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Angewandte Chemie - International Edition

Volumn 55, Issue 40, 2016, Pages 12475-12478

Multifunctional Antibody Agonists Targeting Glucagon-like Peptide-1, Glucagon, and Glucose-Dependent Insulinotropic Polypeptide Receptors

(15) Wang, Ying a Du, Jintang a Zou, Huafei a Liu, Yan a Zhang, Yuhan a Gonzalez, Jose a Chao, Elizabeth a Lu, Lucy a Yang, Pengyu a Parker, Holly a Nguyen Tran, Van a Shen, Weijun a Wang, Danling a Schultz, Peter G a Wang, Feng a

a California Institute for Biomedical Research (United States)

Author keywords

antibodies; dual agonists; obesity; peptides; protein engineering

Indexed keywords

ANTIBODIES; GLUCOSE; MAMMALS; SYSTEM THEORY;

DUAL AGONISTS; FUSION PROTEINS; GLUCAGON-LIKE PEPTIDE-1; GLUCOSE CONTROL; OBESITY; PAIR-WISE COMBINATIONS; PEPTIDE HORMONES; PROTEIN ENGINEERING;

PEPTIDES;

ANTIBODY; FUSION PROTEIN; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; HORMONE RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PEPTIDE;

AGONISTS; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; CHEMISTRY; DRUG EFFECT; FEMALE; GENETICS; HALF LIFE TIME; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; MOUSE MUTANT; PROTEIN ENGINEERING; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIBODIES; BODY WEIGHT; FEMALE; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; HALF-LIFE; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MICE; MICE, OBESE; PEPTIDES; PROTEIN ENGINEERING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GASTROINTESTINAL HORMONE; RECOMBINANT FUSION PROTEINS;

EID: 84990193084 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201606321 Document Type: Article

Times cited : (20)

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