DNA immunization as a technology platform for monoclonal antibody induction

Emerging Microbes and Infections

Volumn 5, Issue , 2016, Pages

  Liu, Shuying ^a   Wang, Shixia ^b   Lu, Shan ^b  

^a SL Consulting   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

antigen delivery; DNA immunization; hybridoma; immunogenicity; monoclonal antibody

Indexed keywords

DNA VACCINE; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANTIBODY RESPONSE; DNA IMMUNIZATION; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; COMMUNICABLE DISEASES, EMERGING; HYBRIDOMA; IMMUNIZATION; IMMUNOLOGY; MOUSE; VACCINE IMMUNOGENICITY;

ANIMALS; ANTIBODIES, MONOCLONAL; COMMUNICABLE DISEASES, EMERGING; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYBRIDOMAS; IMMUNIZATION; IMMUNIZATION SCHEDULE; IMMUNOGENICITY, VACCINE; MICE; MICE, INBRED BALB C; RECOMBINANT PROTEINS; VACCINES, DNA;

EID: 84963642296     PISSN: None     EISSN: 22221751     Source Type: Journal    
DOI: 10.1038/emi.2016.27     Document Type: Review

References (67)

1. Lyon GM, Mehta AK, Varkey JB et al. Clinical care of two patients with Ebola virus disease in the United States. N Engl J Med 2014; 371: 2402-2409.)
2. Ulmer JB, Donnelly JJ, Parker SE et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259: 1745-1749.)
3. Fynan EF, Webster RG, Fuller DH et al. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci USA 1993; 90: 11478-11482.)
4. Wang B, Ugen KE, Srikantan V et al. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1993; 90: 4156-4160.)
5. Wolff JA, Malone RW, Williams P et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 247: 1465-1468.)
6. Jones S, Evans K, McElwaine-Johnn H et al. DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial. Vaccine 2009; 27: 2506-2512.)
7. Kalams SA, Parker SD, Elizaga M et al. Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery. J Infect Dis 2013; 208: 818-829.)
8. Lu S. Heterologous prime-boost vaccination. Curr Opin Immunol 2009; 21: 346-351.)
9. Wang S, Kennedy JS, West K et al. Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers. Vaccine 2008; 26: 3947-3957.)
10. Vaine M, Wang S, Liu Q et al. Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies. PLoS One 2010; 5: e13916.)
11. Ledgerwood JE, Wei CJ, Hu Z et al. DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials. Lancet Infect Dis 2011; 11: 916-924.)
12. Vaine M, Wang S, Hackett A et al. Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity. Vaccine 2010; 28: 2999-3007.)
13. Wang S, Parker C, Taaffe J et al. Heterologous HA DNA vaccine prime-inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses. Vaccine 2008; 26: 3626-3633.)
14. Suguitan Jr AL, Cheng X, Wang W et al. Influenza H5 hemagglutinin DNA primes the antibody response elicited by the live attenuated influenza A/Vietnam/1203/2004 vaccine in ferrets. PLoS One 2011; 6: e21942.)
15. Pal R, Wang S, Kalyanaraman VS et al. Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate. J Med Primatol 2005; 34: 226-236.)
16. Wang S, Arthos J, Lawrence JM et al. Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1. J Virol 2005; 79: 7933-7937.)
17. Boyer JD, Chattergoon MA, Ugen KE et al. Enhancement of cellular immune response in HIV-1 seropositive individuals: A DNA-based trial. Clin Immunol 1999; 90: 100-107.)
18. Boyer JD, Chattergoon M, Shah A et al. HIV-1 DNA based vaccine induces a CD8 mediated cross-clade CTL response. Dev Biol Stand 1998; 95: 147-153.)
19. Costagliola S, Rodien P, Many MC et al. Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. J Immunol 1998; 160: 1458-1465.)
20. Costagliola S, Franssen JD, Bonomi M et al. Generation of a mouse monoclonal TSH receptor antibody with stimulating activity. Biochem Biophys Res Commun 2002; 299: 891-896.)
21. Nagata S, Salvatore G, Pastan I. DNA immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins. J Immunol Methods 2003; 280: 59-72.)
22. Carson SD, Switzer BL, Tracy SM et al. Monoclonal antibody against mouse CAR following genetic immunization. Hybrid Hybridomics 2004; 23: 19-22.)
23. Costagliola S, Bonomi M, Morgenthaler NG et al. Delineation of the discontinuousconformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity. Mol Endocrinol 2004; 18: 3020-3034.)
24. Adriouch S, Dubberke G, Diessenbacher P et al. Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization. Cell Immunol 2005; 236: 72-77.)
25. Bates MK, Zhang G, Sebestyen MG et al. Genetic immunization for antibody generation in research animals by intravenous delivery of plasmid DNA. Biotechniques 2006; 40: 199-208.)
26. Fofana I, Krieger SE, Grunert F et al. Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes. Gastroenterology 2010; 139: 953-964, 64 e1-4.)
27. Takatsuka S, Sekiguchi A, Tokunaga M et al. Generation of a panel of monoclonal antibodies against atypical chemokine receptor CCX-CKR by DNA immunization. J Pharmacol Toxicol Methods 2011; 63: 250-257.)
28. Daftarian P, Chowdhury R, Ames P et al. In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. Hybridoma (Larchmt) 2011; 30: 409-418.)
29. Fofana I, Xiao F, Thumann C et al. A novel monoclonal anti-CD81 antibody produced by genetic immunization efficiently inhibits Hepatitis C virus cell-cell transmission. PLoS One 2013; 8: e64221.)
30. Hazen M, Bhakta S, Vij R et al. An improved and robust DNA immunization method to develop antibodies against extracellular loops of multi-transmembrane proteins. MAbs 2014; 6: 95-107.)
31. Garcia JF, Maestre L, Lucas E et al. Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections. J Histochem Cytochem 2006; 54: 31-38.)
32. Maestre L, Fontan L, Martinez-Climent JA et al. Generation of a new monoclonal antibody against MALT1 by genetic immunization. Hybridoma (Larchmt) 2007; 26: 86-91.)
33. Kilpatrick KE, Cutler T, Whitehorn E et al. Gene gun delivered DNA-based immunizations mediate rapid production of murine monoclonal antibodies to the Flt-3 receptor. Hybridoma 1998; 17: 569-576.)
34. Wongsena W, Sconocchia G, Cho HS et al. Production and characterization of monoclonal antibodies against major histocompatibility complex class I chainrelated gene A. Tissue Antigens 2008; 72: 431-440.)
35. Brady JL, Mannering SI, Kireta S et al. Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates. Immunol Cell Biol 2009; 87: 413-418.)
36. Xue T, Xue XP, Huang QS et al. Monoclonal antibodies against human aspartyl (asparaginyl) beta-hydroxylase developed by DNA immunization. Hybridoma (Larchmt) 2009; 28: 251-257.)
37. Chen Y, Vaine M, Wallace A et al. A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design. J Virol 2013; 87: 10232-10243.)
38. Ulivieri C, Burroni D, Telford JL et al. 1996. Generation of a monoclonal antibody to a defined portion of the Helicobacter pylori vacuolating cytotoxin by DNA immunization. J Biotechnol 1996; 51: 191-194.)
39. Zhang C, Jin K, Xiao Y et al. Potent monoclonal antibodies against Clostridium difficile toxin A elicited by DNA immunization. Hum Vaccin Immunother 2013; 9: 2157-2164.)
40. Yu XF, Liang LH, She M et al. Production of a monoclonal antibody against SARS-CoV spike protein with single intrasplenic immunization of plasmid DNA. Immunol Lett 2005; 100: 177-181.)
41. Puttikhunt C, Kasinrerk W, Srisa-ad S et al. Production of anti-dengue NS1 monoclonal antibodies by DNA immunization. J Virol Methods 2003; 109: 55-61.)
42. Pupa SM, Forti S, Invernizzi AM et al. Monoclonal antibody to fibulin-1 generated by genetic immunization. J Cell Biochem 2003; 89: 647-652.)
43. Koch-Nolte F, Glowacki G, Bannas P et al. Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation. Cell Immunol 2005; 236: 66-71.)
44. Chen Y, Zhang T, Li T et al. Preparation and characterization of a monoclonal antibody against CKLF1 using DNA immunization with in vivo electroporation. Hybridoma (Larchmt) 2005; 24: 305-308.)
45. Leinonen J, Niemela P, Lovgren J et al. Characterization of monoclonal antibodies against prostate specific antigen produced by genetic immunization. J Immunol Methods 2004; 289: 157-167.)
46. Cantelli CP, da Gloria Martins Teixeira M, Santos EA et al. Generation of monoclonal antibodies against human recombinant interferon beta using genetic immunization with simultaneous expression of IgM and IgG isotypes. Hybridoma (Larchmt) 2009; 28: 211-214.)
47. Bian C, Zhang F, Wang F et al. Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization. Acta Biochim Biophys Sin (Shanghai) 2010; 42: 847-853.)
48. Schmolke S, Tacke M, Schmitt U et al. Identification of hepatitis G virus particles in human serum by E2-specific monoclonal antibodies generated by DNA immunization. J Virol 1998; 72: 4541-4545.)
49. Horimoto T, Fukuda N, Iwatsuki-Horimoto K et al. Antigenic differences between H5N1 human influenza viruses isolated in 1997 and 2003. J Vet Med Sci 2004; 66: 303-305.)
50. Ni Y, Ma K, Ni J et al. A rapid and simple approach to preparation of monoclonal antibody based on DNA immunization. Cell Mol Immunol 2004; 1: 295-299.)
51. Martin-Folgar R, Lorenzo G, Boshra H et al. Development and characterization of monoclonal antibodies against Rift Valley fever virus nucleocapsid protein generated by DNA immunization. MAbs 2010; 2: 275-284.)
52. Wei J, Yan B, Chen Z et al. Production and characterization of monoclonal antibodies against the hemagglutinin of H5N1 and antigenic investigation of avian influenza H5N1 viruses isolated from China. Can J Microbiol 2011; 57: 42-48.)
53. Tan GS, Krammer F, Eggink D et al. A pan-H1 anti-hemagglutinin monoclonal antibody with potent broad-spectrum efficacy in vivo. J Virol 2012; 86: 6179-6188.)
54. Velikovsky CA, Cassataro J, Sanchez M et al. Single-shot plasmid DNA intrasplenic immunization for the production of monoclonal antibodies. Persistent expression of DNA. J Immunol Methods 2000; 244: 1-7.)
55. Al-Qaoud KM, Al-Omari MM, Al-Aghbar M et al. Production of monoclonal antibodies against the 8 kDa subunit of Echinococcus granulosus Antigen B (EgAgB8/2) using DNA immunization. Hybridoma (Larchmt) 2008; 27: 431-438.)
56. Oynebraten I, Lovas TO, Thompson K et al. Generation of antibody-producing hybridomas following one single immunization with a targeted DNA vaccine. Scand J Immunol 2012; 75: 379-388.)
57. Kilpatrick KE, Danger DP, Hull-Ryde EA et al. High-affinity monoclonal antibodies to PED/PEA-15 generated using 5 microg of DNA. Hybridoma 2000; 19: 297-302.)
58. Kilpatrick KE, Kerner S, Dixon EP et al. In vivo expression of a GST-fusion protein mediates the rapid generation of affinity matured monoclonal antibodies using DNA-based immunizations. Hybrid Hybridomics 2002; 21: 237-243.)
59. Wang S, Farfan-Arribas DJ, Shen S et al. Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine. Vaccine 2006; 24: 4531-4540.)
60. Groisman A, Simonnet C, Rinberg D Pneumatic capillary gun for ballistic delivery of microscopic particles into tissue. US Patent 7892836 B2, February 22, 2011.)
61. Robinson HL, Torres CA. DNA vaccines. Semin Immunol 1997; 9: 271-283.)
62. Wang S, Joshi S, Lu S. Delivery of DNA to skin by particle bombardment. Methods Mol Biol 2004; 245: 185-196.)
63. Alexandrenne C, Wijkhuisen A, Dkhissi F et al. Generating antibodies against the native form of the human prion protein (hPrP) in wild-type animals: a comparison between DNA and protein immunizations. J Immunol Methods 2009; 341: 41-49.)
64. Wang S, Zhang C, Zhang L et al. The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods. Vaccine 2008; 26: 2100-2010.)
65. Fujimoto A, Kosaka N, Hasegawa H et al. Enhancement of antibody responses to native G protein-coupled receptors using E. coli GroEL as a molecular adjuvant in DNA immunization. J Immunol Methods 2012; 375: 243-251.)
66. Li W, Wang S, Lu S. Pilot Study on the Use of DNA Priming Immunization to Enhance Y. pestis LcrV-Specific B Cell Responses Elicited by a Recombinant LcrV Protein Vaccine. Vaccines (Basel) 2013; 2: 36-48.)
67. Pan R, Chen Y, Vaine M et al. Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding. Emerg Microbes Infect 2015; 4: e44.