-
1
-
-
0035857351
-
Osteoporosis prevention, diagnosis, and therapy
-
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, Therapy
-
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, Therapy 2001 Osteoporosis prevention, diagnosis, and therapy JAMA 285 785 795
-
(2001)
JAMA
, vol.285
, pp. 785-795
-
-
-
3
-
-
33748680524
-
Genetic regulation of bone mass and susceptibility to osteoporosis
-
SH Ralston B de Crombrugghe 2006 Genetic regulation of bone mass and susceptibility to osteoporosis Genes Dev 20 2492 2506
-
(2006)
Genes Dev
, vol.20
, pp. 2492-2506
-
-
Ralston, S.H.1
De Crombrugghe, B.2
-
5
-
-
18044386744
-
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
-
Y Gong RB Slee N Fukai G Rawadi S Roman-Roman 2001 LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development Cell 107 513 523
-
(2001)
Cell
, vol.107
, pp. 513-523
-
-
Gong, Y.1
Slee, R.B.2
Fukai, N.3
Rawadi, G.4
Roman-Roman, S.5
-
6
-
-
0037118285
-
High bone density due to a mutation in LDL-receptor-related protein 5
-
LM Boyden J Mao J Belsky L Mitzner A Farhi MA Mitnick D Wu K Insogna RP Lifton 2002 High bone density due to a mutation in LDL-receptor-related protein 5 N Engl J Med 346 1513 1521
-
(2002)
N Engl J Med
, vol.346
, pp. 1513-1521
-
-
Boyden, L.M.1
Mao, J.2
Belsky, J.3
Mitzner, L.4
Farhi, A.5
Mitnick, M.A.6
Wu, D.7
Insogna, K.8
Lifton, R.P.9
-
7
-
-
0036138175
-
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
-
RD Little JR Carulli RG Del Mastro J Dupuis M Osborne 2002 A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait Am J Hum Genet 70 11 19
-
(2002)
Am J Hum Genet
, vol.70
, pp. 11-19
-
-
Little, R.D.1
Carulli, J.R.2
Del Mastro, R.G.3
Dupuis, J.4
Osborne, M.5
-
8
-
-
33646433058
-
Regulation of bone mass by Wnt signalling
-
V Krishnan HU Bryant BA MacDougald 2006 Regulation of bone mass by Wnt signalling J Clin Invest 116 1202 1209
-
(2006)
J Clin Invest
, vol.116
, pp. 1202-1209
-
-
Krishnan, V.1
Bryant, H.U.2
-
9
-
-
34250823973
-
Targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton
-
R Baron G Rawadi 2007 Targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton Endocrinology 148 2635 2643
-
(2007)
Endocrinology
, vol.148
, pp. 2635-2643
-
-
Baron, R.1
Rawadi, G.2
-
10
-
-
34250848174
-
In vivo analysis of Wnt signaling in bone
-
DA Glass 2nd G Karsenty 2007 In vivo analysis of Wnt signaling in bone Endocrinology 148 2630 2634
-
(2007)
Endocrinology
, vol.148
, pp. 2630-2634
-
-
Glass II, D.A.1
Karsenty, G.2
-
11
-
-
34250840514
-
The genetics of low-density lipoprotein receptor-related protein 5 in bone: A story of extremes
-
W Balemans W Van Hul 2007 The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes Endocrinology 148 2622 2629
-
(2007)
Endocrinology
, vol.148
, pp. 2622-2629
-
-
Balemans, W.1
Van Hul, W.2
-
12
-
-
42449109564
-
Wnt signaling and skeletal development
-
F Liu S Kohlmeier CY Wang 2008 Wnt signaling and skeletal development Cell Signal 20 999 1009
-
(2008)
Cell Signal
, vol.20
, pp. 999-1009
-
-
Liu, F.1
Kohlmeier, S.2
Wang, C.Y.3
-
13
-
-
2342430345
-
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way
-
X He M Semenov K Tamai X Zheg 2004 LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way Development 131 1663 1677
-
(2004)
Development
, vol.131
, pp. 1663-1677
-
-
He, X.1
Semenov, M.2
Tamai, K.3
Zheg, X.4
-
14
-
-
2342441840
-
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
-
OG Kelly KI Pinson WC Skarnes 2004 The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice Development 131 2803 2815
-
(2004)
Development
, vol.131
, pp. 2803-2815
-
-
Kelly, O.G.1
Pinson, K.I.2
Skarnes, W.C.3
-
15
-
-
41549115361
-
Wnt/beta-catenin signaling: New (and old) players and new insights
-
H Huang X He 2008 Wnt/beta-catenin signaling: new (and old) players and new insights Curr Opin Cell Biol 20 119 125
-
(2008)
Curr Opin Cell Biol
, vol.20
, pp. 119-125
-
-
Huang, H.1
He, X.2
-
16
-
-
0037423222
-
Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
-
JC Hsieh L Lee L Zhang S Wefer K Brown C DeRossi ME Wines T Rosenquist BC Holdener 2003 Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity Cell 112 355 367
-
(2003)
Cell
, vol.112
, pp. 355-367
-
-
Hsieh, J.C.1
Lee, L.2
Zhang, L.3
Wefer, S.4
Brown, K.5
Derossi, C.6
Wines, M.E.7
Rosenquist, T.8
Holdener, B.C.9
-
17
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
CY Logan R Nusse 2004 The Wnt signaling pathway in development and disease Annu Rev Cell Dev Biol 20 781 810
-
(2004)
Annu Rev Cell Dev Biol
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
19
-
-
33746808398
-
Wnt/beta-catenin signaling in development and disease
-
H Clevers 2006 Wnt/beta-catenin signaling in development and disease Cell 127 469 480
-
(2006)
Cell
, vol.127
, pp. 469-480
-
-
Clevers, H.1
-
20
-
-
38949145700
-
Wnt signalling in development and disease
-
C Fuerer R Nusse D Ten Berge 2008 Wnt signalling in development and disease EMBO Rep 9 134 138
-
(2008)
EMBO Rep
, vol.9
, pp. 134-138
-
-
Fuerer, C.1
Nusse, R.2
Ten Berge, D.3
-
21
-
-
0037373341
-
Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density
-
L Van Wesenbeeck E Cleiren J Gram RK Beals O Bénichou D Scopelliti L Key T Renton C Bartels Y Gong ML Warman MC De Vernejoul J Bollerslev W Van Hul 2003 Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density Am J Hum Genet 72 763 771
-
(2003)
Am J Hum Genet
, vol.72
, pp. 763-771
-
-
Van Wesenbeeck, L.1
Cleiren, E.2
Gram, J.3
Beals, R.K.4
Bénichou, O.5
Scopelliti, D.6
Key, L.7
Renton, T.8
Bartels, C.9
Gong, Y.10
Warman, M.L.11
De Vernejoul, M.C.12
Bollerslev, J.13
Van Hul, W.14
-
22
-
-
14844284570
-
Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton
-
MA Koay MA Brown 2005 Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton Trends Mol Med 11 129 137
-
(2005)
Trends Mol Med
, vol.11
, pp. 129-137
-
-
Koay, M.A.1
Brown, M.A.2
-
23
-
-
43049181624
-
Bone mineral density, osteoporosis, and osteoporotic fractures: A genome-wide association study
-
JB Richards F Rivadeneira M Inouye TM Pastinen N Soranzo 2008 Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study Lancet 371 1505 1512
-
(2008)
Lancet
, vol.371
, pp. 1505-1512
-
-
Richards, J.B.1
Rivadeneira, F.2
Inouye, M.3
Pastinen, T.M.4
Soranzo, N.5
-
24
-
-
40949146531
-
Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
-
GENOMOS Study
-
JB van Meurs TA Trikalinos SH Ralston S Balcells ML Brandi GENOMOS Study 2008 Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis JAMA 299 1277 1290
-
(2008)
JAMA
, vol.299
, pp. 1277-1290
-
-
Van Meurs, J.B.1
Trikalinos, T.A.2
Ralston, S.H.3
Balcells, S.4
Brandi, M.L.5
-
25
-
-
0037092049
-
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
-
M Kato MS Patel R Levasseur I Lobov BHJ Chang DA Glass II C Hartmann L Li TH Hwang CF Brayton RA Lang G Karsenty L Chan 2002 Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor J Cell Biol 157 303 314
-
(2002)
J Cell Biol
, vol.157
, pp. 303-314
-
-
Kato, M.1
Patel, M.S.2
Levasseur, R.3
Lobov, I.4
Chang, B.H.J.5
Glass Ii, D.A.6
Hartmann, C.7
Li, L.8
Hwang, T.H.9
Brayton, C.F.10
Lang, R.A.11
Karsenty, G.12
Chan, L.13
-
26
-
-
10744224854
-
High bone mass in mice expressing a mutant LRP5 gene
-
P Babij W Zhao C Small Y Kharode PJ Yaworsky ML Bouxsein PS Reddy PW Bodine B Bhat JA Robinson J Marzolf RA Moran F Bex 2003 High bone mass in mice expressing a mutant LRP5 gene J Bone Miner Res 18 960 974
-
(2003)
J Bone Miner Res
, vol.18
, pp. 960-974
-
-
Babij, P.1
Zhao, W.2
Small, C.3
Kharode, Y.4
Yaworsky, P.J.5
Bouxsein, M.L.6
Reddy, P.S.7
Bodine, P.W.8
Bhat, B.9
Robinson, J.A.10
Marzolf, J.11
Moran, R.A.12
Bex, F.13
-
27
-
-
33747674263
-
The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
-
K Sawakami AG Robling M Ai ND Pitner D Liu SJ Warden J Li P Maye DW Rowe RL Duncan ML Warman CH Turner 2006 The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment J Biol Chem 281 23698 23711
-
(2006)
J Biol Chem
, vol.281
, pp. 23698-23711
-
-
Sawakami, K.1
Robling, A.G.2
Ai, M.3
Pitner, N.D.4
Liu, D.5
Warden, S.J.6
Li, J.7
Maye, P.8
Rowe, D.W.9
Duncan, R.L.10
Warman, M.L.11
Turner, C.H.12
-
29
-
-
46449131544
-
PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells
-
A Suzuki K Ozono T Kubota H Kondou K Tachikawa T Michigami 2008 PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells J Cell Biochem 104 304 317
-
(2008)
J Cell Biochem
, vol.104
, pp. 304-317
-
-
Suzuki, A.1
Ozono, K.2
Kubota, T.3
Kondou, H.4
Tachikawa, K.5
Michigami, T.6
-
30
-
-
33846026749
-
Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
-
JA Robinson M Chatterjee-Kishore PJ Yaworsky DM Cullen W Zhao C Li Y Kharode L Sauter P Babij EL Brown AA Hill MP Akhter ML Johnson RR Recker BS Komm FJ Bex 2006 Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone J Biol Chem 281 31720 31728
-
(2006)
J Biol Chem
, vol.281
, pp. 31720-31728
-
-
Robinson, J.A.1
Chatterjee-Kishore, M.2
Yaworsky, P.J.3
Cullen, D.M.4
Zhao, W.5
Li, C.6
Kharode, Y.7
Sauter, L.8
Babij, P.9
Brown, E.L.10
Hill, A.A.11
Akhter, M.P.12
Johnson, M.L.13
Recker, R.R.14
Komm, B.S.15
Bex, F.J.16
-
31
-
-
2442656675
-
The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd
-
Y Zhang Y Wang X Li J Zhang J Mao Z Li J Zheng L Li S Harris D Wu 2004 The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd Mol Cell Biol 24 4677 4684
-
(2004)
Mol Cell Biol
, vol.24
, pp. 4677-4684
-
-
Zhang, Y.1
Wang, Y.2
Li, X.3
Zhang, J.4
Mao, J.5
Li, Z.6
Zheng, J.7
Li, L.8
Harris, S.9
Wu, D.10
-
32
-
-
20344398197
-
Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling
-
M Ai SL Holmen W Van Hul BO Williams ML Warman 2005 Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling Mol Cell Biol 25 4946 4955
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4946-4955
-
-
Ai, M.1
Holmen, S.L.2
Van Hul, W.3
Williams, B.O.4
Warman, M.L.5
-
33
-
-
33845994036
-
LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST
-
MV Semenov X He 2006 LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST J Biol Chem 281 38276 38284
-
(2006)
J Biol Chem
, vol.281
, pp. 38276-38284
-
-
Semenov, M.V.1
He, X.2
-
34
-
-
27244452640
-
Clinical and molecular findings in osteoporosis-pseudoglioma syndrome
-
Osteoporosis-Pseudoglioma Collaborative Group
-
M Ai S Heeger CF Bartels DK Schelling Osteoporosis-Pseudoglioma Collaborative Group 2005 Clinical and molecular findings in osteoporosis- pseudoglioma syndrome Am J Hum Genet 77 741 753
-
(2005)
Am J Hum Genet
, vol.77
, pp. 741-753
-
-
Ai, M.1
Heeger, S.2
Bartels, C.F.3
Schelling, D.K.4
-
36
-
-
13444295117
-
Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6
-
SL Holmen TA Giambernardi CR Zylstra BD Buckner-Berghuis JH Resau JF Hess V Glant ML Bouxsein M Ai ML Warman BO Williams 2004 Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6 J Bone Miner Res 19 2033 2040
-
(2004)
J Bone Miner Res
, vol.19
, pp. 2033-2040
-
-
Holmen, S.L.1
Giambernardi, T.A.2
Zylstra, C.R.3
Buckner-Berghuis, B.D.4
Resau, J.H.5
Hess, J.F.6
Glant, V.7
Bouxsein, M.L.8
Ai, M.9
Warman, M.L.10
Williams, B.O.11
-
37
-
-
9444235153
-
Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
-
C Kokubu U Heinzmann T Kokubu N Sakai T Kubota M Kawai MB Wahl J Galceran R Grosschedl K Ozono K Imai 2004 Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis Development 131 5469 5480
-
(2004)
Development
, vol.131
, pp. 5469-5480
-
-
Kokubu, C.1
Heinzmann, U.2
Kokubu, T.3
Sakai, N.4
Kubota, T.5
Kawai, M.6
Wahl, M.B.7
Galceran, J.8
Grosschedl, R.9
Ozono, K.10
Imai, K.11
-
38
-
-
52949105706
-
Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd
-
T Kubota T Michigami N Sakaguchi C Kokubu A Suzuki N Namba N Sakai S Nakajima K Imai K Ozono 2008 Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd J Bone Miner Res 23 10 1661 1671
-
(2008)
J Bone Miner Res
, vol.23
, Issue.10
, pp. 1661-1671
-
-
Kubota, T.1
Michigami, T.2
Sakaguchi, N.3
Kokubu, C.4
Suzuki, A.5
Namba, N.6
Sakai, N.7
Nakajima, S.8
Imai, K.9
Ozono, K.10
-
39
-
-
33646808104
-
Wnt signaling in osteoblasts regulates expression the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro
-
GJ Spencer JC Utting SL Etheridge TR Arnett PG Genever 2006 Wnt signaling in osteoblasts regulates expression the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro J Cell Sci 119 1283 1296
-
(2006)
J Cell Sci
, vol.119
, pp. 1283-1296
-
-
Spencer, G.J.1
Utting, J.C.2
Etheridge, S.L.3
Arnett, T.R.4
Genever, P.G.5
-
40
-
-
33847656105
-
LRP6 mutation in a family with early coronary disease and metabolic risk factors
-
A Mani J Radhakrishnan H Wang A Mani M-A Mani C Nelson-Williams KS Carew S Mane H Najmabadi D Wu RP Lifton 2007 LRP6 mutation in a family with early coronary disease and metabolic risk factors Science 315 1278 1282
-
(2007)
Science
, vol.315
, pp. 1278-1282
-
-
Mani, A.1
Radhakrishnan, J.2
Wang, H.3
Mani, A.4
Mani, M.-A.5
Nelson-Williams, C.6
Carew, K.S.7
Mane, S.8
Najmabadi, H.9
Wu, D.10
Lifton, R.P.11
-
43
-
-
21244480924
-
Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
-
X Li Y Zhang H Kang W Liu P Liu J Zhang SE Harris D Wu 2005 Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling J Biol Chem 280 19883 19887
-
(2005)
J Biol Chem
, vol.280
, pp. 19883-19887
-
-
Li, X.1
Zhang, Y.2
Kang, H.3
Liu, W.4
Liu, P.5
Zhang, J.6
Harris, S.E.7
Wu, D.8
-
44
-
-
25144448701
-
Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
-
X Li P Liu W Liu P Maye J Zhang Y Zhang M Hurley C Guo A Boskey L Sun SE Harris DW Rowe HZ Ke D Wu 2005 Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation Nat Genet 37 945 952
-
(2005)
Nat Genet
, vol.37
, pp. 945-952
-
-
Li, X.1
Liu, P.2
Liu, W.3
Maye, P.4
Zhang, J.5
Zhang, Y.6
Hurley, M.7
Guo, C.8
Boskey, A.9
Sun, L.10
Harris, S.E.11
Rowe, D.W.12
Ke, H.Z.13
Wu, D.14
-
47
-
-
34347235843
-
Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma
-
S Kang CN Bennett I Gerin LA Rapp KD Hankenson OA Macdougald 2007 Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma J Biol Chem 282 14515 14524
-
(2007)
J Biol Chem
, vol.282
, pp. 14515-14524
-
-
Kang, S.1
Bennett, C.N.2
Gerin, I.3
Rapp, L.A.4
Hankenson, K.D.5
MacDougald, O.A.6
-
49
-
-
38749086157
-
Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation
-
CN Bennett H Ouyang YL Ma Q Zeng I Gerin KM Sousa TF Lane V Krishnan KD Hankenson OA MacDougald 2007 Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation J Bone Miner Res 22 1924 1932
-
(2007)
J Bone Miner Res
, vol.22
, pp. 1924-1932
-
-
Bennett, C.N.1
Ouyang, H.2
Ma, Y.L.3
Zeng, Q.4
Gerin, I.5
Sousa, K.M.6
Lane, T.F.7
Krishnan, V.8
Hankenson, K.D.9
-
50
-
-
35748960839
-
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation
-
I Takada M Mihara M Suzawa F Ohtake S Kobayashi M Igarashi MY Youn K Takeyama T Nakamura Y Mezaki S Takezawa Y Yogiashi H Kitagawa G Yamada S Takada Y Minami H Shibuya K Matsumoto S Kato 2007 A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation Nat Cell Biol 9 1273 1285
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1273-1285
-
-
Takada, I.1
Mihara, M.2
Suzawa, M.3
Ohtake, F.4
Kobayashi, S.5
Igarashi, M.6
Youn, M.Y.7
Takeyama, K.8
Nakamura, T.9
Mezaki, Y.10
Takezawa, S.11
Yogiashi, Y.12
Kitagawa, H.13
Yamada, G.14
Takada, S.15
Minami, Y.16
Shibuya, H.17
Matsumoto, K.18
Kato, S.19
-
51
-
-
2342529836
-
The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
-
PV Bodine W Zhao YP Kharode FJ Bex AJ Lambert MB Goad T Gaur GS Stein JB Lian BS Komm 2004 The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice Mol Endocrinol 18 1222 1237
-
(2004)
Mol Endocrinol
, vol.18
, pp. 1222-1237
-
-
Bodine, P.V.1
Zhao, W.2
Kharode, Y.P.3
Bex, F.J.4
Lambert, A.J.5
Goad, M.B.6
Gaur, T.7
Stein, G.S.8
Lian, J.B.9
Komm, B.S.10
-
52
-
-
18044399916
-
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse
-
M Mukhopadhyay S Shtrom C Rodriguez-Esteban L Chen T Tsukui L Gomer DW Dorward A Glinka A Grinberg SP Huang C Niehrs JC Belmonte H Westphal 2001 Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse Dev Cell 1 423 434
-
(2001)
Dev Cell
, vol.1
, pp. 423-434
-
-
Mukhopadhyay, M.1
Shtrom, S.2
Rodriguez-Esteban, C.3
Chen, L.4
Tsukui, T.5
Gomer, L.6
Dorward, D.W.7
Glinka, A.8
Grinberg, A.9
Huang, S.P.10
Niehrs, C.11
Belmonte, J.C.12
Westphal, H.13
-
53
-
-
33646856033
-
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
-
F Morvan K Boulukos P Clément-Lacroix S Roman Roman I Suc-Royer B Vayssière P Ammann P Martin S Pinho P Pognonec P Mollat C Niehrs R Baron G Rawadi 2006 Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass J Bone Miner Res 21 934 945
-
(2006)
J Bone Miner Res
, vol.21
, pp. 934-945
-
-
Morvan, F.1
Boulukos, K.2
Clément-Lacroix, P.3
Roman Roman, S.4
Suc-Royer, I.5
Vayssière, B.6
Ammann, P.7
Martin, P.8
Pinho, S.9
Pognonec, P.10
Mollat, P.11
Niehrs, C.12
Baron, R.13
Rawadi, G.14
-
54
-
-
33748156090
-
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
-
J Li I Sarosi RC Cattley J Pretorius F Asuncion M Grisanti S Morony S Adamu Z Geng W Qiu P Kostenuik DL Lacey WS Simonet B Bolon X Qian V Shalhoub MS Ominsky H Zhu Ke X Li WG Richards 2006 Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia Bone 39 754 766
-
(2006)
Bone
, vol.39
, pp. 754-766
-
-
Li, J.1
Sarosi, I.2
Cattley, R.C.3
Pretorius, J.4
Asuncion, F.5
Grisanti, M.6
Morony, S.7
Adamu, S.8
Geng, Z.9
Qiu, W.10
Kostenuik, P.11
Lacey, D.L.12
Simonet, W.S.13
Bolon, B.14
Qian, X.15
Shalhoub, V.16
Ominsky, M.S.17
Zhu Ke, H.18
Li, X.19
Richards, W.G.20
more..
-
55
-
-
33846025409
-
Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats
-
FS Wang JY Ko CL Lin HL Wu HJ Ke PJ Tai 2007 Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats Bone 40 485 492
-
(2007)
Bone
, vol.40
, pp. 485-492
-
-
Wang, F.S.1
Ko, J.Y.2
Lin, C.L.3
Wu, H.L.4
Ke, H.J.5
Tai, P.J.6
-
56
-
-
53149105939
-
Structural insight into the mechanisms of Wnt signaling antagonism by Dkk
-
L Chen K Wang Y Shao J Huang X Li J Shan D Wu JJ Zheng 2008 Structural insight into the mechanisms of Wnt signaling antagonism by Dkk J Biol Chem 283 23364 23370
-
(2008)
J Biol Chem
, vol.283
, pp. 23364-23370
-
-
Chen, L.1
Wang, K.2
Shao, Y.3
Huang, J.4
Li, X.5
Shan, J.6
Wu, D.7
Zheng, J.J.8
-
57
-
-
22844445934
-
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
-
M Semënov K Tamai X He 2005 SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor J Biol Chem 280 26770 26775
-
(2005)
J Biol Chem
, vol.280
, pp. 26770-26775
-
-
Semënov, M.1
Tamai, K.2
He, X.3
-
58
-
-
33846449190
-
Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity
-
DL Ellies B Viviano J McCarthy JP Rey N Itasaki S Saunders R Krumlauf 2006 Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity J Bone Miner Res 21 1738 1749
-
(2006)
J Bone Miner Res
, vol.21
, pp. 1738-1749
-
-
Ellies, D.L.1
Viviano, B.2
Rey, J.P.3
Itasaki, N.4
Saunders, S.5
Krumlauf, R.6
-
59
-
-
0035282968
-
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
-
W Balemans M Ebeling N Patel E Van Hul P Olson M Dioszegi C Lacza W Wuyts J Van Den Ende P Willems AF Paes-Alves S Hill M Bueno FJ Ramos P Tacconi FG Dikkers C Stratakis K Lindpaintner B Vickery D Foernzler W Van Hul 2001 Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) Hum Mol Genet 10 537 543
-
(2001)
Hum Mol Genet
, vol.10
, pp. 537-543
-
-
Balemans, W.1
Ebeling, M.2
Patel, N.3
Van Hul, E.4
Olson, P.5
Dioszegi, M.6
Lacza, C.7
Wuyts, W.8
Van Den Ende, J.9
Willems, P.10
Paes-Alves, A.F.11
Hill, S.12
Bueno, M.13
Ramos, F.J.14
Tacconi, P.15
Dikkers, F.G.16
Stratakis, C.17
Lindpaintner, K.18
Vickery, B.19
Foernzler, D.20
Van Hul, W.21
more..
-
60
-
-
0035089781
-
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
-
ME Brunkow JC Gardner J Van Ness BW Paeper BR Kovacevich S Proll JE Skonier L Zhao PJ Sabo Y Fu RS Alisch L Gillett T Colbert P Tacconi D Galas H Hamersma P Beighton J Mulligan 2001 Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein Am J Hum Genet 68 577 589
-
(2001)
Am J Hum Genet
, vol.68
, pp. 577-589
-
-
Brunkow, M.E.1
Gardner, J.C.2
Van Ness, J.3
Paeper, B.W.4
Kovacevich, B.R.5
Proll, S.6
Skonier, J.E.7
Zhao, L.8
Sabo, P.J.9
Fu, Y.10
Alisch, R.S.11
Gillett, L.12
Colbert, T.13
Tacconi, P.14
Galas, D.15
Hamersma, H.16
Beighton, P.17
Mulligan, J.18
-
61
-
-
18244403197
-
Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
-
W Balemans N Patel M Ebeling E Van Hul W Wuyts C Lacza M Dioszegi FG Dikkers P Hildering PJ Willems JB Verheij K Lindpaintner B Vickery D Foernzler W Van Hul 2002 Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease J Med Genet 39 91 97
-
(2002)
J Med Genet
, vol.39
, pp. 91-97
-
-
Balemans, W.1
Patel, N.2
Ebeling, M.3
Van Hul, E.4
Wuyts, W.5
Lacza, C.6
Dioszegi, M.7
Dikkers, F.G.8
Hildering, P.9
Willems, P.J.10
Verheij, J.B.11
Lindpaintner, K.12
Vickery, B.13
Foernzler, D.14
Van Hul, W.15
-
62
-
-
10744221383
-
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
-
DG Winkler MK Sutherland JC Geoghegan C Yu T Hayes JE Skonier D Shpektor M Jonas BR Kovacevich K Staehling-Hampton M Appleby ME Brunkow JA Latham 2003 Osteocyte control of bone formation via sclerostin, a novel BMP antagonist EMBO J 22 6267 6276
-
(2003)
EMBO J
, vol.22
, pp. 6267-6276
-
-
Winkler, D.G.1
Sutherland, M.K.2
Geoghegan, J.C.3
Yu, C.4
Hayes, T.5
Skonier, J.E.6
Shpektor, D.7
Jonas, M.8
Kovacevich, B.R.9
Staehling-Hampton, K.10
Appleby, M.11
Brunkow, M.E.12
Latham, J.A.13
-
63
-
-
44449099165
-
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
-
X Li MS Ominsky QT Niu N Sun B Daugherty D D'Agostin C Kurahara Y Gao J Cao J Gong F Asuncion M Barrero K Warmington D Dwyer M Stolina S Morony I Sarosi PJ Kostenuik DL Lacey WS Simonet HZ Ke C Paszty 2008 Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength J Bone Miner Res 23 860 869
-
(2008)
J Bone Miner Res
, vol.23
, pp. 860-869
-
-
Li, X.1
Ominsky, M.S.2
Niu, Q.T.3
Sun, N.4
Daugherty, B.5
D'Agostin, D.6
Kurahara, C.7
Gao, Y.8
Cao, J.9
Gong, J.10
Asuncion, F.11
Barrero, M.12
Warmington, K.13
Dwyer, D.14
Stolina, M.15
Morony, S.16
Sarosi, I.17
Kostenuik, P.J.18
Lacey, D.L.19
Simonet, W.S.20
Ke, H.Z.21
Paszty, C.22
more..
-
65
-
-
50949131016
-
The osteocyte lineage
-
BS Noble 2008 The osteocyte lineage Arch Biochem Biophys 473 106 111
-
(2008)
Arch Biochem Biophys
, vol.473
, pp. 106-111
-
-
Noble, B.S.1
-
66
-
-
40849106249
-
Osteocytes, mechanosensing and Wnt signaling
-
LF Bonewald ML Johnson 2008 Osteocytes, mechanosensing and Wnt signaling Bone 42 606 615
-
(2008)
Bone
, vol.42
, pp. 606-615
-
-
Bonewald, L.F.1
Johnson, M.L.2
-
67
-
-
38849186793
-
Anti-sclerostin antibody increases markers of bone formation in healthy postmenopausal women
-
D Padhi B Stouch G Jang L Fang M Darling H Glise M Robinson S Harris E Posvar 2007 Anti-sclerostin antibody increases markers of bone formation in healthy postmenopausal women J Bone Miner Res 22 S37
-
(2007)
J Bone Miner Res
, vol.22
, pp. 37
-
-
Padhi, D.1
Stouch, B.2
Jang, G.3
Fang, L.4
Darling, M.5
Glise, H.6
Robinson, M.7
Harris, S.8
Posvar, E.9
-
68
-
-
26844521277
-
Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis
-
T Bellido AA Ali I Gubrij LI Plotkin Q Fu CA O'Brien SC Manolagas RL Jilka 2005 Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis Endocrinology 146 4577 4583
-
(2005)
Endocrinology
, vol.146
, pp. 4577-4583
-
-
Bellido, T.1
Ali, A.A.2
Gubrij, I.3
Plotkin, L.I.4
Fu, Q.5
O'Brien, C.A.6
Manolagas, S.C.7
Jilka, R.L.8
-
69
-
-
21844467220
-
SOST is a target gene for PTH in bone
-
H Keller M Kneissel 2005 SOST is a target gene for PTH in bone Bone 37 148 158
-
(2005)
Bone
, vol.37
, pp. 148-158
-
-
Keller, H.1
Kneissel, M.2
-
71
-
-
41949089764
-
Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
-
AG Robling PJ Niziolek LA Baldridge KW Condon MR Allen I Alam SM Mantila J Gluhak-Heinrich TM Bellido SE Harris CH Turner 2008 Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin J Biol Chem 283 5866 5875
-
(2008)
J Biol Chem
, vol.283
, pp. 5866-5875
-
-
Robling, A.G.1
Niziolek, P.J.2
Baldridge, L.A.3
Condon, K.W.4
Allen, M.R.5
Alam, I.6
Mantila, S.M.7
Gluhak-Heinrich, J.8
Bellido, T.M.9
Harris, S.E.10
Turner, C.H.11
-
72
-
-
51449111663
-
Control of bone mass and remodeling by PTH receptor signaling in osteocytes
-
CA O'Brien LI Plotkin C Galli JJ Goellner AR Gortazar MR Allen AG Robling M Bouxsein E Schipani CH Turner RL Jilka RS Weinstein SC Manolagas T Bellido 2008 Control of bone mass and remodeling by PTH receptor signaling in osteocytes PLoS ONE 3 e2942
-
(2008)
PLoS ONE
, vol.3
, pp. 2942
-
-
O'Brien, C.A.1
Plotkin, L.I.2
Galli, C.3
Goellner, J.J.4
Gortazar, A.R.5
Allen, M.R.6
Robling, A.G.7
Bouxsein, M.8
Schipani, E.9
Turner, C.H.10
Jilka, R.L.11
Weinstein, R.S.12
Manolagas, S.C.13
Bellido, T.14
-
73
-
-
0035413614
-
Glycogen synthase kinase-3: Properties, functions, and regulation
-
A Ali KP Hoeflich JR Woodgett 2001 Glycogen synthase kinase-3: properties, functions, and regulation Chem Rev 101 2527 2540
-
(2001)
Chem Rev
, vol.101
, pp. 2527-2540
-
-
Ali, A.1
Hoeflich, K.P.2
Woodgett, J.R.3
-
74
-
-
28444438846
-
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
-
P Clément-Lacroix M Ai F Morvan S Roman-Roman B Vayssière C Belleville K Estrera ML Warman R Baron G Rawadi 2005 Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice Proc Natl Acad Sci USA 102 17406 17411
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17406-17411
-
-
Clément-Lacroix, P.1
Ai, M.2
Morvan, F.3
Roman-Roman, S.4
Vayssière, B.5
Belleville, C.6
Estrera, K.7
Warman, M.L.8
Baron, R.9
Rawadi, G.10
-
75
-
-
33646414025
-
Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo
-
NH Kulkarni JE Onyia Q Zeng X Tian M Liu DL Halladay CA Frolik T Engler T Wei A Kriauciunas TJ Martin M Sato HU Bryant YL Ma 2006 Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo J Bone Miner Res 21 910 920
-
(2006)
J Bone Miner Res
, vol.21
, pp. 910-920
-
-
Kulkarni, N.H.1
Onyia, J.E.2
Zeng, Q.3
Tian, X.4
Liu, M.5
Halladay, D.L.6
Frolik, C.A.7
Engler, T.8
Wei, T.9
Kriauciunas, A.10
Martin, T.J.11
Sato, M.12
Bryant, H.U.13
Ma, Y.L.14
-
76
-
-
34548511817
-
Fracture risk associated with parkinsonism and anti-Parkinson drugs
-
P Vestergaard L Rejnmark L Mosekilde 2007 Fracture risk associated with parkinsonism and anti-Parkinson drugs Calcif Tissue Int 81 153 161
-
(2007)
Calcif Tissue Int
, vol.81
, pp. 153-161
-
-
Vestergaard, P.1
Rejnmark, L.2
Mosekilde, L.3
-
77
-
-
41049108267
-
GSK-3beta controls osteogenesis through regulating Runx2 activity
-
F Kugimiya H Kawaguchi S Ohba N Kawamura M Hirata H Chikuda Y Azuma JR Woodgett K Nakamura UI Chung 2007 GSK-3beta controls osteogenesis through regulating Runx2 activity PLoS ONE 2 e837
-
(2007)
PLoS ONE
, vol.2
, pp. 837
-
-
Kugimiya, F.1
Kawaguchi, H.2
Ohba, S.3
Kawamura, N.4
Hirata, M.5
Chikuda, H.6
Azuma, Y.7
Woodgett, J.R.8
Nakamura, K.9
Chung, U.I.10
-
78
-
-
17844372752
-
Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
-
TF Day X Guo L Garrett-Beal Y Yang 2005 Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis Dev Cell 8 739 750
-
(2005)
Dev Cell
, vol.8
, pp. 739-750
-
-
Day, T.F.1
Guo, X.2
Garrett-Beal, L.3
Yang, Y.4
-
79
-
-
17844363974
-
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
-
TP Hill D Später MM Taketo W Birchmeier C Hartmann 2005 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes Dev Cell 8 727 738
-
(2005)
Dev Cell
, vol.8
, pp. 727-738
-
-
Hill, T.P.1
Später, D.2
Taketo, M.M.3
Birchmeier, W.4
Hartmann, C.5
-
80
-
-
20244373613
-
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
-
DA Glass II P Bialek JD Ahn M Starbuck MS Patel H Clevers MM Taketo F Long AP McMahon RA Lang G Karsenty 2005 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation Dev Cell 8 751 764
-
(2005)
Dev Cell
, vol.8
, pp. 751-764
-
-
Glass Ii, D.A.1
Bialek, P.2
Ahn, J.D.3
Starbuck, M.4
Patel, M.S.5
Clevers, H.6
Taketo, M.M.7
Long, F.8
Lang, R.A.9
Karsenty, G.10
-
81
-
-
20444376156
-
Essential role of β-catenin in postnatal bone acquisition
-
SL Holmen CR Zylstra A Mukherjee RE Sigler M-C Faugere ML Bouxsein L Deng TL Clemens BO Williams 2005 Essential role of β-catenin in postnatal bone acquisition J Biol Chem 280 21162 21168
-
(2005)
J Biol Chem
, vol.280
, pp. 21162-21168
-
-
Holmen, S.L.1
Zylstra, C.R.2
Mukherjee, A.3
Sigler, R.E.4
Faugere, M.-C.5
Bouxsein, M.L.6
Deng, L.7
Clemens, T.L.8
Williams, B.O.9
-
82
-
-
25844509347
-
Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression
-
T Gaur CJ Lengner H Hovhannisyan RA Bhat PV Bodine BS Komm A Javed AJ van Wijnen JL Stein GS Stein JB Lian 2005 Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression J Biol Chem 280 33132 33140
-
(2005)
J Biol Chem
, vol.280
, pp. 33132-33140
-
-
Gaur, T.1
Lengner, C.J.2
Hovhannisyan, H.3
Bhat, R.A.4
Bodine, P.V.5
Komm, B.S.6
Javed, A.7
Van Wijnen, A.J.8
Stein, J.L.9
Stein, G.S.10
Lian, J.B.11
|