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Volumn 65, Issue 4, 2016, Pages 341-352

High-efficiency antibody discovery achieved with multiplexed microscopy

Author keywords

Antibody discovery; Chicken monoclonal antibody; DR4 DR5; GPCR; Ion channel; Single b cell cloning

Indexed keywords

ANIMALS; CELL CULTURE; CELL PROLIFERATION; CLONING; MONOCLONAL ANTIBODIES;

EID: 84988407736     PISSN: 20505698     EISSN: 20505701     Source Type: Journal    
DOI: 10.1093/jmicro/dfw014     Document Type: Article
Times cited : (31)

References (63)
  • 1
    • 84921352030 scopus 로고    scopus 로고
    • The therapeutic monoclonal antibody market
    • Ecker D M, Jones S D, Levine H L (2015) The therapeutic monoclonal antibody market. MAbs 7: 9-14.
    • (2015) MAbs , vol.7 , pp. 9-14
    • Ecker, D.M.1    Jones, S.D.2    Levine, H.L.3
  • 2
    • 27144431943 scopus 로고    scopus 로고
    • Selecting and screening recombinant antibody libraries
    • Hoogenboom H R (2005) Selecting and screening recombinant antibody libraries. Nat. Biotechnol. 23: 1105-1116.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1105-1116
    • Hoogenboom, H.R.1
  • 4
    • 33749573860 scopus 로고    scopus 로고
    • Harnessing phage and ribosome display for antibody optimisation
    • Dufner P, Jermutus L, Minter R R (2006) Harnessing phage and ribosome display for antibody optimisation. Trends Biotechnol. 24: 523-529.
    • (2006) Trends Biotechnol. , vol.24 , pp. 523-529
    • Dufner, P.1    Jermutus, L.2    Minter, R.R.3
  • 6
    • 3142682191 scopus 로고    scopus 로고
    • Yeast display of antibody fragments: A discovery and characterization platform
    • Feldhaus M J, Siegel R W (2004) Yeast display of antibody fragments:a discovery and characterization platform. J. Immunol. Methods 290: 69-80.
    • (2004) J. Immunol. Methods , vol.290 , pp. 69-80
    • Feldhaus, M.J.1    Siegel, R.W.2
  • 7
    • 84891629425 scopus 로고    scopus 로고
    • Mammalian cell display for the discovery and optimization of antibody therapeutics
    • Bowers P M, Horlick R A, Kehry M R, et al. (2014) Mammalian cell display for the discovery and optimization of antibody therapeutics. Methods 65: 44-56.
    • (2014) Methods , vol.65 , pp. 44-56
    • Bowers, P.M.1    Horlick, R.A.2    Kehry, M.R.3
  • 8
    • 84900871571 scopus 로고    scopus 로고
    • Antibody library display on a mammalian virus vector: Combining the advantages of both phage and yeast display into one technology
    • Smith E S, Zauderer M (2014) Antibody library display on a mammalian virus vector: combining the advantages of both phage and yeast display into one technology. Curr. Drug Discov. Technol. 11: 48-55.
    • (2014) Curr. Drug Discov. Technol. , vol.11 , pp. 48-55
    • Smith, E.S.1    Zauderer, M.2
  • 9
    • 84900839112 scopus 로고    scopus 로고
    • Mammalian cell display and somatic hypermutation in vitro for human antibody discovery
    • King D J, Bowers P M, KehryMR, Horlick R A (2014) Mammalian cell display and somatic hypermutation in vitro for human antibody discovery. Curr. Drug Discov. Technol. 11: 56-64.
    • (2014) Curr. Drug Discov. Technol. , vol.11 , pp. 56-64
    • King, D.J.1    Bowers, P.M.2    Kehry, M.R.3    Horlick, R.A.4
  • 12
    • 80052328890 scopus 로고    scopus 로고
    • Synthetic single-framework antibody library integrated with rapid affinity maturation by VL shuffling
    • Brockmann E-C, Akter S, Savukoski T, et al. (2011) Synthetic single-framework antibody library integrated with rapid affinity maturation by VL shuffling. Protein Eng. Des. Sel. 24: 691-700.
    • (2011) Protein Eng. Des. Sel. , vol.24 , pp. 691-700
    • Brockmann, E.-C.1    Akter, S.2    Savukoski, T.3
  • 13
    • 84876121952 scopus 로고    scopus 로고
    • Discovery of diverse and functional antibodies from large human repertoire antibody libraries
    • Schwimmer L J, Huang B, Giang H, et al. (2013) Discovery of diverse and functional antibodies from large human repertoire antibody libraries. J. Immunol. Methods 391: 60-71.
    • (2013) J. Immunol. Methods , vol.391 , pp. 60-71
    • Schwimmer, L.J.1    Huang, B.2    Giang, H.3
  • 14
    • 84928722182 scopus 로고    scopus 로고
    • Generation and analysis of the improved human HAL9/10 antibody phage display libraries
    • Kügler J, Wilke S, Meier D, et al. (2015) Generation and analysis of the improved human HAL9/10 antibody phage display libraries. BMC Biotechnol. 15: 10.
    • (2015) BMC Biotechnol. , vol.15 , pp. 10
    • Kügler, J.1    Wilke, S.2    Meier, D.3
  • 15
    • 21444439732 scopus 로고    scopus 로고
    • Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
    • Hoet R M, Cohen E H, Kent R B, et al. (2005) Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity. Nat. Biotechnol. 23: 344-348.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 344-348
    • Hoet, R.M.1    Cohen, E.H.2    Kent, R.B.3
  • 16
    • 0037334943 scopus 로고    scopus 로고
    • Generation of chicken single chain antibody variable fragments (scFv) that differentiate and neutralize infectious bursal disease virus (IBDV)
    • Sapats S I, Heine H G, Trinidad L, Gould G J, Foord A J, Doolan S G, Prowse S, Ignjatovic J (2003) Generation of chicken single chain antibody variable fragments (scFv) that differentiate and neutralize infectious bursal disease virus (IBDV). Arch. Virol. 148: 497-515.
    • (2003) Arch. Virol. , vol.148 , pp. 497-515
    • Sapats, S.I.1    Heine, H.G.2    Trinidad, L.3    Gould, G.J.4    Foord, A.J.5    Doolan, S.G.6    Prowse, S.7    Ignjatovic, J.8
  • 18
    • 84859968031 scopus 로고    scopus 로고
    • Generation of a mouse scFv library specific for porcine aminopeptidase N using the T7 phage display system
    • Sun D, Shi H, Chen J, Shi D, Zhu Q, Zhang H, Liu S, Wang Y, Qiu H, Feng L (2012) Generation of a mouse scFv library specific for porcine aminopeptidase N using the T7 phage display system. J. Virol. Methods 182: 99-103.
    • (2012) J. Virol. Methods , vol.182 , pp. 99-103
    • Sun, D.1    Shi, H.2    Chen, J.3    Shi, D.4    Zhu, Q.5    Zhang, H.6    Liu, S.7    Wang, Y.8    Qiu, H.9    Feng, L.10
  • 19
    • 84879167987 scopus 로고    scopus 로고
    • Rapid generation of human-like neutralizing monoclonal antibodies in urgent preparedness for influenza pandemics and virulent infectious diseases
    • Meng W, Pan W, Zhang A J X, et al. (2013) Rapid generation of human-like neutralizing monoclonal antibodies in urgent preparedness for influenza pandemics and virulent infectious diseases. PLoS One 8: e66276.
    • (2013) PLoS One , vol.8
    • Meng, W.1    Pan, W.2    Zhang, A.J.X.3
  • 21
    • 77953063005 scopus 로고    scopus 로고
    • Reducing epitope spread during affinity maturation of an antiganglioside GD2 antibody
    • Hu J, Huang X, Ling C-C, Bundle D R, Cheung N-K V (2009) Reducing epitope spread during affinity maturation of an antiganglioside GD2 antibody. J. Immunol. 183: 5748-5755.
    • (2009) J. Immunol. , vol.183 , pp. 5748-5755
    • Hu, J.1    Huang, X.2    Ling, C.-C.3    Bundle, D.R.4    Cheung, N.-K.V.5
  • 25
    • 0033559934 scopus 로고    scopus 로고
    • High-affinity antibodies from hen’s-egg yolks against human mannose-6-phosphate/insulin-like growth-factor-II receptor (M6P/IGFII-R): Characterization and potential use in clinical cancer studies
    • Lemamy G J, Roger P, Mani J C, Robert M, Rochefort H, Brouillet J P (1999) High-affinity antibodies from hen’s-egg yolks against human mannose-6-phosphate/insulin-like growth-factor-II receptor (M6P/IGFII-R): characterization and potential use in clinical cancer studies. Int. J. Cancer 80: 896-902.
    • (1999) Int. J. Cancer , vol.80 , pp. 896-902
    • Lemamy, G.J.1    Roger, P.2    Mani, J.C.3    Robert, M.4    Rochefort, H.5    Brouillet, J.P.6
  • 26
    • 0032905578 scopus 로고    scopus 로고
    • General applicability of chicken egg yolk antibodies: The performance of IgY immunoglobulins raised against the hypoxia-inducible factor 1alpha
    • Camenisch G, Tini M, Chilov D, Kvietikova I, Srinivas V, Caro J, Spielmann P, Wenger R H, Gassmann M (1999) General applicability of chicken egg yolk antibodies: the performance of IgY immunoglobulins raised against the hypoxia-inducible factor 1alpha. FASEB J. 13: 81-88.
    • (1999) FASEB J. , vol.13 , pp. 81-88
    • Camenisch, G.1    Tini, M.2    Chilov, D.3    Kvietikova, I.4    Srinivas, V.5    Caro, J.6    Spielmann, P.7    Wenger, R.H.8    Gassmann, M.9
  • 29
    • 0025279437 scopus 로고
    • Efficient production of chicken egg yolk antibodies against a conserved mammalian protein
    • Gassmann M, Thommes P, Weiser T, Hubscher U (1990) Efficient production of chicken egg yolk antibodies against a conserved mammalian protein. FASEB J. 4: 2528-2532.
    • (1990) FASEB J. , vol.4 , pp. 2528-2532
    • Gassmann, M.1    Thommes, P.2    Weiser, T.3    Hubscher, U.4
  • 30
    • 0023770833 scopus 로고
    • High affinity antibody from hen’s eggs directed against the human insulin receptor and the human IGF-I receptor
    • Stuart C A, Pietrzyk R A, Furlanetto R W, Green A (1988) High affinity antibody from hen’s eggs directed against the human insulin receptor and the human IGF-I receptor. Anal. Biochem. 173: 142-150.
    • (1988) Anal. Biochem. , vol.173 , pp. 142-150
    • Stuart, C.A.1    Pietrzyk, R.A.2    Furlanetto, R.W.3    Green, A.4
  • 31
    • 0022413479 scopus 로고
    • Antibodies to human plasma kallikrein from egg yolks of an immunized hen: Preparation and characterization
    • Burger D, Ramus M A, Schapira M (1985) Antibodies to human plasma kallikrein from egg yolks of an immunized hen: preparation and characterization. Thromb. Res. 40: 283-288.
    • (1985) Thromb. Res. , vol.40 , pp. 283-288
    • Burger, D.1    Ramus, M.A.2    Schapira, M.3
  • 32
    • 0021999906 scopus 로고
    • Exploitation of phylogenetic distance in cell surface immune labeling: Studies with beta 2-microglobulin
    • Horton J J, Holden C A, Ward P J, MacDonald D M, Sanderson A R (1985) Exploitation of phylogenetic distance in cell surface immune labeling: studies with beta 2-microglobulin. J. Invest. Dermatol. 84: 96-99.
    • (1985) J. Invest. Dermatol. , vol.84 , pp. 96-99
    • Horton, J.J.1    Holden, C.A.2    Ward, P.J.3    MacDonald, D.M.4    Sanderson, A.R.5
  • 33
    • 0020663606 scopus 로고
    • Antibodies to calf thymus RNA polymerase II from egg yolks of immunized hens
    • Carroll S B, Stollar B D (1983) Antibodies to calf thymus RNA polymerase II from egg yolks of immunized hens. J. Biol. Chem. 258: 24-26.
    • (1983) J. Biol. Chem. , vol.258 , pp. 24-26
    • Carroll, S.B.1    Stollar, B.D.2
  • 34
    • 0025904263 scopus 로고
    • A new cell line for the production of chicken monoclonal antibody by hybridoma technology
    • Nishinaka S, Suzuki T, Matsuda H, Murata M (1991) A new cell line for the production of chicken monoclonal antibody by hybridoma technology. J. Immunol. Methods 139: 217-222.
    • (1991) J. Immunol. Methods , vol.139 , pp. 217-222
    • Nishinaka, S.1    Suzuki, T.2    Matsuda, H.3    Murata, M.4
  • 36
    • 0029051030 scopus 로고
    • Production of monoclonal antibodies using a secretion capture report web
    • Kenney J S, Gray F, Ancel M H, Dunne J F (1995) Production of monoclonal antibodies using a secretion capture report web. Biotechnology (NY) 13: 787-790.
    • (1995) Biotechnology (NY) , vol.13 , pp. 787-790
    • Kenney, J.S.1    Gray, F.2    Ancel, M.H.3    Dunne, J.F.4
  • 37
    • 0029029084 scopus 로고
    • Secretion capture and report web: Use of affinity derivatized agarose microdroplets for the selection of hybridoma cells
    • Gray F, Kenney J S, Dunne J F (1995) Secretion capture and report web: use of affinity derivatized agarose microdroplets for the selection of hybridoma cells. J. Immunol. Methods 182: 155-163.
    • (1995) J. Immunol. Methods , vol.182 , pp. 155-163
    • Gray, F.1    Kenney, J.S.2    Dunne, J.F.3
  • 38
    • 0023763121 scopus 로고
    • Gel microdroplets: Rapid detection and enumeration of individual microorganisms by their metabolic activity
    • Weaver J C, Williams G B, Klibanov A, Demain A L (1988) Gel microdroplets: rapid detection and enumeration of individual microorganisms by their metabolic activity. Nat. Biotechnol. 6: 1084-1089.
    • (1988) Nat. Biotechnol. , vol.6 , pp. 1084-1089
    • Weaver, J.C.1    Williams, G.B.2    Klibanov, A.3    Demain, A.L.4
  • 39
    • 80051940629 scopus 로고    scopus 로고
    • Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release
    • Joshi A, Garg H, Ablan S D, Freed E O (2011) Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release. J. Biol. Chem. 286: 29861-29871.
    • (2011) J. Biol. Chem. , vol.286 , pp. 29861-29871
    • Joshi, A.1    Garg, H.2    Ablan, S.D.3    Freed, E.O.4
  • 42
    • 0030996297 scopus 로고    scopus 로고
    • The receptor for the cytotoxic ligand TRAIL
    • Pan G (1997) The receptor for the cytotoxic ligand TRAIL. Science 276: 111-113.
    • (1997) Science , vol.276 , pp. 111-113
    • Pan, G.1
  • 43
    • 68849118441 scopus 로고    scopus 로고
    • A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes
    • Sung E S, Park K J, Lee S H, Jang Y S, Park S K, Park Y H, Kwag W J, Kwon M H, Kim Y S (2009) A novel agonistic antibody to human death receptor 4 induces apoptotic cell death in various tumor cells without cytotoxicity in hepatocytes. Mol. Cancer Ther. 8: 2276-2285.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2276-2285
    • Sung, E.S.1    Park, K.J.2    Lee, S.H.3    Jang, Y.S.4    Park, S.K.5    Park, Y.H.6    Kwag, W.J.7    Kwon, M.H.8    Kim, Y.S.9
  • 44
    • 72949091664 scopus 로고    scopus 로고
    • Humanization of an agonistic anti-death receptor 4 single chain variable fragment antibody and avidity-mediated enhancement of its cell death-inducing activity
    • Lee S-H, Park D-W, Sung E-S, Park H-R, Kim J-K, Kim Y-S (2010) Humanization of an agonistic anti-death receptor 4 single chain variable fragment antibody and avidity-mediated enhancement of its cell death-inducing activity. Mol. Immunol. 47: 816-824.
    • (2010) Mol. Immunol. , vol.47 , pp. 816-824
    • Lee, S.-H.1    Park, D.-W.2    Sung, E.-S.3    Park, H.-R.4    Kim, J.-K.5    Kim, Y.-S.6
  • 45
    • 21044441651 scopus 로고    scopus 로고
    • HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
    • Pukac L, Kanakaraj P, Humphreys R, et al. (2005) HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. Br. J. Cancer 92: 1430-1441.
    • (2005) Br. J. Cancer , vol.92 , pp. 1430-1441
    • Pukac, L.1    Kanakaraj, P.2    Humphreys, R.3
  • 46
    • 1042278174 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site
    • Ruiz de Almodóvar C, Ruiz-Ruiz C, Rodríguez A, Ortiz-Ferrón G, Redondo J M, López-Rivas A (2004) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site. J. Biol. Chem. 279: 4093-4101.
    • (2004) J. Biol. Chem. , vol.279 , pp. 4093-4101
    • Ruiz de Almodóvar, C.1    Ruiz-Ruiz, C.2    Rodríguez, A.3    Ortiz-Ferrón, G.4    Redondo, J.M.5    López-Rivas, A.6
  • 48
    • 24944458177 scopus 로고    scopus 로고
    • Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: Induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death
    • Georgakis G V, Li Y, Humphreys R, Andreeff M, O’Brien S, Younes M, Carbone A, Albert V, Younes A (2005) Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death. Brit. J. Haematol. 130: 501-510.
    • (2005) Brit. J. Haematol. , vol.130 , pp. 501-510
    • Georgakis, G.V.1    Li, Y.2    Humphreys, R.3    Andreeff, M.4    O’Brien, S.5    Younes, M.6    Carbone, A.7    Albert, V.8    Younes, A.9
  • 49
  • 51
    • 0034653980 scopus 로고    scopus 로고
    • CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 in vitro
    • Lopalco L, Barassi C, Pastori C, Longhi R, Burastero S E, Tambussi G, Mazzotta F, Lazzarin A, Clerici M, Siccardi A G (2000) CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 in vitro. J. Immunol. 164: 3426-3433.
    • (2000) J. Immunol. , vol.164 , pp. 3426-3433
    • Lopalco, L.1    Barassi, C.2    Pastori, C.3    Longhi, R.4    Burastero, S.E.5    Tambussi, G.6    Mazzotta, F.7    Lazzarin, A.8    Clerici, M.9    Siccardi, A.G.10
  • 52
  • 53
    • 41949120129 scopus 로고    scopus 로고
    • Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens
    • Pastori C, Clivio A, Diomede L, Consonni R, De Mori G M S, Longhi R, Colombo G, Lopalco L (2008) Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens. J. Virol. 82: 4125-4134.
    • (2008) J. Virol. , vol.82 , pp. 4125-4134
    • Pastori, C.1    Clivio, A.2    Diomede, L.3    Consonni, R.4    De Mori, G.M.S.5    Longhi, R.6    Colombo, G.7    Lopalco, L.8
  • 54
    • 79251504918 scopus 로고    scopus 로고
    • Natural anti-CCR5 antibodies in HIV-infection and -exposure
    • Lopalco L (2011) Natural anti-CCR5 antibodies in HIV-infection and -exposure. J. Transl.Med. 9(Suppl 1): S4.
    • (2011) J. Transl.Med. , vol.9 , pp. S4
    • Lopalco, L.1
  • 55
    • 84926451876 scopus 로고    scopus 로고
    • Physiopathological roles of P2X receptors in the central nervous system
    • Burnstock G (2015) Physiopathological roles of P2X receptors in the central nervous system. Curr. Med. Chem. 22: 819-844.
    • (2015) Curr. Med. Chem. , vol.22 , pp. 819-844
    • Burnstock, G.1
  • 57
    • 84873605796 scopus 로고    scopus 로고
    • Highthroughput sequencing of the paired human immunoglobulin heavy and light chain repertoire
    • DeKosky B J, Ippolito G C, Deschner R P, et al. (2013) Highthroughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat. Biotechnol. 31: 166-169.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 166-169
    • DeKosky, B.J.1    Ippolito, G.C.2    Deschner, R.P.3
  • 58
    • 84930932414 scopus 로고    scopus 로고
    • Humanization of a phosphothreonine peptide-specific chicken antibody by combinatorial library optimization of the phosphoepitope-binding motif
    • Baek D-S, Yong-Sung Kim P D (2015) Humanization of a phosphothreonine peptide-specific chicken antibody by combinatorial library optimization of the phosphoepitope-binding motif. Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2015.05.086.
    • (2015) Biochem. Biophys. Res. Commun.
    • Baek, D.-S.1    Yong-Sung Kim, P.D.2
  • 60
    • 84950117303 scopus 로고    scopus 로고
    • Augmented binary substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies
    • Townsend S, Fennell B J, Apgar J R, et al. (2015) Augmented binary substitution: single-pass CDR germ-lining and stabilization of therapeutic antibodies. Proc. Natl. Acad. Sci. USA 112: 15354-15359.
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 15354-15359
    • Townsend, S.1    Fennell, B.J.2    Apgar, J.R.3
  • 61
    • 84926634120 scopus 로고    scopus 로고
    • A diverse repertoire of human immunoglobulin variable genes in a chicken B cell line is generated by both gene conversion and somatic hypermutation
    • Leighton P A, Schusser B, Yi H, Glanville J, Harriman W (2015) A diverse repertoire of human immunoglobulin variable genes in a chicken B cell line is generated by both gene conversion and somatic hypermutation. Front. Immunol. 6: 126.
    • (2015) Front. Immunol. , vol.6 , pp. 126
    • Leighton, P.A.1    Schusser, B.2    Yi, H.3    Glanville, J.4    Harriman, W.5
  • 62
    • 84890290471 scopus 로고    scopus 로고
    • Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells
    • Schusser B, Collarini E J, Yi H, et al. (2013) Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells. Proc. Natl. Acad. Sci. USA 110: 20170-20175.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 20170-20175
    • Schusser, B.1    Collarini, E.J.2    Yi, H.3


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