-
1
-
-
0025352299
-
β-Arrestin: A protein that regulates β-Adrenergic receptor function
-
Lohse, M. J., and Benovic., J. L., Codina, J., Caron, M. G., and Lefkowitz, R. J. (1990) β-Arrestin: a protein that regulates β-adrenergic receptor function. Science 248, 1547-1550
-
(1990)
Science
, vol.248
, pp. 1547-1550
-
-
Lohse, M.J.1
Benovic, J.L.2
Codina, J.3
Caron, M.G.4
Lefkowitz, R.J.5
-
2
-
-
0023024677
-
Rapid affinity purification of retinal arrestin (48 kDa protein) via its light-dependent binding to phosphorylated rhodopsin
-
Wilden, U., Wüst, E., Weyand, I., and Kühn, H. (1986) Rapid affinity purification of retinal arrestin (48 kDa protein) via its light-dependent binding to phosphorylated rhodopsin. FEBS Lett. 207, 292-295
-
(1986)
FEBS Lett
, vol.207
, pp. 292-295
-
-
Wilden, U.1
Wüst, E.2
Weyand, I.3
Kühn, H.4
-
3
-
-
0026730336
-
β-Arrestin2, a novel member of the arrestin/β-arrestin gene family
-
Attramadal, H., and Arriza., J. L., Aoki, C, and Dawson., T. M., Codina, J., Kwatra, M. M., and Snyder., S. H., Caron, M. G., and Lefkowitz, R. J. (1992) β-Arrestin2, a novel member of the arrestin/β-arrestin gene family. J. Biol. Chem. 267, 17882-17890
-
(1992)
J. Biol. Chem
, vol.267
, pp. 17882-17890
-
-
Attramadal, H.1
Arriza, J.L.2
Aoki, C.3
Dawson, T.M.4
Codina, J.5
Kwatra, M.M.6
Snyder, S.H.7
Caron, M.G.8
Lefkowitz, R.J.9
-
4
-
-
0027939554
-
Cone arrestin identified by targeting expression of a functional family
-
Craft, C. M., and Whitmore., D. H., and Wiechmann, A. F. (1994) Cone arrestin identified by targeting expression of a functional family. J. Biol. Chem. 269, 4613-4619
-
(1994)
J. Biol. Chem
, vol.269
, pp. 4613-4619
-
-
Craft, C.M.1
Whitmore, D.H.2
Wiechmann, A.F.3
-
5
-
-
84860355658
-
An expanded family of arrestins regulate metabolism
-
Patwari, P., and Lee, R. T. (2012) An expanded family of arrestins regulate metabolism. Trends Endocrinol. Metab. 23, 216-222
-
(2012)
Trends Endocrinol. Metab
, vol.23
, pp. 216-222
-
-
Patwari, P.1
Lee, R.T.2
-
6
-
-
0037044843
-
The third intracellular loop of α2-adrenergic receptors determines subtype specificity of arrestin interaction
-
DeGraff, J. L., and Gurevich., V. V., and Benovic, J. L. (2002) The third intracellular loop of α2-adrenergic receptors determines subtype specificity of arrestin interaction. J. Biol. Chem. 277, 43247-43252
-
(2002)
J. Biol. Chem
, vol.277
, pp. 43247-43252
-
-
DeGraff, J.L.1
Gurevich, V.V.2
Benovic, J.L.3
-
7
-
-
84890157678
-
Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking
-
Kang, D. S., Tian, X., and Benovic, J. L. (2014) Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Curr. Opin. Cell Biol. 27, 63-71
-
(2014)
Curr. Opin. Cell Biol
, vol.27
, pp. 63-71
-
-
Kang, D.S.1
Tian, X.2
Benovic, J.L.3
-
8
-
-
33947401068
-
β-Arrestins and cell signaling
-
DeWire, S. M., Ahn, S., Lefkowitz, R. J., and Shenoy, S. K. (2007) β-Arrestins and cell signaling. Annu. Rev. Physiol. 69, 483-510
-
(2007)
Annu. Rev. Physiol
, vol.69
, pp. 483-510
-
-
DeWire, S.M.1
Ahn, S.2
Lefkowitz, R.J.3
Shenoy, S.K.4
-
9
-
-
0030732503
-
β-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to β-adrenergic stimulation
-
Conner, D. A., and Mathier., M. A., Mortensen, R. M., Christe, M., Vatner, S. F., and Seidman., C. E., and Seidman, J. G. (1997) β-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to β-adrenergic stimulation. Circ. Res. 81, 1021-1026
-
(1997)
Circ. Res
, vol.81
, pp. 1021-1026
-
-
Conner, D.A.1
Mathier, M.A.2
Mortensen, R.M.3
Christe, M.4
Vatner, S.F.5
Seidman, C.E.6
Seidman, J.G.7
-
10
-
-
0033601341
-
Enhanced morphine analgesia in mice lacking β-arrestin 2
-
Bohn, L. M., and Lefkowitz., R. J., Gainetdinov, R. R., Peppel, K., Caron, M. G., and Lin, F. T. (1999) Enhanced morphine analgesia in mice lacking β-arrestin 2. Science 286, 2495-2498
-
(1999)
Science
, vol.286
, pp. 2495-2498
-
-
Bohn, L.M.1
Lefkowitz, R.J.2
Gainetdinov, R.R.3
Peppel, K.4
Caron, M.G.5
Lin, F.T.6
-
11
-
-
0035852697
-
β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
-
Kohout, T. A., and Lin., F. S., Perry, S. J., Conner, D. A., and Lefkowitz, R. J. (2001) β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc. Natl. Acad. Sci. U.S.A. 98, 1601-1606
-
(2001)
Proc. Natl. Acad. Sci. U.S.A
, vol.98
, pp. 1601-1606
-
-
Kohout, T.A.1
Lin, F.S.2
Perry, S.J.3
Conner, D.A.4
Lefkowitz, R.J.5
-
12
-
-
0037020264
-
Differential nucleocytoplasmic shuttling ofβ-arrestins: Characterization of aleucine-rich nuclear export signal in β-arrestin2
-
Scott, M. G., Le Rouzic, E., Périanin, A., Pierotti, V., Enslen, H., Benichou, S., Marullo, S., and Benmerah, A. (2002) Differential nucleocytoplasmic shuttling ofβ-arrestins: characterization of aleucine-rich nuclear export signal in β-arrestin2. J. Biol. Chem. 277, 37693-37701
-
(2002)
J. Biol. Chem
, vol.277
, pp. 37693-37701
-
-
Scott, M.G.1
Le Rouzic, E.2
Périanin, A.3
Pierotti, V.4
Enslen, H.5
Benichou, S.6
Marullo, S.7
Benmerah, A.8
-
13
-
-
84891403318
-
Arrestin-3 binds c-jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding
-
Kook, S., Zhan, X., Kaoud, T. S., Dalby, K. N, Gurevich, V. V., and Gurevich, E. V. (2013) Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding. J. Biol. Chem. 288, 37332-37342
-
(2013)
J. Biol. Chem
, vol.288
, pp. 37332-37342
-
-
Kook, S.1
Zhan, X.2
Kaoud, T.S.3
Dalby, K.N.4
Gurevich, V.V.5
Gurevich, E.V.6
-
14
-
-
1542350042
-
Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by β-arrestins 1 and 2
-
Ahn, S., Wei, H., Garrison, T. R., and Lefkowitz, R. J. (2004) Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by β-arrestins 1 and 2. J. Biol. Chem. 279, 7807-7811
-
(2004)
J. Biol. Chem
, vol.279
, pp. 7807-7811
-
-
Ahn, S.1
Wei, H.2
Garrison, T.R.3
Lefkowitz, R.J.4
-
15
-
-
33644857279
-
β-Arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor
-
Shenoy, S. K., and Drake., M. T., Nelson, C D., Houtz, D. A., Xiao, K., Madabushi, S., Reiter, E., Premont, R. T., Lichtarge, O., and Lefkowitz, R. J. (2006) β-Arrestin-dependent, G protein-independent ERK1/2 activation by the β2 adrenergic receptor. J. Biol. Chem. 281, 1261-1273
-
(2006)
J. Biol. Chem
, vol.281
, pp. 1261-1273
-
-
Shenoy, S.K.1
Drake, M.T.2
Nelson, C.D.3
Houtz, D.A.4
Xiao, K.5
Madabushi, S.6
Reiter, E.7
Premont, R.T.8
Lichtarge, O.9
Lefkowitz, R.J.10
-
16
-
-
33744957160
-
Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation
-
Gesty-Palmer, D., Chen, M., Reiter, E., Ahn, S., Nelson, C. D., Wang, S., and Eckhardt., A. E., Cowan, C. L., Spurney, R. F., and Luttrell., L. M., and Lefkowitz, R. J. (2006) Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J. Biol. Chem. 281, 10856-10864
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10856-10864
-
-
Gesty-Palmer, D.1
Chen, M.2
Reiter, E.3
Ahn, S.4
Nelson, C.D.5
Wang, S.6
Eckhardt, A.E.7
Cowan, C.L.8
Spurney, R.F.9
Luttrell, L.M.10
Lefkowitz, R.J.11
-
17
-
-
47849101639
-
Location, location, location ⋯ site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling
-
Tobin, A. B., and Butcher., A. J., and Kong, K. C. (2008) Location, location, location ⋯ site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. Trends Pharmacol. Sci. 29, 413-420
-
(2008)
Trends Pharmacol. Sci
, vol.29
, pp. 413-420
-
-
Tobin, A.B.1
Butcher, A.J.2
Kong, K.C.3
-
18
-
-
84876444777
-
Distinct cellular and subcellular distributions of G proteincoupled receptor kinase and arrestin isoforms in the striatum
-
Bychkov, E., Zurkovsky, L., Garret, M. B., and Ahmed., M. R., and Gurevich, E. V. (2012) Distinct cellular and subcellular distributions of G proteincoupled receptor kinase and arrestin isoforms in the striatum. PLoS ONE 7, e48912
-
(2012)
PLoS ONE
, vol.7
-
-
Bychkov, E.1
Zurkovsky, L.2
Garret, M.B.3
Ahmed, M.R.4
Gurevich, E.V.5
-
19
-
-
0030680131
-
Clathrin-mediated endocytosis of the β-adrenergic receptor is regulated by phosphorylation/dephosphorylation ofβ-arrestin1
-
Lin, F. T., and Krueger., K. M., Kendall, H. E., Daaka, Y., Fredericks, Z. L., and Pitcher., J. A., and Lefkowitz, R. J. (1997) Clathrin-mediated endocytosis of the β-adrenergic receptor is regulated by phosphorylation/dephosphorylation ofβ-arrestin1. J. Biol. Chem. 272, 31051-31057
-
(1997)
J. Biol. Chem
, vol.272
, pp. 31051-31057
-
-
Lin, F.T.1
Krueger, K.M.2
Kendall, H.E.3
Daaka, Y.4
Fredericks, Z.L.5
Pitcher, J.A.6
Lefkowitz, R.J.7
-
20
-
-
0037737763
-
Trafficking patterns of β-arrestin and G protein-coupled receptors determined by the kinetics of β-arrestin deubiquitination
-
Shenoy, S. K., and Lefkowitz, R. J. (2003) Trafficking patterns of β-arrestin and G protein-coupled receptors determined by the kinetics of β-arrestin deubiquitination. J. Biol. Chem. 278, 14498-14506
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14498-14506
-
-
Shenoy, S.K.1
Lefkowitz, R.J.2
-
21
-
-
17144364766
-
Receptor-specific ubiquitination of β-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes
-
Shenoy, S. K., and Lefkowitz, R. J. (2005) Receptor-specific ubiquitination of β-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J. Biol. Chem. 280, 15315-15324
-
(2005)
J. Biol. Chem
, vol.280
, pp. 15315-15324
-
-
Shenoy, S.K.1
Lefkowitz, R.J.2
-
22
-
-
48349131772
-
S-nitrosylation ofβ-arrestin regulates β-adrenergic receptor trafficking
-
Ozawa, K., Whalen, E.J., Nelson, C. D., Mu, Y., Hess, D. T., and Lefkowitz., R. J., and Stamler, J. S. (2008) S-nitrosylation ofβ-arrestin regulates β-adrenergic receptor trafficking. Mol. Cell 31, 395-405
-
(2008)
Mol. Cell
, vol.31
, pp. 395-405
-
-
Ozawa, K.1
Whalen, E.J.2
Nelson, C.D.3
Mu, Y.4
Hess, D.T.5
Lefkowitz, R.J.6
Stamler, J.S.7
-
23
-
-
79952777210
-
Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking
-
Wyatt, D., Malik, R., Vesecky, A. C, and Marchese, A. (2011) Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking. J. Biol. Chem. 286, 3884-3893
-
(2011)
J. Biol. Chem
, vol.286
, pp. 3884-3893
-
-
Wyatt, D.1
Malik, R.2
Vesecky, A.C.3
Marchese, A.4
-
24
-
-
0023515309
-
Functional desensitization of the isolated β-adrenergic receptor by the β-adrenergic receptor kinase: Potential role of an analog of the retinal protein arrestin (48-kDa protein)
-
Benovic, J. L., Kühn, H., Weyand, I., Codina, J., Caron, M. G., and Lefkowitz, R. J. (1987) Functional desensitization of the isolated β-adrenergic receptor by the β-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). Proc. Natl. Acad. Sci. U.S.A. 84, 8879-8882
-
(1987)
Proc. Natl. Acad. Sci. U.S.A
, vol.84
, pp. 8879-8882
-
-
Benovic, J.L.1
Kühn, H.2
Weyand, I.3
Codina, J.4
Caron, M.G.5
Lefkowitz, R.J.6
-
25
-
-
33646365380
-
A β-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors
-
Marion, S., and Oakley., R. H., Kim, K. M., Caron, M. G., and Barak, L. S. (2006) A β-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. J. Biol. Chem. 281, 2932-2938
-
(2006)
J. Biol. Chem
, vol.281
, pp. 2932-2938
-
-
Marion, S.1
Oakley, R.H.2
Kim, K.M.3
Caron, M.G.4
Barak, L.S.5
-
26
-
-
0030593035
-
Role ofβ-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
-
Ferguson, S. S., and Downey., W. E., 3rd, Colapietro, A. M., Barak, L. S., Ménard, L., and Caron, M. G. (1996) Role ofβ-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science 271, 363-366
-
(1996)
Science
, vol.271
, pp. 363-366
-
-
Ferguson, S.S.1
Downey, W.E.2
Colapietro, A.M.3
Barak, L.S.4
Ménard, L.5
Caron, M.G.6
-
27
-
-
0023897940
-
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
-
Bouvier, M., and Hausdorff., W. P., De Blasi, A., O'Dowd, B. F., Kobilka, B. K., Caron, M. G., and Lefkowitz, R. J. (1988) Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature 333, 370-373
-
(1988)
Nature
, vol.333
, pp. 370-373
-
-
Bouvier, M.1
Hausdorff, W.P.2
De Blasi, A.3
O'Dowd, B.F.4
Kobilka, B.K.5
Caron, M.G.6
Lefkowitz, R.J.7
-
28
-
-
0344812247
-
β-Adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
-
Benovic, J. L., and Strasser., R. H., Caron, M. G., and Lefkowitz, R. J. (1986) β-Adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc. Natl. Acad. Sci. U.S.A. 83, 2797-2801
-
(1986)
Proc. Natl. Acad. Si. U.S.A
, vol.83
, pp. 2797-2801
-
-
Benovic, J.L.1
Strasser, R.H.2
Caron, M.G.3
Lefkowitz, R.J.4
-
29
-
-
0026776880
-
Desensitization of the isolated β2-adrenergic receptor by β-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms
-
Pitcher, J., and Lohse., M. J., Codina, J., Caron, M. G., and Lefkowitz, R. J. (1992) Desensitization of the isolated β2-adrenergic receptor by β-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. Biochemistry 31, 3193-3197
-
(1992)
Biochemistry
, vol.31
, pp. 3193-3197
-
-
Pitcher, J.1
Lohse, M.J.2
Codina, J.3
Caron, M.G.4
Lefkowitz, R.J.5
-
30
-
-
33947375174
-
Physiological roles of G protein-coupled receptor kinases and arrestins
-
Premont, R. T., and Gainetdinov, R. R. (2007) Physiological roles of G protein-coupled receptor kinases and arrestins. Annu. Rev. Physiol. 69, 511-534
-
(2007)
Annu. Rev. Physiol
, vol.69
, pp. 511-534
-
-
Premont, R.T.1
Gainetdinov, R.R.2
-
31
-
-
0028181709
-
A β-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the β2-adrenergic receptor
-
Kong, G., Penn, R., and Benovic, J. L. (1994) A β-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the β2-adrenergic receptor. J. Biol. Chem. 269, 13084-13087
-
(1994)
J. Biol. Chem
, vol.269
, pp. 13084-13087
-
-
Kong, G.1
Penn, R.2
Benovic, J.L.3
-
32
-
-
15744379282
-
β-Arrestin binding to the β2-adrenergic receptor requires both receptor phosphorylation and receptor activation
-
Krasel, C, Bünemann, M., Lorenz, K., and Lohse, M. J. (2005) β-Arrestin binding to the β2-adrenergic receptor requires both receptor phosphorylation and receptor activation. J. Biol. Chem. 280, 9528-9535
-
(2005)
J. Biol. Chem
, vol.280
, pp. 9528-9535
-
-
Krasel, C.1
Bünemann, M.2
Lorenz, K.3
Lohse, M.J.4
-
33
-
-
0026756371
-
Sites in the third intracellular loop of the a2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism
-
Liggett, S. B., Ostrowski, J., Chesnut, L. C, Kurose, H., and Raymond., J. R., Caron, M. G., and Lefkowitz, R. J. (1992) Sites in the third intracellular loop of the a2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism. J. Biol. Chem. 267, 4740-4746
-
(1992)
J. Biol. Chem
, vol.267
, pp. 4740-4746
-
-
Liggett, S.B.1
Ostrowski, J.2
Chesnut, L.C.3
Kurose, H.4
Raymond, J.R.5
Caron, M.G.6
Lefkowitz, R.J.7
-
34
-
-
0031009124
-
Two homologous phosphorylation domains differentially contribute to desensitization and internalization of the m2 muscarinic acetylcholine receptor
-
Pals-Rylaarsdam, R., and Hosey, M. M. (1997) Two homologous phosphorylation domains differentially contribute to desensitization and internalization of the m2 muscarinic acetylcholine receptor. J. Biol. Chem. 272, 14152-14158
-
(1997)
J. Biol. Chem
, vol.272
, pp. 14152-14158
-
-
Pals-Rylaarsdam, R.1
Hosey, M.M.2
-
35
-
-
84873033099
-
β-Arrestins and G proteincoupled receptor trafficking
-
Kang, D. S., Tian, X., and Benovic, J. L. (2013) β-Arrestins and G proteincoupled receptor trafficking. Methods Enzymol. 521, 91-108
-
(2013)
Methods Enzymol
, vol.521
, pp. 91-108
-
-
Kang, D.S.1
Tian, X.2
Benovic, J.L.3
-
36
-
-
84876209624
-
Constitutive internalization of theleucine-rich G protein-coupled receptor-5 (LGR5) to the trans-golgi network
-
Snyder, J. C, Rochelle, L. K., and Lyerly., H. K., Caron, M. G., and Barak, L. S. (2013) Constitutive internalization of theleucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. J. Biol. Chem. 288, 10286-10297
-
(2013)
J. Biol. Chem
, vol.288
, pp. 10286-10297
-
-
Snyder, J.C.1
Rochelle, L.K.2
Lyerly, H.K.3
Caron, M.G.4
Barak, L.S.5
-
37
-
-
0032557450
-
Arrestin-independent internalization of the m1, m3, and m4 subtypes of muscarinic cholinergic receptors
-
Lee, K. B., Pals-Rylaarsdam, R., Benovic, J. L., and Hosey, M. M. (1998) Arrestin-independent internalization of the m1, m3, and m4 subtypes of muscarinic cholinergic receptors. J. Biol. Chem. 273, 12967-12972
-
(1998)
J. Biol. Chem
, vol.273
, pp. 12967-12972
-
-
Lee, K.B.1
Pals-Rylaarsdam, R.2
Benovic, J.L.3
Hosey, M.M.4
-
38
-
-
0035896585
-
The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis
-
Bhatnagar, A., and Willins., D. L., Gray, J. A., Woods, J., Benovic, J. L., and Roth, B. L. (2001) The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. J. Biol. Chem. 276, 8269-8277
-
(2001)
J. Biol. Chem
, vol.276
, pp. 8269-8277
-
-
Bhatnagar, A.1
Willins, D.L.2
Gray, J.A.3
Woods, J.4
Benovic, J.L.5
Roth, B.L.6
-
39
-
-
84865527500
-
Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestins
-
Gimenez, L. E., and Vishnivetskiy., S. A., Baameur, F., and Gurevich, V. V. (2012) Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestins. J. Biol. Chem. 287, 29495-29505
-
(2012)
J. Biol. Chem
, vol.287
, pp. 29495-29505
-
-
Gimenez, L.E.1
Vishnivetskiy, S.A.2
Baameur, F.3
Gurevich, V.V.4
-
40
-
-
0033616494
-
The β2-adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
-
Laporte, S. A., and Oakley., R. H., Zhang, J., Holt, J. A., and Ferguson., S. S., Caron, M. G., and Barak, L. S. (1999) The β2-adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc. Natl. Acad. Sci. U.S.A. 96, 3712-3717
-
(1999)
Proc. Natl. Acad. Sci. U.S.A
, vol.96
, pp. 3712-3717
-
-
Laporte, S.A.1
Oakley, R.H.2
Zhang, J.3
Holt, J.A.4
Ferguson, S.S.5
Caron, M.G.6
Barak, L.S.7
-
41
-
-
0035834775
-
β-Arrestin-mediatedADP-ribosylation factor 6 activation and β2-adrenergic receptor endocytosis
-
Claing, A., Chen, W., Miller, W. E., Vitale, N, Moss, J., and Premont., R. T., and Lefkowitz, R.J. (2001) β-Arrestin-mediatedADP-ribosylation factor 6 activation and β2-adrenergic receptor endocytosis. J. Biol. Chem. 276, 42509-42513
-
(2001)
J. Biol. Chem
, vol.276
, pp. 42509-42513
-
-
Claing, A.1
Chen, W.2
Miller, W.E.3
Vitale, N.4
Moss, J.5
Premont, R.T.6
Lefkowitz, R.J.7
-
42
-
-
0033574530
-
Identification of NSF as a β-arrestin1-binding protein. Implications for β2-adrenergic receptor regulation
-
McDonald, P. H., and Cote., N. L., Lin, F. T., Premont, R. T., and Pitcher., J. A., and Lefkowitz, R. J. (1999) Identification of NSF as a β-arrestin1-binding protein. Implications for β2-adrenergic receptor regulation. J. Biol. Chem. 274, 10677-10680
-
(1999)
J. Biol. Chem
, vol.274
, pp. 10677-10680
-
-
McDonald, P.H.1
Cote, N.L.2
Lin, F.T.3
Premont, R.T.4
Pitcher, J.A.5
Lefkowitz, R.J.6
-
43
-
-
0142180197
-
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins
-
Vines, C. M., and Revankar., C. M., Maestas, D. C, LaRusch, L. L., and Cimino., D. F., Kohout, T. A., Lefkowitz, R. J., and Prossnitz, E. R. (2003) N-Formyl peptide receptors internalize but do not recycle in the absence of arrestins. J. Biol. Chem. 278, 41581-41584
-
(2003)
J. Biol. Chem
, vol.278
, pp. 41581-41584
-
-
Vines, C.M.1
Revankar, C.M.2
Maestas, D.C.3
LaRusch, L.L.4
Cimino, D.F.5
Kohout, T.A.6
Lefkowitz, R.J.7
Prossnitz, E.R.8
-
44
-
-
0034595860
-
Differential affinities of visual arrestin, β arrestin1, and β arrestin2 for G protein-coupled receptors delineate two major classes of receptors
-
Oakley, R. H., and Laporte., S. A., Holt, J. A., Caron, M. G., and Barak, L. S. (2000) Differential affinities of visual arrestin, β arrestin1, and β arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J. Biol. Chem. 275, 17201-17210
-
(2000)
J. Biol. Chem
, vol.275
, pp. 17201-17210
-
-
Oakley, R.H.1
Laporte, S.A.2
Holt, J.A.3
Caron, M.G.4
Barak, L.S.5
-
45
-
-
67649856866
-
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
-
Zidar, D. A., and Violin., J. D., Whalen, E. J., and Lefkowitz, R. J. (2009) Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc. Natl. Acad. Sci. U.S.A. 106, 9649-9654
-
(2009)
Proc. Natl. Acad. Sci. U.S.A
, vol.106
, pp. 9649-9654
-
-
Zidar, D.A.1
Violin, J.D.2
Whalen, E.J.3
Lefkowitz, R.J.4
-
46
-
-
0035793059
-
Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus
-
Barak, L. S., and Oakley., R. H., Laporte, S. A., and Caron, M. G. (2001) Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus. Proc. Natl. Acad. Sci. U.S.A. 98, 93-98
-
(2001)
Proc. Natl. Acad. Sci. U.S.A
, vol.98
, pp. 93-98
-
-
Barak, L.S.1
Oakley, R.H.2
Laporte, S.A.3
Caron, M.G.4
-
47
-
-
46449127054
-
β-Arrestin-mediated localization of smoothened to the primary cilium
-
Kovacs, J. J., and Whalen., E. J., Liu, R., Xiao, K., Kim, J., Chen, M., Wang, J., Chen, W., and Lefkowitz, R. J. (2008) β-Arrestin-mediated localization of smoothened to the primary cilium. Science 320, 1777-1781
-
(2008)
Science
, vol.320
, pp. 1777-1781
-
-
Kovacs, J.J.1
Whalen, E.J.2
Liu, R.3
Xiao, K.4
Kim, J.5
Chen, M.6
Wang, J.7
Chen, W.8
Lefkowitz, R.J.9
-
48
-
-
0033613938
-
β-Arrestin-dependent formation of β2 adrenergic receptor-src protein kinase complexes
-
Luttrell, L.M., Ferguson, S.S., Daaka, Y., Miller, W.E., Maudsley, S., Della Rocca, G. J., Lin, F., Kawakatsu, H., Owada, K., Luttrell, D. K., Caron, M. G., and Lefkowitz, R. J. (1999) β-Arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes. Science 283, 655-661
-
(1999)
Science
, vol.283
, pp. 655-661
-
-
Luttrell, L.M.1
Ferguson, S.S.2
Daaka, Y.3
Miller, W.E.4
Maudsley, S.5
Della Rocca, G.J.6
Lin, F.7
Kawakatsu, H.8
Owada, K.9
Luttrell, D.K.10
Caron, M.G.11
Lefkowitz, R.J.12
-
49
-
-
47849128759
-
M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms
-
Luo, J., and Busillo., J. M., and Benovic, J. L. (2008) M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms. Mol. Pharmacol. 74, 338-347
-
(2008)
Mol. Pharmacol
, vol.74
, pp. 338-347
-
-
Luo, J.1
Busillo, J.M.2
Benovic, J.L.3
-
50
-
-
0035956983
-
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
-
Luttrell, L. M., and Roudabush., F. L., Choy, E. W., Miller, W. E., and Field., M. E., Pierce, K. L., and Lefkowitz, R. J. (2001) Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds. Proc. Natl. Acad. Sci. U.S.A. 98, 2449-2454
-
(2001)
Proc. Natl. Acad. Sci. U.S.A
, vol.98
, pp. 2449-2454
-
-
Luttrell, L.M.1
Roudabush, F.L.2
Choy, E.W.3
Miller, W.E.4
Field, M.E.5
Pierce, K.L.6
Lefkowitz, R.J.7
-
51
-
-
0037147145
-
β-Arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation
-
Sun, Y., Cheng, Z., Ma, L., and Pei, G. (2002) β-Arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation. J. Biol. Chem. 277, 49212-49219
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49212-49219
-
-
Sun, Y.1
Cheng, Z.2
Ma, L.3
Pei, G.4
-
52
-
-
33745832645
-
Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes
-
Bruchas, M. R., and Macey., T. A., Lowe, J. D., and Chavkin, C (2006) Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. J. Biol. Chem. 281, 18081-18089
-
(2006)
J. Biol. Chem
, vol.281
, pp. 18081-18089
-
-
Bruchas, M.R.1
Macey, T.A.2
Lowe, J.D.3
Chavkin, C.4
-
53
-
-
84861740178
-
Silent scaffolds: Inhibition of c-jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant
-
Breitman, M., Kook, S., Gimenez, L. E., Lizama, B. N, Palazzo, M. C, Gurevich, E. V., and Gurevich, V. V. (2012) Silent scaffolds: inhibition of c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant. J. Biol. Chem. 287, 19653-19664
-
(2012)
J. Biol. Chem
, vol.287
, pp. 19653-19664
-
-
Breitman, M.1
Kook, S.2
Gimenez, L.E.3
Lizama, B.N.4
Palazzo, M.C.5
Gurevich, E.V.6
Gurevich, V.V.7
-
54
-
-
0035834428
-
Regulation of receptor fate by ubiquitination of activated β2-adrenergic receptor and β-arrestin
-
Shenoy, S.K., McDonald, P. H., Kohout, T.A., and Lefkowitz, R.J. (2001) Regulation of receptor fate by ubiquitination of activated β2-adrenergic receptor and β-arrestin. Science 294, 1307-1313
-
(2001)
Science
, vol.294
, pp. 1307-1313
-
-
Shenoy, S.K.1
McDonald, P.H.2
Kohout, T.A.3
Lefkowitz, R.J.4
-
55
-
-
0242362743
-
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
-
Marchese, A., Raiborg, C, Santini, F., and Keen., J. H., Stenmark, H., and Benovic, J. L. (2003) The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev. Cell 5, 709-722
-
(2003)
Dev. Cell
, vol.5
, pp. 709-722
-
-
Marchese, A.1
Raiborg, C.2
Santini, F.3
Keen, J.H.4
Stenmark, H.5
Benovic, J.L.6
-
56
-
-
77954626403
-
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4
-
Malik, R., and Marchese, A. (2010) Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. Mol. Biol. Cell 21, 2529-2541
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 2529-2541
-
-
Malik, R.1
Marchese, A.2
-
57
-
-
66149116039
-
β-Arrestindependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase mdm2
-
Shenoy, S. K., and Modi., A. S., Shukla, A. K., Xiao, K., Berthouze, M., Ahn, S., Wilkinson, K. D., and Miller., W. E., and Lefkowitz, R. J. (2009) β-Arrestindependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc. Natl. Acad. Sci. U.S.A. 106, 6650-6655
-
(2009)
Proc. Natl. Acad. Sci. U.S.A
, vol.106
, pp. 6650-6655
-
-
Shenoy, S.K.1
Modi, A.S.2
Shukla, A.K.3
Xiao, K.4
Berthouze, M.5
Ahn, S.6
Wilkinson, K.D.7
Miller, W.E.8
Lefkowitz, R.J.9
-
58
-
-
67649556158
-
The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization
-
Berthouze, M., Venkataramanan, V., Li, Y., and Shenoy, S. K. (2009) The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization. EMBO J. 28, 1684-1696
-
(2009)
EMBO J
, vol.28
, pp. 1684-1696
-
-
Berthouze, M.1
Venkataramanan, V.2
Li, Y.3
Shenoy, S.K.4
-
59
-
-
0242384217
-
Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway
-
von Zastrow, M. (2003) Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway. Life Sci. 74, 217-224
-
(2003)
Life Sci
, vol.74
, pp. 217-224
-
-
Von Zastrow, M.1
-
60
-
-
34848820302
-
β-Arrestin-mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection
-
Noma, T., Lemaire, A., Naga Prasad, S. V., Barki-Harrington, L., Tilley, D. G., Chen, J., Le Corvoisier, P., Violin, J. D., Wei, H., Lefkowitz, R. J., and Rockman, H. A. (2007) β-Arrestin-mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J. Clin. Invest. 117, 2445-2458
-
(2007)
J. Clin. Invest
, vol.117
, pp. 2445-2458
-
-
Noma, T.1
Lemaire, A.2
Naga Prasad, S.V.3
Barki-Harrington, L.4
Tilley, D.G.5
Chen, J.6
Le Corvoisier, P.7
Violin, J.D.8
Wei, H.9
Lefkowitz, R.J.10
Rockman, H.A.11
-
61
-
-
2342510314
-
Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-KB pathways
-
Gao, H., Sun, Y., Wu, Y., Luan, B., Wang, Y., Qu, B., and Pei, G. (2004) Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-KB pathways. Mol. Cell 14, 303-317
-
(2004)
Mol. Cell
, vol.14
, pp. 303-317
-
-
Gao, H.1
Sun, Y.2
Wu, Y.3
Luan, B.4
Wang, Y.5
Qu, B.6
Pei, G.7
-
62
-
-
28344452845
-
A nuclear function of β-arrestin1 in GPCR signaling: Regulation of histone acetylation and gene transcription
-
Kang, J., Shi, Y., Xiang, B., Qu, B., Su, W., Zhu, M., Zhang, M., Bao, G., Wang, F., Zhang, X., Yang, R., Fan, F., Chen, X., Pei, G., and Ma, L. (2005) A nuclear function of β-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123, 833-847
-
(2005)
Cell
, vol.123
, pp. 833-847
-
-
Kang, J.1
Shi, Y.2
Xiang, B.3
Qu, B.4
Su, W.5
Zhu, M.6
Zhang, M.7
Bao, G.8
Wang, F.9
Zhang, X.10
Yang, R.11
Fan, F.12
Chen, X.13
Pei, G.14
Ma, L.15
-
63
-
-
84872847980
-
Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβ7 complex
-
Wehbi, V. L., and Stevenson., H. P., Feinstein, T. N, Calero, G., Romero, G., and Vilardaga, J. P. (2013) Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβ7 complex. Proc. Natl. Acad. Sci. U.S.A. 110, 1530-1535
-
(2013)
Proc. Natl. Acad. Sci. U.S.A
, vol.110
, pp. 1530-1535
-
-
Wehbi, V.L.1
Stevenson, H.P.2
Feinstein, T.N.3
Calero, G.4
Romero, G.5
Vilardaga, J.P.6
-
64
-
-
84884761170
-
Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin
-
Feinstein, T. N., Yui, N., Webber, M. J., and Wehbi., V. L., Stevenson, H. P., King, J. D., Jr., Hallows, K. R., Brown, D., Bouley, R., and Vilardaga, J. P. (2013) Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J. Biol. Chem. 288, 27849-27860
-
(2013)
J. Biol. Chem
, vol.288
, pp. 27849-27860
-
-
Feinstein, T.N.1
Yui, N.2
Webber, M.J.3
Wehbi, V.L.4
Stevenson, H.P.5
King, J.D.6
Hallows, K.R.7
Brown, D.8
Bouley, R.9
Vilardaga, J.P.10
-
65
-
-
84875604499
-
Conformational biosensors reveal GPCR signalling from endosomes
-
Irannejad, R., Tomshine, J. C, Tomshine, J. R., Chevalier, M., and Mahoney., J. P., Steyaert, J., Rasmussen, S. G., and Sunahara., R. K., El-Samad, H., Huang, B., and von Zastrow, M. (2013) Conformational biosensors reveal GPCR signalling from endosomes. Nature 495, 534-538
-
(2013)
Nature
, vol.495
, pp. 534-538
-
-
Irannejad, R.1
Tomshine, J.C.2
Tomshine, J.R.3
Chevalier, M.4
Mahoney, J.P.5
Steyaert, J.6
Rasmussen, S.G.7
Sunahara, R.K.8
El-Samad, H.9
Huang, B.10
Von Zastrow, M.11
-
66
-
-
77951844975
-
Teaching old receptors new tricks: Biasing seven-transmembrane receptors
-
Rajagopal, S., Rajagopal, K., and Lefkowitz, R. J. (2010) Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat. Rev. Drug Discov. 9, 373-386
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, pp. 373-386
-
-
Rajagopal, S.1
Rajagopal, K.2
Lefkowitz, R.J.3
-
67
-
-
0021808471
-
The quantification of relative efficacy of agonists
-
Kenakin, T. P. (1985) The quantification of relative efficacy of agonists. J. Pharmacol. Methods 13, 281-308
-
(1985)
J. Pharmacol. Methods
, vol.13
, pp. 281-308
-
-
Kenakin, T.P.1
-
68
-
-
84868668210
-
TRV120027, a novelβ-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure
-
Boerrigter, G., and Soergel., D. G., Violin, J. D., Lark, M. W., and Burnett, J. C, Jr. (2012) TRV120027, a novelβ-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. Circ. Heart Fail. 5, 627-634
-
(2012)
Circ. Heart Fail
, vol.5
, pp. 627-634
-
-
Boerrigter, G.1
Soergel, D.G.2
Violin, J.D.3
Lark, M.W.4
Burnett, J.C.5
-
69
-
-
84938883543
-
Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model
-
Tarigopula, M., and Davis., R. T., 3rd, Mungai, P. T., Ryba, D. M., Wieczorek, D. F., Cowan, C L., Violin, J. D., Wolska, B. M., and Solaro, R. J. (2015) Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model. Cardiovasc. Res. 107, 226-234
-
(2015)
Cardiovasc. Res
, vol.107
, pp. 226-234
-
-
Tarigopula, M.1
Davis, R.T.2
Mungai, P.T.3
Ryba, D.M.4
Wieczorek, D.F.5
Cowan, C.L.6
Violin, J.D.7
Wolska, B.M.8
Solaro, R.J.9
-
70
-
-
84926407374
-
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers
-
Soergel, D. G., and Subach., R. A., Burnham, N, and Lark., M. W., James, I. E., Sadler, B. M., Skobieranda, F., and Violin., J. D., and Webster, L. R. (2014) Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: a randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. Pain 155, 1829-1835
-
(2014)
Pain
, vol.155
, pp. 1829-1835
-
-
Soergel, D.G.1
Subach, R.A.2
Burnham, N.3
Lark, M.W.4
James, I.E.5
Sadler, B.M.6
Skobieranda, F.7
Violin, J.D.8
Webster, L.R.9
-
71
-
-
84937596909
-
Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist
-
Brame, A. L., and Maguire., J. J., Yang, P., Dyson, A., Torella, R., Cheriyan, J., Singer, M., Glen, R. C, Wilkinson, I. B., and Davenport, A. P. (2015) Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension 65, 834-840
-
(2015)
Hypertension
, vol.65
, pp. 834-840
-
-
Brame, A.L.1
Maguire, J.J.2
Yang, P.3
Dyson, A.4
Torella, R.5
Cheriyan, J.6
Singer, M.7
Glen, R.C.8
Wilkinson, I.B.9
Davenport, A.P.10
-
72
-
-
80051979129
-
Quantifying ligand bias at seven-transmembrane receptors
-
Rajagopal, S., Ahn, S., Rominger, D. H, Gowen-MacDonald, W., Lam, C. M., and Dewire., S. M., Violin, J. D., and Lefkowitz, R. J. (2011) Quantifying ligand bias at seven-transmembrane receptors. Mol. Pharmacol. 80, 367-377
-
(2011)
Mol. Pharmacol
, vol.80
, pp. 367-377
-
-
Rajagopal, S.1
Ahn, S.2
Rominger, D.H.3
Gowen-MacDonald, W.4
Lam, C.M.5
Dewire, S.M.6
Violin, J.D.7
Lefkowitz, R.J.8
-
73
-
-
84858775788
-
A simple method for quantifying functional selectivity and agonist bias
-
Kenakin, T., Watson, C, Muniz-Medina, V., Christopoulos, A., and Novick, S. (2012) A simple method for quantifying functional selectivity and agonist bias. ACS Chem. Neurosci. 3, 193-203
-
(2012)
ACS Chem. Neurosci
, vol.3
, pp. 193-203
-
-
Kenakin, T.1
Watson, C.2
Muniz-Medina, V.3
Christopoulos, A.4
Novick, S.5
-
74
-
-
59449084824
-
Estimation of relative microscopic affinity constants of agonists for the active state of the receptor in functional studies on M2 and M3 muscarinic receptors
-
Tran, J. A., Chang, A., Matsui, M., and Ehlert, F. J. (2009) Estimation of relative microscopic affinity constants of agonists for the active state of the receptor in functional studies on M2 and M3 muscarinic receptors. Mol. Pharmacol. 75, 381-396
-
(2009)
Mol. Pharmacol
, vol.75
, pp. 381-396
-
-
Tran, J.A.1
Chang, A.2
Matsui, M.3
Ehlert, F.J.4
-
75
-
-
84921525907
-
Bias analyses of preclinical and clinical D2 dopamine ligands: Studies with immediate and complex signaling pathways
-
Brust, T. F., and Hayes., M. P., Roman, D. L., Burris, K. D., and Watts, V. J. (2015) Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways. J. Pharmacol. Exp. Ther. 352, 480-493
-
(2015)
J. Pharmacol. Exp. Ther
, vol.352
, pp. 480-493
-
-
Brust, T.F.1
Hayes, M.P.2
Roman, D.L.3
Burris, K.D.4
Watts, V.J.5
-
76
-
-
84913535661
-
What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling
-
Onaran, H. O., Rajagopal, S., and Costa, T. (2014) What is biased efficacy? Defining the relationship between intrinsic efficacy and free energy coupling. Trends Pharmacol. Sci. 35, 639-647
-
(2014)
Trends Pharmacol. Sci
, vol.35
, pp. 639-647
-
-
Onaran, H.O.1
Rajagopal, S.2
Costa, T.3
-
77
-
-
13444291851
-
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
-
Kim, J., Ahn, S., Ren, X. R., and Whalen., E. J., Reiter, E., Wei, H., and Lefkowitz, R. J. (2005) Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 102, 1442-1447
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 1442-1447
-
-
Kim, J.1
Ahn, S.2
Ren, X.R.3
Whalen, E.J.4
Reiter, E.5
Wei, H.6
Lefkowitz, R.J.7
-
78
-
-
79953192547
-
Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code
-
Butcher, A. J., Prihandoko, R., Kong, K. C, McWilliams, P., and Edwards., J. M., Bottrill, A., Mistry, S., and Tobin, A. B. (2011) Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code. J. Biol. Chem. 286, 11506-11518
-
(2011)
J. Biol. Chem
, vol.286
, pp. 11506-11518
-
-
Butcher, A.J.1
Prihandoko, R.2
Kong, K.C.3
McWilliams, P.4
Edwards, J.M.5
Bottrill, A.6
Mistry, S.7
Tobin, A.B.8
-
79
-
-
77951230331
-
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
-
Busillo, J. M., Armando, S., Sengupta, R., Meucci, O., Bouvier, M., and Benovic, J. L. (2010) Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J. Biol. Chem. 285, 7805-7817
-
(2010)
J. Biol. Chem
, vol.285
, pp. 7805-7817
-
-
Busillo, J.M.1
Armando, S.2
Sengupta, R.3
Meucci, O.4
Bouvier, M.5
Benovic, J.L.6
-
80
-
-
80051616441
-
Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin
-
Nobles, K. N, Xiao, K., Ahn, S., Shukla, A. K., and Lam., C. M., Rajagopal, S., Strachan, R. T., and Huang., T. Y., Bressler, E. A., Hara, M. R., and Shenoy., S. K., Gygi, S. P., and Lefkowitz, R. J. (2011) Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci. Signal. 4, ra51
-
(2011)
Sci. Signal
, vol.4
, pp. ra51
-
-
Nobles, K.N.1
Xiao, K.2
Ahn, S.3
Shukla, A.K.4
Lam, C.M.5
Rajagopal, S.6
Strachan, R.T.7
Huang, T.Y.8
Bressler, E.A.9
Hara, M.R.10
Shenoy, S.K.11
Gygi, S.P.12
Lefkowitz, R.J.13
-
81
-
-
0033574274
-
The 2.8 Å crystal structure of visual arrestin: A model for arrestin's regulation
-
Hirsch, J. A., Schubert, C., Gurevich, V. V., and Sigler, P. B. (1999) The 2.8 Å crystal structure of visual arrestin: a model for arrestin's regulation. Cell 97, 257-269
-
(1999)
Cell
, vol.97
, pp. 257-269
-
-
Hirsch, J.A.1
Schubert, C.2
Gurevich, V.V.3
Sigler, P.B.4
-
82
-
-
0034802172
-
Crystal structure of β-arrestin at 1.9 Å: Possible mechanism of receptor binding and membrane translocation
-
Han, M., and Gurevich., V. V., Vishnivetskiy, S. A., Sigler, P. B., and Schubert, C. (2001) Crystal structure of β-arrestin at 1.9 Å: possible mechanism of receptor binding and membrane Translocation. Structure 9, 869-880
-
(2001)
Structure
, vol.9
, pp. 869-880
-
-
Han, M.1
Gurevich, V.V.2
Vishnivetskiy, S.A.3
Sigler, P.B.4
Schubert, C.5
-
83
-
-
79551687952
-
Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes
-
Zhan, X., and Gimenez., L. E., Gurevich, V. V., and Spiller, B. W. (2011) Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes. J. Mol. Biol. 406, 467-478
-
(2011)
J. Mol. Biol
, vol.406
, pp. 467-478
-
-
Zhan, X.1
Gimenez, L.E.2
Gurevich, V.V.3
Spiller, B.W.4
-
84
-
-
28144443994
-
Crystal structure of cone arrestin at 2.3 Å: Evolution of receptor specificity
-
Sutton, R. B., and Vishnivetskiy., S. A., Robert, J., Hanson, S. M., Raman, D., and Knox., B. E., Kono, M., Navarro, J., and Gurevich, V. V. (2005) Crystal structure of cone arrestin at 2.3 Å: evolution of receptor specificity. J. Mol. Biol. 354, 1069-1080
-
(2005)
J. Mol. Biol
, vol.354
, pp. 1069-1080
-
-
Sutton, R.B.1
Vishnivetskiy, S.A.2
Robert, J.3
Hanson, S.M.4
Raman, D.5
Knox, B.E.6
Kono, M.7
Navarro, J.8
Gurevich, V.V.9
-
85
-
-
33947577189
-
Structure and function of the visual arrestin oligomer
-
Hanson, S. M., Van Eps, N, Francis, D. J., Altenbach, C, Vishnivetskiy, S. A., Arshavsky, V. Y., Klug, C S., Hubbell, W. L., and Gurevich, V. V. (2007) Structure and function of the visual arrestin oligomer. EMBO J. 26, 1726-1736
-
(2007)
EMBO J
, vol.26
, pp. 1726-1736
-
-
Hanson, S.M.1
Van Eps, N.2
Francis, D.J.3
Altenbach, C.4
Vishnivetskiy, S.A.5
Arshavsky, V.Y.6
Klug, C.S.7
Hubbell, W.L.8
Gurevich, V.V.9
-
86
-
-
33646942810
-
Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding
-
Milano, S. K., and Kim., Y. M., Stefano, F. P., Benovic, J. L., and Brenner, C. (2006) Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding. J. Biol. Chem. 281, 9812-9823
-
(2006)
J. Biol. Chem
, vol.281
, pp. 9812-9823
-
-
Milano, S.K.1
Kim, Y.M.2
Stefano, F.P.3
Benovic, J.L.4
Brenner, C.5
-
87
-
-
0027241013
-
Visual arrestin interaction with rhodopsin: Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin
-
Gurevich, V. V., and Benovic, J. L. (1993) Visual arrestin interaction with rhodopsin: sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin. J. Biol. Chem. 268, 11628-11638
-
(1993)
J. Biol. Chem
, vol.268
, pp. 11628-11638
-
-
Gurevich, V.V.1
Benovic, J.L.2
-
88
-
-
84877581626
-
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide
-
Shukla, A. K., Manglik, A., Kruse, A. C, Xiao, K., and Reis., R. I., Tseng, W. C, Staus, D. P., Hilger, D., Uysal, S., Huang, L. Y., Paduch, M., TripathiShukla, P., Koide, A., Koide, S., and Weis., W. I., et al. (2013) Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature 497, 137-141
-
(2013)
Nature
, vol.497
, pp. 137-141
-
-
Shukla, A.K.1
Manglik, A.2
Kruse, A.C.3
Xiao, K.4
Reis, R.I.5
Tseng, W.C.6
Staus, D.P.7
Hilger, D.8
Uysal, S.9
Huang, L.Y.10
Paduch, M.11
TripathiShukla, P.12
Koide, A.13
Koide, S.14
Weis, W.I.15
-
89
-
-
84946116372
-
Structural evidence for the role of polar core residue Arg175 in arrestin activation
-
Granzin, J., Stadler, A., Cousin, A., Schlesinger, R., and Batra-Safferling, R. (2015) Structural evidence for the role of polar core residue Arg175 in arrestin activation. Sci. Rep. 5, 15808
-
(2015)
Sci. Rep
-
-
Granzin, J.1
Stadler, A.2
Cousin, A.3
Schlesinger, R.4
Batra-Safferling, R.5
-
90
-
-
34547104638
-
The active conformation of β-arrestin1: Direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states ofβ-arrestins1 and -2
-
Nobles, K. N, Guan, Z., Xiao, K., Oas, T. G., and Lefkowitz, R. J. (2007) The active conformation of β-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states ofβ-arrestins1 and -2. J. Biol. Chem. 282, 21370-21381
-
(2007)
J. Biol. Chem
, vol.282
, pp. 21370-21381
-
-
Nobles, K.N.1
Guan, Z.2
Xiao, K.3
Oas, T.G.4
Lefkowitz, R.J.5
-
91
-
-
84877581910
-
Crystal structure of pre-activated arrestin p44
-
Kim, Y. J., and Hofmann., K. P., Ernst, O. P., Scheerer, P., Choe, H. W., and Sommer, M. E. (2013) Crystal structure of pre-activated arrestin p44. Nature 497, 142-146
-
(2013)
Nature
, vol.497
, pp. 142-146
-
-
Kim, Y.J.1
Hofmann, K.P.2
Ernst, O.P.3
Scheerer, P.4
Choe, H.W.5
Sommer, M.E.6
-
92
-
-
33645506641
-
Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin
-
Hanson, S. M., and Francis., D. J., Vishnivetskiy, S. A., Kolobova, E. A., and Hubbell., W. L., Klug, C. S., and Gurevich, V. V. (2006) Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin. Proc. Natl. Acad. Sci. U.S.A. 103, 4900-4905
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 4900-4905
-
-
Hanson, S.M.1
Francis, D.J.2
Vishnivetskiy, S.A.3
Kolobova, E.A.4
Hubbell, W.L.5
Klug, C.S.6
Gurevich, V.V.7
-
93
-
-
84868573187
-
Conformation of receptorbound visual arrestin
-
Kim, M., and Vishnivetskiy., S. A., Van Eps, N, Alexander, N. S., Cleghorn, W. M., Zhan, X., Hanson, S. M., Morizumi, T., Ernst, O. P., Meiler, J., Gurevich, V. V., and Hubbell, W. L. (2012) Conformation of receptorbound visual arrestin. Proc. Natl. Acad. Sci. U.S.A. 109, 18407-18412
-
(2012)
Proc. Natl. Acad. Sci. U.S.A
, vol.109
, pp. 18407-18412
-
-
Kim, M.1
Vishnivetskiy, S.A.2
Van Eps, N.3
Alexander, N.S.4
Cleghorn, W.M.5
Zhan, X.6
Hanson, S.M.7
Morizumi, T.8
Ernst, O.P.9
Meiler, J.10
Gurevich, V.V.11
Hubbell, W.L.12
-
94
-
-
84938359988
-
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
-
Kang, Y., and Zhou., X. E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T. A., Yefanov, O., and Han., G. W., Xu, Q., de Waal, P. W., Ke, J., Tan, M. H, Zhang, C, et al. (2015) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature 523, 561-567
-
(2015)
Nature
, vol.523
, pp. 561-567
-
-
Kang, Y.1
Zhou, X.E.2
Gao, X.3
He, Y.4
Liu, W.5
Ishchenko, A.6
Barty, A.7
White, T.A.8
Yefanov, O.9
Han, G.W.10
Xu, Q.11
De Waal, P.W.12
Ke, J.13
Tan, M.H.14
Zhang, C.15
-
95
-
-
84916610476
-
Crystal structure of a common GPCR-binding interface for G protein and arrestin
-
Szczepek, M., Beyrière, F., Hofmann, K. P., Elgeti, M., Kazmin, R., Rose, A., Bartl, F. J., von Stetten, D., Heck, M., Sommer, M. E., and Hildebrand., P. W., and Scheerer, P. (2014) Crystal structure of a common GPCR-binding interface for G protein and arrestin. Nat. Commun. 5, 4801
-
(2014)
Nat. Commun
, vol.5
, pp. 4801
-
-
Szczepek, M.1
Beyrière, F.2
Hofmann, K.P.3
Elgeti, M.4
Kazmin, R.5
Rose, A.6
Bartl, F.J.7
Von Stetten, D.8
Heck, M.9
Sommer, M.E.10
Hildebrand, P.W.11
Scheerer, P.12
-
96
-
-
70449591430
-
Helix formation in arrestin accompanies recognition of photoactivated rhodopsin
-
Feuerstein, S. E., Pulvermüller, A., Hartmann, R., Granzin, J., Stoldt, M., Henklein, P., and Ernst., O. P., Heck, M., Willbold, D., and Koenig, B. W. (2009) Helix formation in arrestin accompanies recognition of photoactivated rhodopsin. Biochemistry 48, 10733-10742
-
(2009)
Biochemistry
, vol.48
, pp. 10733-10742
-
-
Feuerstein, S.E.1
Pulvermüller, A.2
Hartmann, R.3
Granzin, J.4
Stoldt, M.5
Henklein, P.6
Ernst, O.P.7
Heck, M.8
Willbold, D.9
Koenig, B.W.10
-
97
-
-
80051658642
-
s protein complex
-
s protein complex. Nature 477, 549-555
-
(2011)
Nature
, vol.477
, pp. 549-555
-
-
Rasmussen, S.G.1
DeVree, B.T.2
Zou, Y.3
Kruse, A.C.4
Chung, K.Y.5
Kobilka, T.S.6
Thian, F.S.7
Chae, P.S.8
Pardon, E.9
Calinski, D.10
Mathiesen, J.M.11
Shah, S.T.12
Lyons, J.A.13
Caffrey, M.14
Gellman, S.H.15
-
98
-
-
84906232914
-
Visualization of arrestin recruitment by a G-protein-coupled receptor
-
Shukla, A. K., and Westfield., G. H., Xiao, K., Reis, R. I., and Huang., L. Y., TripathiShukla, P., Qian, J., Li, S., Blanc, A., Oleskie, A. N, Dosey, A. M., Su, M., and Liang., C. R., Gu, L. L., Shan, J. M., et al. (2014) Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature 512, 218-222
-
(2014)
Nature
, vol.512
, pp. 218-222
-
-
Shukla, A.K.1
Westfield, G.H.2
Xiao, K.3
Reis, R.I.4
Huang, L.Y.5
TripathiShukla, P.6
Qian, J.7
Li, S.8
Blanc, A.9
Oleskie, A.N.10
Dosey, A.M.11
Su, M.12
Liang, C.R.13
Gu, L.L.14
Shan, J.M.15
-
99
-
-
70350351401
-
Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking
-
Kang, D. S., Kern, R. C, Puthenveedu, M. A., von Zastrow, M., Williams, J. C, and Benovic, J. L. (2009) Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. J. Biol. Chem. 284, 29860-29872
-
(2009)
J. Biol. Chem
, vol.284
, pp. 29860-29872
-
-
Kang, D.S.1
Kern, R.C.2
Puthenveedu, M.A.3
Von Zastrow, M.4
Williams, J.C.5
Benovic, J.L.6
-
100
-
-
84941048021
-
19F-NMR
-
19F-NMR. Nat. Commun. 6, 8202
-
(2015)
Nat. Commun
, vol.6
, pp. 8202
-
-
Yang, F.1
Yu, X.2
Liu, C.3
Qu, C.X.4
Gong, Z.5
Liu, H.D.6
Li, F.H.7
Wang, H.M.8
He, D.F.9
Yi, F.10
Song, C.11
Tian, C.L.12
Xiao, K.H.13
Wang, J.Y.14
Sun, J.P.15
|