Brain penetration, target engagement, and disposition of the blood-brain barrier-crossing bispecific antibody antagonist of metabotropic glutamate receptor type 1

FASEB Journal

Volumn 30, Issue 5, 2016, Pages 1927-1940

  Webster, Carl I ^a   Caram Salas, Nadia ^c   Haqqani, Arsalan S ^c   Thom, George ^a   Brown, Lee ^b   Rennie, Kerry ^c   Yogi, Alvaro ^c   Costain, Willard ^c   Brunette, Eric ^c   Stanimirovic, Danica B ^c  

^a MEDIMMUNE   (United States)

^b Translational Sciences   (United Kingdom)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Brain endothelial cells; Mass spectrometry; Pain; Receptor mediated transcytosis

Indexed keywords

G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN G; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 1 BISPECIFIC ANTIBODY ANTAGONIST; METABOTROPIC RECEPTOR 1 IMMUNOGLOBULIN G; METABOTROPIC RECEPTOR ANTAGONIST; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; ANALGESIC AGENT; ANTIBODY CONJUGATE; BIOLOGICAL PRODUCT; BISPECIFIC ANTIBODY; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN NERVE CELL; BRAIN TISSUE; CHRONIC INFLAMMATORY PAIN; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG TARGETING; HYPERALGESIA; IMMUNOFLUORESCENCE; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THALAMUS; THERMAL HYPERALGESIA; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CAMELID; CELL MEMBRANE; DRUG EFFECTS; HEAT; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; METABOLISM; PAIN; PROCEDURES; PROTEIN ENGINEERING; TRANSPORT AT THE CELLULAR LEVEL;

ANALGESICS; ANIMALS; ANTIBODIES, BISPECIFIC; BIOLOGICAL PRODUCTS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CAMELIDAE; CELL MEMBRANE; HEK293 CELLS; HOT TEMPERATURE; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN G; PAIN; PROTEIN ENGINEERING; RATS; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 84966280633     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201500078     Document Type: Article

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