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Volumn 171, Issue 5, 2014, Pages 1195-1209

WNT/Frizzled signalling: Receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3

Author keywords

Dishevelled; Frizzled; GPCR; heterotrimeric G proteins; WNT

Indexed keywords

DISHEVELLED 1; DISHEVELLED 2; DISHEVELLED 3; DISHEVELLED PROTEIN; FRIZZLED PROTEIN; FRIZZLED PROTEIN 1; FRIZZLED PROTEIN 10; FRIZZLED PROTEIN 2; FRIZZLED PROTEIN 3; FRIZZLED PROTEIN 4; FRIZZLED PROTEIN 5; FRIZZLED PROTEIN 6; FRIZZLED PROTEIN 7; FRIZZLED PROTEIN 8; FRIZZLED PROTEIN 9; GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84895192951     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12364     Document Type: Review
Times cited : (156)

References (167)
  • 4
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • van Amerongen R, Nusse R, (2009). Towards an integrated view of Wnt signaling in development. Development 136: 3205-3214.
    • (2009) Development , vol.136 , pp. 3205-3214
    • Van Amerongen, R.1    Nusse, R.2
  • 5
    • 55749102279 scopus 로고    scopus 로고
    • Alternative wnt signaling is initiated by distinct receptors
    • van Amerongen R, Mikels A, Nusse R, (2008). Alternative wnt signaling is initiated by distinct receptors. Sci Signal 1: re9.
    • (2008) Sci Signal , vol.1
    • Van Amerongen, R.1    Mikels, A.2    Nusse, R.3
  • 6
    • 84871846692 scopus 로고    scopus 로고
    • WNT signalling pathways as therapeutic targets in cancer
    • Anastas JN, Moon RT, (2013). WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 13: 11-26.
    • (2013) Nat Rev Cancer , vol.13 , pp. 11-26
    • Anastas, J.N.1    Moon, R.T.2
  • 7
    • 77952546990 scopus 로고    scopus 로고
    • Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
    • Ayers KL, Therond PP, (2010). Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling. Trends Cell Biol 20: 287-298.
    • (2010) Trends Cell Biol , vol.20 , pp. 287-298
    • Ayers, K.L.1    Therond, P.P.2
  • 8
    • 58749097656 scopus 로고    scopus 로고
    • The canonical Wnt/beta-catenin signalling pathway
    • Barker N, (2008). The canonical Wnt/beta-catenin signalling pathway. Methods Mol Biol 468: 5-15.
    • (2008) Methods Mol Biol , vol.468 , pp. 5-15
    • Barker, N.1
  • 9
    • 77949906745 scopus 로고    scopus 로고
    • CGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells
    • Bazhin AV, Tambor V, Dikov B, Philippov PP, Schadendorf D, Eichmuller SB, (2010). cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. Cell Mol Life Sci 67: 817-828.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 817-828
    • Bazhin, A.V.1    Tambor, V.2    Dikov, B.3    Philippov, P.P.4    Schadendorf, D.5    Eichmuller, S.B.6
  • 10
    • 60849114984 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases and Wnt/beta-catenin signaling: Molecular conversations among signaling pathways
    • Bikkavilli RK, Malbon CC, (2009). Mitogen-activated protein kinases and Wnt/beta-catenin signaling: molecular conversations among signaling pathways. Commun Integr Biol 2: 46-49.
    • (2009) Commun Integr Biol , vol.2 , pp. 46-49
    • Bikkavilli, R.K.1    Malbon, C.C.2
  • 11
    • 34250827150 scopus 로고    scopus 로고
    • Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
    • Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, et al. (2007). Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 316: 1619-1622.
    • (2007) Science , vol.316 , pp. 1619-1622
    • Bilic, J.1    Huang, Y.L.2    Davidson, G.3    Zimmermann, T.4    Cruciat, C.M.5    Bienz, M.6
  • 12
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, et al. (2001). Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65: 135-172.
    • (2001) Prog Neurobiol , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.4    Benabid, A.L.5    Sadoul, R.6
  • 13
    • 34249856025 scopus 로고    scopus 로고
    • Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo
    • Bryja V, Gradl D, Schambony A, Arenas E, Schulte G, (2007a). Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. Proc Natl Acad Sci U S A 104: 6690-6695.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6690-6695
    • Bryja, V.1    Gradl, D.2    Schambony, A.3    Arenas, E.4    Schulte, G.5
  • 14
    • 33947312488 scopus 로고    scopus 로고
    • Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism
    • Bryja V, Schulte G, Rawal N, Grahn A, Arenas E, (2007b). Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J Cell Sci 120 (Pt 4): 586-595.
    • (2007) J Cell Sci , vol.120 , Issue.PART 4 , pp. 586-595
    • Bryja, V.1    Schulte, G.2    Rawal, N.3    Grahn, A.4    Arenas, E.5
  • 15
    • 39549095427 scopus 로고    scopus 로고
    • Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP
    • Carmon KS, Loose DS, (2008). Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP. Biochem Biophys Res Commun 368: 285-291.
    • (2008) Biochem Biophys Res Commun , vol.368 , pp. 285-291
    • Carmon, K.S.1    Loose, D.S.2
  • 16
    • 77952885408 scopus 로고    scopus 로고
    • Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors
    • Carmon KS, Loose DS, (2010). Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors. Anal Biochem 401: 288-294.
    • (2010) Anal Biochem , vol.401 , pp. 288-294
    • Carmon, K.S.1    Loose, D.S.2
  • 17
    • 28544444039 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis
    • Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS, (2005). Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 310: 1504-1510.
    • (2005) Science , vol.310 , pp. 1504-1510
    • Castellone, M.D.1    Teramoto, H.2    Williams, B.O.3    Druey, K.M.4    Gutkind, J.S.5
  • 18
    • 0242363167 scopus 로고    scopus 로고
    • Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    • Castelo-Branco G, Wagner J, Rodriguez FJ, Kele J, Sousa K, Rawal N, et al. (2003). Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A 100: 12747-12752.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12747-12752
    • Castelo-Branco, G.1    Wagner, J.2    Rodriguez, F.J.3    Kele, J.4    Sousa, K.5    Rawal, N.6
  • 19
    • 78751692388 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6
    • Cervenka I, Wolf J, Masek J, Krejci P, Wilcox WR, Kozubik A, et al. (2011). Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6. Mol Cell Biol 31: 179-189.
    • (2011) Mol Cell Biol , vol.31 , pp. 179-189
    • Cervenka, I.1    Wolf, J.2    Masek, J.3    Krejci, P.4    Wilcox, W.R.5    Kozubik, A.6
  • 20
    • 49649088889 scopus 로고    scopus 로고
    • Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers
    • Chacon MA, Varela-Nallar L, Inestrosa NC, (2008). Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers. J Cell Physiol 217: 215-227.
    • (2008) J Cell Physiol , vol.217 , pp. 215-227
    • Chacon, M.A.1    Varela-Nallar, L.2    Inestrosa, N.C.3
  • 21
    • 12744262866 scopus 로고    scopus 로고
    • Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins
    • Chen AE, Ginty DD, Fan CM, (2005). Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature 433: 317-322.
    • (2005) Nature , vol.433 , pp. 317-322
    • Chen, A.E.1    Ginty, D.D.2    Fan, C.M.3
  • 22
    • 70350489312 scopus 로고    scopus 로고
    • The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling
    • Chen M, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, et al. (2009). The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry 48: 10267-10274.
    • (2009) Biochemistry , vol.48 , pp. 10267-10274
    • Chen, M.1    Wang, J.2    Lu, J.3    Bond, M.C.4    Ren, X.R.5    Lyerly, H.K.6
  • 23
    • 0041470133 scopus 로고    scopus 로고
    • Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4
    • Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, et al. (2003). Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 301: 1391-1394.
    • (2003) Science , vol.301 , pp. 1391-1394
    • Chen, W.1    Ten Berge, D.2    Brown, J.3    Ahn, S.4    Hu, L.A.5    Miller, W.E.6
  • 24
    • 34249814024 scopus 로고    scopus 로고
    • WNTS and WNT receptors as therapeutic tools and targets in human disease processes
    • Chien AJ, Moon RT, (2007). WNTS and WNT receptors as therapeutic tools and targets in human disease processes. Front Biosci 12: 448-457.
    • (2007) Front Biosci , vol.12 , pp. 448-457
    • Chien, A.J.1    Moon, R.T.2
  • 25
    • 67449150167 scopus 로고    scopus 로고
    • A Wnt survival guide: From flies to human disease
    • Chien AJ, Conrad WH, Moon RT, (2009). A Wnt survival guide: from flies to human disease. J Invest Dermatol 129: 1614-1627.
    • (2009) J Invest Dermatol , vol.129 , pp. 1614-1627
    • Chien, A.J.1    Conrad, W.H.2    Moon, R.T.3
  • 26
    • 80053357815 scopus 로고    scopus 로고
    • Conformational changes in the G protein Gs induced by the beta2 adrenergic receptor
    • Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, et al. (2011). Conformational changes in the G protein Gs induced by the beta2 adrenergic receptor. Nature 477: 611-615.
    • (2011) Nature , vol.477 , pp. 611-615
    • Chung, K.Y.1    Rasmussen, S.G.2    Liu, T.3    Li, S.4    Devree, B.T.5    Chae, P.S.6
  • 27
    • 1342282917 scopus 로고    scopus 로고
    • Casein kinase Iepsilon modulates the signaling specificities of dishevelled
    • Cong F, Schweizer L, Varmus H, (2004a). Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol 24: 2000-2011.
    • (2004) Mol Cell Biol , vol.24 , pp. 2000-2011
    • Cong, F.1    Schweizer, L.2    Varmus, H.3
  • 28
    • 8444223093 scopus 로고    scopus 로고
    • Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
    • Cong F, Schweizer L, Varmus H, (2004b). Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131: 5103-5115.
    • (2004) Development , vol.131 , pp. 5103-5115
    • Cong, F.1    Schweizer, L.2    Varmus, H.3
  • 29
    • 0035811492 scopus 로고    scopus 로고
    • Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
    • Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ, (2001). Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412: 86-90.
    • (2001) Nature , vol.412 , pp. 86-90
    • Dann, C.E.1    Hsieh, J.C.2    Rattner, A.3    Sharma, D.4    Nathans, J.5    Leahy, D.J.6
  • 30
    • 33845350346 scopus 로고    scopus 로고
    • The ups and downs of Wnt signaling in prevalent neurological disorders
    • De Ferrari GV, Moon RT, (2006). The ups and downs of Wnt signaling in prevalent neurological disorders. Oncogene 25: 7545-7553.
    • (2006) Oncogene , vol.25 , pp. 7545-7553
    • De Ferrari, G.V.1    Moon, R.T.2
  • 31
    • 0019137579 scopus 로고
    • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
    • De Lean A, Stadel JM, Lefkowitz RJ, (1980). A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J Biol Chem 255: 7108-7117.
    • (1980) J Biol Chem , vol.255 , pp. 7108-7117
    • De Lean, A.1    Stadel, J.M.2    Lefkowitz, R.J.3
  • 32
    • 33746990262 scopus 로고    scopus 로고
    • Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42- casein kinase 1alpha signaling in human mammary epithelial cells
    • Dejmek J, Safholm A, Kamp Nielsen C, Andersson T, Leandersson K, (2006). Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. Mol Cell Biol 26: 6024-6036.
    • (2006) Mol Cell Biol , vol.26 , pp. 6024-6036
    • Dejmek, J.1    Safholm, A.2    Kamp Nielsen, C.3    Andersson, T.4    Leandersson, K.5
  • 33
    • 84864374811 scopus 로고    scopus 로고
    • Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling
    • Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, et al. (2012). Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. Stem Cells 30: 1597-1610.
    • (2012) Stem Cells , vol.30 , pp. 1597-1610
    • Despeaux, M.1    Chicanne, G.2    Rouer, E.3    De Toni-Costes, F.4    Bertrand, J.5    Mansat-De Mas, V.6
  • 34
    • 0033572358 scopus 로고    scopus 로고
    • The G protein subunit gene families
    • Downes GB, Gautam N, (1999). The G protein subunit gene families. Genomics 62: 544-552.
    • (1999) Genomics , vol.62 , pp. 544-552
    • Downes, G.B.1    Gautam, N.2
  • 35
    • 65949106610 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling regulates cytokine-induced human inducible nitric oxide synthase expression by inhibiting nuclear factor-kappaB activation in cancer cells
    • Du Q, Zhang X, Cardinal J, Cao Z, Guo Z, Shao L, et al. (2009). Wnt/beta-catenin signaling regulates cytokine-induced human inducible nitric oxide synthase expression by inhibiting nuclear factor-kappaB activation in cancer cells. Cancer Res 69: 3764-3771.
    • (2009) Cancer Res , vol.69 , pp. 3764-3771
    • Du, Q.1    Zhang, X.2    Cardinal, J.3    Cao, Z.4    Guo, Z.5    Shao, L.6
  • 36
    • 73949113486 scopus 로고    scopus 로고
    • The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway
    • Egger-Adam D, Katanaev VL, (2010). The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway. Dev Dyn 239: 168-183.
    • (2010) Dev Dyn , vol.239 , pp. 168-183
    • Egger-Adam, D.1    Katanaev, V.L.2
  • 37
    • 41149156857 scopus 로고    scopus 로고
    • Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism
    • Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, et al. (2008). Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol 28: 2368-2379.
    • (2008) Mol Cell Biol , vol.28 , pp. 2368-2379
    • Endo, Y.1    Beauchamp, E.2    Woods, D.3    Taylor, W.G.4    Toretsky, J.A.5    Uren, A.6
  • 40
    • 73949092833 scopus 로고    scopus 로고
    • A study on the interactions between heparan sulfate proteoglycans and Wnt proteins
    • Fuerer C, Habib SJ, Nusse R, (2010). A study on the interactions between heparan sulfate proteoglycans and Wnt proteins. Dev Dyn 239: 184-190.
    • (2010) Dev Dyn , vol.239 , pp. 184-190
    • Fuerer, C.1    Habib, S.J.2    Nusse, R.3
  • 41
    • 61349183717 scopus 로고    scopus 로고
    • Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma
    • Fukukawa C, Nagayama S, Tsunoda T, Toguchida J, Nakamura Y, Katagiri T, (2009). Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. Oncogene 28: 1110-1120.
    • (2009) Oncogene , vol.28 , pp. 1110-1120
    • Fukukawa, C.1    Nagayama, S.2    Tsunoda, T.3    Toguchida, J.4    Nakamura, Y.5    Katagiri, T.6
  • 42
    • 77951888466 scopus 로고    scopus 로고
    • Dishevelled: The hub of Wnt signaling
    • Gao C, Chen YG, (2010). Dishevelled: the hub of Wnt signaling. Cell Signal 22: 717-727.
    • (2010) Cell Signal , vol.22 , pp. 717-727
    • Gao, C.1    Chen, Y.G.2
  • 43
    • 77957587076 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in T-cell immunity and cancer immunotherapy
    • Gattinoni L, Ji Y, Restifo NP, (2010). Wnt/beta-catenin signaling in T-cell immunity and cancer immunotherapy. Clin Cancer Res 16: 4695-4701.
    • (2010) Clin Cancer Res , vol.16 , pp. 4695-4701
    • Gattinoni, L.1    Ji, Y.2    Restifo, N.P.3
  • 44
    • 84880784812 scopus 로고    scopus 로고
    • Structure of the C-terminal region of the frizzled receptor 1 in detergent micelles
    • Gayen S, Li Q, Kim YM, Kang C, (2013). Structure of the C-terminal region of the frizzled receptor 1 in detergent micelles. Molecules 18: 8579-8590.
    • (2013) Molecules , vol.18 , pp. 8579-8590
    • Gayen, S.1    Li, Q.2    Kim, Y.M.3    Kang, C.4
  • 45
    • 0033613394 scopus 로고    scopus 로고
    • Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response
    • Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, et al. (1999). Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene 18: 5959-5966.
    • (1999) Oncogene , vol.18 , pp. 5959-5966
    • Gazit, A.1    Yaniv, A.2    Bafico, A.3    Pramila, T.4    Igarashi, M.5    Kitajewski, J.6
  • 46
    • 2442548880 scopus 로고    scopus 로고
    • The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt beta-catenin signaling cascade
    • Golan T, Yaniv A, Bafico A, Liu G, Gazit A, (2004). The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. J Biol Chem 279: 14879-14888.
    • (2004) J Biol Chem , vol.279 , pp. 14879-14888
    • Golan, T.1    Yaniv, A.2    Bafico, A.3    Liu, G.4    Gazit, A.5
  • 47
    • 84873290930 scopus 로고    scopus 로고
    • Pertussis toxin-sensitive heterotrimeric G(alphai/o) proteins mediate WNT/beta-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A
    • Halleskog C, Schulte G, (2013a). Pertussis toxin-sensitive heterotrimeric G(alphai/o) proteins mediate WNT/beta-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A. Cell Signal 25: 822-828.
    • (2013) Cell Signal , vol.25 , pp. 822-828
    • Halleskog, C.1    Schulte, G.2
  • 48
    • 84878748115 scopus 로고    scopus 로고
    • WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia
    • Halleskog C, Schulte G, (2013b). WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia. J Neurochem 125: 803-808.
    • (2013) J Neurochem , vol.125 , pp. 803-808
    • Halleskog, C.1    Schulte, G.2
  • 51
    • 70350439474 scopus 로고    scopus 로고
    • Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner
    • Hansen C, Howlin J, Tengholm A, Dyachok O, Vogel WF, Nairn AC, et al. (2009). Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner. J Biol Chem 284: 27533-27543.
    • (2009) J Biol Chem , vol.284 , pp. 27533-27543
    • Hansen, C.1    Howlin, J.2    Tengholm, A.3    Dyachok, O.4    Vogel, W.F.5    Nairn, A.C.6
  • 52
    • 33751333923 scopus 로고    scopus 로고
    • Wnt lipid modifications: Not as saturated as we thought
    • Hausmann G, Basler K, (2006). Wnt lipid modifications: not as saturated as we thought. Dev Cell 11: 751-752.
    • (2006) Dev Cell , vol.11 , pp. 751-752
    • Hausmann, G.1    Basler, K.2
  • 53
    • 0030941498 scopus 로고    scopus 로고
    • A member of the Frizzled protein family mediating axis induction by Wnt-5A
    • He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H, (1997). A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275: 1652-1654.
    • (1997) Science , vol.275 , pp. 1652-1654
    • He, X.1    Saint-Jeannet, J.P.2    Wang, Y.3    Nathans, J.4    Dawid, I.5    Varmus, H.6
  • 54
    • 79955608017 scopus 로고    scopus 로고
    • Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway
    • Heinonen KM, Vanegas JR, Lew D, Krosl J, Perreault C, (2011). Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS ONE 6: e19279.
    • (2011) PLoS ONE , vol.6
    • Heinonen, K.M.1    Vanegas, J.R.2    Lew, D.3    Krosl, J.4    Perreault, C.5
  • 55
    • 84856393994 scopus 로고    scopus 로고
    • Inhibition of Wnt/beta-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8
    • Hendaoui I, Lavergne E, Lee HS, Hong SH, Kim HZ, Parent C, et al. (2012). Inhibition of Wnt/beta-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. PLoS ONE 7: e30601.
    • (2012) PLoS ONE , vol.7
    • Hendaoui, I.1    Lavergne, E.2    Lee, H.S.3    Hong, S.H.4    Kim, H.Z.5    Parent, C.6
  • 56
    • 41649116120 scopus 로고    scopus 로고
    • Non-conventional Frizzled ligands and Wnt receptors
    • Hendrickx M, Leyns L, (2008). Non-conventional Frizzled ligands and Wnt receptors. Dev Growth Differ 50: 229-243.
    • (2008) Dev Growth Differ , vol.50 , pp. 229-243
    • Hendrickx, M.1    Leyns, L.2
  • 58
    • 0035155579 scopus 로고    scopus 로고
    • Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis
    • Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, et al. (2001). Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128: 25-33.
    • (2001) Development , vol.128 , pp. 25-33
    • Ishikawa, T.1    Tamai, Y.2    Zorn, A.M.3    Yoshida, H.4    Seldin, M.F.5    Nishikawa, S.6
  • 60
    • 33646532114 scopus 로고    scopus 로고
    • The Wnt-dependent signaling pathways as target in oncology drug discovery
    • Janssens N, Janicot M, Perera T, (2006). The Wnt-dependent signaling pathways as target in oncology drug discovery. Invest New Drugs 24: 263-280.
    • (2006) Invest New Drugs , vol.24 , pp. 263-280
    • Janssens, N.1    Janicot, M.2    Perera, T.3
  • 61
    • 0037020253 scopus 로고    scopus 로고
    • Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling
    • Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ, (2002). Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. J Biol Chem 277: 37479-37486.
    • (2002) J Biol Chem , vol.277 , pp. 37479-37486
    • Karasawa, T.1    Yokokura, H.2    Kitajewski, J.3    Lombroso, P.J.4
  • 62
    • 52949136599 scopus 로고    scopus 로고
    • Transcriptional control of skeletogenesis
    • Karsenty G, (2008). Transcriptional control of skeletogenesis. Annu Rev Genomics Hum Genet 9: 183-196.
    • (2008) Annu Rev Genomics Hum Genet , vol.9 , pp. 183-196
    • Karsenty, G.1
  • 63
    • 70349355268 scopus 로고    scopus 로고
    • Frizzled proteins are bona fide G protein-coupled receptors
    • hdl:10101/npre.2009.2765.1.
    • Katanaev VL, Buestorf S, (2009). Frizzled proteins are bona fide G protein-coupled receptors. Nat Proc hdl:10101/npre.2009.2765.1.
    • (2009) Nat Proc
    • Katanaev, V.L.1    Buestorf, S.2
  • 64
    • 11844299003 scopus 로고    scopus 로고
    • Trimeric G protein-dependent frizzled signaling in Drosophila
    • Katanaev VL, Ponzielli R, Semeriva M, Tomlinson A, (2005). Trimeric G protein-dependent frizzled signaling in Drosophila. Cell 120: 111-122.
    • (2005) Cell , vol.120 , pp. 111-122
    • Katanaev, V.L.1    Ponzielli, R.2    Semeriva, M.3    Tomlinson, A.4
  • 65
    • 84874885773 scopus 로고    scopus 로고
    • The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration
    • Kaucka M, Plevova K, Pavlova S, Janovska P, Mishra A, Verner J, et al. (2013). The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration. Cancer Res 73: 1491-1501.
    • (2013) Cancer Res , vol.73 , pp. 1491-1501
    • Kaucka, M.1    Plevova, K.2    Pavlova, S.3    Janovska, P.4    Mishra, A.5    Verner, J.6
  • 66
    • 34948906833 scopus 로고    scopus 로고
    • Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal
    • Kawasaki A, Torii K, Yamashita Y, Nishizawa K, Kanekura K, Katada M, et al. (2007). Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal. Cell Signal 19: 2498-2506.
    • (2007) Cell Signal , vol.19 , pp. 2498-2506
    • Kawasaki, A.1    Torii, K.2    Yamashita, Y.3    Nishizawa, K.4    Kanekura, K.5    Katada, M.6
  • 67
    • 34447502405 scopus 로고    scopus 로고
    • Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling
    • Kemp CR, Willems E, Wawrzak D, Hendrickx M, Agbor Agbor T, Leyns L, (2007). Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling. Dev Dyn 236: 2011-2019.
    • (2007) Dev Dyn , vol.236 , pp. 2011-2019
    • Kemp, C.R.1    Willems, E.2    Wawrzak, D.3    Hendrickx, M.4    Agbor Agbor, T.5    Leyns, L.6
  • 68
    • 78650414896 scopus 로고    scopus 로고
    • WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins
    • Kilander MB, Dijksterhuis JP, Ganji RS, Bryja V, Schulte G, (2011a). WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins. Cell Signal 23: 550-554.
    • (2011) Cell Signal , vol.23 , pp. 550-554
    • Kilander, M.B.1    Dijksterhuis, J.P.2    Ganji, R.S.3    Bryja, V.4    Schulte, G.5
  • 69
    • 80054003106 scopus 로고    scopus 로고
    • Recombinant WNTs differentially activate beta-catenin-dependent and -independent signalling in mouse microglia-like cells
    • Kilander MB, Halleskog C, Schulte G, (2011b). Recombinant WNTs differentially activate beta-catenin-dependent and -independent signalling in mouse microglia-like cells. Acta Physiol (Oxf) 203: 363-372.
    • (2011) Acta Physiol (Oxf) , vol.203 , pp. 363-372
    • Kilander, M.B.1    Halleskog, C.2    Schulte, G.3
  • 70
    • 40949086754 scopus 로고    scopus 로고
    • Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells
    • Kim M, Lee HC, Tsedensodnom O, Hartley R, Lim YS, Yu E, et al. (2008). Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 48: 780-791.
    • (2008) J Hepatol , vol.48 , pp. 780-791
    • Kim, M.1    Lee, H.C.2    Tsedensodnom, O.3    Hartley, R.4    Lim, Y.S.5    Yu, E.6
  • 71
    • 84856209607 scopus 로고    scopus 로고
    • Frizzled7 as an emerging target for cancer therapy
    • King TD, Zhang W, Suto MJ, Li Y, (2012). Frizzled7 as an emerging target for cancer therapy. Cell Signal 24: 846-851.
    • (2012) Cell Signal , vol.24 , pp. 846-851
    • King, T.D.1    Zhang, W.2    Suto, M.J.3    Li, Y.4
  • 72
    • 40949117599 scopus 로고    scopus 로고
    • Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway
    • Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, et al. (2008). Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 47: 1018-1031.
    • (2008) Hepatology , vol.47 , pp. 1018-1031
    • Klein, D.1    Demory, A.2    Peyre, F.3    Kroll, J.4    Augustin, H.G.5    Helfrich, W.6
  • 73
    • 84869424345 scopus 로고    scopus 로고
    • Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells
    • Kolben T, Perobner I, Fernsebner K, Lechner F, Geissler C, Ruiz-Heinrich L, et al. (2012). Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells. Biol Chem 393: 1433-1447.
    • (2012) Biol Chem , vol.393 , pp. 1433-1447
    • Kolben, T.1    Perobner, I.2    Fernsebner, K.3    Lechner, F.4    Geissler, C.5    Ruiz-Heinrich, L.6
  • 74
    • 78751483422 scopus 로고    scopus 로고
    • Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins
    • Koval A, Katanaev VL, (2011). Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins. Biochem J 433: 435-440.
    • (2011) Biochem J , vol.433 , pp. 435-440
    • Koval, A.1    Katanaev, V.L.2
  • 75
    • 84870326949 scopus 로고    scopus 로고
    • Platforms for high-throughput screening of Wnt/Frizzled antagonists
    • Koval A, Katanaev VL, (2012). Platforms for high-throughput screening of Wnt/Frizzled antagonists. Drug Discov Today 17: 1316-1322.
    • (2012) Drug Discov Today , vol.17 , pp. 1316-1322
    • Koval, A.1    Katanaev, V.L.2
  • 76
    • 72049122388 scopus 로고    scopus 로고
    • Europium-labeled GTP as a general nonradioactive substitute for [(35)S]GTPgammaS in high-throughput G protein studies
    • Koval A, Kopein D, Purvanov V, Katanaev VL, (2010). Europium-labeled GTP as a general nonradioactive substitute for [(35)S]GTPgammaS in high-throughput G protein studies. Anal Biochem 397: 202-207.
    • (2010) Anal Biochem , vol.397 , pp. 202-207
    • Koval, A.1    Kopein, D.2    Purvanov, V.3    Katanaev, V.L.4
  • 77
    • 80054685356 scopus 로고    scopus 로고
    • Yellow submarine of the Wnt/Frizzled signaling: Submerging from the G protein harbor to the targets
    • Koval A, Purvanov V, Egger-Adam D, Katanaev VL, (2011). Yellow submarine of the Wnt/Frizzled signaling: submerging from the G protein harbor to the targets. Biochem Pharmacol 82: 1311-1319.
    • (2011) Biochem Pharmacol , vol.82 , pp. 1311-1319
    • Koval, A.1    Purvanov, V.2    Egger-Adam, D.3    Katanaev, V.L.4
  • 79
    • 0034214847 scopus 로고    scopus 로고
    • The Wnt/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape
    • Kuhl M, Sheldahl LC, Park M, Miller JR, Moon RT, (2000). The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 16: 279-283.
    • (2000) Trends Genet , vol.16 , pp. 279-283
    • Kuhl, M.1    Sheldahl, L.C.2    Park, M.3    Miller, J.R.4    Moon, R.T.5
  • 80
    • 79960123794 scopus 로고    scopus 로고
    • A Wnt1 regulated Frizzled-1/beta-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
    • L'Episcopo F, Serapide MF, Tirolo C, Testa N, Caniglia S, Morale MC, et al. (2011). A Wnt1 regulated Frizzled-1/beta-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegener 6: 49.
    • (2011) Mol Neurodegener , vol.6 , pp. 49
    • L'Episcopo, F.1    Serapide, M.F.2    Tirolo, C.3    Testa, N.4    Caniglia, S.5    Morale, M.C.6
  • 81
    • 66049092616 scopus 로고    scopus 로고
    • Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells
    • Le Grand F, Jones AE, Seale V, Scime A, Rudnicki MA, (2009). Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell 4: 535-547.
    • (2009) Cell Stem Cell , vol.4 , pp. 535-547
    • Le Grand, F.1    Jones, A.E.2    Seale, V.3    Scime, A.4    Rudnicki, M.A.5
  • 82
    • 80051772933 scopus 로고    scopus 로고
    • WNT5A signaling contributes to Abeta-induced neuroinflammation and neurotoxicity
    • Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ, (2011). WNT5A signaling contributes to Abeta-induced neuroinflammation and neurotoxicity. PLoS ONE 6: e22920.
    • (2011) PLoS ONE , vol.6
    • Li, B.1    Zhong, L.2    Yang, X.3    Andersson, T.4    Huang, M.5    Tang, S.J.6
  • 83
    • 39849091185 scopus 로고    scopus 로고
    • Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
    • Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, et al. (2008). Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol 9: 11.
    • (2008) BMC Mol Biol , vol.9 , pp. 11
    • Li, C.1    Chen, H.2    Hu, L.3    Xing, Y.4    Sasaki, T.5    Villosis, M.F.6
  • 84
    • 0037039162 scopus 로고    scopus 로고
    • Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis
    • Lisovsky M, Itoh K, Sokol SY, (2002). Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis. Curr Biol 12: 53-58.
    • (2002) Curr Biol , vol.12 , pp. 53-58
    • Lisovsky, M.1    Itoh, K.2    Sokol, S.Y.3
  • 85
    • 45949098158 scopus 로고    scopus 로고
    • An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus
    • Liu C, Wang Y, Smallwood PM, Nathans J, (2008). An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci 28: 5641-5653.
    • (2008) J Neurosci , vol.28 , pp. 5641-5653
    • Liu, C.1    Wang, Y.2    Smallwood, P.M.3    Nathans, J.4
  • 86
    • 0033585001 scopus 로고    scopus 로고
    • Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function
    • Liu T, Liu X, Wang H, Moon RT, Malbon CC, (1999). Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function. J Biol Chem 274: 33539-33544.
    • (1999) J Biol Chem , vol.274 , pp. 33539-33544
    • Liu, T.1    Liu, X.2    Wang, H.3    Moon, R.T.4    Malbon, C.C.5
  • 87
    • 0035368394 scopus 로고    scopus 로고
    • G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway
    • Liu T, DeCostanzo AJ, Liu X, Wang H, Hallagan S, Moon RT, et al. (2001). G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway. Science 292: 1718-1722.
    • (2001) Science , vol.292 , pp. 1718-1722
    • Liu, T.1    Decostanzo, A.J.2    Liu, X.3    Wang, H.4    Hallagan, S.5    Moon, R.T.6
  • 88
    • 27844516613 scopus 로고    scopus 로고
    • Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins
    • Liu X, Rubin JS, Kimmel AR, (2005). Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol 15: 1989-1997.
    • (2005) Curr Biol , vol.15 , pp. 1989-1997
    • Liu, X.1    Rubin, J.S.2    Kimmel, A.R.3
  • 89
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R, (2004). The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20: 781-810.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 91
    • 27244446782 scopus 로고    scopus 로고
    • Role of the Norrie disease pseudoglioma gene in sprouting angiogenesis during development of the retinal vasculature
    • Luhmann UF, Lin J, Acar N, Lammel S, Feil S, Grimm C, et al. (2005). Role of the Norrie disease pseudoglioma gene in sprouting angiogenesis during development of the retinal vasculature. Invest Ophthalmol Vis Sci 46: 3372-3382.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 3372-3382
    • Luhmann, U.F.1    Lin, J.2    Acar, N.3    Lammel, S.4    Feil, S.5    Grimm, C.6
  • 92
    • 3242681470 scopus 로고    scopus 로고
    • Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: Functional implications of Wnt/beta-catenin activity in kidney epithelial cells
    • Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, et al. (2004). Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp Cell Res 298: 369-387.
    • (2004) Exp Cell Res , vol.298 , pp. 369-387
    • Lyons, J.P.1    Mueller, U.W.2    Ji, H.3    Everett, C.4    Fang, X.5    Hsieh, J.C.6
  • 93
    • 33750047472 scopus 로고    scopus 로고
    • Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway
    • Ma L, Wang HY, (2006). Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway. J Biol Chem 281: 30990-31001.
    • (2006) J Biol Chem , vol.281 , pp. 30990-31001
    • Ma, L.1    Wang, H.Y.2
  • 94
    • 84870727005 scopus 로고    scopus 로고
    • Frizzled and LRP5/6 receptors for Wnt/beta-catenin signaling
    • MacDonald BT, He X, (2012). Frizzled and LRP5/6 receptors for Wnt/beta-catenin signaling. Cold Spring Harb Perspect Biol 4: a007880.
    • (2012) Cold Spring Harb Perspect Biol , vol.4
    • MacDonald, B.T.1    He, X.2
  • 95
    • 36849055111 scopus 로고    scopus 로고
    • SnapShot: Wnt/beta-catenin signaling
    • Macdonald BT, Semenov MV, He X, (2007). SnapShot: Wnt/beta-catenin signaling. Cell 131: 1204.
    • (2007) Cell , vol.131 , pp. 1204
    • Macdonald, B.T.1    Semenov, M.V.2    He, X.3
  • 96
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X, (2009). Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 97
    • 84856500662 scopus 로고    scopus 로고
    • Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle
    • von Maltzahn J, Bentzinger CF, Rudnicki MA, (2012). Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle. Nat Cell Biol 14: 186-191.
    • (2012) Nat Cell Biol , vol.14 , pp. 186-191
    • Von Maltzahn, J.1    Bentzinger, C.F.2    Rudnicki, M.A.3
  • 98
    • 33845398385 scopus 로고    scopus 로고
    • Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2
    • Masckauchan TN, Agalliu D, Vorontchikhina M, Ahn A, Parmalee NL, Li CM, et al. (2006). Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell 17: 5163-5172.
    • (2006) Mol Biol Cell , vol.17 , pp. 5163-5172
    • Masckauchan, T.N.1    Agalliu, D.2    Vorontchikhina, M.3    Ahn, A.4    Parmalee, N.L.5    Li, C.M.6
  • 99
    • 84856328262 scopus 로고    scopus 로고
    • Regulation of focal adhesion dynamics by Wnt5a signaling
    • Matsumoto S, Kikuchi A, (2012). Regulation of focal adhesion dynamics by Wnt5a signaling. Methods Mol Biol 839: 215-227.
    • (2012) Methods Mol Biol , vol.839 , pp. 215-227
    • Matsumoto, S.1    Kikuchi, A.2
  • 100
    • 84880169315 scopus 로고    scopus 로고
    • Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling
    • Miao CG, Yang YY, He X, Li XF, Huang C, Huang Y, et al. (2013). Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling. Cell Signal 25: 2069-2078.
    • (2013) Cell Signal , vol.25 , pp. 2069-2078
    • Miao, C.G.1    Yang, Y.Y.2    He, X.3    Li, X.F.4    Huang, C.5    Huang, Y.6
  • 101
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context
    • Mikels AJ, Nusse R, (2006). Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol 4: e115.
    • (2006) PLoS Biol , vol.4
    • Mikels, A.J.1    Nusse, R.2
  • 104
    • 78751578854 scopus 로고    scopus 로고
    • Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma
    • Nambotin SB, Lefrancois L, Sainsily X, Berthillon P, Kim M, Wands JR, et al. (2011). Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma. J Hepatol 54: 288-299.
    • (2011) J Hepatol , vol.54 , pp. 288-299
    • Nambotin, S.B.1    Lefrancois, L.2    Sainsily, X.3    Berthillon, P.4    Kim, M.5    Wands, J.R.6
  • 105
    • 84860328433 scopus 로고    scopus 로고
    • FZD6 encoding the Wnt receptor frizzled 6 is mutated in autosomal-recessive nail dysplasia
    • Naz G, Pasternack SM, Perrin C, Mattheisen M, Refke M, Khan S, et al. (2012). FZD6 encoding the Wnt receptor frizzled 6 is mutated in autosomal-recessive nail dysplasia. Br J Dermatol 166: 1088-1094.
    • (2012) Br J Dermatol , vol.166 , pp. 1088-1094
    • Naz, G.1    Pasternack, S.M.2    Perrin, C.3    Mattheisen, M.4    Refke, M.5    Khan, S.6
  • 106
    • 0036490096 scopus 로고    scopus 로고
    • Regulators of G-protein signalling as new central nervous system drug targets
    • Neubig RR, Siderovski DP, (2002). Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov 1: 187-197.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 187-197
    • Neubig, R.R.1    Siderovski, D.P.2
  • 107
    • 78649828281 scopus 로고    scopus 로고
    • Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages
    • Neumann J, Schaale K, Farhat K, Endermann T, Ulmer AJ, Ehlers S, et al. (2010). Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages. FASEB J 24: 4599-4612.
    • (2010) FASEB J , vol.24 , pp. 4599-4612
    • Neumann, J.1    Schaale, K.2    Farhat, K.3    Endermann, T.4    Ulmer, A.J.5    Ehlers, S.6
  • 108
    • 1842640504 scopus 로고    scopus 로고
    • Analysis of Fz10 expression in mouse embryos
    • Nunnally AP, Parr BA, (2004). Analysis of Fz10 expression in mouse embryos. Dev Genes Evol 214: 144-148.
    • (2004) Dev Genes Evol , vol.214 , pp. 144-148
    • Nunnally, A.P.1    Parr, B.A.2
  • 109
    • 57049085407 scopus 로고    scopus 로고
    • G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
    • Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ, (2008). G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature 456: 967-970.
    • (2008) Nature , vol.456 , pp. 967-970
    • Ogden, S.K.1    Fei, D.L.2    Schilling, N.S.3    Ahmed, Y.F.4    Hwa, J.5    Robbins, D.J.6
  • 110
    • 80052580449 scopus 로고    scopus 로고
    • Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4
    • Ohta K, Ito A, Kuriyama S, Lupo G, Kosaka M, Ohnuma S, et al. (2011). Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4. Proc Natl Acad Sci U S A 108: 14962-14967.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14962-14967
    • Ohta, K.1    Ito, A.2    Kuriyama, S.3    Lupo, G.4    Kosaka, M.5    Ohnuma, S.6
  • 111
    • 51149123490 scopus 로고    scopus 로고
    • Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation
    • Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, et al. (2008). Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science 321: 1350-1353.
    • (2008) Science , vol.321 , pp. 1350-1353
    • Pan, W.1    Choi, S.C.2    Wang, H.3    Qin, Y.4    Volpicelli-Daley, L.5    Swan, L.6
  • 112
    • 0037447932 scopus 로고    scopus 로고
    • Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation
    • Penzo-Mendez A, Umbhauer M, Djiane A, Boucaut JC, Riou JF, (2003). Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev Biol 257: 302-314.
    • (2003) Dev Biol , vol.257 , pp. 302-314
    • Penzo-Mendez, A.1    Umbhauer, M.2    Djiane, A.3    Boucaut, J.C.4    Riou, J.F.5
  • 113
    • 0023797851 scopus 로고
    • Structural and functional relationships of guanosine triphosphate binding proteins
    • Pfeuffer T, Helmreich EJ, (1988). Structural and functional relationships of guanosine triphosphate binding proteins. Curr Top Cell Regul 29: 129-216.
    • (1988) Curr Top Cell Regul , vol.29 , pp. 129-216
    • Pfeuffer, T.1    Helmreich, E.J.2
  • 114
    • 59349106501 scopus 로고    scopus 로고
    • Hedgehog signaling: Is Smo a G protein-coupled receptor?
    • Philipp M, Caron MG, (2009). Hedgehog signaling: is Smo a G protein-coupled receptor? Curr Biol 19: R125-R127.
    • (2009) Curr Biol , vol.19
    • Philipp, M.1    Caron, M.G.2
  • 115
    • 68849124264 scopus 로고    scopus 로고
    • Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins
    • Punchihewa C, Ferreira AM, Cassell R, Rodrigues P, Fujii N, (2009). Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci 18: 994-1002.
    • (2009) Protein Sci , vol.18 , pp. 994-1002
    • Punchihewa, C.1    Ferreira, A.M.2    Cassell, R.3    Rodrigues, P.4    Fujii, N.5
  • 116
    • 0142089889 scopus 로고    scopus 로고
    • Transcriptional regulation of cyclo-oxygenase expression: Three pillars of control
    • Ramsay RG, Ciznadija D, Vanevski M, Mantamadiotis T, (2003). Transcriptional regulation of cyclo-oxygenase expression: three pillars of control. Int J Immunopathol Pharmacol 16 (2 Suppl.): 59-67.
    • (2003) Int J Immunopathol Pharmacol , vol.16 , Issue.2 SUPPL. , pp. 59-67
    • Ramsay, R.G.1    Ciznadija, D.2    Vanevski, M.3    Mantamadiotis, T.4
  • 118
    • 34247857432 scopus 로고    scopus 로고
    • Pathways of signal transduction employed by vertebrate Hedgehogs
    • Riobo NA, Manning DR, (2007). Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J 403: 369-379.
    • (2007) Biochem J , vol.403 , pp. 369-379
    • Riobo, N.A.1    Manning, D.R.2
  • 120
    • 0036789449 scopus 로고    scopus 로고
    • Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
    • Robitaille J, MacDonald ML, Kaykas A, Sheldahl LC, Zeisler J, Dube MP, et al. (2002). Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat Genet 32: 326-330.
    • (2002) Nat Genet , vol.32 , pp. 326-330
    • Robitaille, J.1    MacDonald, M.L.2    Kaykas, A.3    Sheldahl, L.C.4    Zeisler, J.5    Dube, M.P.6
  • 121
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, Yu X, et al. (2001). Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 194: 1639-1647.
    • (2001) J Exp Med , vol.194 , pp. 1639-1647
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3    Simon, R.4    Davis, R.E.5    Yu, X.6
  • 122
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    • Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P, (1996). Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272: 1023-1026.
    • (1996) Science , vol.272 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 123
    • 77953310084 scopus 로고    scopus 로고
    • Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis
    • Sahores M, Gibb A, Salinas PC, (2010). Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. Development 137: 2215-2225.
    • (2010) Development , vol.137 , pp. 2215-2225
    • Sahores, M.1    Gibb, A.2    Salinas, P.C.3
  • 124
    • 0037118064 scopus 로고    scopus 로고
    • The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos
    • Saneyoshi T, Kume S, Amasaki Y, Mikoshiba K, (2002). The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 417: 295-299.
    • (2002) Nature , vol.417 , pp. 295-299
    • Saneyoshi, T.1    Kume, S.2    Amasaki, Y.3    Mikoshiba, K.4
  • 125
    • 75649084593 scopus 로고    scopus 로고
    • Wnt5a regulates distinct signalling pathways by binding to Frizzled2
    • Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A, (2010). Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J 29: 41-54.
    • (2010) EMBO J , vol.29 , pp. 41-54
    • Sato, A.1    Yamamoto, H.2    Sakane, H.3    Koyama, H.4    Kikuchi, A.5
  • 126
    • 78650150896 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors
    • Schulte G, (2010). International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors. Pharmacol Rev 62: 632-667.
    • (2010) Pharmacol Rev , vol.62 , pp. 632-667
    • Schulte, G.1
  • 127
    • 34748812548 scopus 로고    scopus 로고
    • The Frizzled family of unconventional G-protein-coupled receptors
    • Schulte G, Bryja V, (2007). The Frizzled family of unconventional G-protein-coupled receptors. Trends Pharmacol Sci 28: 518-525.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 518-525
    • Schulte, G.1    Bryja, V.2
  • 128
    • 15244360639 scopus 로고    scopus 로고
    • Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation
    • Schulte G, Bryja V, Rawal N, Castelo-Branco G, Sousa KM, Arenas E, (2005). Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. J Neurochem 92: 1550-1553.
    • (2005) J Neurochem , vol.92 , pp. 1550-1553
    • Schulte, G.1    Bryja, V.2    Rawal, N.3    Castelo-Branco, G.4    Sousa, K.M.5    Arenas, E.6
  • 129
    • 29244462476 scopus 로고    scopus 로고
    • The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles
    • Schwarz-Romond T, Merrifield C, Nichols BJ, Bienz M, (2005). The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J Cell Sci 118: 5269-5277.
    • (2005) J Cell Sci , vol.118 , pp. 5269-5277
    • Schwarz-Romond, T.1    Merrifield, C.2    Nichols, B.J.3    Bienz, M.4
  • 130
    • 37349025355 scopus 로고    scopus 로고
    • SnapShot: Noncanonical Wnt signaling pathways
    • Semenov MV, Habas R, Macdonald BT, He X, (2007). SnapShot: noncanonical Wnt signaling pathways. Cell 131: 1378.
    • (2007) Cell , vol.131 , pp. 1378
    • Semenov, M.V.1    Habas, R.2    Macdonald, B.T.3    He, X.4
  • 132
    • 0033166245 scopus 로고    scopus 로고
    • Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner
    • Sheldahl LC, Park M, Malbon CC, Moon RT, (1999). Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr Biol 9: 695-698.
    • (1999) Curr Biol , vol.9 , pp. 695-698
    • Sheldahl, L.C.1    Park, M.2    Malbon, C.C.3    Moon, R.T.4
  • 134
    • 0031456672 scopus 로고    scopus 로고
    • Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling
    • Slusarski DC, Corces VG, Moon RT, (1997a). Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390: 410-413.
    • (1997) Nature , vol.390 , pp. 410-413
    • Slusarski, D.C.1    Corces, V.G.2    Moon, R.T.3
  • 135
    • 0031080919 scopus 로고    scopus 로고
    • Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A
    • Slusarski DC, Yang-Snyder J, Busa WB, Moon RT, (1997b). Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Dev Biol 182: 114-120.
    • (1997) Dev Biol , vol.182 , pp. 114-120
    • Slusarski, D.C.1    Yang-Snyder, J.2    Busa, W.B.3    Moon, R.T.4
  • 136
    • 33748938039 scopus 로고    scopus 로고
    • The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13
    • Stemmle LN, Fields TA, Casey PJ, (2006). The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. Mol Pharmacol 70: 1461-1468.
    • (2006) Mol Pharmacol , vol.70 , pp. 1461-1468
    • Stemmle, L.N.1    Fields, T.A.2    Casey, P.J.3
  • 137
    • 33745637502 scopus 로고    scopus 로고
    • Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila
    • Strutt H, Price MA, Strutt D, (2006). Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. Curr Biol 16: 1329-1336.
    • (2006) Curr Biol , vol.16 , pp. 1329-1336
    • Strutt, H.1    Price, M.A.2    Strutt, D.3
  • 138
    • 84864194496 scopus 로고    scopus 로고
    • Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche
    • Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, et al. (2012). Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell 150: 351-365.
    • (2012) Cell , vol.150 , pp. 351-365
    • Sugimura, R.1    He, X.C.2    Venkatraman, A.3    Arai, F.4    Box, A.5    Semerad, C.6
  • 139
    • 0036483577 scopus 로고    scopus 로고
    • Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT-beta-catenin-TCF signaling pathway
    • Terasaki H, Saitoh T, Shiokawa K, Katoh M, (2002). Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT-beta-catenin-TCF signaling pathway. Int J Mol Med 9: 107-112.
    • (2002) Int J Mol Med , vol.9 , pp. 107-112
    • Terasaki, H.1    Saitoh, T.2    Shiokawa, K.3    Katoh, M.4
  • 140
    • 0043234811 scopus 로고    scopus 로고
    • Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    • Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y, (2003). Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol 162: 899-908.
    • (2003) J Cell Biol , vol.162 , pp. 899-908
    • Topol, L.1    Jiang, X.2    Choi, H.3    Garrett-Beal, L.4    Carolan, P.J.5    Yang, Y.6
  • 141
    • 33845802651 scopus 로고    scopus 로고
    • Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation
    • Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, et al. (2007). Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 12: 113-127.
    • (2007) Dev Cell , vol.12 , pp. 113-127
    • Tu, X.1    Joeng, K.S.2    Nakayama, K.I.3    Nakayama, K.4    Rajagopal, J.5    Carroll, T.J.6
  • 142
    • 0034665045 scopus 로고    scopus 로고
    • The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling
    • Umbhauer M, Djiane A, Goisset C, Penzo-Mendez A, Riou JF, Boucaut JC, et al. (2000). The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J 19: 4944-4954.
    • (2000) EMBO J , vol.19 , pp. 4944-4954
    • Umbhauer, M.1    Djiane, A.2    Goisset, C.3    Penzo-Mendez, A.4    Riou, J.F.5    Boucaut, J.C.6
  • 143
    • 0030067337 scopus 로고    scopus 로고
    • Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties
    • Van de Wetering M, Castrop J, Korinek V, Clevers H, (1996). Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol Cell Biol 16: 745-752.
    • (1996) Mol Cell Biol , vol.16 , pp. 745-752
    • Van De Wetering, M.1    Castrop, J.2    Korinek, V.3    Clevers, H.4
  • 144
    • 84878112106 scopus 로고    scopus 로고
    • Structure of the human smoothened receptor bound to an antitumour agent
    • Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, et al. (2013). Structure of the human smoothened receptor bound to an antitumour agent. Nature 497: 338-343.
    • (2013) Nature , vol.497 , pp. 338-343
    • Wang, C.1    Wu, H.2    Katritch, V.3    Han, G.W.4    Huang, X.P.5    Liu, W.6
  • 145
    • 60149105643 scopus 로고    scopus 로고
    • Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells
    • Wang HX, Tekpetey FR, Kidder GM, (2009). Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol Hum Reprod 15: 11-17.
    • (2009) Mol Hum Reprod , vol.15 , pp. 11-17
    • Wang, H.X.1    Tekpetey, F.R.2    Kidder, G.M.3
  • 146
    • 84866162082 scopus 로고    scopus 로고
    • Dvl3 translocates IPMK to the cell membrane in response to Wnt
    • Wang Y, Wang HY, (2012). Dvl3 translocates IPMK to the cell membrane in response to Wnt. Cell Signal 24: 2389-2395.
    • (2012) Cell Signal , vol.24 , pp. 2389-2395
    • Wang, Y.1    Wang, H.Y.2
  • 147
    • 33845951172 scopus 로고    scopus 로고
    • Order from disorder: Self-organization in mammalian hair patterning
    • Wang Y, Badea T, Nathans J, (2006a). Order from disorder: self-organization in mammalian hair patterning. Proc Natl Acad Sci U S A 103: 19800-19805.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 19800-19805
    • Wang, Y.1    Badea, T.2    Nathans, J.3
  • 148
    • 33645637038 scopus 로고    scopus 로고
    • The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells
    • Wang Y, Guo N, Nathans J, (2006b). The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci 26: 2147-2156.
    • (2006) J Neurosci , vol.26 , pp. 2147-2156
    • Wang, Y.1    Guo, N.2    Nathans, J.3
  • 149
    • 0031043863 scopus 로고    scopus 로고
    • A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23
    • Wang YK, Samos CH, Peoples R, Perez-Jurado LA, Nusse R, Francke U, (1997). A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23. Hum Mol Genet 6: 465-472.
    • (1997) Hum Mol Genet , vol.6 , pp. 465-472
    • Wang, Y.K.1    Samos, C.H.2    Peoples, R.3    Perez-Jurado, L.A.4    Nusse, R.5    Francke, U.6
  • 150
    • 0345034604 scopus 로고    scopus 로고
    • Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome
    • Wang YK, Sporle R, Paperna T, Schughart K, Francke U, (1999). Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics 57: 235-248.
    • (1999) Genomics , vol.57 , pp. 235-248
    • Wang, Y.K.1    Sporle, R.2    Paperna, T.3    Schughart, K.4    Francke, U.5
  • 151
    • 20344377886 scopus 로고    scopus 로고
    • Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5
    • Wang Z, Shu W, Lu MM, Morrisey EE, (2005). Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol 25: 5022-5030.
    • (2005) Mol Cell Biol , vol.25 , pp. 5022-5030
    • Wang, Z.1    Shu, W.2    Lu, M.M.3    Morrisey, E.E.4
  • 152
    • 0032402450 scopus 로고    scopus 로고
    • Molecular basis of receptor/G-protein-coupling selectivity
    • Wess J, (1998). Molecular basis of receptor/G-protein-coupling selectivity. Pharmacol Ther 80: 231-264.
    • (1998) Pharmacol Ther , vol.80 , pp. 231-264
    • Wess, J.1
  • 153
    • 79952488185 scopus 로고    scopus 로고
    • Therapeutic potential of beta-arrestin- and G protein-biased agonists
    • Whalen EJ, Rajagopal S, Lefkowitz RJ, (2011). Therapeutic potential of beta-arrestin- and G protein-biased agonists. Trends Mol Med 17: 126-139.
    • (2011) Trends Mol Med , vol.17 , pp. 126-139
    • Whalen, E.J.1    Rajagopal, S.2    Lefkowitz, R.J.3
  • 156
    • 58749083774 scopus 로고    scopus 로고
    • Isolation and application of bioactive Wnt proteins
    • Willert KH, (2008). Isolation and application of bioactive Wnt proteins. Methods Mol Biol 468: 17-29.
    • (2008) Methods Mol Biol , vol.468 , pp. 17-29
    • Willert, K.H.1
  • 157
    • 0035950183 scopus 로고    scopus 로고
    • Frizzled-7 signalling controls tissue separation during Xenopus gastrulation
    • Winklbauer R, Medina A, Swain RK, Steinbeisser H, (2001). Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature 413: 856-860.
    • (2001) Nature , vol.413 , pp. 856-860
    • Winklbauer, R.1    Medina, A.2    Swain, R.K.3    Steinbeisser, H.4
  • 158
    • 51449094916 scopus 로고    scopus 로고
    • The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling
    • Wu J, Mlodzik M, (2008). The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signaling. Dev Cell 15: 462-469.
    • (2008) Dev Cell , vol.15 , pp. 462-469
    • Wu, J.1    Mlodzik, M.2
  • 159
    • 37549039500 scopus 로고    scopus 로고
    • Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila
    • Wu J, Jenny A, Mirkovic I, Mlodzik M, (2008). Frizzled-Dishevelled signaling specificity outcome can be modulated by Diego in Drosophila. Mech Dev 125: 30-42.
    • (2008) Mech Dev , vol.125 , pp. 30-42
    • Wu, J.1    Jenny, A.2    Mirkovic, I.3    Mlodzik, M.4
  • 160
    • 44349149348 scopus 로고    scopus 로고
    • A model for familial exudative vitreoretinopathy caused by LPR5 mutations
    • Xia CH, Liu H, Cheung D, Wang M, Cheng C, Du X, et al. (2008). A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet 17: 1605-1612.
    • (2008) Hum Mol Genet , vol.17 , pp. 1605-1612
    • Xia, C.H.1    Liu, H.2    Cheung, D.3    Wang, M.4    Cheng, C.5    Du, X.6
  • 161
    • 12144289950 scopus 로고    scopus 로고
    • Vascular development in the retina and inner ear: Control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair
    • Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, et al. (2004). Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116: 883-895.
    • (2004) Cell , vol.116 , pp. 883-895
    • Xu, Q.1    Wang, Y.2    Dabdoub, A.3    Smallwood, P.M.4    Williams, J.5    Woods, C.6
  • 162
    • 58549101669 scopus 로고    scopus 로고
    • Expression of Frizzled10 in mouse central nervous system
    • Yan Y, Li Y, Hu C, Gu X, Liu J, Hu YA, et al. (2009). Expression of Frizzled10 in mouse central nervous system. Gene Expr Patterns 9: 173-177.
    • (2009) Gene Expr Patterns , vol.9 , pp. 173-177
    • Yan, Y.1    Li, Y.2    Hu, C.3    Gu, X.4    Liu, J.5    Hu, Y.A.6
  • 163
    • 80055040407 scopus 로고    scopus 로고
    • FZD7 has a critical role in cell proliferation in triple negative breast cancer
    • Yang L, Wu X, Wang Y, Zhang K, Wu J, Yuan YC, et al. (2011). FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene 30: 4437-4446.
    • (2011) Oncogene , vol.30 , pp. 4437-4446
    • Yang, L.1    Wu, X.2    Wang, Y.3    Zhang, K.4    Wu, J.5    Yuan, Y.C.6
  • 164
    • 84868552930 scopus 로고    scopus 로고
    • Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: Evidence for a network of interacting genes
    • Yu H, Ye X, Guo N, Nathans J, (2012). Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes. Development 139: 4383-4394.
    • (2012) Development , vol.139 , pp. 4383-4394
    • Yu, H.1    Ye, X.2    Guo, N.3    Nathans, J.4
  • 165
    • 79953186674 scopus 로고    scopus 로고
    • An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy
    • Zhang K, Harada Y, Wei X, Shukla D, Rajendran A, Tawansy K, et al. (2011). An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy. J Biol Chem 286: 10210-10215.
    • (2011) J Biol Chem , vol.286 , pp. 10210-10215
    • Zhang, K.1    Harada, Y.2    Wei, X.3    Shukla, D.4    Rajendran, A.5    Tawansy, K.6
  • 166
    • 20444446375 scopus 로고    scopus 로고
    • Frizzled9 protein is regionally expressed in the developing medial cortical wall and the cells derived from this region
    • Zhao C, Pleasure SJ, (2005). Frizzled9 protein is regionally expressed in the developing medial cortical wall and the cells derived from this region. Brain Res Dev Brain Res 157: 93-97.
    • (2005) Brain Res Dev Brain Res , vol.157 , pp. 93-97
    • Zhao, C.1    Pleasure, S.J.2
  • 167
    • 21644448850 scopus 로고    scopus 로고
    • Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval
    • Zhao C, Aviles C, Abel RA, Almli CR, McQuillen P, Pleasure SJ, (2005). Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval. Development 132: 2917-2927.
    • (2005) Development , vol.132 , pp. 2917-2927
    • Zhao, C.1    Aviles, C.2    Abel, R.A.3    Almli, C.R.4    McQuillen, P.5    Pleasure, S.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.