Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

Science

Volumn 347, Issue 6226, 2015, Pages 1117-1122

  Qin, Ling ^a   Kufareva, Irina ^a   Holden, Lauren G ^a   Wang, Chong ^b   Zheng, Yi ^a   Zhao, Chunxia ^a   Fenalti, Gustavo ^b   Wu, Huixian ^b   Han, Gye Won ^c   Cherezov, Vadim ^c   Abagyan, Ruben ^a   Stevens, Raymond C ^c   Handel, Tracy M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CHEMOKINE; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; PROTEIN BINDING; STROMAL CELL DERIVED FACTOR 1; VMIP-II;

CRYSTAL STRUCTURE; IMMUNE SYSTEM; LIGAND; NUTATION; PROTEIN; SIGNALING; STOICHIOMETRY;

ARTICLE; CELL MIGRATION; CRYSTAL STRUCTURE; INFLAMMATION; MOLECULAR INTERACTION; MUTAGENESIS; NEOPLASM; PRIORITY JOURNAL; PROTEIN BINDING; STOICHIOMETRY; AGONISTS; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMICAL MODEL; CHEMISTRY; DRUG DESIGN; HUMAN; MOLECULAR GENETICS; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CHEMOKINE CXCL12; CHEMOKINES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; RECEPTORS, CXCR4; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84924565531     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1261064     Document Type: Article

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