Potent antiviral synergy between monoclonal antibody and small-molecule CCR5 inhibitors of human immunodeficiency virus type 1

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 10, 2006, Pages 3289-3296

  Murga, Jose D ^a   Franti, Michael ^a   Pevear, Daniel C ^a,b   Maddon, Paul J ^a   Olson, William C ^a  

^a A Subsidiary of Lantheus Holdings   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZOYL 1 [(4 METHOXY 1H PYRROLO[2,3 B]PYRIDIN 3 YL)OXOACETYL] 2 METHYLPIPERAZINE; CD4 IMMUNOGLOBULIN G2; CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; ENFUVIRTIDE; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; MARAVIROC; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2D7; MONOCLONAL ANTIBODY LEU 3A; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PRO 140; RANTES; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; VICRIVIROC; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING COMPETITION; CD4+ T LYMPHOCYTE; COMBINATION INDEX METHOD; CONTROLLED STUDY; DATA ANALYSIS; DRUG DOSE REDUCTION; DRUG POTENCY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; TARGET CELL; VIRUS CELL INTERACTION; VIRUS ENVELOPE; VIRUS INHIBITION;

ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; CELL LINE; CYCLOHEXANES; DRUG SYNERGISM; HELA CELLS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV-1; HUMANS; MEMBRANE FUSION; PIPERAZINES; PYRIMIDINES; RECEPTORS, CCR5; REVERSE TRANSCRIPTASE INHIBITORS; TRIAZOLES;

EID: 33749517200     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00699-06     Document Type: Article

References (49)

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