.8
Guiguemde, W.A.9
Sigal, M.10
Clark, J.A.11
Wilson, E.12
Tang, L.13
Connelly, M.C.14
DeRisi, J.L.15
Kyle, D.E.16
Mirsalis, J.17
Guy, R.K.18
-
49
-
-
84859738849
-
A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development
-
doi:10.1038/srep00118
-
Malleret, B., Claser, C., Ong, A. S., Suwanarusk, R., Sriprawat, K., Howland, S.W., Russell, B., Nosten, F. and Renia, L. (2011). A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development. Scientific Reports 1, 118. doi:10.1038/srep00118
-
(2011)
Scientific Reports
, vol.1
, pp. 118
-
-
Malleret, B.1
Claser, C.2
Ong, A.S.3
Suwanarusk, R.4
Sriprawat, K.5
Howland, S.W.6
Russell, B.7
Nosten, F.8
Renia, L.9
-
50
-
-
37849002525
-
Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model
-
doi:10.1128/AAC.00878-07
-
Moore, B. R., Batty, K. T., Andrzejewski, C., Jago, J. D., Page-Sharp, M. and Ilett, K. F. (2008). Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrobial Agents and Chemotherapy 52, 306-311. doi:10.1128/AAC.00878-07
-
(2008)
Antimicrobial Agents and Chemotherapy
, vol.52
, pp. 306-311
-
-
Moore, B.R.1
Batty, K.T.2
Andrzejewski, C.3
Jago, J.D.4
Page-Sharp, M.5
Ilett, K.F.6
-
51
-
-
67649994372
-
Piperaquine pharmacodynamics and parasite viability in a murine malaria model
-
doi: 10.1128/AAC.00056-09
-
Moore, B. R., Ilett, K. F., Page-Sharp, M., Jago, J. D. and Batty, K. T. (2009). Piperaquine pharmacodynamics and parasite viability in a murine malaria model. Antimicrobial Agents and Chemotherapy 53, 2707-2713 doi: 10.1128/AAC.00056-09
-
(2009)
Antimicrobial Agents and Chemotherapy
, vol.53
, pp. 2707-2713
-
-
Moore, B.R.1
Ilett, K.F.2
Page-Sharp, M.3
Jago, J.D.4
Batty, K.T.5
-
52
-
-
79960322124
-
Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model
-
doi: 10.1128/AAC.00067-11
-
Moore, B. R., Page-Sharp, M., Stoney, J. R., Ilett, K. F., Jago, J. D. and Batty, K. T. (2011). Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model. Antimicrobial Agents and Chemotherapy 55, 3899-3907 doi: 10.1128/AAC.00067-11
-
(2011)
Antimicrobial Agents and Chemotherapy
, vol.55
, pp. 3899-3907
-
-
Moore, B.R.1
Page-Sharp, M.2
Stoney, J.R.3
Ilett, K.F.4
Jago, J.D.5
Batty, K.T.6
-
53
-
-
0029005515
-
Maintenance of the human malarial parasite Plasmodium falciparum in scid mice and transmission of gametocytes to mosquitoes
-
doi: 10.1084/ jem.181.6.2265
-
Moore, J. M., Kumar, N., Shultz, L. D. and Rajan, T. V. (1995). Maintenance of the human malarial parasite Plasmodium falciparum in scid mice and transmission of gametocytes to mosquitoes. Journal of Experimental Medicine 181, 2265-2270 doi: 10.1084/ jem.181.6.2265
-
(1995)
Journal of Experimental Medicine
, vol.181
, pp. 2265-2270
-
-
Moore, J.M.1
Kumar, N.2
Shultz, L.D.3
Rajan, T.V.4
-
54
-
-
0035008536
-
Human malaria in immunocompromised mice: New in vivo model for chemotherapy studies
-
doi:10.1128/AAC.45.6.1847-1853.2001
-
Moreno, A., Badell, E., Van Rooijen, N. and Druilhe, P. (2001). Human malaria in immunocompromised mice: New in vivo model for chemotherapy studies. Antimicrobial Agents and Chemotherapy 45, 1847-1853. doi:10.1128/AAC.45.6.1847- 1853.2001
-
(2001)
Antimicrobial Agents and Chemotherapy
, vol.45
, pp. 1847-1853
-
-
Moreno, A.1
Badell, E.2
Van Rooijen, N.3
Druilhe, P.4
-
55
-
-
33645347305
-
Liver-stage development of Plasmodium falciparum, in a humanized mouse model
-
doi:10.1086/ 500840
-
Morosan, S., Hez-Deroubaix, S., Lunel, F., Renia, L., Giannini, C., Van Rooijen, N., Battaglia, S., Blanc, C., Eling, W., Sauerwein, R., Hannoun, L., Belghiti, J., Brechot, C., Kremsdorf, D. and Druilhe, P. (2006). Liver-stage development of Plasmodium falciparum, in a humanized mouse model. Journal of Infectious Diseases 193, 996-1004. doi:10.1086/ 500840
-
(2006)
Journal of Infectious Diseases
, vol.193
, pp. 996-1004
-
-
Morosan, S.1
Hez-Deroubaix, S.2
Lunel, F.3
Renia, L.4
Giannini, C.5
Van Rooijen, N.6
Battaglia, S.7
Blanc, C.8
Eling, W.9
Sauerwein, R.10
Hannoun, L.11
Belghiti, J.12
Brechot, C.13
Kremsdorf, D.14
Druilhe, P.15
-
56
-
-
84861054503
-
Imidazolopiperazines: Lead optimization of the second-generation antimalarial agents
-
doi:10.1021/jm300041e.
-
Nagle, A., Wu, T., Kuhen, K., Gagaring, K., Borboa, R., Francek, C., Chen, Z., Plouffe, D., Lin, X., Caldwell, C., Ek, J., Skolnik, S., Liu, F., Wang, J., Chang, J., Li, C., Liu, B., Hollenbeck, T., Tuntland, T., Isbell, J., Chuan, T., Alper, P. B., Fischli, C., Brun, R., Lakshminarayana, S. B., Rottmann, M., Diagana, T. T., Winzeler, E. A., Glynne, R., Tully, D. C. and Chatterjee, A. K. (2012). Imidazolopiperazines: Lead optimization of the second-generation antimalarial agents. Journal of Medicinal Chemistry 55, 4244-4273. doi:10.1021/jm300041e.
-
(2012)
Journal of Medicinal Chemistry
, vol.55
, pp. 4244-4273
-
-
Nagle, A.1
Wu, T.2
Kuhen, K.3
Gagaring, K.4
Borboa, R.5
Francek, C.6
Chen, Z.7
Plouffe, D.8
Lin, X.9
Caldwell, C.10
Ek, J.11
Skolnik, S.12
Liu, F.13
Wang, J.14
Chang, J.15
Li, C.16
Liu, B.17
Hollenbeck, T.18
Tuntland, T.19
Isbell, J.20
Chuan, T.21
Alper, P.B.22
Fischli, C.23
Brun, R.24
Lakshminarayana, S.B.25
Rottmann, M.26
Diagana, T.T.27
Winzeler, E.A.28
Glynne, R.29
Tully, D.C.30
Chatterjee, A.K.31
more..
-
57
-
-
79951649476
-
Some lessons for the future from the global malaria eradication programme 1955-1969
-
doi:10.1371/ journal.pmed 1000412
-
Nájera, J. A., González-Silva, M. and Alonso, P. L. (2011). Some lessons for the future from the Global Malaria Eradication Programme (1955-1969). PLoS Medicine 8, e1000412. doi:10.1371/ journal.pmed.1000412
-
(2011)
PLoS Medicine
, vol.8
-
-
Nájera, J.A.1
González-Silva, M.2
Alonso, P.L.3
-
58
-
-
84876002292
-
Quinolone-3-diarylethers: A new class of antimalarial drug
-
177ra137. doi:10.1126/ scitranslmed.3005029
-
Nilsen, A., LaCrue, A. N., White, K. L., Forquer, I. P., Cross, R. M., Marfurt, J., Mather, M.W., Delves, M. J., Shackleford, D. M., Saenz, F. E., Morrisey, J. M., Steuten, J., Mutka, T., Li, Y., Wirjanata, G., Ryan, E., Duffy, S., Kelly, J. X., Sebayang, B. F., Zeeman, A-M., Noviyanti, R., Sinden, R. E., Kocken, C. H. M., Price, R. N., Avery, V. M., Angulo-Barturen, I., Jiménez-Díaz, M. B., Ferrer, S., Herreros, E., Sanz, L. M., Gamo, F-J., Bathurst, I., Burrows, J. N., Siegl, P., Guy, R. K., Winter, R.W., Vaidya, A. B., Charman, S. A., Kyle, D. E., Manetsch, R. and Riscoe, M. K. (2013). Quinolone-3-Diarylethers: A new class of antimalarial drug. Science Translational Medicine 5, 177ra137. doi:10.1126/ scitranslmed.3005029
-
(2013)
Science Translational Medicine
, vol.5
-
-
Nilsen, A.1
LaCrue, A.N.2
White, K.L.3
Forquer, I.P.4
Cross, R.M.5
Marfurt, J.6
Mather, M.W.7
Delves, M.J.8
Shackleford, D.M.9
Saenz, F.E.10
Morrisey, J.M.11
Steuten, J.12
Mutka, T.13
Li, Y.14
Wirjanata, G.15
Ryan, E.16
Duffy, S.17
Kelly, J.X.18
Sebayang, B.F.19
Zeeman, A.-M.20
Noviyanti, R.21
Sinden, R.E.22
Kocken, C.H.M.23
Price, R.N.24
Avery, V.M.25
Angulo-Barturen, I.26
Jiménez-Díaz, M.B.27
Ferrer, S.28
Herreros, E.29
Sanz, L.M.30
Gamo, F.-J.31
Bathurst, I.32
Burrows, J.N.33
Siegl, P.34
Guy, R.K.35
Winter, R.W.36
Vaidya, A.B.37
Charman, S.A.38
Kyle, D.E.39
Manetsch, R.40
Riscoe, M.K.41
more..
-
59
-
-
67749093299
-
Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum
-
doi:10.1128/AAC.00471-09
-
Obaldia, N., Kotecka, B. M., Edstein, M. D., Haynes, R. K., Fugmann, B., Kyle, D. E. and Rieckmann, K.H. (2009). Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 53, 3592-3594. doi:10.1128/AAC.00471-09
-
(2009)
Antimicrobial Agents and Chemotherapy
, vol.53
, pp. 3592-3594
-
-
Obaldia, N.1
Kotecka, B.M.2
Edstein, M.D.3
Haynes, R.K.4
Fugmann, B.5
Kyle, D.E.6
Rieckmann, K.H.7
-
60
-
-
80054973132
-
Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum
-
doi:10.1097/QCO.0b013e32834cd3ed.
-
O'Brien, C., Henrich, P. P., Passi, N. and Fidock, D. A. (2011). Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum. Current Opinion in Infectious Diseases 24, 570-577. doi:10.1097/QCO.0b013e32834cd3ed.
-
(2011)
Current Opinion in Infectious Diseases
, vol.24
, pp. 570-577
-
-
O'Brien, C.1
Henrich, P.P.2
Passi, N.3
Fidock, D.A.4
-
61
-
-
17444388515
-
History of U.S military contributions to the study of malaria
-
Ockenhouse, C. F., Magill, A., Smith, D. and Milhous, W. (2005). History of U.S. military contributions to the study of malaria. Military Medicine 170, 12-16
-
(2005)
Military Medicine
, vol.170
, pp. 12-16
-
-
Ockenhouse, C.F.1
Magill, A.2
Smith, D.3
Milhous, W.4
-
62
-
-
0041704534
-
Mixed models: Getting the best use of parasitological data
-
doi:10.1016/S1471-492203 00149-00151
-
Paterson, S. and Lello, J. (2003). Mixed models: Getting the best use of parasitological data. Trends in Parasitology 19, 370-375. doi:10.1016/S1471- 4922(03)00149-1
-
(2003)
Trends in Parasitology
, vol.19
, pp. 370-375
-
-
Paterson, S.1
Lello, J.2
-
63
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
doi: 10.1038/nrd2201
-
Payne, D. J., Gwynn, M. N., Holmes, D. J. and Pompliano, D. L. (2007). Drugs for bad bugs: Confronting the challenges of antibacterial discovery. Nature Reviews Drug Discovery 6, 29-40 doi: 10.1038/nrd2201
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
64
-
-
79959227019
-
In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine
-
doi: 10.1128/AAC.01566-10
-
Pereira, M. R., Henrich, P. P., Sidhu, A. B., Johnson, D., Hardink, J., Van Deusen, J., Lin, J., Gore, K., O'Brien, C., Wele, M., Djimde, A., Chandra, R. and Fidock, D. A. (2011). In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine. Antimicrobial Agents and Chemotherapy 55, 3115-3124 doi: 10.1128/AAC.01566-10
-
(2011)
Antimicrobial Agents and Chemotherapy
, vol.55
, pp. 3115-3124
-
-
Pereira, M.R.1
Henrich, P.P.2
Sidhu, A.B.3
Johnson, D.4
Hardink, J.5
Van Deusen, J.6
Lin, J.7
Gore, K.8
O'Brien, C.9
Wele, M.10
Djimde, A.11
Chandra, R.12
Fidock, D.A.13
-
65
-
-
3042541376
-
Malaria
-
(ed. Zak, O. and Sande, M. A. Academic Press, London
-
Peters, W. and Robinson, B. L. (1999). Malaria. In Handbook of Animal Models of Infection (ed. Zak, O. and Sande, M. A.), pp. 757-773. Academic Press, London
-
(1999)
Handbook of Animal Models of Infection
, pp. 757-773
-
-
Peters, W.1
Robinson, B.L.2
-
66
-
-
48249095940
-
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-Throughput screen
-
doi:10.1073/pnas.0802982105
-
Plouffe, D., Brinker, A., McNamara, C., Henson, K., Kato, N., Kuhen, K., Nagle, A., Adrian, F., Matzen, J. T., Anderson, P., Nam, T. G., Gray, N. S., Chatterjee, A., Janes, J., Yan, S. F., Trager, R., Caldwell, J. S., Schultz, P. G., Zhou, Y. and Winzeler, E. A. (2008). In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-Throughput screen. Proceedings of the National Academy of Sciences, USA 105, 9059-9064. doi:10.1073/pnas.0802982105
-
(2008)
Proceedings of the National Academy of Sciences, USA
, vol.105
, pp. 9059-9064
-
-
Plouffe, D.1
Brinker, A.2
McNamara, C.3
Henson, K.4
Kato, N.5
Kuhen, K.6
Nagle, A.7
Adrian, F.8
Matzen, J.T.9
Anderson, P.10
Nam, T.G.11
Gray, N.S.12
Chatterjee, A.13
Janes, J.14
Yan, S.F.15
Trager, R.16
Caldwell, J.S.17
Schultz, P.G.18
Zhou, Y.19
Winzeler, E.A.20
more..
-
67
-
-
84860200986
-
MK-4815, a potential new oral agent for treatment of malaria
-
doi:10.1128/ AAC.05326-11
-
Powles, M. A., Allocco, J., Yeung, L., Nare, B., Liberator, P. and Schmatz, D. (2012). MK-4815, a potential new oral agent for treatment of malaria. Antimicrobial Agents and Chemotherapy 56, 2414-2419. doi:10.1128/ AAC.05326-11
-
(2012)
Antimicrobial Agents and Chemotherapy
, vol.56
, pp. 2414-2419
-
-
Powles, M.A.1
Allocco, J.2
Yeung, L.3
Nare, B.4
Liberator, P.5
Schmatz, D.6
-
68
-
-
51249098250
-
Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents
-
doi:10.1186/1471-2148-8-223
-
Prugnolle, F., McGee, K., Keebler, J. and Awadalla, P. (2008). Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents. BMC Evolutionary Biology 8, 223. doi:10.1186/1471-2148- 8-223
-
(2008)
BMC Evolutionary Biology
, vol.8
, pp. 223
-
-
Prugnolle, F.1
McGee, K.2
Keebler, J.3
Awadalla, P.4
-
69
-
-
79961044556
-
African monkeys are infected by Plasmodium falciparum nonhuman primate-specific strains
-
doi:10.1073/pnas.1109368108
-
Prugnolle, F., Ollomo, B., Durand, P., Yalcindag, E., Arnathau, C. l., Elguero, E., Berry, A., Pourrut, X., Gonzalez, J-P., Nkoghe, D., Akiana, J., Verrier, D., Leroy, E., Ayala, F. J. and Renaud, F. (2011). African monkeys are infected by Plasmodium falciparum nonhuman primate-specific strains. Proceedings of the National Academy of Sciences, USA 108, 11948-11953. doi:10.1073/pnas. 1109368108
-
(2011)
Proceedings of the National Academy of Sciences USA
, vol.108
, pp. 11948-11953
-
-
Prugnolle, F.1
Ollomo, B.2
Durand, P.3
Yalcindag, E.4
Arnathau, C.L.5
Elguero, E.6
Berry, A.7
Pourrut, X.8
Gonzalez, J.-P.9
Nkoghe, D.10
Akiana, J.11
Verrier, D.12
Leroy, E.13
Ayala, F.J.14
Renaud, F.15
-
70
-
-
77956280420
-
Spiroindolones, a potent compound class for the treatment of malaria
-
doi:10.1126/science.1193225
-
Rottmann, M., McNamara, C., Yeung, B. K. S., Lee, M. C. S., Zou, B., Russell, B., Seitz, P., Plouffe, D. M., Dharia, N. V., Tan, J., Cohen, S. B., Spencer, K. R., González-Páez, G. E., Lakshminarayana, S. B., Goh, A., Suwanarusk, R., Jegla, T., Schmitt, E. K., Beck, H. P., Brun, R., Nosten, F., Renia, L., Dartois, V., Keller, T. H., Fidock, D. A., Winzeler, E. A. and Diagana, T. T. (2010). Spiroindolones, a potent compound class for the treatment of malaria. Science 329, 1175-1180. doi:10.1126/science.1193225
-
(2010)
Science
, vol.329
, pp. 1175-1180
-
-
Rottmann, M.1
McNamara, C.2
Yeung, B.K.S.3
Lee, M.C.S.4
Zou, B.5
Russell, B.6
Seitz, P.7
Plouffe, D.M.8
Dharia, N.V.9
Tan, J.10
Cohen, S.B.11
Spencer, K.R.12
González- Páez, G.E.13
Lakshminarayana, S.B.14
Goh, A.15
Suwanarusk, R.16
Jegla, T.17
Schmitt, E.K.18
Beck, H.P.19
Brun, R.20
Nosten, F.21
Renia, L.22
Dartois, V.23
Keller, T.H.24
Fidock, D.A.25
Winzeler, E.A.26
Diagana, T.T.27
more..
-
71
-
-
33644856082
-
Plasmodium falciparum infection and exoerythrocytic development in mice 2with chimeric human livers
-
doi: 10.1016/j. ijpara 2005 10014
-
Sacci, J. B., Jr., Alam, U., Douglas, D., Lewis, J., Tyrrell, D. L., Azad, A. F. and Kneteman, N. M. (2006). Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers. International Journal for Parasitology 36, 353-360 doi: 10.1016/j. ijpara.2005.10.014
-
(2006)
International Journal for Parasitology
, vol.36
, pp. 353-360
-
-
Sacci Jr., J.B.1
Alam, U.2
Douglas, D.3
Lewis, J.4
Tyrrell, D.L.5
Azad, A.F.6
Kneteman, N.M.7
-
72
-
-
84865440072
-
Novel 4-Aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro
-
doi:10.1128/AAC.01061-12
-
Saenz, F. E., Mutka, T., Udenze, K., Oduola, A. M. J. and Kyle, D. E. (2012). Novel 4-Aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro. Antimicrobial Agents and Chemotherapy 56, 4685-4692. doi:10.1128/AAC.01061-12
-
(2012)
Antimicrobial Agents and Chemotherapy
, vol.56
, pp. 4685-4692
-
-
Saenz, F.E.1
Mutka, T.2
Udenze, K.3
Oduola, A.M.J.4
Kyle, D.E.5
-
73
-
-
12844284664
-
Dual molecules as new antimalarials
-
doi: 10.2174/1386207053328219
-
Salom-Roig, X. J., Hamze, A., Calas, M. and Vial, H. J. (2005). Dual molecules as new antimalarials. Combinatorial Chemistry and High Throughput Screen 8, 49-62 doi: 10.2174/1386207053328219
-
(2005)
Combinatorial Chemistry and High Throughput Screen
, vol.8
, pp. 49-62
-
-
Salom-Roig, X.J.1
Hamze, A.2
Calas, M.3
Vial, H.J.4
-
74
-
-
0036047222
-
Mouse models for eryhtrocytic-stage malaria
-
(ed. Doolan, D. L. Humana. Press, Inc., Totowa
-
Sanni, L. A., Fonseca, L. F. and Langhorne, J. (2002). Mouse models for eryhtrocytic-stage malaria. In Malaria Methods and Protocols (ed. Doolan, D. L.), pp. 57-76. Humana. Press, Inc., Totowa
-
(2002)
Malaria Methods and Protocols
, pp. 57-76
-
-
Sanni, L.A.1
Fonseca, L.F.2
Langhorne, J.3
-
75
-
-
81555221105
-
Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen
-
doi:10.1128/AAC.05188-11
-
Sanz, L. M., Jiménez-Díaz, M. B., Crespo, B., De Cózar, C., Almela, M. J., Angulo-Barturen, I., Castañeda, P., Ibañez, J., Fernandez, E. P., Ferrer, S., Herreros, E., Lozano, S., Martínez, M. S., Rueda, L., Burrows, J. N., García-Bustos, J. F. and Gamo, F. J. (2011). Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen. Antimicrobial Agents and Chemotherapy 55, 5740-5745. doi:10.1128/AAC.05188-11
-
(2011)
Antimicrobial Agents and Chemotherapy
, vol.55
, pp. 5740-5745
-
-
Sanz, L.M.1
Jiménez-Díaz, M.B.2
Crespo, B.3
De Cózar, C.4
Almela, M.J.5
Angulo-Barturen, I.6
Castañeda, P.7
Ibañez, J.8
Fernandez, E.P.9
Ferrer, S.10
Herreros, E.11
Lozano, S.12
Martínez, M.S.13
Rueda, L.14
Burrows, J.N.15
García-Bustos, J.F.16
Gamo, F.J.17
-
76
-
-
0028097030
-
Susceptibility of different strains of mice to hepatic infection with Plasmodium berghei
-
Scheller, L. F., Wirtz, R. A. and Azad, A. F. (1994). Susceptibility of different strains of mice to hepatic infection with Plasmodium berghei. Infection and Immunity 62, 4844-4847
-
(1994)
Infection and Immunity
, vol.62
, pp. 4844-4847
-
-
Scheller, L.F.1
Wirtz, R.A.2
Azad, A.F.3
-
77
-
-
84867898654
-
Humanized mice for immune system investigation progress promise and challenges
-
doi:10.1038/nri3311
-
Shultz, L. D., Brehm, M. A., García-Martínez, J. V. and Greiner, D. L. (2012). Humanized mice for immune system investigation: Progress, promise and challenges. Nature Reviews Immunology 12, 786-798. doi:10.1038/nri3311
-
(2012)
Nature Reviews Immunology
, vol.12
, pp. 786-798
-
-
Shultz, L.D.1
Brehm, M.A.2
García-Martínez, J.V.3
Greiner, D.L.4
-
78
-
-
80052624721
-
Optimization of potent inhibitors of P falciparum dihydroorotate dehydrogenase for the treatment of malaria
-
doi: 10.1021/ ml200143c.
-
Skerlj, R. T., Bastos, C. M., Booker, M. L., Kramer, M. L., Barker, R. H., Celatka, C. A., O'Shea, T. J., Munoz, B., Sidhu, A. B., Cortese, J. F., Wittlin, S., Papastogiannidis, P., Angulo-Barturen, I., Jiménez- Díaz, M. B. and Sybertz, E. (2011). Optimization of potent inhibitors of P. falciparum dihydroorotate dehydrogenase for the treatment of malaria. ACS Medicinal Chemistry Letters 2, 708-713 doi: 10.1021/ ml200143c.
-
(2011)
ACS Medicinal Chemistry Letters
, vol.2
, pp. 708-713
-
-
Skerlj, R.T.1
Bastos, C.M.2
Booker, M.L.3
Kramer, M.L.4
Barker, R.H.5
Celatka, C.A.6
O'Shea, T.J.7
Munoz, B.8
Sidhu, A.B.9
Cortese, J.F.10
Wittlin, S.11
Papastogiannidis, P.12
Angulo-Barturen, I.13
Jiménez-Díaz, M.B.14
Sybertz, E.15
-
79
-
-
22144436635
-
Malarial birds: Modeling infectious human disease in animals
-
doi: 10.1353/ bhm 2005 0092
-
Slater, L. B. (2005). Malarial birds: Modeling infectious human disease in animals. Bulletin of the History of Medicine 79, 261-294 doi: 10.1353/ bhm.2005.0092
-
(2005)
Bulletin of the History of Medicine
, vol.79
, pp. 261-294
-
-
Slater, L.B.1
-
80
-
-
0345724864
-
Plasmodium vivax under the microscope: The Aotus model
-
doi: S1471492203002812
-
Stewart, V. A. (2003). Plasmodium vivax under the microscope: The Aotus model. Trends in Parasitology 19, 589-594 doi: S1471492203002812
-
(2003)
Trends in Parasitology
, vol.19
, pp. 589-594
-
-
Stewart, V.A.1
-
81
-
-
79957703902
-
A research agenda for malaria eradication: Drugs
-
The MalERA Consultative Group On Drugs doi:10.1371/ journal.pmed 1000402
-
The malERA Consultative Group on Drugs (2011). A research agenda for malaria eradication: Drugs. PLoS Medicine 8, e1000402. doi:10.1371/ journal.pmed.1000402
-
(2011)
PLoS Medicine
, vol.8
-
-
-
83
-
-
77950679333
-
Can animal models of disease reliably inform human studies?
-
doi:10.1371/journal.pmed.1000245
-
van der Worp, H B., Howells, D.W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V. and Macleod, M. R. (2010). Can animal models of disease reliably inform human studies? PLoS Medicine 7, e1000245. doi:10.1371/journal. pmed.1000245
-
(2010)
PLoS Medicine
, vol.7
-
-
Van Der Worp, H.B.1
Howells, D.W.2
Sena, E.S.3
Porritt, M.J.4
Rewell, S.5
O'Collins, V.6
Macleod, M.R.7
-
84
-
-
84867154422
-
Complete Plasmodium falciparum liver-stage development in liverchimeric mice
-
doi:62684 doi doi:62684 doi: 10.1172/JCI62684
-
Vaughan, A. M., Mikolajczak, S. A., Wilson, E. M., Grompe, M., Kaushansky, A., Camargo, N., Bial, J., Ploss, A. and Kappe, S. H. (2012). Complete Plasmodium falciparum liver-stage development in liverchimeric mice. Journal of Clinical Investigation 122, 3618-3628. doi:62684 doi: 10.1172/JCI62684
-
(2012)
Journal of Clinical Investigation
, vol.122
, pp. 3618-3628
-
-
Vaughan, A.M.1
Mikolajczak, S.A.2
Wilson, E.M.3
Grompe, M.4
Kaushansky, A.5
Camargo, N.6
Bial, J.7
Ploss, A.8
Kappe, S.H.9
-
85
-
-
33746169858
-
Searching for new antimalarial therapeutics amongst known drugs
-
doiJPP391 doi doi:JPP391 doi:10.1111/j.1747-0285 200600391x
-
Weisman, J. L., Liou, A. P., Shelat, A. A., Cohen, F. E., Guy, R. K. and DeRisi, J. L. (2006). Searching for new antimalarial therapeutics amongst known drugs. Chemical Biology and Drug Design 67, 409-416. doi:JPP391 doi:10.1111/j.1747-0285.2006.00391.x.
-
(2006)
Chemical Biology and Drug Design
, vol.67
, pp. 409-416
-
-
Weisman, J.L.1
Liou, A.P.2
Shelat, A.A.3
Cohen, F.E.4
Guy, R.K.5
DeRisi, J.L.6
-
86
-
-
0037083529
-
A class of potent antimalarials and their specific accumulation in infected erythrocytes
-
doi:10.1126/ science.1067236
-
Wengelnik, K., Vidal, V., Ancelin, M. L., Cathiard, A. M., Morgat, J. L., Kocken, C. H., Calas, M., Herrera, S., Thomas, A.W. and Vial, H. J. (2002). A class of potent antimalarials and their specific accumulation in infected erythrocytes. Science 295, 1311-1314. doi:10.1126/ science.1067236
-
(2002)
Science
, vol.295
, pp. 1311-1314
-
-
Wengelnik, K.1
Vidal, V.2
Ancelin, M.L.3
Cathiard, A.M.4
Morgat, J.L.5
Kocken, C.H.6
Calas, M.7
Herrera, S.8
Thomas, A.W.9
Vial, H.J.10
-
87
-
-
39449099400
-
Plasmodium knowlesi: The fifth human malaria parasite
-
doi:10.1086/524889
-
White, N. J. (2008). Plasmodium knowlesi: The fifth human malaria parasite. Clinical Infectious Diseases 46, 172-173. doi:10.1086/524889
-
(2008)
Clinical Infectious Diseases
, vol.46
, pp. 172-173
-
-
White, N.J.1
-
88
-
-
80053173631
-
The parasite clearance curve
-
doi 1475-2875-10-278 doi doi: 1475-2875-10-278 doi:10.1186/1475-2875-10- 278
-
White, N. J. (2011). The parasite clearance curve. Malaria Journal 10, 278 doi: 1475-2875-10-278 doi:10.1186/1475-2875-10-278
-
(2011)
Malaria Journal
, vol.10
, pp. 278
-
-
White, N.J.1
-
90
-
-
79952193925
-
-
WHO World Health Organization Geneva Switzerland
-
WHO(2010b).World Malaria Report. World Health Organization, Geneva, Switzerland
-
(2010)
World Malaria Report
-
-
-
91
-
-
42949139813
-
Synthesis and structure-Activity relationships of 4-pyridones as potential antimalarials
-
doi: 10.1021/ jm0705760
-
Yeates, C. L., Batchelor, J. F., Capon, E. C., Cheesman, N. J., Fry, M., Hudson, A. T., Pudney, M., Trimming, H., Woolven, J., Bueno, J. M., Chicharro, J., Fernandez, E., Fiandor, J. M., Gargallo-Viola, D., Gomez de las Heras, F., Herreros, E. and Leon, M. L. (2008). Synthesis and structure-Activity relationships of 4-pyridones as potential antimalarials. Journal of Medicinal Chemistry 51, 2845-2852 doi: 10.1021/ jm0705760
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, pp. 2845-2852
-
-
Yeates, C.L.1
Batchelor, J.F.2
Capon, E.C.3
Cheesman, N.J.4
Fry, M.5
Hudson, A.T.6
Pudney, M.7
Trimming, H.8
Woolven, J.9
Bueno, J.M.10
Chicharro, J.11
Fernandez, E.12
Fiandor, J.M.13
Gargallo-Viola, D.14
Gomez De Las Heras, F.15
Herreros, E.16
Leon, M.L.17
-
92
-
-
84859798468
-
3,5-Diaryl-2-Aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential
-
doi:10.1021/jm3001373
-
Younis, Y., Douelle, F., Feng, T. S., Gonzalez Cabrera, D., Le Manach, C., Nchinda, A. T., Duffy, S., White, K. L., Shackleford, D. M., Morizzi, J., Mannila, J., Katneni, K., Bhamidipati, R., Zabiulla, K. M., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Hardick, D., Wittlin, S., Avery, V., Charman, S. A. and Chibale, K. (2012). 3,5-Diaryl-2-Aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential. Journal of Medicinal Chemistry 55, 3479-3487. doi:10.1021/jm3001373
-
(2012)
Journal of Medicinal Chemistry
, vol.55
, pp. 3479-3487
-
-
Younis, Y.1
Douelle, F.2
Feng, T.S.3
Gonzalez Cabrera, D.4
Le Manach, C.5
Nchinda, A.T.6
Duffy, S.7
White, K.L.8
Shackleford, D.M.9
Morizzi, J.10
Mannila, J.11
Katneni, K.12
Bhamidipati, R.13
Zabiulla, K.M.14
Joseph, J.T.15
Bashyam, S.16
Waterson, D.17
Witty, M.J.18
Hardick, D.19
Wittlin, S.20
Avery, V.21
Charman, S.A.22
Chibale, K.23
more..
-
93
-
-
84861017466
-
Lead optimization of 3-carboxyl-4(1 H)-quinolones to deliver orally bioavailable antimalarials
-
doi:10.1021/jm201642z.
-
Zhang, Y., Clark, J. A., Connelly, M. C., Zhu, F., Min, J., Guiguemde, W. A., Pradhan, A., Iyer, L., Furimsky, A., Gow, J., Parman, T., El Mazouni, F., Phillips, M. A., Kyle, D. E., Mirsalis, J. and Guy, R. K. (2012). Lead optimization of 3-carboxyl-4(1 H)-quinolones to deliver orally bioavailable antimalarials. Journal of Medicinal Chemistry 55, 4205-4219. doi:10.1021/jm201642z.
-
(2012)
Journal of Medicinal Chemistry
, vol.55
, pp. 4205-4219
-
-
Zhang, Y.1
Clark, J.A.2
Connelly, M.C.3
Zhu, F.4
Min, J.5
Guiguemde, W.A.6
Pradhan, A.7
Iyer, L.8
Furimsky, A.9
Gow, J.10
Parman, T.11
El Mazouni, F.12
Phillips, M.A.13
Kyle, D.E.14
Mirsalis, J.15
Guy, R.K.16
|