-
1
-
-
84888056396
-
Recent developments in biased agonism
-
Wisler, J.W.; Xiao, K.; Thomsen, A.R.; Lefkowitz, R.J. Recent developments in biased agonism. Curr. Opin. Cell Biol. 2014, 27, 18–24.
-
(2014)
Curr. Opin. Cell Biol
, vol.27
, pp. 18-24
-
-
Wisler, J.W.1
Xiao, K.2
Thomsen, A.R.3
Lefkowitz, R.J.4
-
2
-
-
84872048999
-
The potential for selective pharmacological therapies through biased receptor signaling
-
Kenakin, T. The potential for selective pharmacological therapies through biased receptor signaling. BMC Pharmacol. Toxicol. 2012, 13, 3.
-
(2012)
BMC Pharmacol. Toxicol
, vol.13
, pp. 3
-
-
Kenakin, T.1
-
3
-
-
84895156496
-
Biased signalling and proteinase-activated receptors (PARs): Targeting inflammatory disease
-
Hollenberg, M.D.; Mihara, K.; Polley, D.; Suen, J.Y.; Han, A.; Fairlie, D.P.; Ramachandran, R. Biased signalling and proteinase-activated receptors (PARs): Targeting inflammatory disease. Br. J. Pharmacol. 2014, 171, 1180–1194.
-
(2014)
Br. J. Pharmacol
, vol.171
, pp. 1180-1194
-
-
Hollenberg, M.D.1
Mihara, K.2
Polley, D.3
Suen, J.Y.4
Han, A.5
Fairlie, D.P.6
Ramachandran, R.7
-
4
-
-
84884594350
-
Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis
-
Feigin, M.E. Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis. FEBS J. 2013, 280, 4729–4738.
-
(2013)
FEBS J
, vol.280
, pp. 4729-4738
-
-
Feigin, M.E.1
-
5
-
-
79952488185
-
Therapeutic potential of β-arrestin- and G protein-biased agonists
-
Whalen, E.J.; Rajagopal, S.; Lefkowitz, R.J. Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends Mol. Med. 2011, 17, 126–139.
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 126-139
-
-
Whalen, E.J.1
Rajagopal, S.2
Lefkowitz, R.J.3
-
6
-
-
84894528689
-
β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells
-
Cianfrocca, R.; Tocci, P.; Semprucci, E.; Spinella, F.; di Castro, V.; Bagnato, A.; Rosanò, L. β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells. Life Sci. 2014, 118, 179–184.
-
(2014)
Life Sci
, vol.118
, pp. 179-184
-
-
Cianfrocca, R.1
Tocci, P.2
Semprucci, E.3
Spinella, F.4
Di Castro, V.5
Bagnato, A.6
Rosanò, L.7
-
7
-
-
84886100276
-
β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling
-
Rosanò, L.; Cianfrocca, R.; Tocci, P.; Spinella, F.; di Castro, V.; Spadaro, F.; Salvati, E.; Biroccio, A.M.; Natali, P.G.; Bagnato, A. β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling. Oncogene 2013, 32, 5066–5077.
-
(2013)
Oncogene
, vol.32
, pp. 5066-5077
-
-
Rosanò, L.1
Cianfrocca, R.2
Tocci, P.3
Spinella, F.4
Di Castro, V.5
Spadaro, F.6
Salvati, E.7
Biroccio, A.M.8
Natali, P.G.9
Bagnato, A.10
-
8
-
-
78650845707
-
Protein-coupled receptors: Novel targets for drugdiscovery in cancer. Nat
-
Lappano, R.; Maggiolini, M. G protein-coupled receptors: Novel targets for drugdiscovery in cancer. Nat. Rev. Drug Discov. 2011, 10, 47–60.
-
(2011)
Rev. Drug Discov
, vol.10
, pp. 47-60
-
-
Lappano, R.1
Maggiolini, M.G.2
-
9
-
-
33846474121
-
G-protein-coupled receptors and cancer
-
Dorsam, R.T.; Gutkind, J.S. G-protein-coupled receptors and cancer. Nat. Rev. Cancer. 2007, 7, 79–94.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 79-94
-
-
Dorsam, R.T.1
Gutkind, J.S.2
-
10
-
-
0027217195
-
A mutant α subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells
-
Xu, N.; Bradley, L.; Ambdukar, I.; Gutkind, J.S. A mutant α subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. Proc. Natl. Acad. Sci. USA 1993, 90, 6741–6745.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6741-6745
-
-
Xu, N.1
Bradley, L.2
Ambdukar, I.3
Gutkind, J.S.4
-
11
-
-
0027303269
-
The transforming activity of activated G α 12
-
Jiang, H.; Wu, D.; Simon, M.I. The transforming activity of activated G α 12. FEBS Lett. 1993, 330, 319–322.
-
(1993)
FEBS Lett
, vol.330
, pp. 319-322
-
-
Jiang, H.1
Wu, D.2
Simon, M.I.3
-
12
-
-
0028100892
-
Mutant α subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts
-
Voyno-Yasenetskaya, T.A.; Pace, A.M.; Bourne, H.R. Mutant α subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts. Oncogene 1994, 9, 2559–2565.
-
(1994)
Oncogene
, vol.9
, pp. 2559-2565
-
-
Voyno-Yasenetskaya, T.A.1
Pace, A.M.2
Bourne, H.R.3
-
14
-
-
0000201075
-
+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways
-
+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways. J. Biol. Chem. 1996, 271, 6152–6158.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 6152-6158
-
-
Hooley, R.1
Yu, C.Y.2
Symons, M.3
Barber, D.L.4
-
15
-
-
0031015426
-
Vascular system defects and impaired cell chemokinesis as a result of Gα13 deficiency
-
Offermanns, S.; Mancino, V.; Revel, J.P.; Simon, M.I. Vascular system defects and impaired cell chemokinesis as a result of Gα13 deficiency. Science 1997, 275, 533–536.
-
(1997)
Science
, vol.275
, pp. 533-536
-
-
Offermanns, S.1
Mancino, V.2
Revel, J.P.3
Simon, M.I.4
-
16
-
-
77956034731
-
Aiming drug discovery at lysophosphatidic acid targets
-
Tigyi, G. Aiming drug discovery at lysophosphatidic acid targets. Br. J. Pharmacol. 2010, 161, 241–247.
-
(2010)
Br. J. Pharmacol
, vol.161
, pp. 241-247
-
-
Tigyi, G.1
-
17
-
-
0033669622
-
Lysophosphatidic acid receptors
-
Contos, J.J.; Ishii, I.; Chun, J. Lysophosphatidic acid receptors. Mol. Pharmacol. 2000, 58, 1188–1196.
-
(2000)
Mol. Pharmacol
, vol.58
, pp. 1188-1196
-
-
Contos, J.J.1
Ishii, I.2
Chun, J.3
-
18
-
-
84881230811
-
Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focused review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays
-
Willier, S.; Butt, E.; Grunewald, T.G. Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focused review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays. Biol. Cell 2013, 105, 317–333.
-
(2013)
Biol. Cell
, vol.105
, pp. 317-333
-
-
Willier, S.1
Butt, E.2
Grunewald, T.G.3
-
19
-
-
57349178989
-
Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandin-endoperoxide synthase 2 expression in the porcine uterus
-
Seo, H.; Kim, M.; Choi, Y.; Lee, C.K.; Ka, H. Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandin-endoperoxide synthase 2 expression in the porcine uterus. Endocrinology 2008, 149, 6166–6167.
-
(2008)
Endocrinology
, vol.149
, pp. 6166-6167
-
-
Seo, H.1
Kim, M.2
Choi, Y.3
Lee, C.K.4
Ka, H.5
-
20
-
-
33846931370
-
The lysophosphatidic acid (LPA) receptors their expression and significance in epithelial ovarian neoplasms. Gynecol
-
Wang, P.; Wu, X.; Chen, W.; Liu, J.; Wang, X. The lysophosphatidic acid (LPA) receptors their expression and significance in epithelial ovarian neoplasms. Gynecol. Oncol. 2007, 104, 714–720.
-
(2007)
Oncol
, vol.104
, pp. 714-720
-
-
Wang, P.1
Wu, X.2
Chen, W.3
Liu, J.4
Wang, X.5
-
21
-
-
84883153220
-
Endothelin 1 in cancer: Biological implications and therapeutic opportunities
-
Rosanò, L.; Spinella, F.; Bagnato, A. Endothelin 1 in cancer: Biological implications and therapeutic opportunities. Nat. Rev. Cancer. 2013, 13, 637–651.
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 637-651
-
-
Rosanò, L.1
Spinella, F.2
Bagnato, A.3
-
22
-
-
84873685831
-
Molecular signatures of G-protein-coupled receptors
-
Venkatakrishnan, A.J.; Deupi, X.; Lebon, G.; Tate, C.G.; Schertler, G.F.; Babu, M.M. Molecular signatures of G-protein-coupled receptors. Nature 2013, 494, 185–194.
-
(2013)
Nature
, vol.494
, pp. 185-194
-
-
Venkatakrishnan, A.J.1
Deupi, X.2
Lebon, G.3
Tate, C.G.4
Schertler, G.F.5
Babu, M.M.6
-
23
-
-
40349094705
-
Nicotinic acid: An old drug with a promising future
-
Bodor, E.T.; Offermanns, S. Nicotinic acid: An old drug with a promising future. Br. J. Pharmacol. 2008, 153, S68–S75.
-
(2008)
Br. J. Pharmacol
, vol.153
, pp. S68-S75
-
-
Bodor, E.T.1
Offermanns, S.2
-
24
-
-
84936818543
-
N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias
-
Soto, A.G.; Smith, T.H.; Chen, B.; Bhattacharya, S.; Cordova, I.C.; Kenakin, T.; Vaidehi, N.; Trejo, J. N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias. Proc. Natl. Acad. Sci. USA 2015, 112, E3600–E3608.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. E3600-E3608
-
-
Soto, A.G.1
Smith, T.H.2
Chen, B.3
Bhattacharya, S.4
Cordova, I.C.5
Kenakin, T.6
Vaidehi, N.7
Trejo, J.8
-
25
-
-
78751498756
-
Functional selectivity and biased receptor signaling
-
Kenakin, T. Functional selectivity and biased receptor signaling. J. Pharmacol. Exp. Ther. 2011, 336, 296–302.
-
(2011)
J. Pharmacol. Exp. Ther
, vol.336
, pp. 296-302
-
-
Kenakin, T.1
-
26
-
-
33744957160
-
Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation
-
Gesty-Palmer, D.; Chen, M.; Reiter, E.; Ahn, S.; Nelson, C.D.; Wang, S.; Eckhardt, A.E.; Cowan, C.L.; Spurney, R.F.; Luttrell, L.M.; et al. Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. J. Biol. Chem. 2006, 281, 10856–10864.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 10856-10864
-
-
Gesty-Palmer, D.1
Chen, M.2
Reiter, E.3
Ahn, S.4
Nelson, C.D.5
Wang, S.6
Eckhardt, A.E.7
Cowan, C.L.8
Spurney, R.F.9
Luttrell, L.M.10
-
27
-
-
34249856025
-
B-arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo
-
Bryja, V.; Gradl, D.; Schambony, A.; Arenas, E.; Schulte, G. B-arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo. Proc. Natl. Acad. Sci. USA 2007, 104, 6690–6695.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 6690-6695
-
-
Bryja, V.1
Gradl, D.2
Schambony, A.3
Arenas, E.4
Schulte, G.5
-
28
-
-
62449145673
-
B-arrestin links endothelin A receptor to β-catenin signaling to induce ovarian cancer cell invasion and metastasis
-
Rosanò, L.; Cianfrocca, R.; Masi, S.; Spinella, F.; di Castro, V.; Biroccio, A.; Salvati, E.; Nicotra, M.R.; Natali, P.G.; Bagnato, A. B-arrestin links endothelin A receptor to β-catenin signaling to induce ovarian cancer cell invasion and metastasis. Proc. Natl. Acad. Sci. USA 2009, 106, 2806–2811.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2806-2811
-
-
Rosanò, L.1
Cianfrocca, R.2
Masi, S.3
Spinella, F.4
Di Castro, V.5
Biroccio, A.6
Salvati, E.7
Nicotra, M.R.8
Natali, P.G.9
Bagnato, A.10
-
29
-
-
0022536710
-
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains
-
Young, D.; Waitches, G.; Birchmeier, C.; Fasano, O.; Wigler, M. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell 1986, 45, 711–719.
-
(1986)
Cell
, vol.45
, pp. 711-719
-
-
Young, D.1
Waitches, G.2
Birchmeier, C.3
Fasano, O.4
Wigler, M.5
-
30
-
-
84878371294
-
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligands
-
Davenport, A.P.; Alexander, S.P.; Sharman, J.L.; Pawson, A.J.; Benson, H.E.; Monaghan, A.E.; Liew, W.C.; Mpamhanga, C.P.; Bonner, T.I.; Neubig, R.R.; et al. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligands. Pharmacol. Rev. 2013, 65, 967–986.
-
(2013)
Pharmacol. Rev
, vol.65
, pp. 967-986
-
-
Davenport, A.P.1
Alexander, S.P.2
Sharman, J.L.3
Pawson, A.J.4
Benson, H.E.5
Monaghan, A.E.6
Liew, W.C.7
Mpamhanga, C.P.8
Bonner, T.I.9
Neubig, R.R.10
-
31
-
-
0034632681
-
G2A is an oncogenic G protein-coupled receptor
-
Zohn, I.E.; Klinger, M.; Karp, X.; Kirk, H.; Symons, M.; Chrzanowska-Wodnicka, M.; Der, C.J.; Kay, R.J. G2A is an oncogenic G protein-coupled receptor. Oncogene 2000, 19, 3866–3877.
-
(2000)
Oncogene
, vol.19
, pp. 3866-3877
-
-
Zohn, I.E.1
Klinger, M.2
Karp, X.3
Kirk, H.4
Symons, M.5
Chrzanowska-Wodnicka, M.6
Der, C.J.7
Kay, R.J.8
-
32
-
-
0032514679
-
A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M
-
Weng, Z.; Fluckiger, A.C.; Nisitani, S.; Wahl, M.I.; Le, L.Q.; Hunter, C.A.; Fernal, A.A.; Le Beau, M.M.; Witte, O.N. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc. Natl. Acad. Sci. USA 1998, 95, 12334–12339.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 12334-12339
-
-
Weng, Z.1
Fluckiger, A.C.2
Nisitani, S.3
Wahl, M.I.4
Le, L.Q.5
Hunter, C.A.6
Fernal, A.A.7
Le Beau, M.M.8
Witte, O.N.9
-
33
-
-
0035848718
-
The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways
-
Martin, C.B.; Mahon, G.M.; Klinger, M.B.; Kay, R.J.; Symons, M.; Der, C.J.; Whitehead, I.P. The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. Oncogene 2001, 20, 1953–1963.
-
(2001)
Oncogene
, vol.20
, pp. 1953-1963
-
-
Martin, C.B.1
Mahon, G.M.2
Klinger, M.B.3
Kay, R.J.4
Symons, M.5
Der, C.J.6
Whitehead, I.P.7
-
34
-
-
0028889967
-
Expression cloning of oncogenes by retroviral transfer of cDNA libraries
-
Whitehead, I.; Kirk, H.; Kay, R. Expression cloning of oncogenes by retroviral transfer of cDNA libraries. Mol. Cell. Biol. 1995, 15, 704–710.
-
(1995)
Mol. Cell. Biol
, vol.15
, pp. 704-710
-
-
Whitehead, I.1
Kirk, H.2
Kay, R.3
-
35
-
-
0031927754
-
Thrombin receptor overexpression in malignant and physiological invasion processes
-
Even-Ram, S.; Uziely, B.; Cohen, P.; Grisaru-Granovsky, S.; Maoz, M.; Ginzburg, Y.; Reich, R.; Vlodavsky, I.; Bar-Shavit, R. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat. Med. 1998, 4, 909–914.
-
(1998)
Nat. Med
, vol.4
, pp. 909-914
-
-
Even-Ram, S.1
Uziely, B.2
Cohen, P.3
Grisaru-Granovsky, S.4
Maoz, M.5
Ginzburg, Y.6
Reich, R.7
Vlodavsky, I.8
Bar-Shavit, R.9
-
36
-
-
0028338743
-
Potent transforming activity of the G13α subunit defines a novel family of oncogenes
-
Xu, N.; Voyno-Yasenetskaya, T.; Gutkind, J.S. Potent transforming activity of the G13α subunit defines a novel family of oncogenes. Biochem. Biophys. Res. Commun. 1994, 201, 603–609.
-
(1994)
Biochem. Biophys. Res. Commun
, vol.201
, pp. 603-609
-
-
Xu, N.1
Voyno-Yasenetskaya, T.2
Gutkind, J.S.3
-
37
-
-
0036156350
-
Molecular mechanism for endothelin-1-induced stress-fiber formation: Analysis of G proteins using a mutant endothelin(A) receptor
-
Kawanabe, Y.; Okamoto, Y.; Nozaki, K.; Hashimoto, N.; Miwa, S.; Masaki, T. Molecular mechanism for endothelin-1-induced stress-fiber formation: Analysis of G proteins using a mutant endothelin(A) receptor. Mol. Pharmacol. 2002, 61, 277–284.
-
(2002)
Mol. Pharmacol
, vol.61
, pp. 277-284
-
-
Kawanabe, Y.1
Okamoto, Y.2
Nozaki, K.3
Hashimoto, N.4
Miwa, S.5
Masaki, T.6
-
38
-
-
34250177985
-
Biologic functions of the G12 subfamily of heterotrimeric G proteins
-
Kelly, P.; Casey, P.J.; Meigs, E. Biologic functions of the G12 subfamily of heterotrimeric G proteins: Growth, migration, and metastasis. Biochemistry 2007, 46, 6677–6687.
-
(2007)
Growth, Migration, and Metastasis. Biochemistry
, vol.46
, pp. 6677-6687
-
-
Kelly, P.1
Casey, P.J.2
Meigs, E.3
-
39
-
-
62049085214
-
The Gep oncogenes, Gα and Gα, upregulate the transforming growth factor-β1 gene
-
Lee, S.J.; Yang, J.W.; Cho, I.J.; Kim, W.D.; Cho, M.K.; Lee, C.H.; Kim, S.G. The Gep oncogenes, Gα and Gα, upregulate the transforming growth factor-β1 gene. Oncogene 2009, 28, 1230–1240.
-
(2009)
Oncogene
, vol.28
, pp. 1230-1240
-
-
Lee, S.J.1
Yang, J.W.2
Cho, I.J.3
Kim, W.D.4
Cho, M.K.5
Lee, C.H.6
Kim, S.G.7
-
40
-
-
0025834532
-
Diversity of G proteins in signal transduction
-
Simon, M.I.; Strathmann, M.P.; Gautam, N. Diversity of G proteins in signal transduction. Science 1991, 252, 802–808.
-
(1991)
Science
, vol.252
, pp. 802-808
-
-
Simon, M.I.1
Strathmann, M.P.2
Gautam, N.3
-
42
-
-
0027318238
-
Structural elements of G α subunits that interact with Gβγ, receptors, and effectors
-
Conklin, B.R.; Bourne, H.R. Structural elements of G α subunits that interact with Gβγ, receptors, and effectors. Cell 1993, 73, 631–641.
-
(1993)
Cell
, vol.73
, pp. 631-641
-
-
Conklin, B.R.1
Bourne, H.R.2
-
43
-
-
0027497516
-
Expression cDNA cloning of a transforming gene encoding the wild-type Gα12 gene product
-
Chan, A.M.; Fleming, T.P.; McGovern, E.S.; Chedid, M.; Miki, T.; Aaronson, S.A. Expression cDNA cloning of a transforming gene encoding the wild-type Gα12 gene product. Mol. Cell. Biol. 1993, 13, 762–768.
-
(1993)
Mol. Cell. Biol
, vol.13
, pp. 762-768
-
-
Chan, A.M.1
Fleming, T.P.2
McGovern, E.S.3
Chedid, M.4
Miki, T.5
Aaronson, S.A.6
-
44
-
-
0030153427
-
Signaling by the G12 class of G proteins
-
Dhanasekaran, N.; Dermott, J.M. Signaling by the G12 class of G proteins. Cell Signal. 1996, 8, 235–245.
-
(1996)
Cell Signal
, vol.8
, pp. 235-245
-
-
Dhanasekaran, N.1
Dermott, J.M.2
-
45
-
-
34248587328
-
G protein regulation of MAPK networks
-
Goldsmith, Z.G.; Dhanasekaran, D.N. G protein regulation of MAPK networks. Oncogene 2007, 26, 3122–3142.
-
(2007)
Oncogene
, vol.26
, pp. 3122-3142
-
-
Goldsmith, Z.G.1
Dhanasekaran, D.N.2
-
46
-
-
0036925329
-
Characterization of the expression of PDZ-RhoGEF, LARG and G(α)12/G(α)13 proteins in the murine nervous system
-
Kuner, R.; Swiercz, J.M.; Zywietz, A.; Tappe, A.; Offermanns, S. Characterization of the expression of PDZ-RhoGEF, LARG and G(α)12/G(α)13 proteins in the murine nervous system. Eur. J. Neurosci. 2002, 16, 2333–2340.
-
(2002)
Eur. J. Neurosci.
, vol.16
, pp. 2333-2340
-
-
Kuner, R.1
Swiercz, J.M.2
Zywietz, A.3
Tappe, A.4
Offermanns, S.5
-
47
-
-
0242289621
-
Gα12 and Gα13 as key regulatory mediator in signal transduction
-
Kurose, H. Gα12 and Gα13 as key regulatory mediator in signal transduction. Life Sci. 2003, 74, 155–161.
-
(2003)
Life Sci
, vol.74
, pp. 155-161
-
-
Kurose, H.1
-
48
-
-
20744441519
-
Gα12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts
-
Fujii, T.; Onohara, N.; Maruyama, Y.; Tanabe, S.; Kobayashi, H.; Fukutomi, M.; Nagamatsu, Y.; Nishihara, N.; Inoue, R.; Sumimoto, H.; et al. Gα12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. J. Biol. Chem. 2005, 280, 23041–23047.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23041-23047
-
-
Fujii, T.1
Onohara, N.2
Maruyama, Y.3
Tanabe, S.4
Kobayashi, H.5
Fukutomi, M.6
Nagamatsu, Y.7
Nishihara, N.8
Inoue, R.9
Sumimoto, H.10
-
49
-
-
32544452895
-
Neoplastic transformation by the Gep oncogene, Gα12, involves signaling by STAT3
-
Kumar, R.N.; Shore, S.K.; Dhanasekaran, N. Neoplastic transformation by the Gep oncogene, Gα12, involves signaling by STAT3. Oncogene 2006, 25, 899–906.
-
(2006)
Oncogene
, vol.25
, pp. 899-906
-
-
Kumar, R.N.1
Shore, S.K.2
Dhanasekaran, N.3
-
50
-
-
0038152846
-
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
-
Noguchi, K.; Ishii, S.; Shimizu, T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. 2003, 278, 25600–25606.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 25600-25606
-
-
Noguchi, K.1
Ishii, S.2
Shimizu, T.3
-
51
-
-
33747685338
-
GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5
-
Lee, C.W.; Rivera, R.; Gardell, S.; Dubin, A.E.; Chun, J. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J. Biol. Chem. 2006, 281, 23589–23597.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 23589-23597
-
-
Lee, C.W.1
Rivera, R.2
Gardell, S.3
Dubin, A.E.4
Chun, J.5
-
52
-
-
34948889998
-
The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor
-
Tabata, K.; Baba, K.; Shiraishi, A.; Ito, M.; Fujita, N. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun. 2007, 363, 861–866.
-
(2007)
Biochem. Biophys. Res. Commun
, vol.363
, pp. 861-866
-
-
Tabata, K.1
Baba, K.2
Shiraishi, A.3
Ito, M.4
Fujita, N.5
-
53
-
-
0042887042
-
The emerging role of lysophosphatidic acid in cancer. Nat
-
Mills, G.B.; Moolenaar, W.H. The emerging role of lysophosphatidic acid in cancer. Nat. Rev. Cancer 2003, 3, 582–591.
-
(2003)
Rev. Cancer
, vol.3
, pp. 582-591
-
-
Mills, G.B.1
Moolenaar, W.H.2
-
54
-
-
17844382139
-
Protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway
-
Yang, M.; Zhong, W.W.; Srivastava, N.; Slavin, A.; Yang, J.; Hoey, T.; An, S. G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway. Proc. Natl. Acad. Sci. USA 2005, 102, 6027–6032.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 6027-6032
-
-
Yang, M.1
Zhong, W.W.2
Srivastava, N.3
Slavin, A.4
Yang, J.5
Hoey, T.6
An, S.G.7
-
55
-
-
34250630498
-
LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells
-
Chen, M.; Towers, L.N.; O’Connor, K.L. LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells. Am. J. Physiol. Cell Physiol. 2007, 292, C1927–C1933.
-
(2007)
Am. J. Physiol. Cell Physiol
, vol.292
, pp. C1927-C1933
-
-
Chen, M.1
Towers, L.N.2
O’Connor, K.L.3
-
56
-
-
33645740350
-
The G12/13-Rho a signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration
-
Bian, D.; Mahanivong, C.; Yu, J.; Frisch, S.M.; Pan, Z.K.; Ye, R.D.; Huang, S. The G12/13-Rho a signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration. Oncogene 2006, 25, 2234–2244.
-
(2006)
Oncogene
, vol.25
, pp. 2234-2244
-
-
Bian, D.1
Mahanivong, C.2
Yu, J.3
Frisch, S.M.4
Pan, Z.K.5
Ye, R.D.6
Huang, S.7
-
57
-
-
0037073806
-
Serum lysophosphatidic acid is produced through diverse phospholipase pathways
-
Aoki, J.; Taira, A.; Takanezawa, Y.; Kishi, Y.; Hama, K.; Kishimoto, T.; Mizuno, K.; Saku, K.; Taguchi, R.; Arai, H. Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J. Biol. Chem. 2002, 277, 48737–48744.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 48737-48744
-
-
Aoki, J.1
Taira, A.2
Takanezawa, Y.3
Kishi, Y.4
Hama, K.5
Kishimoto, T.6
Mizuno, K.7
Saku, K.8
Taguchi, R.9
Arai, H.10
-
58
-
-
3042822267
-
Cancer and the chemokine network
-
Balkwill, F. Cancer and the chemokine network. Nat. Rev. Cancer 2004, 4, 540–550.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 540-550
-
-
Balkwill, F.1
-
59
-
-
80052094283
-
Homeostatic chemokine receptors and organ-specific metastasis
-
Zlotnik, A.; Burkhardt, A.M.; Homey, B. Homeostatic chemokine receptors and organ-specific metastasis. Nat. Rev. Immunol. 2011, 11, 597–606.
-
(2011)
Nat. Rev. Immunol
, vol.11
, pp. 597-606
-
-
Zlotnik, A.1
Burkhardt, A.M.2
Homey, B.3
-
60
-
-
38949205852
-
Chemokines and cancer: Migration, intracellular signalling and intercellular communication in the microenvironment
-
O’Hayre, M.; Salanga, C.L.; Handel, T.M.; Allen, S.J. Chemokines and cancer: Migration, intracellular signalling and intercellular communication in the microenvironment. Biochem. J. 2008, 409, 635–649.
-
(2008)
Biochem. J
, vol.409
, pp. 635-649
-
-
O’Hayre, M.1
Salanga, C.L.2
Handel, T.M.3
Allen, S.J.4
-
61
-
-
0035282432
-
Involvement of chemokine receptors in breast cancer metastasis
-
Müller, A.; Homey, B.; Soto, H.; Ge, N.; Catron, D.; Buchanan, M.E.; McClanahan, T.; Murphy, E.; Yuan, W.; Wagner, S.N.; et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001, 410, 50–56.
-
(2001)
Nature
, vol.410
, pp. 50-56
-
-
Müller, A.1
Homey, B.2
Soto, H.3
Ge, N.4
Catron, D.5
Buchanan, M.E.6
McClanahan, T.7
Murphy, E.8
Yuan, W.9
Wagner, S.N.10
-
62
-
-
0036674501
-
Dissemination and growth of cancer cells in metastatic sites
-
Chambers, A.F.; Groom, A.C.; MacDonald, I.C. Dissemination and growth of cancer cells in metastatic sites. Nat. Rev. Cancer 2002, 2, 563–572.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 563-572
-
-
Chambers, A.F.1
Groom, A.C.2
Macdonald, I.C.3
-
63
-
-
33344464945
-
CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment
-
Burger, J.A.; Kipps, T.J. CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006, 107, 1761–1767.
-
(2006)
Blood
, vol.107
, pp. 1761-1767
-
-
Burger, J.A.1
Kipps, T.J.2
-
64
-
-
0141828145
-
Chemokine receptor CXCR4 down regulated by von Hippel-Lindau tumour suppressor pVHL
-
Staller, P.; Sulitkova, J.; Lisztwan, J.; Moch, H.; Oakeley, E.J.; Krek, W. Chemokine receptor CXCR4 down regulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003, 425, 307–311.
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
Moch, H.4
Oakeley, E.J.5
Krek, W.6
-
65
-
-
80053124540
-
A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells
-
ra60
-
Yagi, H.; Tan, W.; Dillenburg-Pilla, P.; Armando, S.; Amornphimoltham, P.; Simaan, M.; Weigert, R.; Molinolo, A.A.; Bouvier, M.; Gutkind, J.S. A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Sci. Signal. 2011, 4, ra60.
-
(2011)
Sci. Signal
, vol.4
-
-
Yagi, H.1
Tan, W.2
Dillenburg-Pilla, P.3
Armando, S.4
Amornphimoltham, P.5
Simaan, M.6
Weigert, R.7
Molinolo, A.A.8
Bouvier, M.9
Gutkind, J.S.10
-
66
-
-
33746808398
-
Wnt/β-catenin signaling in development and disease
-
Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 2006, 127, 469–480.
-
(2006)
Cell
, vol.127
, pp. 469-480
-
-
Clevers, H.1
-
67
-
-
19644373254
-
Wnt signaling in disease and in development
-
Nusse, R. Wnt signaling in disease and in development. Cell Res. 2005, 15, 28–32.
-
(2005)
Cell Res
, vol.15
, pp. 28-32
-
-
Nusse, R.1
-
68
-
-
0030975671
-
−/− colon carcinoma
-
−/− colon carcinoma. Science 1997, 275, 1784–1787.
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
Van Wichen, D.4
De Weger, R.5
Kinzler, K.W.6
Vogelstein, B.7
Clevers, H.8
-
69
-
-
84862171364
-
The many faces and functions of β-catenin
-
Valenta, T.; Hausmann, G.; Basler, K. The many faces and functions of β-catenin. EMBO J. 2012, 31, 2714–2736.
-
(2012)
EMBO J
, vol.31
, pp. 2714-2736
-
-
Valenta, T.1
Hausmann, G.2
Basler, K.3
-
71
-
-
11844299003
-
Protein-dependent frizzled signaling in Drosophila
-
Katanaev, V.L.; Ponzielli, R.; Sémériva, M.; Tomlinson, A. Trimeric G protein-dependent frizzled signaling in Drosophila. Cell 2005, 120, 111–122.
-
(2005)
Cell
, vol.120
, pp. 111-122
-
-
Katanaev, V.L.1
Ponzielli, R.2
Sémériva, M.3
Tomlinson, A.4
Trimeric, G.5
-
72
-
-
0035368394
-
G protein signaling from activated rat frizzled-1 to the β catenin-Lef-Tcf pathway
-
Liu, T.; DeCostanzo, A.J.; Liu, X.; Wang, Hy.; Hallagan, S.; Moon, R.T.; Malbon, C.C. G protein signaling from activated rat frizzled-1 to the β catenin-Lef-Tcf pathway. Science 2001, 292, 1718–1722.
-
(2001)
Science
, vol.292
, pp. 1718-1722
-
-
Liu, T.1
Decostanzo, A.J.2
Liu, X.3
Wang, H.Y.4
Hallagan, S.5
Moon, R.T.6
Malbon, C.C.7
-
73
-
-
0031456672
-
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling
-
Slusarski, D.C.; Corces, V.G.; Moon, R.T. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 1997, 390, 410–413.
-
(1997)
Nature
, vol.390
, pp. 410-413
-
-
Slusarski, D.C.1
Corces, V.G.2
Moon, R.T.3
-
74
-
-
58249087390
-
New regulators of Wnt/β-catenin signaling revealed by integrative molecular screening
-
ra12
-
Major, M.B.; Roberts, B.S.; Berndt, J.D.; Marine, S.; Anastas, J.; Chung, N.; Ferrer, M.; Yi, X.; Stoick-Cooper, C.L.; von Haller, P.D.; et al. New regulators of Wnt/β-catenin signaling revealed by integrative molecular screening. Sci. Signal. 2008, 1, ra12.
-
(2008)
Sci. Signal
, vol.1
-
-
Major, M.B.1
Roberts, B.S.2
Berndt, J.D.3
Marine, S.4
Anastas, J.5
Chung, N.6
Ferrer, M.7
Yi, X.8
Stoick-Cooper, C.L.9
Von Haller, P.D.10
-
75
-
-
84055181339
-
Wnt/B-catenin signaling is differentially regulated by Ga proteins and contributes to fibrous dysplasia
-
Regard, J.B.; Cherman, N.; Palmer, D.; Kuznetsov, S.A.; Celi, F.S.; Guettier, J.M.; Chen, M.; Bhattacharyya, N.; Wess, J.; Coughlin, S.R.; et al. Wnt/B-catenin signaling is differentially regulated by Ga proteins and contributes to fibrous dysplasia. Proc. Natl. Acad. Sci. USA 2011, 108, 20101–20106.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 20101-20106
-
-
Regard, J.B.1
Cherman, N.2
Palmer, D.3
Kuznetsov, S.A.4
Celi, F.S.5
Guettier, J.M.6
Chen, M.7
Bhattacharyya, N.8
Wess, J.9
Coughlin, S.R.10
-
76
-
-
84865455267
-
Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP
-
Miller, E.; Yang, J.; DeRan, M.; Wu, C.; Su, A.I.; Bonamy, G.M.; Liu, J.; Peters, E.C.; Wu, X. Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. Chem. Biol. 2012, 19, 955–962.
-
(2012)
Chem. Biol
, vol.19
, pp. 955-962
-
-
Miller, E.1
Yang, J.2
Deran, M.3
Wu, C.4
Su, A.I.5
Bonamy, G.M.6
Liu, J.7
Peters, E.C.8
Wu, X.9
-
77
-
-
84867182034
-
Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)
-
Mo, J.S.; Yu, F.X.; Gong, R.; Brown, J.H.; and Guan, K.L. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev. 2012, 26, 2138–2143.
-
(2012)
Genes Dev
, vol.26
, pp. 2138-2143
-
-
Mo, J.S.1
Yu, F.X.2
Gong, R.3
Brown, J.H.4
Guan, K.L.5
-
78
-
-
84865260845
-
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
-
Yu, F.X.; Zhao, B.; Panupinthu, N.; Jewell, J.L.; Lian, I.; Wang, L.H.; Zhao, J.; Yuan, H.; Tumaneng, K.; Li, H.; et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 2012, 150, 780–791.
-
(2012)
Cell
, vol.150
, pp. 780-791
-
-
Yu, F.X.1
Zhao, B.2
Panupinthu, N.3
Jewell, J.L.4
Lian, I.5
Wang, L.H.6
Zhao, J.7
Yuan, H.8
Tumaneng, K.9
Li, H.10
-
79
-
-
84902515862
-
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP
-
Yu, F.X.; Luo, J.; Mo, J.S.; Liu, G.; Kim, Y.C.; Meng, Z.; Zhao, L.; Peyman, G.; Ouyang, H.; Jiang, W.; et al. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell 2014, 25, 822–830.
-
(2014)
Cancer Cell
, vol.25
, pp. 822-830
-
-
Yu, F.X.1
Luo, J.2
Mo, J.S.3
Liu, G.4
Kim, Y.C.5
Meng, Z.6
Zhao, L.7
Peyman, G.8
Ouyang, H.9
Jiang, W.10
-
80
-
-
77957883342
-
The hippo signaling pathway in development and cancer
-
Pan, D. The hippo signaling pathway in development and cancer. Dev. Cell 2010, 19, 491–505.
-
(2010)
Dev. Cell
, vol.19
, pp. 491-505
-
-
Pan, D.1
-
81
-
-
84878868616
-
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation
-
Yu, F.X.; Zhang, Y.; Park, H.W.; Jewell, J.L.; Chen, Q.; Deng, Y.; Pan, D.; Taylor, S.S.; Lai, Z.C.; Guan, K.L. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013, 27, 1223–1232.
-
(2013)
Genes Dev
, vol.27
, pp. 1223-1232
-
-
Yu, F.X.1
Zhang, Y.2
Park, H.W.3
Jewell, J.L.4
Chen, Q.5
Deng, Y.6
Pan, D.7
Taylor, S.S.8
Lai, Z.C.9
Guan, K.L.10
-
82
-
-
84862764408
-
The Hippo signaling pathway and stem cell biology
-
Ramos, A.; Camargo, F.D. The Hippo signaling pathway and stem cell biology. Trends Cell Biol. 2012, 22, 339–346.
-
(2012)
Trends Cell Biol
, vol.22
, pp. 339-346
-
-
Ramos, A.1
Camargo, F.D.2
-
83
-
-
77951837150
-
The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version
-
Zhao, B.; Li, L.; Lei, Q.; Guan, K.L. The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version. Genes Dev. 2010, 24, 862–874.
-
(2010)
Genes Dev
, vol.24
, pp. 862-874
-
-
Zhao, B.1
Li, L.2
Lei, Q.3
Guan, K.L.4
-
84
-
-
0028997651
-
Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain
-
Sudol, M.; Bork, P.; Einbond, A.; Kastury, K.; Druck, T.; Negrini, M.; Huebner, K.; Lehman, D. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J. Biol. Chem. 1995, 270, 14733–14741.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14733-14741
-
-
Sudol, M.1
Bork, P.2
Einbond, A.3
Kastury, K.4
Druck, T.5
Negrini, M.6
Huebner, K.7
Lehman, D.8
-
85
-
-
84902482143
-
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry
-
Feng, X.; Degese, M.S.; Iglesias-Bartolome, R.; Vaque, J.P.; Molinolo, A.A.; Rodrigues, M.; Zaidi, M.R.; Ksander, B.R.; Merlino, G.; Sodhi, A.; et al. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell 2014, 25, 831–845.
-
(2014)
Cancer Cell
, vol.25
, pp. 831-845
-
-
Feng, X.1
Degese, M.S.2
Iglesias-Bartolome, R.3
Vaque, J.P.4
Molinolo, A.A.5
Rodrigues, M.6
Zaidi, M.R.7
Ksander, B.R.8
Merlino, G.9
Sodhi, A.10
-
86
-
-
84938100880
-
Alternative Wnt signaling activates YAP/TAZ
-
Park, H.W.; Kim, Y.C.; Yu, B.; Moroishi, T.; Mo, J.S.; Plouffe, S.W.; Meng, Z.; Lin, K.C.; Yu, F.X.; Alexander, C.M.; et al. Alternative Wnt signaling activates YAP/TAZ. Cell 2015, 162, 780–789.
-
(2015)
Cell
, vol.162
, pp. 780-789
-
-
Park, H.W.1
Kim, Y.C.2
Yu, B.3
Moroishi, T.4
Mo, J.S.5
Plouffe, S.W.6
Meng, Z.7
Lin, K.C.8
Yu, F.X.9
Alexander, C.M.10
-
87
-
-
84871576111
-
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
-
Rosenbluh, J.; Nijhawan, D.; Cox, G.; Li, X.; Neal, J.T.; Schafer, E.J.; Zack, T.I.; Wang, X.; Tsherniak, A.; Schinzel, A.C.; et al. β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell 2012, 151, 1457–1473.
-
(2012)
Cell
, vol.151
, pp. 1457-1473
-
-
Rosenbluh, J.1
Nijhawan, D.2
Cox, G.3
Li, X.4
Neal, J.T.5
Schafer, E.J.6
Zack, T.I.7
Wang, X.8
Tsherniak, A.9
Schinzel, A.C.10
-
88
-
-
28644432882
-
Comparative genomic analysis of human and chimpanzee proteases
-
Puente, X.S.; Gutiérrez-Fernández, A.; Ordóñez, G.R.; Hillier, L.W.; López-Otín, C. Comparative genomic analysis of human and chimpanzee proteases. Genomics 2005, 86, 638–647.
-
(2005)
Genomics
, vol.86
, pp. 638-647
-
-
Puente, X.S.1
Gutiérrez-Fernández, A.2
Ordóñez, G.R.3
Hillier, L.W.4
López-Otín, C.5
-
89
-
-
0014941657
-
Proteolytic enzymes initiating cell division and escape from contact inhibition of growth
-
Burger, M.M. Proteolytic enzymes initiating cell division and escape from contact inhibition of growth. Nature 1970, 227, 170–171.
-
(1970)
Nature
, vol.227
, pp. 170-171
-
-
Burger, M.M.1
-
90
-
-
0016432831
-
Mitogenic activity of blood components. I. Thrombin and prothrombin
-
Chen, L.B.; Buchanan, J.M. Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc. Natl. Acad. Sci. USA 1975, 72, 131–135.
-
(1975)
Proc. Natl. Acad. Sci. USA
, vol.72
, pp. 131-135
-
-
Chen, L.B.1
Buchanan, J.M.2
-
91
-
-
0017622250
-
Initiation of check cell division by trypsin action at the cell surface
-
Carney, D.H.; Cunningham, D.D. Initiation of check cell division by trypsin action at the cell surface. Nature 1977, 268, 602–606.
-
(1977)
Nature
, vol.268
, pp. 602-606
-
-
Carney, D.H.1
Cunningham, D.D.2
-
92
-
-
0017881943
-
Cell surface action of thrombin is sufficient to initiate division of chick cells
-
Carney, D.H.; Cunningham, D.D. Cell surface action of thrombin is sufficient to initiate division of chick cells. Cell 1978, 14, 811–823.
-
(1978)
Cell
, vol.14
, pp. 811-823
-
-
Carney, D.H.1
Cunningham, D.D.2
-
93
-
-
0025784847
-
2+ mobilization
-
2+ mobilization. FEBS Lett. 1991, 288, 123–128.
-
(1991)
FEBS Lett
, vol.288
, pp. 123-128
-
-
Rasmussen, U.B.1
Vouret-Craviari, V.2
Jallat, S.3
Schlesinger, Y.4
Pagès, G.5
Pavirani, A.6
Lecocq, J.P.7
Pouysségur, J.8
Van Obberghen-Schilling, E.9
-
94
-
-
0026035523
-
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
-
Vu, T.K.; Hung, D.T.; Wheaton, V.I.; Coughlin, S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991, 64, 1057–1068.
-
(1991)
Cell
, vol.64
, pp. 1057-1068
-
-
Vu, T.K.1
Hung, D.T.2
Wheaton, V.I.3
Coughlin, S.R.4
-
95
-
-
0028031081
-
Protease-activated receptors start a family
-
Coughlin, S.R. Protease-activated receptors start a family. Proc. Natl. Acad. Sci. USA 1994, 91, 9200–9202.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9200-9202
-
-
Coughlin, S.R.1
-
96
-
-
0030979972
-
Protease-activated receptor 3 is a second thrombin receptor in humans
-
Ishihara, H.; Connolly, A.J.; Zeng, D.; Kahn, M.L.; Zheng, Y.W.; Timmons, C.; Tram, T.; Coughlin, S.R. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997, 386, 502–506.
-
(1997)
Nature
, vol.386
, pp. 502-506
-
-
Ishihara, H.1
Connolly, A.J.2
Zeng, D.3
Kahn, M.L.4
Zheng, Y.W.5
Timmons, C.6
Tram, T.7
Coughlin, S.R.8
-
97
-
-
0032514474
-
A dual thrombin receptor system for platelet activation
-
Kahn, M.L.; Zheng, Y.W.; Huang, W.; Bigornia, V.; Zeng, D.; Moff, S.; Farese, R.V.J.; Tam, C.; Coughlin, S.R. A dual thrombin receptor system for platelet activation. Nature 1998, 394, 690–694.
-
(1998)
Nature
, vol.394
, pp. 690-694
-
-
Kahn, M.L.1
Zheng, Y.W.2
Huang, W.3
Bigornia, V.4
Zeng, D.5
Moff, S.6
Farese, R.V.J.7
Tam, C.8
Coughlin, S.R.9
-
98
-
-
0032499696
-
Cloning and characterization of human protease-activated receptor 4
-
Xu, W.F.; Andersen, H.; Whitmore, T.E.; Presnell, S.R.; Yee, D.P.; Ching, A.; Gilbert, T.; Davie, E.W.; Foster, D.C. Cloning and characterization of human protease-activated receptor 4. Proc. Natl. Acad. Sci. USA 1998, 95, 6642–6646.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6642-6646
-
-
Xu, W.F.1
Andersen, H.2
Whitmore, T.E.3
Presnell, S.R.4
Yee, D.P.5
Ching, A.6
Gilbert, T.7
Davie, E.W.8
Foster, D.C.9
-
99
-
-
0027933068
-
Molecular cloning of a potential proteinase activated receptor
-
Nystedt, S.; Emilsson, K.; Wahlestedt, C.; Sundelin, J. Molecular cloning of a potential proteinase activated receptor. Proc. Natl. Acad. Sci. USA 1994, 91, 9208–9210.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9208-9210
-
-
Nystedt, S.1
Emilsson, K.2
Wahlestedt, C.3
Sundelin, J.4
-
100
-
-
0033613183
-
How the protease thrombin talks to cells
-
Coughlin, S.R. How the protease thrombin talks to cells. Proc. Natl. Acad. Sci. USA 1999, 96, 11023–11027.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11023-11027
-
-
Coughlin, S.R.1
-
102
-
-
84948166420
-
1&2 endow breast cancer growth. Nat
-
1&2 endow breast cancer growth. Nat. Commun. 2015, 6, 8853–8865.
-
(2015)
Commun
, vol.6
, pp. 8853-8865
-
-
Kancharla, A.1
Maoz, M.2
Jaber, M.3
Agranovich, D.4
Peretz, T.5
Grisaru-Granovsky, S.6
Uziely, B.7
Bar-Shavit, R.8
-
103
-
-
0028670203
-
The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C zeta. Biochem. Biophys. Res
-
Konishi, H.; Kuroda, S.; Kikkawa, U. The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C zeta. Biochem. Biophys. Res. Commun. 1994, 205, 1770–1775.
-
(1994)
Commun
, vol.205
, pp. 1770-1775
-
-
Konishi, H.1
Kuroda, S.2
Kikkawa, U.3
-
104
-
-
0028564915
-
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C
-
Yao, L.; Kawakami, Y.; Kawakami, T. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. USA 1994, 91, 9175–9179.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9175-9179
-
-
Yao, L.1
Kawakami, Y.2
Kawakami, T.3
-
105
-
-
0035815711
-
Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the α vβ 5 integrin
-
Even-Ram, S.C.; Maoz, M.; Pokroy, E.; Reich, R.; Katz, B.Z.; Gutwein, P.; Altevogt, P.; Bar-Shavit, R. Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the α vβ 5 integrin. J. Biol. Chem. 2001, 276, 10952–10962.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 10952-10962
-
-
Even-Ram, S.C.1
Maoz, M.2
Pokroy, E.3
Reich, R.4
Katz, B.Z.5
Gutwein, P.6
Altevogt, P.7
Bar-Shavit, R.8
-
106
-
-
84867083414
-
The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion
-
Jeong, K.J.; Park, S.Y.; Cho, K.H.; Sohn, J.S.; Lee, J.; Kim, Y.K.; Kang, J.; Park, C.G.; Han, J.W.; Lee, H.Y. The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion. Oncogene 2012, 31, 4279–4289.
-
(2012)
Oncogene
, vol.31
, pp. 4279-4289
-
-
Jeong, K.J.1
Park, S.Y.2
Cho, K.H.3
Sohn, J.S.4
Lee, J.5
Kim, Y.K.6
Kang, J.7
Park, C.G.8
Han, J.W.9
Lee, H.Y.10
-
107
-
-
84893817918
-
Lysophosphatidic acid activates β-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19–7 cells
-
Sun, Y.; Kim, N.H.; Ji, L.; Kim, S.H.; Lee, J.; Rhee, H.J. Lysophosphatidic acid activates β-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19–7 cells. Mol. Med. Rep. 2013, 8, 1729–1733.
-
(2013)
Mol. Med. Rep
, vol.8
, pp. 1729-1733
-
-
Sun, Y.1
Kim, N.H.2
Ji, L.3
Kim, S.H.4
Lee, J.5
Rhee, H.J.6
-
108
-
-
84941356210
-
Lysophosphatidic acid initiates epithelial to mesenchymal transition and induces β-catenin-mediated transcription in epithelial ovarian carcinoma
-
Burkhalter, R.J.; Westfall, S.D.; Liu, Y.; Stack, M.S. Lysophosphatidic acid initiates epithelial to mesenchymal transition and induces β-catenin-mediated transcription in epithelial ovarian carcinoma. J. Biol. Chem. 2015, 290, 22143–22154.
-
(2015)
J. Biol. Chem
, vol.290
, pp. 22143-22154
-
-
Burkhalter, R.J.1
Westfall, S.D.2
Liu, Y.3
Stack, M.S.4
-
109
-
-
34447522119
-
Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5
-
Zhang, H.; Bialkowska, A.; Rusovici, R.; Chanchevalap, S.; Shim, H.; Katz, J.P.; Yang, V.W.; Yun, C.C. Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5. J. Biol. Chem. 2007, 282, 15541–15549.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 15541-15549
-
-
Zhang, H.1
Bialkowska, A.2
Rusovici, R.3
Chanchevalap, S.4
Shim, H.5
Katz, J.P.6
Yang, V.W.7
Yun, C.C.8
-
110
-
-
84933508767
-
A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
-
Moroishi, T.; Park, H.W.; Qin, B.; Chen, Q.; Meng, Z.; Plouffe, S.W.; Taniguchi, K.; Yu, F.X.; Karin, M.; Pan, D.; et al. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015, 29, 1271–1284.
-
(2015)
Genes Dev
, vol.29
, pp. 1271-1284
-
-
Moroishi, T.1
Park, H.W.2
Qin, B.3
Chen, Q.4
Meng, Z.5
Plouffe, S.W.6
Taniguchi, K.7
Yu, F.X.8
Karin, M.9
Pan, D.10
-
111
-
-
33744931129
-
Mammary gland tissue targeted overexpression of human protease-activated receptor 1 reveals a novel link to β-catenin stabilization
-
Yin, Y.J.; Katz, V.; Salah, Z.; Maoz, M.; Cohen, I.; Uziely, B.; Turm, H.; Grisaru-Granovsky, S.; Suzuki, H.; Bar-Shavit, R. Mammary gland tissue targeted overexpression of human protease-activated receptor 1 reveals a novel link to β-catenin stabilization. Cancer Res. 2006, 66, 5224–5233.
-
(2006)
Cancer Res
, vol.66
, pp. 5224-5233
-
-
Yin, Y.J.1
Katz, V.2
Salah, Z.3
Maoz, M.4
Cohen, I.5
Uziely, B.6
Turm, H.7
Grisaru-Granovsky, S.8
Suzuki, H.9
Bar-Shavit, R.10
-
112
-
-
77952047728
-
Protease-activated receptor-1 (PAR1) acts via a novel Gα13-dishevelled axis to stabilize β-catenin levels
-
Turm, H.; Maoz, M.; Katz, V.; Yin, Y.J.; Offermanns, S.; Bar-Shavit, R. Protease-activated receptor-1 (PAR1) acts via a novel Gα13-dishevelled axis to stabilize β-catenin levels. J. Biol. Chem. 2010, 285, 15137–15148.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 15137-15148
-
-
Turm, H.1
Maoz, M.2
Katz, V.3
Yin, Y.J.4
Offermanns, S.5
Bar-Shavit, R.6
-
113
-
-
77952004118
-
Parathyroid hormone receptor directly interacts with dishevelled to regulate β-Catenin signaling and osteoclastogenesis
-
Romero, G.; Sneddon, W.B.; Yang, Y.; Wheeler, D.; Blair, H.C.; Friedman, P.A. Parathyroid hormone receptor directly interacts with dishevelled to regulate β-Catenin signaling and osteoclastogenesis. J. Biol. Chem. 2010, 285, 14756–14763.
-
(2010)
J. Biol. Chem
, vol.285
, pp. 14756-14763
-
-
Romero, G.1
Sneddon, W.B.2
Yang, Y.3
Wheeler, D.4
Blair, H.C.5
Friedman, P.A.6
-
114
-
-
2442708165
-
Frizzleds: New members of the superfamily of G-protein-coupled receptors
-
Malbon, C.C. Frizzleds: New members of the superfamily of G-protein-coupled receptors. Front. Biosci. 2004, 9, 1048–1058.
-
(2004)
Front. Biosci
, vol.9
, pp. 1048-1058
-
-
Malbon, C.C.1
-
115
-
-
84885237107
-
Emerging targets in cancer management: Role of the CXCL12/CXCR4 axis. Onco
-
Cojoc, M.; Peitzsch, C.; Trautmann, F.; Polishchuk, L.; Telegeev, G.D.; Dubrovska, A. Emerging targets in cancer management: Role of the CXCL12/CXCR4 axis. Onco. Targets Ther. 2013, 6, 1347–1361.
-
(2013)
Targets Ther
, vol.6
, pp. 1347-1361
-
-
Cojoc, M.1
Peitzsch, C.2
Trautmann, F.3
Polishchuk, L.4
Telegeev, G.D.5
Dubrovska, A.6
-
118
-
-
4444291042
-
Receptors: Targets for treatment and prevention of colorectal cancer?
-
Hull, M.A.; Ko, S.C.; Hawcroft, G. Prostaglandin EP receptors: Targets for treatment and prevention of colorectal cancer? Mol. Cancer Ther. 2004, 3, 1031–1039.
-
(2004)
Mol. Cancer Ther
, vol.3
, pp. 1031-1039
-
-
Hull, M.A.1
Ko, S.C.2
Hawcroft, G.3
Prostaglandin, E.P.4
-
119
-
-
84956723869
-
Prostaglandin E2 and the EP receptors in malignancy: Possible therapeutic targets
-
O’Callaghan, G.; Houston, A. Prostaglandin E2 and the EP receptors in malignancy: Possible therapeutic targets? Br. J. Pharmacol. 2015, 172, 5239–5250.
-
(2015)
Br. J. Pharmacol
, vol.172
, pp. 5239-5250
-
-
O’Callaghan, G.1
Houston, A.2
-
120
-
-
0037729000
-
Bradykinin receptor subtype 1 expression and function in prostate cancer
-
Taub, J.S.; Guo, R.L.; Leeb-Lundberg, M.F.; Madden, J.F.; Daaka, Y. Bradykinin receptor subtype 1 expression and function in prostate cancer. Cancer Res. 2003, 63, 2037–2041.
-
(2003)
Cancer Res
, vol.63
, pp. 2037-2041
-
-
Taub, J.S.1
Guo, R.L.2
Leeb-Lundberg, M.F.3
Madden, J.F.4
Daaka, Y.5
-
121
-
-
84962727767
-
G protein-coupled receptors as promising cancer targets
-
Liu, Y.; An, S.; Ward, R.; Yang, Y.; Guo, X.X.; Li, W.; Xu, T.R. G protein-coupled receptors as promising cancer targets. Cancer Lett. 2016, 376, 226–239.
-
(2016)
Cancer Lett
, vol.376
, pp. 226-239
-
-
Liu, Y.1
An, S.2
Ward, R.3
Yang, Y.4
Guo, X.X.5
Li, W.6
Xu, T.R.7
|