Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

Science

Volumn 347, Issue 6226, 2015, Pages 1113-1117

  Burg, John S ^a   Ingram, Jessica R ^b   Venkatakrishnan, A J ^a,c   Jude, Kevin M ^a   Dukkipati, Abhiram ^a   Feinberg, Evan N ^a,c   Angelini, Alessandro ^d   Waghray, Deepa ^a   Dror, Ron O ^a,c   Ploegh, Hidde L ^b   Garcia, K Christopher ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c Stanford University   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; FRACTALKINE; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; MARAVIROC; NANOBODY; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHEMOKINE RECEPTOR CXCR4; CX3CL1 PROTEIN, HUMAN; CYCLOHEXANE DERIVATIVE; LIGAND; PIPERIDINE DERIVATIVE; PROTEIN BINDING; TRIAZOLE DERIVATIVE; US28 RECEPTOR, CYTOMEGALOVIRUS; VIRUS PROTEIN; VUF 2274;

AMINO ACID; IMMUNE SYSTEM; LIGAND; PROTEIN; SIGNALING; SIMULATION;

ARTICLE; CRYSTAL STRUCTURE; DISULFIDE BOND; DNA LIBRARY; HUMAN CYTOMEGALOVIRUS; HYDROGEN BOND; LIGAND BINDING; MASS SPECTROMETRY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; SIMULATION; AGONISTS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

HUMAN HERPESVIRUS 5;

CCR5 RECEPTOR ANTAGONISTS; CHEMOKINE CX3CL1; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANES; HUMANS; LIGANDS; PIPERIDINES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR4; TRIAZOLES; VIRAL PROTEINS;

EID: 84924561288     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa5026     Document Type: Article

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