Allosteric model of maraviroc binding to CC Chemokine Receptor 5 (CCR5)

Journal of Biological Chemistry

Volumn 286, Issue 38, 2011, Pages 33409-33421

  Garcia Perez, Javier ^a,b   Rueda, Patricia ^a   Alcami, Jose ^b   Rognan, Didier ^c   Arenzana Seisdedos, Fernando ^a   Lagane, Bernard ^a   Kellenberger, Esther ^c  

^a INSTITUT PASTEUR   (France)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MECHANISMS; ALLOSTERIC MODEL; AUTOMATED DOCKING; CHEMOKINE RECEPTORS; CHEMOKINES; DIMER INTERFACE; DIMERIC STRUCTURE; ENVELOPE GLYCOPROTEINS; EXTRACELLULAR LOOP 2; G PROTEIN COUPLED RECEPTORS; HOMOLOGY MODELING; HUMAN IMMUNODEFICIENCY VIRUS TYPE-1; INCOMPLETE KNOWLEDGE; LIGAND-BINDING SITES; MOLECULAR UNDERSTANDING; PROTEIN DATA BANK; SITE DIRECTED MUTAGENESIS; SMALL MOLECULES; THERAPEUTIC ARSENAL; TRANSMEMBRANES; VIRTUAL SCREENING;

DIMERS; DISEASES; ENZYME ACTIVITY; LIGANDS; PATIENT TREATMENT; VIRUSES;

BINDING SITES;

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CVX15 PEPTIDE; CYCLOPEPTIDE; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN GP 120; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MARAVIROC; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; DISSOCIATION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND BINDING; MOLECULAR DOCKING; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANES; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, CCR5; SMALL MOLECULE LIBRARIES; TRIAZOLES; USER-COMPUTER INTERFACE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80053025493     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.279596     Document Type: Article

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