-
1
-
-
0027531638
-
Expression cloning and signaling properties of the rat glucagon receptor
-
Jelinek LJ, et al. (1993) Expression cloning and signaling properties of the rat glucagon receptor. Science 259:1614-1616. (Pubitemid 23114641)
-
(1993)
Science
, vol.259
, Issue.5101
, pp. 1614-1616
-
-
Jelinek, L.J.1
Lok, S.2
Rosenberg, G.B.3
Smith, R.A.4
Grant, F.J.5
Biggs, S.6
Bensch, P.A.7
Kuijper, J.L.8
Sheppard, P.O.9
Sprecher, C.A.10
O'Hara, P.J.11
Foster, D.12
Walker, K.M.13
Chen, L.H.J.14
McKernan, P.A.15
Kindsvogel, W.16
-
2
-
-
84855459920
-
Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
-
Unger RH, Cherrington AD (2012) Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover. J Clin Invest 122:4-12.
-
(2012)
J Clin Invest
, vol.122
, pp. 4-12
-
-
Unger, R.H.1
Cherrington, A.D.2
-
3
-
-
4644301168
-
Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists
-
DOI 10.1016/j.ejphar.2004.08.023, PII S0014299904009355
-
Dallas-Yang Q, et al. (2004) Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists. Eur J Pharmacol 501:225-234. (Pubitemid 39298956)
-
(2004)
European Journal of Pharmacology
, vol.501
, Issue.1-3
, pp. 225-234
-
-
Dallas-Yang, Q.1
Shen, X.2
Strowski, M.3
Brady, E.4
Saperstein, R.5
Gibson, R.E.6
Szalkowski, D.7
Qureshi, S.A.8
Candelore, M.R.9
Fenyk-Melody, J.E.10
Parmee, E.R.11
Zhang, B.B.12
Jiang, G.13
-
4
-
-
0000261609
-
Synthetic peptide antagonists of glucagon
-
DOI 10.1073/pnas.84.12.4083
-
Unson CG, Andreu D, Gurzenda EM, Merrifield RB (1987) Synthetic peptide antagonists of glucagon. Proc Natl Acad Sci USA 84:4083-4087. (Pubitemid 17090879)
-
(1987)
Proceedings of the National Academy of Sciences of the United States of America
, vol.84
, Issue.12
, pp. 4083-4087
-
-
Unson, C.G.1
Andreu, D.2
Gurzenda, E.M.3
Merrifield, R.B.4
-
5
-
-
0035195977
-
Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
-
DOI 10.1007/s001250100006
-
Petersen KF, Sullivan JT (2001) Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia 44: 2018-2024. (Pubitemid 33124047)
-
(2001)
Diabetologia
, vol.44
, Issue.11
, pp. 2018-2024
-
-
Petersen, K.F.1
Sullivan, J.T.2
-
6
-
-
85047693695
-
Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
-
DOI 10.1172/JCI200420911
-
Sloop KW, et al. (2004) Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors. J Clin Invest 113: 1571-1581. (Pubitemid 39071680)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.11
, pp. 1571-1581
-
-
Sloop, K.W.1
Cao, J.X.-C.2
Siesky, A.M.3
Zhang, H.Y.4
Bodenmiller, D.M.5
Cox, A.L.6
Jacobs, S.J.7
Moyers, J.S.8
Owens, R.A.9
Showalter, A.D.10
Brenner, M.B.11
Raap, A.12
Gromada, J.13
Berridge, B.R.14
Monteith, D.K.B.15
Porksen, N.16
McKay, R.A.17
Monia, B.P.18
Bhanot, S.19
Watts, L.M.20
Michael, M.D.21
more..
-
7
-
-
73349089955
-
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia
-
Gu W, et al. (2009) Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia. J Pharmacol Exp Ther 331:871-881.
-
(2009)
J Pharmacol Exp Ther
, vol.331
, pp. 871-881
-
-
Gu, W.1
-
8
-
-
63849296798
-
Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys
-
Yan H, et al. (2009) Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J Pharmacol Exp Ther 329:102-111.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 102-111
-
-
Yan, H.1
-
9
-
-
0028848010
-
A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus
-
Hager J, et al. (1995) A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Nat Genet 9:299-304.
-
(1995)
Nat Genet
, vol.9
, pp. 299-304
-
-
Hager, J.1
-
10
-
-
70350666371
-
Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor
-
Zhou C, Dhall D, Nissen NN, Chen CR, Yu R (2009) Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor. Pancreas 38:941-946.
-
(2009)
Pancreas
, vol.38
, pp. 941-946
-
-
Zhou, C.1
Dhall, D.2
Nissen, N.N.3
Chen, C.R.4
Yu, R.5
-
11
-
-
0030025597
-
Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding
-
DOI 10.1073/pnas.93.1.310
-
Unson CG, et al. (1996) Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding. Proc Natl Acad Sci USA 93:310-315. (Pubitemid 26038149)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.1
, pp. 310-315
-
-
Unson, C.G.1
Cypess, A.M.2
Wu, C.-R.3
Goldsmith, P.K.4
Merrifield, R.B.5
Sakmar, T.P.6
-
12
-
-
0037349103
-
Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity
-
DOI 10.1038/sj.bjp.0705120
-
Runge S, Wulff BS, Madsen K, Bräuner-Osborne H, Knudsen LB (2003) Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity. Br J Pharmacol 138:787-794. (Pubitemid 36390634)
-
(2003)
British Journal of Pharmacology
, vol.138
, Issue.5
, pp. 787-794
-
-
Runge, S.1
Wulff, B.S.2
Madsen, K.3
Brauner-Osborne, H.4
Knudsen, L.B.5
-
13
-
-
0346463044
-
Importance of the amino terminus in secretin family G protein-coupled receptors: Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor
-
DOI 10.1074/jbc.M305719200
-
Dong M, Pinon DI, Cox RF, Miller LJ (2004) Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptor. J Biol Chem 279:1167-1175. (Pubitemid 38082639)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.2
, pp. 1167-1175
-
-
Dong, M.1
Pinon, D.I.2
Cox, R.F.3
Miller, L.J.4
-
14
-
-
67149136711
-
Passing the baton in class B GPCRs: Peptide hormone activation via helix induction?
-
Parthier C, Reedtz-Runge S, Rudolph R, Stubbs MT (2009) Passing the baton in class B GPCRs: Peptide hormone activation via helix induction? Trends Biochem Sci 34: 303-310.
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 303-310
-
-
Parthier, C.1
Reedtz-Runge, S.2
Rudolph, R.3
Stubbs, M.T.4
-
15
-
-
78651411166
-
Structure of a nanobody-stabilized active state of the β(2) adrenoceptor
-
Rasmussen SG, et al. (2011) Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature 469:175-180.
-
(2011)
Nature
, vol.469
, pp. 175-180
-
-
Rasmussen, S.G.1
-
16
-
-
4444351153
-
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor
-
DOI 10.1073/pnas.0404702101
-
Grace CR, et al. (2004) NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Proc Natl Acad Sci USA 101:12836-12841. (Pubitemid 39167545)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.35
, pp. 12836-12841
-
-
Grace, C.R.R.1
Perrin, M.H.2
DiGruccio, M.R.3
Miller, C.L.4
Rivier, J.E.5
Vale, W.W.6
Riek, R.7
-
17
-
-
57749102733
-
Molecular recognition of corticotropin- releasing factor by its G-protein-coupled receptor CRFR1
-
Pioszak AA, Parker NR, Suino-Powell K, Xu HE (2008) Molecular recognition of corticotropin- releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem 283: 32900-32912.
-
(2008)
J Biol Chem
, vol.283
, pp. 32900-32912
-
-
Pioszak, A.A.1
Parker, N.R.2
Suino-Powell, K.3
Xu, H.E.4
-
19
-
-
45549086826
-
Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
-
Runge S, Thøgersen H, Madsen K, Lau J, Rudolph R (2008) Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem 283: 11340-11347.
-
(2008)
J Biol Chem
, vol.283
, pp. 11340-11347
-
-
Runge, S.1
Thøgersen, H.2
Madsen, K.3
Lau, J.4
Rudolph, R.5
-
20
-
-
73649107900
-
Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor
-
Underwood CR, et al. (2010) Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. J Biol Chem 285:723-730.
-
(2010)
J Biol Chem
, vol.285
, pp. 723-730
-
-
Underwood, C.R.1
-
21
-
-
34249944220
-
S
-
DOI 10.1073/pnas.0611397104
-
Sun C, et al. (2007) Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. Proc Natl Acad Sci USA 104:7875-7880. (Pubitemid 47185844)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.19
, pp. 7875-7880
-
-
Sun, C.1
Song, D.2
Davis-Taber, R.A.3
Barrett, L.W.4
Scott, V.E.5
Richardson, P.L.6
Pereda-Lopez, A.7
Uchic, M.E.8
Solomon, L.R.9
Lake, M.R.10
Walter, K.A.11
Hajduk, P.J.12
Olejniczak, E.T.13
-
22
-
-
79956281483
-
Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors
-
Kumar S, Pioszak A, Zhang C, Swaminathan K, Xu HE (2011) Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors. PLoS ONE 6:e19682.
-
(2011)
PLoS ONE
, vol.6
-
-
Kumar, S.1
Pioszak, A.2
Zhang, C.3
Swaminathan, K.4
Xu, H.E.5
-
23
-
-
77956336134
-
Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism
-
ter Haar E, et al. (2010) Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure 18:1083-1093.
-
(2010)
Structure
, vol.18
, pp. 1083-1093
-
-
Ter Haar, E.1
-
24
-
-
0028046153
-
Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding
-
Carruthers CJ, Unson CG, Kim HN, Sakmar TP (1994) Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding. J Biol Chem 269:29321-29328.
-
(1994)
J Biol Chem
, vol.269
, pp. 29321-29328
-
-
Carruthers, C.J.1
Unson, C.G.2
Kim, H.N.3
Sakmar, T.P.4
-
25
-
-
77957282717
-
Mutational and cysteine scanning analysis of the glucagon receptor N-terminal domain
-
Prévost M, et al. (2010) Mutational and cysteine scanning analysis of the glucagon receptor N-terminal domain. J Biol Chem 285:30951-30958.
-
(2010)
J Biol Chem
, vol.285
, pp. 30951-30958
-
-
Prévost, M.1
-
26
-
-
0016709043
-
X-ray analysis of glucagon and its relationship to receptor binding
-
Sasaki K, Dockerill S, Adamiak DA, Tickle IJ, Blundell T (1975) X-ray analysis of glucagon and its relationship to receptor binding. Nature 257:751-757.
-
(1975)
Nature
, vol.257
, pp. 751-757
-
-
Sasaki, K.1
Dockerill, S.2
Adamiak, D.A.3
Tickle, I.J.4
Blundell, T.5
-
27
-
-
79751495037
-
Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action
-
Day JW, et al. (2011) Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action. J Pept Sci 17:218-225.
-
(2011)
J Pept Sci
, vol.17
, pp. 218-225
-
-
Day, J.W.1
-
28
-
-
0027297275
-
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
-
Lefkowitz RJ, Cotecchia S, Samama P, Costa T (1993) Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol Sci 14:303-307. (Pubitemid 23242583)
-
(1993)
Trends in Pharmacological Sciences
, vol.14
, Issue.8
, pp. 303-307
-
-
Lefkowitz, R.J.1
Cotecchia, S.2
Samama, P.3
Costa, T.4
-
29
-
-
0036468505
-
Mechanisms of inverse agonism at G-protein-coupled receptors
-
Strange PG (2002) Mechanisms of inverse agonism at G-protein-coupled receptors. Trends Pharmacol Sci 23:89-95.
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 89-95
-
-
Strange, P.G.1
-
30
-
-
0027236844
-
Molecular basis of the little mouse phenotype and implications for cell type-specific growth
-
Lin SC, et al. (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature 364:208-213.
-
(1993)
Nature
, vol.364
, pp. 208-213
-
-
Lin, S.C.1
-
31
-
-
0027265595
-
GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
-
DOI 10.1038/ng0793-227
-
Godfrey P, et al. (1993) GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet 4:227-232. (Pubitemid 23205169)
-
(1993)
Nature Genetics
, vol.4
, Issue.3
, pp. 227-232
-
-
Godfrey, P.1
Rahal, J.O.2
Beamer, W.G.3
Copeland, N.G.4
Jenkins, N.A.5
Mayo, K.E.6
-
32
-
-
80051801366
-
Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function
-
Barwell J, Conner A, Poyner DR (2011) Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. Biochim Biophys Acta 1813:1906-1916.
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 1906-1916
-
-
Barwell, J.1
Conner, A.2
Poyner, D.R.3
-
33
-
-
66249144426
-
The structure and function of G-protein- coupled receptors
-
Rosenbaum DM, Rasmussen SG, Kobilka BK (2009) The structure and function of G-protein- coupled receptors. Nature 459:356-363.
-
(2009)
Nature
, vol.459
, pp. 356-363
-
-
Rosenbaum, D.M.1
Rasmussen, S.G.2
Kobilka, B.K.3
-
34
-
-
0035800850
-
Activation of the β-2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
-
Ballesteros JA, et al. (2001) Activation of the β-2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J Biol Chem 276:29171-29177.
-
(2001)
J Biol Chem
, vol.276
, pp. 29171-29177
-
-
Ballesteros, J.A.1
-
35
-
-
3042628452
-
The activation mechanism of class-C G-protein coupled receptors
-
Pin JP, et al. (2004) The activation mechanism of class-C G-protein coupled receptors. Biol Cell 96:335-342.
-
(2004)
Biol Cell
, vol.96
, pp. 335-342
-
-
Pin, J.P.1
-
36
-
-
84857254248
-
Crystal structure of a lipid G protein-coupled receptor
-
Hanson MA, et al. (2012) Crystal structure of a lipid G protein-coupled receptor. Science 335:851- 855.
-
(2012)
Science
, vol.335
, pp. 851-855
-
-
Hanson, M.A.1
|