The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways

Oncogene

Volumn 20, Issue 16, 2001, Pages 1953-1963

  Martin, Carol B ^a   Mahon, Gwendolyn M ^b   Klinger, Mark B ^c   Kay, Robert J ^c   Symons, Marc ^d   Der, Channing J ^a   Whitehead, Ian P ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d PICOWER INST FOR MEDICAL RESEARCH   (United States)

Author keywords

PAR 1; RhoA; Thrombin; Transformation

Indexed keywords

COMPLEMENTARY DNA; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PERTUSSIS TOXIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SERUM RESPONSE FACTOR; THROMBIN INHIBITOR; THROMBIN RECEPTOR; THROMBIN RECEPTOR PAR 1; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL STRAIN 3T3; CELL TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

3T3 CELLS; ACTINS; ANIMALS; CELL ADHESION; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HETEROTRIMERIC GTP-BINDING PROTEINS; MICE; MYELOID CELLS; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA; RICKETTSIA SP. PAR; SUIDAE;

EID: 0035848718     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1204281     Document Type: Article

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