메뉴 건너뛰기




Volumn 97, Issue 4, 2015, Pages 347-361

Targeted Delivery of Protein and Gene Medicines Through the Blood–Brain Barrier

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL PRODUCT; RECOMBINANT PROTEIN;

EID: 84929138470     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/CPT.18     Document Type: Article
Times cited : (108)

References (75)
  • 1
    • 0344076149 scopus 로고    scopus 로고
    • The BDNF Study Group. A controlled trial of recombinant methionyl human BDNF in ALS (Phase III)
    • The BDNF Study Group. A controlled trial of recombinant methionyl human BDNF in ALS (Phase III). Neurology 52, 1427–1433 (1999).
    • (1999) Neurology , vol.52 , pp. 1427-1433
  • 2
    • 9044219848 scopus 로고    scopus 로고
    • A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis
    • Miller, R.G. et al. A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group. Ann. Neurol. 39, 256–260 (1996).
    • (1996) Ann. Neurol. , vol.39 , pp. 256-260
    • Miller, R.G.1
  • 3
    • 0029928170 scopus 로고    scopus 로고
    • Permeability at the blood-brain and bloodnerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF
    • Poduslo, J.F. & Curran, G.L. Permeability at the blood-brain and bloodnerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Brain Res. Mol. Brain Res. 36, 280–286 (1996).
    • (1996) Brain Res. Mol. Brain Res. , vol.36 , pp. 280-286
    • Poduslo, J.F.1    Curran, G.L.2
  • 4
    • 34250658083 scopus 로고    scopus 로고
    • Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS
    • Garbuzova-Davis, S. et al. Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS. Brain Res. 1157, 126–137 (2007).
    • (2007) Brain Res , vol.1157 , pp. 126-137
    • Garbuzova-Davis, S.1
  • 5
    • 0036968150 scopus 로고    scopus 로고
    • Fiblast (trafermin) in acute stroke: Results of the European-Australian phase II/III safety and efficacy trial
    • Bogousslavsky, J. et al. Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial. Cerebrovasc. Dis. 14, 239–251 (2002).
    • (2002) Cerebrovasc. Dis. , vol.14 , pp. 239-251
    • Bogousslavsky, J.1
  • 6
    • 0028791689 scopus 로고
    • Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats
    • Fisher, M. et al. Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 15, 953– 959 (1995).
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 953-959
    • Fisher, M.1
  • 8
    • 0030580410 scopus 로고    scopus 로고
    • Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats
    • Belayev, L., Busto, R., Zhao, W. & Ginsberg, M.D. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 739, 88–96 (1996).
    • (1996) Brain Res , vol.739 , pp. 88-96
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Ginsberg, M.D.4
  • 9
    • 0037435511 scopus 로고    scopus 로고
    • Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    • Nutt, J.G. et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60, 69–73 (2003).
    • (2003) Neurology , vol.60 , pp. 69-73
    • Nutt, J.G.1
  • 10
    • 0027969192 scopus 로고
    • The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor
    • Yan, Q., Matheson, C., Lopez, O.T. & Miller, J.A. The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor. J. Neurosci. 14, 5281–5291 (1994).
    • (1994) J. Neurosci. , vol.14 , pp. 5281-5291
    • Yan, Q.1    Matheson, C.2    Lopez, O.T.3    Miller, J.A.4
  • 11
    • 84868573143 scopus 로고    scopus 로고
    • Drug transport across the blood-brain barrier
    • Pardridge, W.M. Drug transport across the blood-brain barrier. J. Cereb. Blood Flow. Metab. 32, 1959–1972 (2012).
    • (2012) J. Cereb. Blood Flow. Metab. , vol.32 , pp. 1959-1972
    • Pardridge, W.M.1
  • 12
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    • Lang, A.E. et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann. Neurol. 59, 459–466 (2006).
    • (2006) Ann. Neurol. , vol.59 , pp. 459-466
    • Lang, A.E.1
  • 13
    • 33750609664 scopus 로고    scopus 로고
    • Point source concentration of GDNF may explain failure of phase II clinical trial
    • Salvatore, M.F. et al. Point source concentration of GDNF may explain failure of phase II clinical trial. Exp. Neurol. 202, 497–505 (2006).
    • (2006) Exp. Neurol. , vol.202 , pp. 497-505
    • Salvatore, M.F.1
  • 14
    • 70949095435 scopus 로고    scopus 로고
    • Recombinant human erythropoietin in the treatment of acute ischemic stroke
    • Ehrenreich, H. et al. Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke 40, e647–e656 (2009).
    • (2009) Stroke , vol.40 , pp. e647-e656
    • Ehrenreich, H.1
  • 15
    • 8844236181 scopus 로고    scopus 로고
    • Passage of erythropoietic agents across the blood-brain barrier: A comparison of human and murine erythropoietin and the analog darbepoetin alfa
    • Banks, W.A., Jumbe, N.L., Farrell, C.L., Niehoff, M.L. & Heatherington, A.C. Passage of erythropoietic agents across the blood-brain barrier: a comparison of human and murine erythropoietin and the analog darbepoetin alfa. Eur. J. Pharmacol. 505, 93–101 (2004).
    • (2004) Eur. J. Pharmacol. , vol.505 , pp. 93-101
    • Banks, W.A.1    Jumbe, N.L.2    Farrell, C.L.3    Niehoff, M.L.4    Heatherington, A.C.5
  • 16
    • 77952329581 scopus 로고    scopus 로고
    • Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse
    • Boado, R.J., Hui, E.K., Lu, J.Z. & Pardridge, W.M. Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse. J. Pharmacol. Exp. Ther. 333, 961–969 (2010).
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 961-969
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Pardridge, W.M.4
  • 17
    • 0142257913 scopus 로고    scopus 로고
    • Proteins in cerebrospinal fluid and blood: Barriers, CSF flow rate and source-related dynamics
    • Reiber, H. Proteins in cerebrospinal fluid and blood: barriers, CSF flow rate and source-related dynamics. Restor. Neurol. Neurosci. 21, 79– 96 (2003).
    • (2003) Restor. Neurol. Neurosci. , vol.21 , pp. 79-96
    • Reiber, H.1
  • 18
    • 84882308754 scopus 로고    scopus 로고
    • Designing drug trials for Alzheimer’s disease: What we have learned from the release of the phase III antibody trials: A report from the EU/US/CTAD Task Force
    • Vellas, B. et al. Designing drug trials for Alzheimer’s disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force. Alzheimers Dement. 9, 438–444 (2013).
    • (2013) Alzheimers Dement , vol.9 , pp. 438-444
    • Vellas, B.1
  • 19
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F. et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6, 916–919 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 916-919
    • Bard, F.1
  • 20
    • 33947686655 scopus 로고    scopus 로고
    • Fusion antibody for Alzheimer’s disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation
    • Boado, R.J., Zhang, Y., Zhang, Y., Xia, C.F. & Pardridge, W.M. Fusion antibody for Alzheimer’s disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation. Bioconjug. Chem. 18, 447–455 (2007).
    • (2007) Bioconjug. Chem. , vol.18 , pp. 447-455
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Xia, C.F.4    Pardridge, W.M.5
  • 21
    • 0023125913 scopus 로고
    • Examination of bloodbrain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomography
    • Schlageter, N.L., Carson, R.E. & Rapoport, S.I. Examination of bloodbrain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomography. J. Cereb. Blood Flow. Metab. 7, 1–8 (1987).
    • (1987) J. Cereb. Blood Flow. Metab. , vol.7 , pp. 1-8
    • Schlageter, N.L.1    Carson, R.E.2    Rapoport, S.I.3
  • 22
    • 37849012608 scopus 로고    scopus 로고
    • Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse
    • Seubert, P. et al. Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse. Neurodegener. Dis. 5, 65–71 (2008).
    • (2008) Neurodegener. Dis. , vol.5 , pp. 65-71
    • Seubert, P.1
  • 23
    • 0022626910 scopus 로고
    • Bloodbrain barrier: Interface between internal medicine and the brain
    • Pardridge, W.M., Oldendorf, W.H., Cancilla, P. & Frank, H.J. Bloodbrain barrier: interface between internal medicine and the brain. Ann. Intern. Med. 105, 82–95 (1986).
    • (1986) Ann. Intern. Med. , vol.105 , pp. 82-95
    • Pardridge, W.M.1    Oldendorf, W.H.2    Cancilla, P.3    Frank, H.J.4
  • 25
    • 0029911355 scopus 로고    scopus 로고
    • Glut1 glucose transporter activity in human brain injury
    • Cornford, E.M., Hyman, S., Cornford, M.E. & Caron, M.J. Glut1 glucose transporter activity in human brain injury. J. Neurotrauma 13, 523–536 (1996).
    • (1996) J. Neurotrauma , vol.13 , pp. 523-536
    • Cornford, E.M.1    Hyman, S.2    Cornford, M.E.3    Caron, M.J.4
  • 26
    • 84855597543 scopus 로고    scopus 로고
    • Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier
    • Pardridge, W.M. & Boado, R.J. Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier. Methods Enzymol. 503, 269–292 (2012).
    • (2012) Methods Enzymol , vol.503 , pp. 269-292
    • Pardridge, W.M.1    Boado, R.J.2
  • 27
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • Pardridge, W.M. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2, 3–14 (2005).
    • (2005) Neurorx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 28
    • 79953686193 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
    • Uchida, Y. et al. Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J. Neurochem. 117, 333–345 (2011).
    • (2011) J. Neurochem. , vol.117 , pp. 333-345
    • Uchida, Y.1
  • 29
    • 13044258426 scopus 로고    scopus 로고
    • Selective expression of the large neutral amino acid transporter at the blood-brain barrier
    • Boado, R.J., Li, J.Y., Nagaya, M., Zhang, C. & Pardridge, W.M. Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc. Natl. Acad. Sci. USA. 96, 12079–12084 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA. , vol.96 , pp. 12079-12084
    • Boado, R.J.1    Li, J.Y.2    Nagaya, M.3    Zhang, C.4    Pardridge, W.M.5
  • 30
    • 17344392837 scopus 로고    scopus 로고
    • The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier
    • Kageyama, T. et al. The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res. 879, 115–121 (2000).
    • (2000) Brain Res , vol.879 , pp. 115-121
    • Kageyama, T.1
  • 31
    • 0021841594 scopus 로고
    • Human blood-brain barrier insulin receptor
    • Pardridge, W.M., Eisenberg, J. & Yang, J. Human blood-brain barrier insulin receptor. J. Neurochem. 44, 1771–1778 (1985).
    • (1985) J. Neurochem. , vol.44 , pp. 1771-1778
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 32
    • 0023227218 scopus 로고
    • Human blood-brain barrier transferrin receptor
    • Pardridge, W.M., Eisenberg, J. & Yang, J. Human blood-brain barrier transferrin receptor. Metabolism 36, 892–895 (1987).
    • (1987) Metabolism , vol.36 , pp. 892-895
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 33
    • 0023636719 scopus 로고
    • Blood-brain barrier transcytosis of insulin in developing rabbits
    • Duffy, K.R. & Pardridge, W.M. Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Res. 420, 32–38 (1987).
    • (1987) Brain Res , vol.420 , pp. 32-38
    • Duffy, K.R.1    Pardridge, W.M.2
  • 34
  • 35
    • 0028979838 scopus 로고
    • Transport of [125I]transferrin through the rat blood-brain barrier
    • Skarlatos, S., Yoshikawa, T. & Pardridge, W.M. Transport of [125I]transferrin through the rat blood-brain barrier. Brain Res. 683, 164–171 (1995).
    • (1995) Brain Res , vol.683 , pp. 164-171
    • Skarlatos, S.1    Yoshikawa, T.2    Pardridge, W.M.3
  • 36
    • 0029009048 scopus 로고
    • Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate
    • Pardridge, W.M., Kang, Y.S., Buciak, J.L. & Yang, J. Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate. Pharm. Res. 12, 807–816 (1995).
    • (1995) Pharm. Res. , vol.12 , pp. 807-816
    • Pardridge, W.M.1    Kang, Y.S.2    Buciak, J.L.3    Yang, J.4
  • 37
    • 0025836586 scopus 로고
    • Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo
    • Pardridge, W.M., Buciak, J.L. & Friden, P.M. Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo. J. Pharmacol. Exp. Ther. 259, 66–70 (1991).
    • (1991) J. Pharmacol. Exp. Ther. , vol.259 , pp. 66-70
    • Pardridge, W.M.1    Buciak, J.L.2    Friden, P.M.3
  • 38
    • 84864619415 scopus 로고    scopus 로고
    • Selective plasma pharmacokinetics and brain uptake in the mouse of enzyme fusion proteins derived from species-specific receptor-targeted antibodies
    • Zhou, Q.H., Boado, R.J. & Pardridge, W.M. Selective plasma pharmacokinetics and brain uptake in the mouse of enzyme fusion proteins derived from species-specific receptor-targeted antibodies. J. Drug Target 20, 715–719 (2012).
    • (2012) J. Drug Target , vol.20 , pp. 715-719
    • Zhou, Q.H.1    Boado, R.J.2    Pardridge, W.M.3
  • 39
    • 60549101321 scopus 로고    scopus 로고
    • Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse
    • Boado, R.J., Zhang, Y., Wang, Y. & Pardridge, W.M. Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse. Biotechnol. Bioeng. 102, 1251–1258 (2009).
    • (2009) Biotechnol. Bioeng. , vol.102 , pp. 1251-1258
    • Boado, R.J.1    Zhang, Y.2    Wang, Y.3    Pardridge, W.M.4
  • 40
    • 84872588784 scopus 로고    scopus 로고
    • IgG-enzyme fusion protein: Pharmacokinetics and anti-drug antibody response in rhesus monkeys
    • Boado, R.J., Hui, E.K., Lu, J.Z. & Pardridge, W.M. IgG-enzyme fusion protein: pharmacokinetics and anti-drug antibody response in rhesus monkeys. Bioconjug. Chem. 24, 97–104 (2013).
    • (2013) Bioconjug. Chem. , vol.24 , pp. 97-104
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Pardridge, W.M.4
  • 41
    • 84925258031 scopus 로고    scopus 로고
    • Insulin receptor antibody-iduronate 2-sulfatase fusion protein: Pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys
    • Boado, R.J., Ka-Wai Hui, E., Zhiqiang Lu, J. & Pardridge, W.M. Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys. Biotechnol. Bioeng. 111, 2317–2325 (2014).
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 2317-2325
    • Boado, R.J.1    Ka-Wai Hui, E.2    Zhiqiang Lu, J.3    Pardridge, W.M.4
  • 42
    • 78049266766 scopus 로고    scopus 로고
    • The roles of TNF in brain dysfunction and disease
    • Clark, I.A., Alleva, L.M. & Vissel, B. The roles of TNF in brain dysfunction and disease. Pharmacol. Ther. 128, 519–548 (2010).
    • (2010) Pharmacol. Ther. , vol.128 , pp. 519-548
    • Clark, I.A.1    Alleva, L.M.2    Vissel, B.3
  • 43
    • 77249163613 scopus 로고    scopus 로고
    • Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein
    • Boado, R.J., Hui, E.K., Lu, J.Z., Zhou, Q.H. & Pardridge, W.M. Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein. J. Biotechnol. 146, 84–91 (2010).
    • (2010) J. Biotechnol. , vol.146 , pp. 84-91
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Zhou, Q.H.4    Pardridge, W.M.5
  • 45
    • 84867070961 scopus 로고    scopus 로고
    • Brain protection from stroke with intravenous TNFalpha decoy receptor-Trojan horse fusion protein
    • Sumbria, R.K., Boado, R.J. & Pardridge, W.M. Brain protection from stroke with intravenous TNFalpha decoy receptor-Trojan horse fusion protein. J. Cereb. Blood Flow Metab. 32, 1933–1938 (2012).
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 1933-1938
    • Sumbria, R.K.1    Boado, R.J.2    Pardridge, W.M.3
  • 46
    • 71049162181 scopus 로고    scopus 로고
    • Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey
    • Boado, R.J. & Pardridge, W.M. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey. Drug Metab. Dispos. 37, 2299– 2304 (2009).
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 2299-2304
    • Boado, R.J.1    Pardridge, W.M.2
  • 47
    • 79959444718 scopus 로고    scopus 로고
    • Chronic dosing of mice with a transferrin receptor monoclonal antibody-glialderived neurotrophic factor fusion protein
    • Zhou, Q.H., Boado, R.J., Hui, E.K., Lu, J.Z. & Pardridge, W.M. Chronic dosing of mice with a transferrin receptor monoclonal antibody-glialderived neurotrophic factor fusion protein. Drug Metab. Dispos. 39, 1149–1154 (2011).
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 1149-1154
    • Zhou, Q.H.1    Boado, R.J.2    Hui, E.K.3    Lu, J.Z.4    Pardridge, W.M.5
  • 48
    • 44449128659 scopus 로고    scopus 로고
    • GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier
    • Boado, R.J., Zhang, Y., Zhang, Y., Wang, Y. & Pardridge, W.M. GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier. Biotechnol. Bioeng. 100, 387–396 (2008).
    • (2008) Biotechnol. Bioeng. , vol.100 , pp. 387-396
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Wang, Y.4    Pardridge, W.M.5
  • 49
    • 77950269160 scopus 로고    scopus 로고
    • Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse
    • Zhou, Q.H., Boado, R.J., Lu, J.Z., Hui, E.K. & Pardridge, W.M. Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse. Drug Metab. Dispos. 38, 566–572 (2010).
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 566-572
    • Zhou, Q.H.1    Boado, R.J.2    Lu, J.Z.3    Hui, E.K.4    Pardridge, W.M.5
  • 50
    • 78649949022 scopus 로고    scopus 로고
    • Reengineering erythropoietin as an IgG fusion protein that penetrates the blood-brain barrier in the mouse
    • Zhou, Q.H., Boado, R.J., Lu, J.Z., Hui, E.K., & Pardridge, W.M. Reengineering erythropoietin as an IgG fusion protein that penetrates the blood-brain barrier in the mouse. Mol. Pharm. 7, 2148–2155 (2010).
    • (2010) Mol. Pharm. , vol.7 , pp. 2148-2155
    • Zhou, Q.H.1    Boado, R.J.2    Lu, J.Z.3    Hui, E.K.4    Pardridge, W.M.5
  • 51
    • 77956178352 scopus 로고    scopus 로고
    • Intravenous treatment of experimental Parkinson’s disease in the mouse with an IgG-GDNF fusion protein that penetrates the bloodbrain barrier
    • Fu, A., Zhou, Q.H., Hui, E.K., Lu, J.Z., Boado, R.J. & Pardridge, W.M. Intravenous treatment of experimental Parkinson’s disease in the mouse with an IgG-GDNF fusion protein that penetrates the bloodbrain barrier. Brain Res. 1352, 208–213 (2010).
    • (2010) Brain Res , vol.1352 , pp. 208-213
    • Fu, A.1    Zhou, Q.H.2    Hui, E.K.3    Lu, J.Z.4    Boado, R.J.5    Pardridge, W.M.6
  • 52
    • 79952538290 scopus 로고    scopus 로고
    • Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson’s disease in the mouse
    • Zhou, Q.H., Hui, E.K., Lu, J.Z., Boado, R.J. & Pardridge, W.M. Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson’s disease in the mouse. Brain Res. 1382, 315–320 (2011).
    • (2011) Brain Res , vol.1382 , pp. 315-320
    • Zhou, Q.H.1    Hui, E.K.2    Lu, J.Z.3    Boado, R.J.4    Pardridge, W.M.5
  • 53
    • 84875839926 scopus 로고    scopus 로고
    • Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins
    • Sumbria, R.K., Boado, R.J. & Pardridge, W.M. Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins. Brain Res. 1507, 91–96 (2013).
    • (2013) Brain Res , vol.1507 , pp. 91-96
    • Sumbria, R.K.1    Boado, R.J.2    Pardridge, W.M.3
  • 54
    • 79957439772 scopus 로고    scopus 로고
    • Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
    • Yu, Y.J. et al. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci. Transl. Med. 3, 84ra44 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , pp. 84ra44
    • Yu, Y.J.1
  • 55
    • 84891804917 scopus 로고    scopus 로고
    • Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle
    • Niewoehner, J. et al. Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle. Neuron 81, 49–60 (2014).
    • (2014) Neuron , vol.81 , pp. 49-60
    • Niewoehner, J.1
  • 56
    • 84855366636 scopus 로고    scopus 로고
    • Generation of dual-variable-domain immunoglobulin molecules for dual-specific targeting
    • Gu, J. & Ghayur, T. Generation of dual-variable-domain immunoglobulin molecules for dual-specific targeting. Methods Enzymol. 502, 25–41 (2012).
    • (2012) Methods Enzymol , vol.502 , pp. 25-41
    • Gu, J.1    Ghayur, T.2
  • 57
    • 79957452852 scopus 로고    scopus 로고
    • A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo
    • Atwal, J.K. et al. A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo. Sci. Transl. Med. 3, 84ra43 (2011).
    • (2011) Sci. Transl. Med. , vol.3 , pp. 84ra43
    • Atwal, J.K.1
  • 58
    • 84883591583 scopus 로고    scopus 로고
    • Disaggregation of amyloid plaque in brain of Alzheimer’s disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide
    • Sumbria, R.K., Hui, E.K., Lu, J.Z., Boado, R.J. & Pardridge, W.M. Disaggregation of amyloid plaque in brain of Alzheimer’s disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide. Mol. Pharm. 10, 3507–3513 (2013).
    • (2013) Mol. Pharm. , vol.10 , pp. 3507-3513
    • Sumbria, R.K.1    Hui, E.K.2    Lu, J.Z.3    Boado, R.J.4    Pardridge, W.M.5
  • 59
    • 0042526080 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Gene therapy of lysosomal storage disorders
    • Cheng, S.H. & Smith, A.E. Gene therapy progress and prospects: gene therapy of lysosomal storage disorders. Gene Ther. 10, 1275– 1281 (2003).
    • (2003) Gene Ther , vol.10 , pp. 1275-1281
    • Cheng, S.H.1    Smith, A.E.2
  • 60
    • 70350236476 scopus 로고    scopus 로고
    • AGT-181: Expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys
    • Boado, R.J., Hui, E.K., Lu, J.Z. & Pardridge, W.M. AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys. J. Biotechnol. 144, 135– 141 (2009).
    • (2009) J. Biotechnol. , vol.144 , pp. 135-141
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Pardridge, W.M.4
  • 61
    • 79961050726 scopus 로고    scopus 로고
    • Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein
    • Boado, R.J., Hui, E.K., Lu, J.Z., Zhou, Q.H. & Pardridge, W.M. Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein. Mol. Pharm. 8, 1342–1350 (2011).
    • (2011) Mol. Pharm. , vol.8 , pp. 1342-1350
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Zhou, Q.H.4    Pardridge, W.M.5
  • 62
    • 38449110954 scopus 로고    scopus 로고
    • Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier
    • Boado, R.J., Zhang, Y., Zhang, Y., Xia, C.F., Wang, Y. & Pardridge, W.M. Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier. Biotechnol. Bioeng. 99, 475–484 (2008).
    • (2008) Biotechnol. Bioeng. , vol.99 , pp. 475-484
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Xia, C.F.4    Wang, Y.5    Pardridge, W.M.6
  • 63
    • 84905511762 scopus 로고    scopus 로고
    • Insulin receptor antibody-sulfamidase fusion protein penetrates the primate bloodbrain barrier and reduces glycosoaminoglycans in Sanfilippo type a cells
    • Boado, R.J., Lu, J.Z., Hui, E.K. & Pardridge, W.M. Insulin receptor antibody-sulfamidase fusion protein penetrates the primate bloodbrain barrier and reduces glycosoaminoglycans in Sanfilippo type a cells. Mol. Pharm. 11, 2928–2934 (2014).
    • (2014) Mol. Pharm. , vol.11 , pp. 2928-2934
    • Boado, R.J.1    Lu, J.Z.2    Hui, E.K.3    Pardridge, W.M.4
  • 64
    • 84875544291 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase A and a monoclonal antibody against the human insulin receptor
    • Boado, R.J., Lu, J.Z., Hui, E.K., Sumbria, R.K. & Pardridge, W.M. Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase A and a monoclonal antibody against the human insulin receptor. Biotechnol. Bioeng. 110, 1456–1465 (2013).
    • (2013) Biotechnol. Bioeng. , vol.110 , pp. 1456-1465
    • Boado, R.J.1    Lu, J.Z.2    Hui, E.K.3    Sumbria, R.K.4    Pardridge, W.M.5
  • 65
    • 0030930364 scopus 로고    scopus 로고
    • Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
    • Wu, D., Yang, J. & Pardridge, W.M. Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J. Clin. Invest. 100, 1804–1812 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 1804-1812
    • Wu, D.1    Yang, J.2    Pardridge, W.M.3
  • 66
    • 80051767213 scopus 로고    scopus 로고
    • Delivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein
    • Zhou, Q.H., Lu, J.Z., Hui, E.K., Boado, R.J. & Pardridge, W.M. Delivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein. Bioconjug. Chem. 22, 1611–1618 (2011).
    • (2011) Bioconjug. Chem. , vol.22 , pp. 1611-1618
    • Zhou, Q.H.1    Lu, J.Z.2    Hui, E.K.3    Boado, R.J.4    Pardridge, W.M.5
  • 67
    • 0033572574 scopus 로고    scopus 로고
    • Imaging brain tumors by targeting peptide radiopharmaceuticals through the blood-brain barrier
    • Kurihara, A. & Pardridge, W.M. Imaging brain tumors by targeting peptide radiopharmaceuticals through the blood-brain barrier. Cancer Res. 59, 6159–6163 (1999).
    • (1999) Cancer Res , vol.59 , pp. 6159-6163
    • Kurihara, A.1    Pardridge, W.M.2
  • 68
    • 10044244293 scopus 로고    scopus 로고
    • Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology
    • Suzuki, T., Wu, D., Schlachetzki, F., Li, J.Y., Boado, R.J. & Pardridge, W.M. Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology. J. Nucl. Med. 45, 1766–1775 (2004).
    • (2004) J. Nucl. Med. , vol.45 , pp. 1766-1775
    • Suzuki, T.1    Wu, D.2    Schlachetzki, F.3    Li, J.Y.4    Boado, R.J.5    Pardridge, W.M.6
  • 69
    • 0037249449 scopus 로고    scopus 로고
    • Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism
    • Zhang, Y., Calon, F., Zhu, C., Boado, R.J. & Pardridge, W.M. Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism. Hum. Gene Ther. 14, 1–12 (2003).
    • (2003) Hum. Gene Ther. , vol.14 , pp. 1-12
    • Zhang, Y.1    Calon, F.2    Zhu, C.3    Boado, R.J.4    Pardridge, W.M.5
  • 70
    • 0037222013 scopus 로고    scopus 로고
    • Global non-viral gene transfer to the primate brain following intravenous administration
    • Zhang, Y., Schlachetzki, F. & Pardridge, W.M. Global non-viral gene transfer to the primate brain following intravenous administration. Mol. Ther. 7, 11–18 (2003).
    • (2003) Mol. Ther. , vol.7 , pp. 11-18
    • Zhang, Y.1    Schlachetzki, F.2    Pardridge, W.M.3
  • 71
    • 0347555450 scopus 로고    scopus 로고
    • Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer
    • Zhang, Y., Schlachetzki, F., Li, J.Y., Boado, R.J. & Pardridge, W.M. Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer. Mol. Vis. 9, 465–472 (2003).
    • (2003) Mol. Vis. , vol.9 , pp. 465-472
    • Zhang, Y.1    Schlachetzki, F.2    Li, J.Y.3    Boado, R.J.4    Pardridge, W.M.5
  • 72
    • 13644249272 scopus 로고    scopus 로고
    • Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice
    • Zhu, C., Zhang, Y., Zhang, Y.F., Li, J.Y., Boado, R.J. & Pardridge, W.M. Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice. J. Gene Med. 6, 906–912 (2004).
    • (2004) J. Gene Med. , vol.6 , pp. 906-912
    • Zhu, C.1    Zhang, Y.2    Zhang, Y.F.3    Li, J.Y.4    Boado, R.J.5    Pardridge, W.M.6
  • 73
    • 1842636306 scopus 로고    scopus 로고
    • Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter
    • Zhang, Y., Schlachetzki, F., Zhang, Y.F., Boado, R.J. & Pardridge, W.M. Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter. Hum. Gene Ther. 15, 339–350 (2004).
    • (2004) Hum. Gene Ther. , vol.15 , pp. 339-350
    • Zhang, Y.1    Schlachetzki, F.2    Zhang, Y.F.3    Boado, R.J.4    Pardridge, W.M.5
  • 74
    • 0036665418 scopus 로고    scopus 로고
    • Antisense gene therapy of brain cancer with an artificial virus gene delivery system
    • Zhang, Y., Zhu, C. & Pardridge, W.M. Antisense gene therapy of brain cancer with an artificial virus gene delivery system. Mol. Ther. 6, 67– 72 (2002).
    • (2002) Mol. Ther. , vol.6 , pp. 67-72
    • Zhang, Y.1    Zhu, C.2    Pardridge, W.M.3
  • 75
    • 2542561420 scopus 로고    scopus 로고
    • Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer
    • Zhang, Y., Bryant, J., Zhang, Y.F., Charles, A., Boado, R.J. & Pardridge, W.M. Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin. Cancer Res. 10, 3667–3677 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3667-3677
    • Zhang, Y.1    Bryant, J.2    Zhang, Y.F.3    Charles, A.4    Boado, R.J.5    Pardridge, W.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.