Targeting the sonic hedgehog signaling pathway: Review of smoothened and GLI inhibitors

Cancers

Volumn 8, Issue 2, 2016, Pages

  Rimkus, Tadas K ^a   Carpenter, Richard L ^a   Qasem, Shadi ^a   Chan, Michael ^a   Lo, Hui Wen ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

GLI; Inhibitors; PTCH; Smoothened; Sonic hedgehog pathway; Targeted therapy; tGLI1

Indexed keywords

6 ETHYL 4,5 DIHYDRO N [1 (HYDROXYACETYL) 4 PIPERIDINYL] 1 METHYL 4 OXO 5 (2 OXO 2 PHENYLETHYL) 3 (2,2,2 TRIFLUOROETHOXY) 1H PYRROLO[3,2 C]PYRIDINE 2 CARBOXAMIDE; ARSENIC TRIOXIDE; AXITINIB; BMS 833923; CABOZANTINIB; CYCLOPAMINE; GLASDEGIB; GLI ANTAGONIST; GLIOMA ASSOCIATED ONCOGENE HOMOLOG PROTEIN INHIBITOR; JERVINE; LENVATINIB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5E1; MRT 92; NATURAL PRODUCT; PATIDEGIB; PAZOPANIB; PROTEIN INHIBITOR; RAMUCIRUMAB; REGORAFENIB; RU SKI 43; SONIC HEDGEHOG PROTEIN; SONIDEGIB; SORAFENIB; SUNITINIB; TALADEGIB; UNCLASSIFIED DRUG; VANDETANIB; VISMODEGIB;

ANTINEOPLASTIC ACTIVITY; BINDING SITE; CANCER STEM CELL; DRUG APPROVAL; DRUG EFFICACY; DRUG PROTEIN BINDING; FOOD AND DRUG ADMINISTRATION; GENE MUTATION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MOLECULARLY TARGETED THERAPY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; SONIC HEDGEHOG SIGNALING PATHWAY; TRANSCRIPTION REGULATION;

EID: 84958751503     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers8020022     Document Type: Review

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