Drug-like properties and the causes of poor solubility and poor permeability

Journal of Pharmacological and Toxicological Methods

Volumn 44, Issue 1, 2000, Pages 235-249

  Lipinski, Christopher A ^a  

^a PFIZER INC   (United States)

Author keywords

Absorption; ADME; Chemical diversity; Clinical candidate; Drug like; Merck; Permeability; Pfizer; Solubility

Indexed keywords

(2 CYCLOPENTYL 6,7 DICHLORO 2 METHYL 1 OXO 5 INDANYLOXY)ACETIC ACID; 2 AMINOMETHYL 4 TERT BUTYL 6 IODOPHENOL; 3A,4,5,6,7,7A HEXAHYDRO 3 (1 METHYL 5 NITRO 1H IMIDAZOL 2 YL) 1,2 BENZISOXAZOLE; 5 (N,N DIMETHYL)AMILORIDE; 6 CHLORO 2 (1 PIPERAZINYL)PYRAZINE; ABAMECTIN; ALLOCLAMIDE; AMILORIDE; AMITRIPTYLINE; ARPRINOCID; CARBIDOPA; CEFOXITIN; CLORSULON; CYCLOBENZAPRINE; DEXAMETHASONE; DIFLUNISAL; DIZOCILPINE; ENALAPRILAT; ETACRYNIC ACID; FOSFOMYCIN; IMIPENEM; LISINOPRIL; METHYLDOPA; MEVINOLIN; PROTRIPTYLINE; RAFOXANIDE; TIABENDAZOLE; TIMOLOL MALEATE; UNINDEXED DRUG; ZERANOL;

ARTICLE; COMBINATORIAL CHEMISTRY; DRUG ABSORPTION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PENETRATION; DRUG RESEARCH; DRUG SCREENING; DRUG SOLUBILITY; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR WEIGHT;

DRUG INDUSTRY; HUMANS; HYDROGEN BONDING; MOLECULAR WEIGHT; PERMEABILITY; PHARMACOKINETICS; SOLUBILITY;

EID: 0034461768     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(00)00107-6     Document Type: Article

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