GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

Cell

Volumn 166, Issue 4, 2016, Pages 907-919

  Thomsen, Alex R B ^a   Plouffe, Bianca ^b   Cahill, Thomas J ^a   Shukla, Arun K ^a,f   Tarrasch, Jeffrey T ^c   Dosey, Annie M ^c   Kahsai, Alem W ^a   Strachan, Ryan T ^a   Pani, Biswaranjan ^a   Mahoney, Jacob P ^d   Huang, Liyin ^a   Breton, Billy ^b,g   Heydenreich, Franziska M ^b,h   Sunahara, Roger K ^d,e   Skiniotis, Georgios ^c   Bouvier, Michel ^b   Lefkowitz, Robert J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e San Diego   (United States)

^f INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

^g Domain Therapeutics NA Inc   (Canada)

^h PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MEGESTROL ACETATE; MULTIPROTEIN COMPLEX; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; ELECTRON MICROSCOPY; EMBRYO; ENDOSOME; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; INTRACELLULAR SPACE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AGONISTS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; METABOLISM;

BETA-ARRESTINS; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER TECHNIQUES; CYCLIC AMP; ENDOSOMES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEK293 CELLS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MULTIPROTEIN COMPLEXES; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84981517053     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.07.004     Document Type: Article

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