메뉴 건너뛰기




Volumn 16, Issue 9, 2017, Pages 635-661

Therapeutic targeting of the angiopoietin-TIE pathway

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN RECEPTOR; TIE 1 RECEPTOR; TIE RECEPTOR; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; VASCULOTROPIN A;

EID: 85028701474     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2016.278     Document Type: Review
Times cited : (411)

References (313)
  • 1
    • 84881232071 scopus 로고    scopus 로고
    • Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
    • Welti, J., Loges, S., Dimmeler, S. & Carmeliet, P. Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J. Clin. Invest. 123, 3190-3200 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 3190-3200
    • Welti, J.1    Loges, S.2    Dimmeler, S.3    Carmeliet, P.4
  • 2
    • 84960482943 scopus 로고    scopus 로고
    • Molecular pathogenesis of retinal and choroidal vascular diseases
    • Campochiaro, P. A. Molecular pathogenesis of retinal and choroidal vascular diseases. Prog. Retin. Eye Res. 49, 67-81 (2015).
    • (2015) Prog. Retin. Eye Res. , vol.49 , pp. 67-81
    • Campochiaro, P.A.1
  • 3
    • 84954569855 scopus 로고    scopus 로고
    • Ten years of anti-vascular endothelial growth factor therapy
    • Ferrara, N. & Adamis, A. P. Ten years of anti-vascular endothelial growth factor therapy. Nat. Rev. Drug Discov. 15, 385-403 (2016).
    • (2016) Nat. Rev. Drug Discov. , vol.15 , pp. 385-403
    • Ferrara, N.1    Adamis, A.P.2
  • 4
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon α in patients with metastatic renal cell carcinoma
    • Motzer, R. J. et al. Overall survival and updated results for sunitinib compared with interferon α in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27, 3584-3590 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3584-3590
    • Motzer, R.J.1
  • 5
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin, H. G., Koh, G. Y., Thurston, G. & Alitalo, K. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat. Rev. Mol. Cell Biol. 10, 165-177 (2009).
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 6
    • 84875807200 scopus 로고    scopus 로고
    • The complex role of angiopoietin-2 in the angiopoietin-Tie signaling pathway
    • Thurston, G. & Daly, C. The complex role of angiopoietin-2 in the angiopoietin-Tie signaling pathway. Cold Spring Harb. Perspect. Med. 2, a006550 (2012).
    • (2012) Cold Spring Harb. Perspect. Med. , vol.2 , pp. a006550
    • Thurston, G.1    Daly, C.2
  • 7
    • 84877109717 scopus 로고    scopus 로고
    • Angiopoietin signaling in the vasculature
    • Eklund, L. & Saharinen, P. Angiopoietin signaling in the vasculature. Exp. Cell Res. 319, 1271-1280 (2013).
    • (2013) Exp. Cell Res. , vol.319 , pp. 1271-1280
    • Eklund, L.1    Saharinen, P.2
  • 8
    • 79960227968 scopus 로고    scopus 로고
    • And angiopoietin signaling in tumor angiogenesis and metastasis
    • Saharinen, P., Eklund, L., Pulkki, K., Bono, P. & Alitalo, K. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol. Med. 17, 347-362 (2011).
    • (2011) Trends Mol. Med. , vol.17 , pp. 347-362
    • Saharinen, P.1    Eklund, L.2    Pulkki, K.3    Bono, P.4    Vegf, A.K.5
  • 9
    • 0026545092 scopus 로고
    • A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains
    • Partanen, J. et al. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol. Cell. Biol. 12, 1698-1707 (1992).
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1698-1707
    • Partanen, J.1
  • 10
    • 0026695259 scopus 로고
    • A novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
    • Dumont, D. J., Yamaguchi, T. P., Conlon, R. A., Rossant, J. & Breitman, M. L. Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene 7, 1471-1480 (1992).
    • (1992) Oncogene , vol.7 , pp. 1471-1480
    • Dumont, D.J.1    Yamaguchi, T.P.2    Conlon, R.A.3    Rossant, J.4    Tek, L.B.M.5
  • 11
    • 13344295087 scopus 로고    scopus 로고
    • The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells
    • Batard, P. et al. The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells. Blood 87, 2212-2220 (1996).
    • (1996) Blood , vol.87 , pp. 2212-2220
    • Batard, P.1
  • 12
    • 13344259324 scopus 로고    scopus 로고
    • Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells
    • Hashiyama, M. et al. Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells. Blood 87, 93-101 (1996).
    • (1996) Blood , vol.87 , pp. 93-101
    • Hashiyama, M.1
  • 13
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • De Palma, M. et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8, 211-226 (2005).
    • (2005) Cancer Cell , vol.8 , pp. 211-226
    • De Palma, M.1
  • 14
    • 69249249201 scopus 로고    scopus 로고
    • Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal
    • Abou-Khalil, R. et al. Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal. Cell Stem Cell 5, 298-309 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 298-309
    • Abou-Khalil, R.1
  • 15
    • 84991108288 scopus 로고    scopus 로고
    • Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance
    • Ito, K. et al. Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 354, 1156-1160 (2016).
    • (2016) Science , vol.354 , pp. 1156-1160
    • Ito, K.1
  • 16
    • 18544365981 scopus 로고    scopus 로고
    • Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2
    • Saharinen, P. et al. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J. Cell Biol. 169, 239-243 (2005).
    • (2005) J. Cell Biol. , vol.169 , pp. 239-243
    • Saharinen, P.1
  • 17
    • 43049116169 scopus 로고    scopus 로고
    • Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
    • Fukuhara, S. et al. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat. Cell Biol. 10, 513-526 (2008).
    • (2008) Nat. Cell Biol. , vol.10 , pp. 513-526
    • Fukuhara, S.1
  • 18
    • 43049116513 scopus 로고    scopus 로고
    • Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts
    • Saharinen, P. et al. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat. Cell Biol. 10, 527-537 (2008).
    • (2008) Nat. Cell Biol. , vol.10 , pp. 527-537
    • Saharinen, P.1
  • 19
    • 84987818362 scopus 로고    scopus 로고
    • Tie1 controls angiopoietin function in vascular remodeling and inflammation
    • Korhonen, E. A. et al. Tie1 controls angiopoietin function in vascular remodeling and inflammation. J. Clin. Invest. 126, 3495-3510 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 3495-3510
    • Korhonen, E.A.1
  • 20
    • 84942828055 scopus 로고    scopus 로고
    • The orphan receptor Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells
    • Savant, S. et al. The orphan receptor Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells. Cell Rep. 12, 1761-1773 (2015).
    • (2015) Cell Rep. , vol.12 , pp. 1761-1773
    • Savant, S.1
  • 21
    • 84893859971 scopus 로고    scopus 로고
    • Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy
    • D'Amico, G. et al. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J. Clin. Invest. 124, 824-834 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 824-834
    • D'Amico, G.1
  • 22
    • 84871719489 scopus 로고    scopus 로고
    • Orchestral actions of angiopoietin-1 in vascular regeneration
    • Koh, G. Y. Orchestral actions of angiopoietin-1 in vascular regeneration. Trends Mol. Med. 19, 31-39 (2013).
    • (2013) Trends Mol. Med. , vol.19 , pp. 31-39
    • Koh, G.Y.1
  • 23
    • 0006677050 scopus 로고    scopus 로고
    • Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway
    • Kim, I. et al. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway. Circ. Res. 86, 24-29 (2000).
    • (2000) Circ. Res. , vol.86 , pp. 24-29
    • Kim, I.1
  • 24
    • 0036181270 scopus 로고    scopus 로고
    • The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis
    • Kontos, C. D., Cha, E. H., York, J. D. & Peters, K. G. The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol. Cell. Biol. 22, 1704-1713 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1704-1713
    • Kontos, C.D.1    Cha, E.H.2    York, J.D.3    Peters, K.G.4
  • 25
    • 2442608732 scopus 로고    scopus 로고
    • Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
    • Daly, C. et al. Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Genes Dev. 18, 1060-1071 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 1060-1071
    • Daly, C.1
  • 26
    • 84955112522 scopus 로고    scopus 로고
    • FOXO1 couples metabolic activity and growth state in the vascular endothelium
    • Wilhelm, K. et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature 529, 216-220 (2016).
    • (2016) Nature , vol.529 , pp. 216-220
    • Wilhelm, K.1
  • 27
    • 0033601357 scopus 로고    scopus 로고
    • Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    • Thurston, G. et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286, 2511-2514 (1999).
    • (1999) Science , vol.286 , pp. 2511-2514
    • Thurston, G.1
  • 28
    • 58149152854 scopus 로고    scopus 로고
    • Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
    • Limaye, N. et al. Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations. Nat. Genet. 41, 118-124 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 118-124
    • Limaye, N.1
  • 29
    • 84951850124 scopus 로고    scopus 로고
    • Somatic activating PIK3CA mutations cause venous malformation
    • Limaye, N. et al. Somatic activating PIK3CA mutations cause venous malformation. Am. J. Hum. Genet. 97, 914-921 (2015).
    • (2015) Am. J. Hum. Genet. , vol.97 , pp. 914-921
    • Limaye, N.1
  • 30
    • 84962634604 scopus 로고    scopus 로고
    • Somatic PIK3CA mutations as a driver of sporadic venous malformations
    • Castel, P. et al. Somatic PIK3CA mutations as a driver of sporadic venous malformations. Sci. Transl Med. 8, 332-342 (2016).
    • (2016) Sci. Transl Med. , vol.8 , pp. 332-342
    • Castel, P.1
  • 31
    • 84962778934 scopus 로고    scopus 로고
    • Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans
    • Castillo, S. D. et al. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci. Transl Med. 8, 332-343 (2016).
    • (2016) Sci. Transl Med. , vol.8 , pp. 332-343
    • Castillo, S.D.1
  • 32
    • 84907010946 scopus 로고    scopus 로고
    • The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel
    • Aspelund, A. et al. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J. Clin. Invest. 124, 3975-3986 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 3975-3986
    • Aspelund, A.1
  • 33
    • 84907487891 scopus 로고    scopus 로고
    • A lymphatic defect causes ocular hypertension and glaucoma in mice
    • Thomson, B. R. et al. A lymphatic defect causes ocular hypertension and glaucoma in mice. J. Clin. Invest. 124, 4320-4324 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 4320-4324
    • Thomson, B.R.1
  • 34
    • 84978431523 scopus 로고    scopus 로고
    • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity
    • Souma, T. et al. Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J. Clin. Invest. 126, 2575-2587 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 2575-2587
    • Souma, T.1
  • 35
    • 0034730784 scopus 로고    scopus 로고
    • Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions
    • Gamble, J. R. et al. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circ. Res. 87, 603-607 (2000).
    • (2000) Circ. Res. , vol.87 , pp. 603-607
    • Gamble, J.R.1
  • 36
    • 80054953975 scopus 로고    scopus 로고
    • Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense. Arterioscler
    • David, S., Ghosh, C. C., Mukherjee, A. & Parikh, S. M. Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense. Arterioscler. Thromb. Vasc. Biol. 31, 2643-2652 (2011).
    • (2011) Thromb. Vasc. Biol. , vol.31 , pp. 2643-2652
    • David, S.1    Ghosh, C.C.2    Mukherjee, A.3    Parikh, S.M.4
  • 37
    • 37848998838 scopus 로고    scopus 로고
    • Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    • Gavard, J., Patel, V. & Gutkind, J. S. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev. Cell 14, 25-36 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 25-36
    • Gavard, J.1    Patel, V.2    Gutkind, J.S.3
  • 38
    • 84961218854 scopus 로고    scopus 로고
    • Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie 2 in the absence of VE cadherin
    • Frye, M. et al. Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie 2 in the absence of VE cadherin. J. Exp. Med. (2015).
    • (2015) J. Exp. Med.
    • Frye, M.1
  • 39
    • 2542453735 scopus 로고    scopus 로고
    • The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    • Fiedler, U. et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103, 4150-4156 (2004).
    • (2004) Blood , vol.103 , pp. 4150-4156
    • Fiedler, U.1
  • 40
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • Maisonpierre, P. C. et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277, 55-60 (1997).
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1
  • 41
    • 0032547764 scopus 로고    scopus 로고
    • Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
    • Mandriota, S. J. & Pepper, M. S. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Circ. Res. 83, 852-859 (1998).
    • (1998) Circ. Res. , vol.83 , pp. 852-859
    • Mandriota, S.J.1    Pepper, M.S.2
  • 42
    • 0032985888 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
    • Oh, H. et al. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J. Biol. Chem. 274, 15732-15739 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 15732-15739
    • Oh, H.1
  • 43
    • 54049146968 scopus 로고    scopus 로고
    • The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
    • Simon, M. P., Tournaire, R. & Pouyssegur, J. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J. Cell. Physiol. 217, 809-818 (2008).
    • (2008) J. Cell. Physiol. , vol.217 , pp. 809-818
    • Simon, M.P.1    Tournaire, R.2    Pouyssegur, J.3
  • 44
    • 84929207538 scopus 로고    scopus 로고
    • Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2
    • Choi, H. J. et al. Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Nat. Commun. 6, 6943 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 6943
    • Choi, H.J.1
  • 45
    • 84937575236 scopus 로고    scopus 로고
    • Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis
    • Ghosh, C. C. et al. Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis. Crit. Care Med. 43, e230-e240 (2015).
    • (2015) Crit. Care Med. , vol.43 , pp. e230-e240
    • Ghosh, C.C.1
  • 46
    • 32244436305 scopus 로고    scopus 로고
    • Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation
    • Fiedler, U. et al. Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation. Nat. Med. 12, 235-239 (2006).
    • (2006) Nat. Med. , vol.12 , pp. 235-239
    • Fiedler, U.1
  • 47
    • 33645355399 scopus 로고    scopus 로고
    • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans
    • Parikh, S. M. et al. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PloS Med. 3, e46 (2006).
    • (2006) PloS Med. , vol.3 , pp. e46
    • Parikh, S.M.1
  • 48
    • 84952027392 scopus 로고    scopus 로고
    • Endothelial destabilization by angiopoietin-2 via integrin β1 activation
    • Hakanpaa, L. et al. Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nat. Commun. 6, 5962 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 5962
    • Hakanpaa, L.1
  • 49
    • 84987806983 scopus 로고    scopus 로고
    • Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
    • Kim, M. et al. Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J. Clin. Invest. 126, 3511-3525 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 3511-3525
    • Kim, M.1
  • 50
    • 84871989305 scopus 로고    scopus 로고
    • Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition
    • Daly, C. et al. Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res. 73, 108-118 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 108-118
    • Daly, C.1
  • 51
    • 18644382318 scopus 로고    scopus 로고
    • Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1
    • Gale, N. W. et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1. Dev. Cell 3, 411-423 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 411-423
    • Gale, N.W.1
  • 52
    • 24944468632 scopus 로고    scopus 로고
    • Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1
    • Cascone, I., Napione, L., Maniero, F., Serini, G. & Bussolino, F. Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1. J. Cell Biol. 170, 993-1004 (2005).
    • (2005) J. Cell Biol. , vol.170 , pp. 993-1004
    • Cascone, I.1    Napione, L.2    Maniero, F.3    Serini, G.4    Bussolino, F.5
  • 53
    • 84991271321 scopus 로고    scopus 로고
    • Constitutive association of Tie1 and Tie2 with endothelial integrins is functionally modulated by angiopoietin-1 and fibronectin
    • Dalton, A. C., Shlamkovitch, T., Papo, N. & Barton, W. A. Constitutive association of Tie1 and Tie2 with endothelial integrins is functionally modulated by angiopoietin-1 and fibronectin. PloS ONE 11, e0163732 (2016).
    • (2016) PloS ONE , vol.11 , pp. e0163732
    • Dalton, A.C.1    Shlamkovitch, T.2    Papo, N.3    Barton, W.A.4
  • 54
    • 84884686050 scopus 로고    scopus 로고
    • Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy
    • Lee, J. et al. Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy. Sci. Transl Med. 5, 203-127 (2013).
    • (2013) Sci. Transl Med. , vol.5 , pp. 127-203
    • Lee, J.1
  • 55
    • 84909619196 scopus 로고    scopus 로고
    • Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with α5β1 integrin
    • Lee, H. S. et al. Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with α5β1 integrin. J. Biol. Chem. 289, 31330-31340 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 31330-31340
    • Lee, H.S.1
  • 56
    • 84906675773 scopus 로고    scopus 로고
    • Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy
    • Park, S. W. et al. Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy. Diabetes 63, 3057-3068 (2014).
    • (2014) Diabetes , vol.63 , pp. 3057-3068
    • Park, S.W.1
  • 57
    • 84861820220 scopus 로고    scopus 로고
    • Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
    • Felcht, M. et al. Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J. Clin. Invest. 122, 1991-2005 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 1991-2005
    • Felcht, M.1
  • 58
    • 0037428670 scopus 로고    scopus 로고
    • Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival
    • Sfiligoi, C. et al. Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. Int. J. Cancer 103, 466-474 (2003).
    • (2003) Int. J. Cancer , vol.103 , pp. 466-474
    • Sfiligoi, C.1
  • 59
    • 63149188174 scopus 로고    scopus 로고
    • Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma
    • Helfrich, I. et al. Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin. Cancer Res. 15, 1384-1392 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1384-1392
    • Helfrich, I.1
  • 60
    • 78049268477 scopus 로고    scopus 로고
    • Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy
    • Goede, V. et al. Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy. Br. J. Cancer 103, 1407-1414 (2010).
    • (2010) Br. J. Cancer , vol.103 , pp. 1407-1414
    • Goede, V.1
  • 61
    • 84902511625 scopus 로고    scopus 로고
    • The role of angiopoietins as potential therapeutic targets in renal cell carcinoma
    • Wang, X. et al. The role of angiopoietins as potential therapeutic targets in renal cell carcinoma. Transl Oncol. 7, 188-195 (2014).
    • (2014) Transl Oncol. , vol.7 , pp. 188-195
    • Wang, X.1
  • 62
    • 84956829295 scopus 로고    scopus 로고
    • Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma
    • Scholz, A. et al. Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma. EMBO Mol. Med. 8, 35-57 (2015).
    • (2015) EMBO Mol. Med. , vol.8 , pp. 35-57
    • Scholz, A.1
  • 63
    • 84964762506 scopus 로고    scopus 로고
    • Association of angiopoietin-2 and Ki-67 expression with vascular density and sunitinib response in metastatic renal cell carcinoma
    • Rautiola, J. et al. Association of angiopoietin-2 and Ki-67 expression with vascular density and sunitinib response in metastatic renal cell carcinoma. PLoS ONE 11, e0153745 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0153745
    • Rautiola, J.1
  • 64
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash, J. et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284, 1994-1998 (1999).
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1
  • 65
    • 7944220649 scopus 로고    scopus 로고
    • Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
    • Oliner, J. et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 6, 507-516 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 507-516
    • Oliner, J.1
  • 66
    • 84859089030 scopus 로고    scopus 로고
    • Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis
    • Holopainen, T. et al. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J. Natl Cancer Inst. 104, 461-475 (2012).
    • (2012) J. Natl Cancer Inst. , vol.104 , pp. 461-475
    • Holopainen, T.1
  • 67
    • 77950254591 scopus 로고    scopus 로고
    • Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth
    • Hashizume, H. et al. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res. 70, 2213-2223 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 2213-2223
    • Hashizume, H.1
  • 68
    • 84890667775 scopus 로고    scopus 로고
    • Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy
    • Kienast, Y. et al. Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy. Clin. Cancer Res. 19, 6730-6740 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 6730-6740
    • Kienast, Y.1
  • 69
    • 84919466750 scopus 로고    scopus 로고
    • Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth
    • Srivastava, K. et al. Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell 26, 880-895 (2014).
    • (2014) Cancer Cell , vol.26 , pp. 880-895
    • Srivastava, K.1
  • 70
    • 73649112748 scopus 로고    scopus 로고
    • Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels
    • Falcon, B. L. et al. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am. J. Pathol. 175, 2159-2170 (2009).
    • (2009) Am. J. Pathol. , vol.175 , pp. 2159-2170
    • Falcon, B.L.1
  • 71
    • 77958042477 scopus 로고    scopus 로고
    • Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: Implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody
    • Coxon, A. et al. Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol. Cancer Ther. 9, 2641-2651 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2641-2651
    • Coxon, A.1
  • 72
    • 23844547202 scopus 로고    scopus 로고
    • Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period
    • Thurston, G. et al. Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period. Development 132, 3317-3326 (2005).
    • (2005) Development , vol.132 , pp. 3317-3326
    • Thurston, G.1
  • 73
    • 33847036675 scopus 로고    scopus 로고
    • In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin
    • Kim, K. E. et al. In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin. Arterioscler. Thromb. Vasc. Biol. 27, 564-570 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 564-570
    • Kim, K.E.1
  • 74
    • 20444389049 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes lymphatic sprouting and hyperplasia
    • Tammela, T. et al. Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood 105, 4642-4648, (2005).
    • (2005) Blood , vol.105 , pp. 4642-4648
    • Tammela, T.1
  • 75
    • 20444414142 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation
    • Morisada, T. et al. Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood 105, 4649-4656 (2005).
    • (2005) Blood , vol.105 , pp. 4649-4656
    • Morisada, T.1
  • 76
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler, F. et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6, 553-563 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1
  • 77
    • 84929142111 scopus 로고    scopus 로고
    • Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2
    • Keskin, D. et al. Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Rep. 10, 1066-1081 (2015).
    • (2015) Cell Rep. , vol.10 , pp. 1066-1081
    • Keskin, D.1
  • 78
    • 84924616997 scopus 로고    scopus 로고
    • Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade
    • Rigamonti, N. et al. Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade. Cell Rep. 8, 696-706 (2014).
    • (2014) Cell Rep. , vol.8 , pp. 696-706
    • Rigamonti, N.1
  • 79
    • 84964402874 scopus 로고    scopus 로고
    • Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
    • Kloepper, J. et al. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc. Natl Acad. Sci. USA 113, 4476-4481 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 4476-4481
    • Kloepper, J.1
  • 80
    • 84964409623 scopus 로고    scopus 로고
    • Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
    • Peterson, T. E. et al. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proc. Natl Acad. Sci. USA 113, 4470-4475 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 4470-4475
    • Peterson, T.E.1
  • 81
    • 84907494958 scopus 로고    scopus 로고
    • Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature
    • Shen, J. et al. Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. J. Clin. Invest. 124, 4564-4576 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 4564-4576
    • Shen, J.1
  • 82
    • 84883174690 scopus 로고    scopus 로고
    • Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression
    • Goel, S. et al. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J. Natl Cancer Inst. 105, 1188-1201 (2013).
    • (2013) J. Natl Cancer Inst. , vol.105 , pp. 1188-1201
    • Goel, S.1
  • 83
    • 84898056728 scopus 로고    scopus 로고
    • Recurrent PTPRB and PLCG1 mutations in angiosarcoma
    • Behjati, S. et al. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nat. Genet. 46, 376-379 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 376-379
    • Behjati, S.1
  • 84
    • 84946893390 scopus 로고    scopus 로고
    • Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway
    • Murali, R. et al. Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway. Oncotarget 6, 36041-36052 (2015).
    • (2015) Oncotarget , vol.6 , pp. 36041-36052
    • Murali, R.1
  • 85
    • 63049090100 scopus 로고    scopus 로고
    • From dissemination to organ-specific colonization
    • Nguyen, D. X., Bos, P. D. & Massague, J. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 9, 274-284 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Metastasis, M.J.3
  • 86
    • 84930736841 scopus 로고    scopus 로고
    • Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer
    • Rohan, T. E. et al. Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. J. Natl Cancer Inst. 106, dju136 (2014).
    • (2014) J. Natl Cancer Inst. , vol.106 , pp. dju136
    • Rohan, T.E.1
  • 87
    • 84941784087 scopus 로고    scopus 로고
    • Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage-derived VEGFA
    • Harney, A. S. et al. Real-time imaging reveals local, transient vascular permeability, and tumor cell intravasation stimulated by TIE2hi macrophage-derived VEGFA. Cancer Discov. 5, 932-943 (2015).
    • (2015) Cancer Discov. , vol.5 , pp. 932-943
    • Harney, A.S.1
  • 88
    • 85002801826 scopus 로고    scopus 로고
    • Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy
    • Chen, L. et al. Tie2 expression on macrophages is required for blood vessel reconstruction and tumor relapse after chemotherapy. Cancer Res. 76, 6828-6838 (2016).
    • (2016) Cancer Res. , vol.76 , pp. 6828-6838
    • Chen, L.1
  • 89
    • 84883303630 scopus 로고    scopus 로고
    • The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases
    • Minami, T. et al. The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases. Cell Rep. 4, 709-723 (2013).
    • (2013) Cell Rep. , vol.4 , pp. 709-723
    • Minami, T.1
  • 90
    • 79953750307 scopus 로고    scopus 로고
    • Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
    • Mazzieri, R. et al. Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell 19, 512-526 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 512-526
    • Mazzieri, R.1
  • 91
    • 84869506980 scopus 로고    scopus 로고
    • G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency
    • Im, J. H. et al. G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency. Int. J. Cancer 132, 315-326 (2013).
    • (2013) Int. J. Cancer , vol.132 , pp. 315-326
    • Im, J.H.1
  • 92
    • 0034036689 scopus 로고    scopus 로고
    • Angiopoietin-1 protects the adult vasculature against plasma leakage
    • Thurston, G. et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat. Med. 6, 460-463 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 460-463
    • Thurston, G.1
  • 93
    • 33644800621 scopus 로고    scopus 로고
    • Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules
    • Baffert, F., Le, T., Thurston, G. & McDonald, D. M. Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules. Am. J. Physiol. Heart Circ. Physiol. 290, H107-H118 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290 , pp. H107-H118
    • Baffert Le, F.T.1    Thurston, G.2    McDonald, D.M.3
  • 94
    • 84881116481 scopus 로고    scopus 로고
    • Angiopoietin-2 is critical for cytokine-induced vascular leakage
    • Benest, A. V. et al. Angiopoietin-2 is critical for cytokine-induced vascular leakage. PLoS ONE 8, e70459 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e70459
    • Benest, A.V.1
  • 95
    • 33750349223 scopus 로고    scopus 로고
    • Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells
    • Daly, C. et al. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc. Natl Acad. Sci. USA 103, 15491-15496 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 15491-15496
    • Daly, C.1
  • 96
    • 79957880117 scopus 로고    scopus 로고
    • Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
    • Jeansson, M. et al. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J. Clin. Invest. 121, 2278-2289 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2278-2289
    • Jeansson, M.1
  • 97
    • 84877788239 scopus 로고    scopus 로고
    • VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation
    • Hayashi, M. et al. VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat. Commun. 4, 1672 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 1672
    • Hayashi, M.1
  • 98
    • 78650191646 scopus 로고    scopus 로고
    • Angiopoietin-2-driven vascular remodeling in airway inflammation
    • Tabruyn, S. P. et al. Angiopoietin-2-driven vascular remodeling in airway inflammation. Am. J. Pathol. 177, 3233-3243 (2010).
    • (2010) Am. J. Pathol. , vol.177 , pp. 3233-3243
    • Tabruyn, S.P.1
  • 99
    • 84868196659 scopus 로고    scopus 로고
    • Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis
    • David, S. et al. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis. Crit. Care Med. 40, 3034-3041 (2012).
    • (2012) Crit. Care Med. , vol.40 , pp. 3034-3041
    • David, S.1
  • 100
    • 84882661563 scopus 로고    scopus 로고
    • Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS
    • Parikh, S. M. Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence 4, 517-524 (2013).
    • (2013) Virulence , vol.4 , pp. 517-524
    • Parikh, S.M.1
  • 101
    • 64649084437 scopus 로고    scopus 로고
    • Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium
    • Yuan, H. T., Khankin, E. V., Karumanchi, S. A. & Parikh, S. M. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol. Cell. Biol. 29, 2011-2022 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 2011-2022
    • Yuan, H.T.1    Khankin, E.V.2    Karumanchi, S.A.3    Parikh, S.M.4
  • 102
    • 84855301889 scopus 로고    scopus 로고
    • The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling
    • Singh, H., Hansen, T. M., Patel, N. & Brindle, N. P. The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling. PLoS ONE 7, e29319 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e29319
    • Singh, H.1    Hansen, T.M.2    Patel, N.3    Brindle, N.P.4
  • 103
    • 79959546082 scopus 로고    scopus 로고
    • Acute administration of recombinant angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis
    • David, S. et al. Acute administration of recombinant angiopoietin-1 ameliorates multiple-organ dysfunction syndrome and improves survival in murine sepsis. Cytokine 55, 251-259 (2011).
    • (2011) Cytokine , vol.55 , pp. 251-259
    • David, S.1
  • 104
    • 84881246880 scopus 로고    scopus 로고
    • Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis
    • Ziegler, T. et al. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J. Clin. Invest. 123, 3436-3445 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 3436-3445
    • Ziegler, T.1
  • 105
    • 84914170847 scopus 로고    scopus 로고
    • Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis
    • Stiehl, T. et al. Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis. Crit. Care Med. 42, e654-e662 (2014).
    • (2014) Crit. Care Med. , vol.42 , pp. e654-e662
    • Stiehl, T.1
  • 106
    • 84964490181 scopus 로고    scopus 로고
    • Amelioration of sepsis by TIE2 activation-induced vascular protection
    • Han, S. et al. Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci. Transl Med. 8, 335-355 (2016).
    • (2016) Sci. Transl Med. , vol.8 , pp. 335-355
    • Han, S.1
  • 107
    • 45849146933 scopus 로고    scopus 로고
    • Regulation of angiopoietin expression by bacterial lipopolysaccharide
    • Mofarrahi, M. et al. Regulation of angiopoietin expression by bacterial lipopolysaccharide. Am. J. Physiol. Lung Cell. Mol. Physiol. 294, L955-L963 (2008).
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.294 , pp. L955-L963
    • Mofarrahi, M.1
  • 108
    • 84879115058 scopus 로고    scopus 로고
    • The flow dependency of Tie2 expression in endotoxemia
    • Kurniati, N. F. et al. The flow dependency of Tie2 expression in endotoxemia. Intensive Care Med. 39, 1262-1271 (2013).
    • (2013) Intensive Care Med. , vol.39 , pp. 1262-1271
    • Kurniati, N.F.1
  • 109
    • 84959264724 scopus 로고    scopus 로고
    • Gene control of tyrosine kinase TIE2 and vascular manifestations of infections
    • Ghosh, C. C. et al. Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Proc. Natl Acad. Sci. USA 113, 2472-2477 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. 2472-2477
    • Ghosh, C.C.1
  • 110
    • 84911371938 scopus 로고    scopus 로고
    • Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
    • Rasmussen, A. L. et al. Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science 346, 987-991 (2014).
    • (2014) Science , vol.346 , pp. 987-991
    • Rasmussen, A.L.1
  • 111
    • 84945318797 scopus 로고    scopus 로고
    • Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation
    • Le, C. T. et al. Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation. Am. J. Pathol. 185, 2949-2968 (2015).
    • (2015) Am. J. Pathol. , vol.185 , pp. 2949-2968
    • Le, C.T.1
  • 112
    • 84901626646 scopus 로고    scopus 로고
    • Role of angiopoietin-2 in corneal lymphangiogenesis
    • Yuen, D. et al. Role of angiopoietin-2 in corneal lymphangiogenesis. Invest. Ophthalmol. Vis. Sci. 55, 3320-3327 (2014).
    • (2014) Invest. Ophthalmol. Vis. Sci. , vol.55 , pp. 3320-3327
    • Yuen, D.1
  • 113
    • 0032538385 scopus 로고    scopus 로고
    • Increased vascularization in mice overexpressing angiopoietin-1
    • Suri, C. et al. Increased vascularization in mice overexpressing angiopoietin-1. Science 282, 468-471 (1998).
    • (1998) Science , vol.282 , pp. 468-471
    • Suri, C.1
  • 114
    • 22144447473 scopus 로고    scopus 로고
    • Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow
    • Cho, C. H. et al. Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow. Circ. Res. 97, 86-94 (2005).
    • (2005) Circ. Res. , vol.97 , pp. 86-94
    • Cho, C.H.1
  • 115
    • 84899411522 scopus 로고    scopus 로고
    • Angiopoietin-2 inhibition prevents transplant ischemia-reperfusion injury and chronic rejection in rat cardiac allografts
    • Syrjala, S. O. et al. Angiopoietin-2 inhibition prevents transplant ischemia-reperfusion injury and chronic rejection in rat cardiac allografts. Am. J. Transplant 14, 1096-1108 (2014).
    • (2014) Am. J. Transplant , vol.14 , pp. 1096-1108
    • Syrjala, S.O.1
  • 116
    • 84901227961 scopus 로고    scopus 로고
    • Circulating angiopoietin-2 levels predict mortality in kidney transplant recipients: A 4-year prospective case-cohort study
    • Molnar, M. Z. et al. Circulating angiopoietin-2 levels predict mortality in kidney transplant recipients: a 4-year prospective case-cohort study. Transpl. Int. 27, 541-552 (2014).
    • (2014) Transpl. Int. , vol.27 , pp. 541-552
    • Molnar, M.Z.1
  • 117
    • 0037432292 scopus 로고    scopus 로고
    • Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis
    • Nykanen, A. I. et al. Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis. Circulation 107, 1308-1314 (2003).
    • (2003) Circulation , vol.107 , pp. 1308-1314
    • Nykanen, A.I.1
  • 118
    • 84937521843 scopus 로고    scopus 로고
    • Donor heart treatment with COMP-Ang1 limits ischemia-reperfusion injury and rejection of cardiac allografts
    • Syrjala, S. O. et al. Donor heart treatment with COMP-Ang1 limits ischemia-reperfusion injury and rejection of cardiac allografts. Am. J. Transplant 15, 2075-2084 (2015).
    • (2015) Am. J. Transplant , vol.15 , pp. 2075-2084
    • Syrjala, S.O.1
  • 119
    • 84928254049 scopus 로고    scopus 로고
    • Recent insights into the cellular biology of atherosclerosis
    • Tabas, I., Garcia-Cardena, G. & Owens, G. K. Recent insights into the cellular biology of atherosclerosis. J. Cell Biol. 209, 13-22 (2015).
    • (2015) J. Cell Biol. , vol.209 , pp. 13-22
    • Tabas, I.1    Garcia-Cardena, G.2    Owens, G.K.3
  • 120
    • 1242342715 scopus 로고    scopus 로고
    • Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies
    • Porat, R. M. et al. Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies. Circ. Res. 94, 394-401 (2004).
    • (2004) Circ. Res. , vol.94 , pp. 394-401
    • Porat, R.M.1
  • 121
    • 35148838914 scopus 로고    scopus 로고
    • Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2 dependent mechanism. Arterioscler
    • Tressel, S. L., Huang, R. P., Tomsen, N. & Jo, H. Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2 dependent mechanism. Arterioscler. Thromb. Vasc. Biol. 27, 2150-2156 (2007).
    • (2007) Thromb. Vasc. Biol. , vol.27 , pp. 2150-2156
    • Tressel, S.L.1    Huang, R.P.2    Tomsen, N.3    Jo, H.4
  • 122
    • 0642303635 scopus 로고    scopus 로고
    • Transcriptional and post-translation regulation of the Tie1 receptor by fluid shear stress changes in vascular endothelial cells
    • Chen-Konak, L. et al. Transcriptional and post-translation regulation of the Tie1 receptor by fluid shear stress changes in vascular endothelial cells. FASEB J. 17, 2121-2123 (2003).
    • (2003) FASEB J. , vol.17 , pp. 2121-2123
    • Chen-Konak, L.1
  • 123
    • 79953304687 scopus 로고    scopus 로고
    • Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner
    • Woo, K. V. et al. Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner. J. Clin. Invest. 121, 1624-1635 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 1624-1635
    • Woo, K.V.1
  • 124
    • 84936064097 scopus 로고    scopus 로고
    • Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice
    • Theelen, T. L. et al. Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice. Atherosclerosis 241, 297-304 (2015).
    • (2015) Atherosclerosis , vol.241 , pp. 297-304
    • Theelen, T.L.1
  • 125
    • 84983544922 scopus 로고    scopus 로고
    • Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation
    • Zhou, H. J. et al. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat. Med. 22, 1033-1042 (2016).
    • (2016) Nat. Med. , vol.22 , pp. 1033-1042
    • Zhou, H.J.1
  • 127
    • 76749117069 scopus 로고    scopus 로고
    • High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1
    • Singh, H., Brindle, N. P. & Zammit, V. A. High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1. Microvasc. Res. 79, 121-127 (2010).
    • (2010) Microvasc. Res. , vol.79 , pp. 121-127
    • Singh, H.1    Brindle, N.P.2    Zammit, V.A.3
  • 128
    • 84891784154 scopus 로고    scopus 로고
    • Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease
    • Dessapt-Baradez, C. et al. Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease. J. Am. Soc. Nephrol. 25, 33-42 (2014).
    • (2014) J. Am. Soc. Nephrol. , vol.25 , pp. 33-42
    • Dessapt-Baradez, C.1
  • 129
    • 33846677486 scopus 로고    scopus 로고
    • Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes
    • Lee, S. et al. Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes. Nephrol. Dial Transplant 22, 396-408 (2007).
    • (2007) Nephrol. Dial Transplant , vol.22 , pp. 396-408
    • Lee, S.1
  • 130
    • 84920911189 scopus 로고    scopus 로고
    • Arterial stiffness in diabetes mellitus
    • Prenner, S. B. & Chirinos, J. A. Arterial stiffness in diabetes mellitus. Atherosclerosis 238, 370-379 (2015).
    • (2015) Atherosclerosis , vol.238 , pp. 370-379
    • Prenner, S.B.1    Chirinos, J.A.2
  • 131
    • 84871769122 scopus 로고    scopus 로고
    • Angiopoietin-2 levels predict mortality in CKD patients
    • David, S. et al. Angiopoietin-2 levels predict mortality in CKD patients. Nephrol. Dial Transplant 27, 1867-1872 (2012).
    • (2012) Nephrol. Dial Transplant , vol.27 , pp. 1867-1872
    • David, S.1
  • 132
    • 84906097639 scopus 로고    scopus 로고
    • Angiopoietin-2-induced arterial stiffness in CKD
    • Chang, F. C. et al. Angiopoietin-2-induced arterial stiffness in CKD. J. Am. Soc. Nephrol. 25, 1198-1209 (2014).
    • (2014) J. Am. Soc. Nephrol. , vol.25 , pp. 1198-1209
    • Chang, F.C.1
  • 133
    • 33645508703 scopus 로고    scopus 로고
    • COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model
    • Cho, C. H. et al. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Proc. Natl Acad. Sci. USA 103, 4946-4951 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 4946-4951
    • Cho, C.H.1
  • 134
    • 44449157228 scopus 로고    scopus 로고
    • Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression
    • Bitto, A. et al. Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression. Clin. Sci. (Lond.) 114, 707-718 (2008).
    • (2008) Clin. Sci. (Lond.) , vol.114 , pp. 707-718
    • Bitto, A.1
  • 135
    • 84857839482 scopus 로고    scopus 로고
    • COMP-angiopoietin-1 recovers molecular biomarkers of neuropathy and improves vascularisation in sciatic nerve of ob/ob mice
    • Kosacka, J. et al. COMP-angiopoietin-1 recovers molecular biomarkers of neuropathy and improves vascularisation in sciatic nerve of ob/ob mice. PLoS ONE 7, e32881 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e32881
    • Kosacka, J.1
  • 137
    • 0033882191 scopus 로고    scopus 로고
    • Angiopoietin 2 expression in the retina: Upregulation during physiologic and pathologic neovascularization
    • Hackett, S. F. et al. Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J. Cell. Physiol. 184, 275-284 (2000).
    • (2000) J. Cell. Physiol. , vol.184 , pp. 275-284
    • Hackett, S.F.1
  • 138
    • 2342526664 scopus 로고    scopus 로고
    • Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor
    • Oshima, Y. et al. Angiopoietin-2 enhances retinal vessel sensitivity to vascular endothelial growth factor. J. Cell. Physiol. 199, 412-417 (2004).
    • (2004) J. Cell. Physiol. , vol.199 , pp. 412-417
    • Oshima, Y.1
  • 139
    • 20444437236 scopus 로고    scopus 로고
    • Different effects of angiopoietin-2 in different vascular beds: New vessels are most sensitive
    • Oshima, Y. et al. Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive. FASEB J. 19, 963-965 (2005).
    • (2005) FASEB J. , vol.19 , pp. 963-965
    • Oshima, Y.1
  • 140
    • 20144374351 scopus 로고    scopus 로고
    • Angiopoietin 1 prevents retinal detachment in an aggressive model of proliferative retinopathy, but has no effect on established neovascularization
    • Nambu, H. et al. Angiopoietin 1 prevents retinal detachment in an aggressive model of proliferative retinopathy, but has no effect on established neovascularization. J. Cell. Physiol. 204, 227-235 (2005).
    • (2005) J. Cell. Physiol. , vol.204 , pp. 227-235
    • Nambu, H.1
  • 141
    • 34848817406 scopus 로고    scopus 로고
    • Non-responders to bevacizumab (Avastin) therapy of choroidal neovascular lesions
    • Lux, A., Llacer, H., Heussen, F. M. & Joussen, A. M. Non-responders to bevacizumab (Avastin) therapy of choroidal neovascular lesions. Br. J. Ophthalmol. 91, 1318-1322 (2007).
    • (2007) Br. J. Ophthalmol. , vol.91 , pp. 1318-1322
    • Lux, A.1    Llacer, H.2    Heussen, F.M.3    Joussen, A.M.4
  • 142
    • 75149116508 scopus 로고    scopus 로고
    • Intravitreal bevacizumab and ranibizumab for age-related macular degeneration a multicenter, retrospective study
    • Fong, D. S., Custis, P., Howes, J. & Hsu, J. W. Intravitreal bevacizumab and ranibizumab for age-related macular degeneration a multicenter, retrospective study. Ophthalmology 117, 298-302 (2010).
    • (2010) Ophthalmology , vol.117 , pp. 298-302
    • Fong, D.S.1    Custis, P.2    Howes, J.3    Hsu, J.W.4
  • 143
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld, P. J. et al. Ranibizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1419-1431 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1
  • 144
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown, D. M. et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1432-1444 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 1432-1444
    • Brown, D.M.1
  • 145
    • 84908281444 scopus 로고    scopus 로고
    • Neurons limit angiogenesis by titrating VEGF in retina
    • Okabe, K. et al. Neurons limit angiogenesis by titrating VEGF in retina. Cell 159, 584-596 (2014).
    • (2014) Cell , vol.159 , pp. 584-596
    • Okabe, K.1
  • 146
    • 84898723171 scopus 로고    scopus 로고
    • Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage
    • Lee, J. et al. Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage. Invest. Ophthalmol. Vis. Sci. 55, 2191-2199 (2014).
    • (2014) Invest. Ophthalmol. Vis. Sci. , vol.55 , pp. 2191-2199
    • Lee, J.1
  • 147
    • 84878218816 scopus 로고    scopus 로고
    • Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox
    • Costa, P. Z. & Soares, R. Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox. Life Sci. 92, 1037-1045 (2013).
    • (2013) Life Sci. , vol.92 , pp. 1037-1045
    • Costa, P.Z.1    Soares, R.2
  • 148
    • 84947048299 scopus 로고    scopus 로고
    • Poor glycemic control associates with high intravitreal angiopoietin-2 levels in patients with diabetic retinopathy
    • Tuuminen, R., Haukka, J. & Loukovaara, S. Poor glycemic control associates with high intravitreal angiopoietin-2 levels in patients with diabetic retinopathy. Acta Ophthalmol. 93, e515-e516 (2015).
    • (2015) Acta Ophthalmol. , vol.93 , pp. e515-e516
    • Tuuminen, R.1    Haukka, J.2    Loukovaara, S.3
  • 149
    • 84957961431 scopus 로고    scopus 로고
    • Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina
    • Qiu, Y. et al. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 53, 81-89 (2016).
    • (2016) Acta Diabetol. , vol.53 , pp. 81-89
    • Qiu, Y.1
  • 150
    • 79955953053 scopus 로고    scopus 로고
    • A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy
    • Rangasamy, S., Srinivasan, R., Maestas, J., McGuire, P. G. & Das, A. A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 52, 3784-3791 (2011).
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 3784-3791
    • Rangasamy, S.1    Srinivasan, R.2    Maestas, J.3    McGuire, P.G.4    Das, A.5
  • 151
    • 12144286666 scopus 로고    scopus 로고
    • Angiopoietin-2 causes pericyte dropout in the normal retina: Evidence for involvement in diabetic retinopathy
    • Hammes, H. P. et al. Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy. Diabetes 53, 1104-1110 (2004).
    • (2004) Diabetes , vol.53 , pp. 1104-1110
    • Hammes, H.P.1
  • 152
    • 85019656342 scopus 로고    scopus 로고
    • Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown
    • Ogura, S. et al. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight 2, e90905 (2017).
    • (2017) JCI Insight , vol.2 , pp. e90905
    • Ogura, S.1
  • 153
    • 84962191237 scopus 로고    scopus 로고
    • Intravitreal AAV2. COMP-Ang1 prevents neurovascular degeneration in a murine model of diabetic retinopathy
    • Cahoon, J. M. et al. Intravitreal AAV2. COMP-Ang1 prevents neurovascular degeneration in a murine model of diabetic retinopathy. Diabetes 64, 4247-4259 (2015).
    • (2015) Diabetes , vol.64 , pp. 4247-4259
    • Cahoon, J.M.1
  • 154
    • 84904296460 scopus 로고    scopus 로고
    • Angiopoietin-1 is regulated by MIR-204 and contributes to corneal neovascularization in KLEIP-deficient mice
    • Kather, J. N. et al. Angiopoietin-1 is regulated by miR-204 and contributes to corneal neovascularization in KLEIP-deficient mice. Invest. Ophthalmol. Vis. Sci. 55, 4295-4303 (2014).
    • (2014) Invest. Ophthalmol. Vis. Sci. , vol.55 , pp. 4295-4303
    • Kather, J.N.1
  • 155
    • 84903517779 scopus 로고    scopus 로고
    • Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): A randomised, multicentre, double-blind, placebo-controlled phase 3 trial
    • Monk, B. J. et al. Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial. Lancet Oncol. 15, 799-808 (2014).
    • (2014) Lancet Oncol. , vol.15 , pp. 799-808
    • Monk, B.J.1
  • 156
    • 84990186704 scopus 로고    scopus 로고
    • Final results of a phase 3 study of trebananib plus weekly paclitaxel in recurrent ovarian cancer (TRINOVA-1): Long-term survival, impact of ascites, and progression-free survival-2
    • Monk, B. J. et al. Final results of a phase 3 study of trebananib plus weekly paclitaxel in recurrent ovarian cancer (TRINOVA-1): long-term survival, impact of ascites, and progression-free survival-2. Gynecol. Oncol. 143, 27-34 (2016).
    • (2016) Gynecol. Oncol. , vol.143 , pp. 27-34
    • Monk, B.J.1
  • 157
    • 84924082631 scopus 로고    scopus 로고
    • Treatment of diabetic macular edema with an inhibitor of vascular endothelial-protein tyrosine phosphatase that activates Tie2
    • Campochiaro, P. A. et al. Treatment of diabetic macular edema with an inhibitor of vascular endothelial-protein tyrosine phosphatase that activates Tie2. Ophthalmology 122, 545-554 (2015).
    • (2015) Ophthalmology , vol.122 , pp. 545-554
    • Campochiaro, P.A.1
  • 158
    • 84969927106 scopus 로고    scopus 로고
    • Enhanced benefit in diabetic macular edema from AKB-9778 Tie2 activation combined with vascular endothelial growth factor suppression
    • Campochiaro, P. A. et al. Enhanced benefit in diabetic macular edema from AKB-9778 Tie2 activation combined with vascular endothelial growth factor suppression. Ophthalmology 123, 1722-1730 (2016).
    • (2016) Ophthalmology , vol.123 , pp. 1722-1730
    • Campochiaro, P.A.1
  • 159
    • 67649345892 scopus 로고    scopus 로고
    • Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx
    • Salmon, A. H. et al. Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx. Cardiovasc. Res. 1, 24-33 (2009).
    • (2009) Cardiovasc. Res. , vol.1 , pp. 24-33
    • Salmon, A.H.1
  • 160
    • 84866552180 scopus 로고    scopus 로고
    • Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis
    • Kanakaraj, P. et al. Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. MAbs 4, 600-613 (2012).
    • (2012) MAbs , vol.4 , pp. 600-613
    • Kanakaraj, P.1
  • 161
    • 0037219502 scopus 로고    scopus 로고
    • Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering
    • Davis, S. et al. Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering. Nat. Struct. Biol. 10, 38-44 (2003).
    • (2003) Nat. Struct. Biol. , vol.10 , pp. 38-44
    • Davis, S.1
  • 162
    • 21244434808 scopus 로고    scopus 로고
    • Oligomerization and multimerization is critical for angiopoietin-1 to bind and phosphorylate Tie2
    • Kim, K. T. et al. Oligomerization and multimerization is critical for angiopoietin-1 to bind and phosphorylate Tie2. J. Biol. Chem. 280, 20126-20131 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 20126-20131
    • Kim, K.T.1
  • 164
    • 60749124285 scopus 로고    scopus 로고
    • Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade
    • Huang, J. et al. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int. J. Oncol. 34, 79-87 (2009).
    • (2009) Int. J. Oncol. , vol.34 , pp. 79-87
    • Huang, J.1
  • 165
    • 0037008879 scopus 로고    scopus 로고
    • Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice
    • Zhang, Z. G., Zhang, L., Croll, S. D. & Chopp, M. Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice. Neuroscience 113, 683-687 (2002).
    • (2002) Neuroscience , vol.113 , pp. 683-687
    • Zhang, Z.G.1    Zhang, L.2    Croll, S.D.3    Chopp, M.4
  • 166
    • 84945183684 scopus 로고    scopus 로고
    • A designed angiopoietin-1 variant, dimeric CMP-Ang1 activates Tie2 and stimulates angiogenesis and vascular stabilization in N-glycan dependent manner
    • Oh, N. et al. A designed angiopoietin-1 variant, dimeric CMP-Ang1 activates Tie2 and stimulates angiogenesis and vascular stabilization in N-glycan dependent manner. Sci. Rep. 5, 15291 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 15291
    • Oh, N.1
  • 167
    • 11144357304 scopus 로고    scopus 로고
    • COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity
    • Cho, C. H. et al. COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. Proc. Natl Acad. Sci. USA 101, 5547-5552 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 5547-5552
    • Cho, C.H.1
  • 168
    • 84866928765 scopus 로고    scopus 로고
    • Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis
    • Alfieri, A. et al. Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis. Crit. Care 16, R182 (2012).
    • (2012) Crit. Care , vol.16 , pp. R182
    • Alfieri, A.1
  • 169
    • 84925002597 scopus 로고    scopus 로고
    • Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse
    • Ryu, J. K. et al. Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse. Sci. Rep. 5, 9222 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 9222
    • Ryu, J.K.1
  • 170
    • 79952404359 scopus 로고    scopus 로고
    • Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse
    • Jin, H. R. et al. Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse. Diabetes 60, 969-980 (2011).
    • (2011) Diabetes , vol.60 , pp. 969-980
    • Jin, H.R.1
  • 171
    • 84859577496 scopus 로고    scopus 로고
    • The effects of designed angiopoietin-1 variant on lipid droplet diameter, vascular endothelial cell density and metabolic parameters in diabetic db/db mice
    • Jung, Y. J. et al. The effects of designed angiopoietin-1 variant on lipid droplet diameter, vascular endothelial cell density and metabolic parameters in diabetic db/db mice. Biochem. Biophys. Res. Commun. 420, 498-504 (2012).
    • (2012) Biochem. Biophys. Res. Commun. , vol.420 , pp. 498-504
    • Jung, Y.J.1
  • 172
    • 68049094930 scopus 로고    scopus 로고
    • COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice
    • Sung, H. K. et al. COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice. Am. J. Physiol. Endocrinol. Metab. 297, E402-E409 (2009).
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , pp. E402-E409
    • Sung, H.K.1
  • 173
    • 11144355412 scopus 로고    scopus 로고
    • Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis
    • Cho, C. H. et al. Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis. Proc. Natl Acad. Sci. USA 101, 5553-5558 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 5553-5558
    • Cho, C.H.1
  • 174
    • 72949100522 scopus 로고    scopus 로고
    • COMP-angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury
    • Kim, D. H. et al. COMP-angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury. Kidney Int. 76, 1180-1191 (2009).
    • (2009) Kidney Int. , vol.76 , pp. 1180-1191
    • Kim, D.H.1
  • 175
    • 46449133564 scopus 로고    scopus 로고
    • Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury
    • Kim, S. R. et al. Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury. Exp. Mol. Med. 40, 320-331 (2008).
    • (2008) Exp. Mol. Med. , vol.40 , pp. 320-331
    • Kim, S.R.1
  • 176
    • 84864628161 scopus 로고    scopus 로고
    • Angiopoietin-1 protects heart against ischemia/reperfusion injury through VE-cadherin dephosphorylation and myocardiac integrin-β1/ERK/caspase-9 phosphorylation cascade
    • Lee, S. W. et al. Angiopoietin-1 protects heart against ischemia/reperfusion injury through VE-cadherin dephosphorylation and myocardiac integrin-β1/ERK/caspase-9 phosphorylation cascade. Mol. Med. 17, 1095-1106 (2011).
    • (2011) Mol. Med. , vol.17 , pp. 1095-1106
    • Lee, S.W.1
  • 177
    • 79955959619 scopus 로고    scopus 로고
    • COMP-Ang1 stimulates HIF-1α-mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment
    • Youn, S. W. et al. COMP-Ang1 stimulates HIF-1α-mediated SDF-1 overexpression and recovers ischemic injury through BM-derived progenitor cell recruitment. Blood 117, 4376-4386 (2011).
    • (2011) Blood , vol.117 , pp. 4376-4386
    • Youn, S.W.1
  • 178
    • 77950111925 scopus 로고    scopus 로고
    • Protective role of COMP-Ang1 in ischemic rat brain
    • Shin, H. Y. et al. Protective role of COMP-Ang1 in ischemic rat brain. J. Neurosci. Res. 88, 1052-1063 (2010).
    • (2010) J. Neurosci. Res. , vol.88 , pp. 1052-1063
    • Shin, H.Y.1
  • 179
    • 70349647202 scopus 로고    scopus 로고
    • Peritubular capillary preservation with COMP-angiopoietin-1 decreases ischemia-reperfusion-induced acute kidney injury
    • Jung, Y. J. et al. Peritubular capillary preservation with COMP-angiopoietin-1 decreases ischemia-reperfusion-induced acute kidney injury. Am. J. Physiol. Renal Physiol. 297, F952-F960 (2009).
    • (2009) Am. J. Physiol. Renal Physiol. , vol.297 , pp. F952-F960
    • Jung, Y.J.1
  • 180
    • 36348947430 scopus 로고    scopus 로고
    • Cartilage oligometric matrix protein-angiopoietin-1 promotes revascularization through increased survivin expression in dermal endothelial cells of skin grafts in mice
    • Byun, S. J. et al. Cartilage oligometric matrix protein-angiopoietin-1 promotes revascularization through increased survivin expression in dermal endothelial cells of skin grafts in mice. Am. J. Pathol. 171, 1682-1690 (2007).
    • (2007) Am. J. Pathol. , vol.171 , pp. 1682-1690
    • Byun, S.J.1
  • 181
    • 74249106462 scopus 로고    scopus 로고
    • COMP-Ang1, a chimeric form of angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation
    • Jeong, B. C. et al. COMP-Ang1, a chimeric form of angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation. Bone 46, 479-486 (2010).
    • (2010) Bone , vol.46 , pp. 479-486
    • Jeong, B.C.1
  • 182
    • 84908126118 scopus 로고    scopus 로고
    • COMP-angiopoietin1 potentiates the effects of bone morphogenic protein-2 on ischemic necrosis of the femoral head in rats
    • Zhou, L. et al. COMP-angiopoietin1 potentiates the effects of bone morphogenic protein-2 on ischemic necrosis of the femoral head in rats. PLoS ONE 9, e110593 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e110593
    • Zhou, L.1
  • 183
    • 77951257275 scopus 로고    scopus 로고
    • COMP-angiopoietin-1 accelerates bone formation during distraction osteogenesis
    • Park, B. H. et al. COMP-angiopoietin-1 accelerates bone formation during distraction osteogenesis. Bone 46, 1442-1448 (2010).
    • (2010) Bone , vol.46 , pp. 1442-1448
    • Park, B.H.1
  • 184
    • 84949035856 scopus 로고    scopus 로고
    • The angiopoietin-1 variant COMP-Ang1 enhances BMP2-induced bone regeneration with recruiting pericytes in critical sized calvarial defects
    • Choi, H. et al. The angiopoietin-1 variant COMP-Ang1 enhances BMP2-induced bone regeneration with recruiting pericytes in critical sized calvarial defects. PLoS ONE 10, e0140502 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0140502
    • Choi, H.1
  • 185
    • 84873104951 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis
    • Anisimov, A. et al. Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation 127, 424-434 (2013).
    • (2013) Circulation , vol.127 , pp. 424-434
    • Anisimov, A.1
  • 186
    • 70249114453 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors
    • Herbst, R. S. et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J. Clin. Oncol. 27, 3557-3565 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3557-3565
    • Herbst, R.S.1
  • 187
    • 84882453744 scopus 로고    scopus 로고
    • Incidence and management of edema associated with trebananib (AMG 386)
    • Monk, B. J. et al. Incidence and management of edema associated with trebananib (AMG 386). Gynecol. Oncol. 130, 636-641 (2013).
    • (2013) Gynecol. Oncol. , vol.130 , pp. 636-641
    • Monk, B.J.1
  • 188
    • 84945231947 scopus 로고    scopus 로고
    • Trebananib (AMG 386) in combination with sunitinib in patients with metastatic renal cell cancer: An open-la-uppressed-enter, Phase II study
    • Atkins, M. B. et al. Trebananib (AMG 386) in combination with sunitinib in patients with metastatic renal cell cancer: an open-la-uppressed-enter, Phase II study. J. Clin. Oncol. 33, 3431-3438 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. 3431-3438
    • Atkins, M.B.1
  • 189
    • 32944474182 scopus 로고    scopus 로고
    • VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    • Kamba, T. et al. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am. J. Physiol. Heart Circ. Physiol. 290, H560-H576 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290 , pp. H560-H576
    • Kamba, T.1
  • 190
    • 34250365240 scopus 로고    scopus 로고
    • Mechanisms of adverse effects of anti-VEGF therapy for cancer
    • Kamba, T. & McDonald, D. M. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br. J. Cancer 96, 1788-1795 (2007).
    • (2007) Br. J. Cancer , vol.96 , pp. 1788-1795
    • Kamba, T.1    McDonald, D.M.2
  • 191
    • 84873545836 scopus 로고    scopus 로고
    • A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to pan-angiopoietin-1/-2 inhibitors
    • Thomas, M. et al. A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to pan-angiopoietin-1/-2 inhibitors. PLoS ONE 8, e54923 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e54923
    • Thomas, M.1
  • 192
    • 84925545307 scopus 로고    scopus 로고
    • Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma
    • Motzer, R. J. et al. Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma. Cancer Chemother. Pharmacol. 74, 739-750 (2014).
    • (2014) Cancer Chemother. Pharmacol. , vol.74 , pp. 739-750
    • Motzer, R.J.1
  • 193
    • 0242443253 scopus 로고    scopus 로고
    • Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function
    • Veikkola, T. et al. Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. FASEB J. 17, 2006-2013 (2003)
    • (2003) FASEB J. , vol.17 , pp. 2006-2013
    • Veikkola, T.1
  • 194
    • 84924308784 scopus 로고    scopus 로고
    • Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation
    • Pemovska, T. et al. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation. Nature 519, 102-105 (2015).
    • (2015) Nature , vol.519 , pp. 102-105
    • Pemovska, T.1
  • 195
    • 13044292625 scopus 로고    scopus 로고
    • Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans
    • Valenzuela, D. M. et al. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc. Natl Acad. Sci. USA 96, 1904-1909 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 1904-1909
    • Valenzuela, D.M.1
  • 196
    • 0032998010 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3
    • Kim, I. et al. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. FEBS Lett. 443, 353-356 (1999).
    • (1999) FEBS Lett. , vol.443 , pp. 353-356
    • Kim, I.1
  • 197
    • 0032945883 scopus 로고    scopus 로고
    • Angiopoietin-3, a novel member of the angiopoietin family
    • Nishimura, M. et al. Angiopoietin-3, a novel member of the angiopoietin family. FEBS Lett. 448, 254-256 (1999).
    • (1999) FEBS Lett. , vol.448 , pp. 254-256
    • Nishimura, M.1
  • 198
    • 0034832905 scopus 로고    scopus 로고
    • Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats
    • Abdulmalek, K. et al. Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats. Am. J. Physiol. Lung Cell. Mol. Physiol. 281, L582-L590 (2001).
    • (2001) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.281 , pp. L582-L590
    • Abdulmalek, K.1
  • 199
    • 0141640863 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
    • Yamakawa, M. et al. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ. Res. 93, 664-673 (2003).
    • (2003) Circ. Res. , vol.93 , pp. 664-673
    • Yamakawa, M.1
  • 200
    • 4644231084 scopus 로고    scopus 로고
    • Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: Regulation by hypoxia and participation in angiogenesis
    • Yamakawa, M. et al. Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. Am. J. Physiol. Renal Physiol. 287, F649-F657 (2004).
    • (2004) Am. J. Physiol. Renal Physiol. , vol.287 , pp. F649-F657
    • Yamakawa, M.1
  • 201
    • 3442875258 scopus 로고    scopus 로고
    • Biological characterization of angiopoietin-3 and angiopoietin-4
    • Lee, H. J. et al. Biological characterization of angiopoietin-3 and angiopoietin-4. FASEB J. 18, 1200-1208 (2004).
    • (2004) FASEB J. , vol.18 , pp. 1200-1208
    • Lee, H.J.1
  • 202
    • 84889100066 scopus 로고    scopus 로고
    • Effect of intracavernous administration of angiopoietin-4 on erectile function in the streptozotocin-induced diabetic mouse
    • Kwon, M. H. et al. Effect of intracavernous administration of angiopoietin-4 on erectile function in the streptozotocin-induced diabetic mouse. J. Sex. Med. 10, 2912-2927 (2013).
    • (2013) J. Sex. Med. , vol.10 , pp. 2912-2927
    • Kwon, M.H.1
  • 203
    • 84877293027 scopus 로고    scopus 로고
    • Variable somatic TIE2 mutations in half of sporadic venous malformations
    • Soblet, J., Limaye, N., Uebelhoer, M., Boon, L. M. & Vikkula, M. Variable somatic TIE2 mutations in half of sporadic venous malformations. Mol. Syndromol. 4, 179-183 (2013).
    • (2013) Mol. Syndromol. , vol.4 , pp. 179-183
    • Soblet, J.1    Limaye, N.2    Uebelhoer, M.3    Boon, L.M.4    Vikkula, M.5
  • 204
    • 82955198442 scopus 로고    scopus 로고
    • Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations
    • Ye, C. et al. Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations. J. Vasc. Surg. 54, 1760-1768 (2011).
    • (2011) J. Vasc. Surg. , vol.54 , pp. 1760-1768
    • Ye, C.1
  • 205
    • 85006815923 scopus 로고    scopus 로고
    • Blue rubber bleb nevus (BRBN) syndrome is caused by somatic TEK (TIE2) mutations
    • Soblet, J. et al. Blue rubber bleb nevus (BRBN) syndrome is caused by somatic TEK (TIE2) mutations. J. Invest. Dermatol. 137, 207-216 (2016).
    • (2016) J. Invest. Dermatol. , vol.137 , pp. 207-216
    • Soblet, J.1
  • 206
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels, Y. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554 (2004).
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1
  • 207
    • 84945470445 scopus 로고    scopus 로고
    • Clinical and genetic aspects of the segmental overgrowth spectrum due to somatic mutations in PIK3CA
    • Kang, H. C., Baek, S. T., Song, S. & Gleeson, J. G. Clinical and genetic aspects of the segmental overgrowth spectrum due to somatic mutations in PIK3CA. J. Pediatr. 167, 957-962 (2015).
    • (2015) J. Pediatr. , vol.167 , pp. 957-962
    • Kang, H.C.1    Baek, S.T.2    Song, S.3    Gleeson, J.G.4
  • 208
    • 84933279834 scopus 로고    scopus 로고
    • Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA
    • Luks, V. L. et al. Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA. J. Pediatr. 166, 1048-1054 (2015).
    • (2015) J. Pediatr. , vol.166 , pp. 1048-1054
    • Luks, V.L.1
  • 209
    • 84922469410 scopus 로고    scopus 로고
    • Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothelial cells isolated from lymphatic malformations
    • Osborn, A. J. et al. Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothelial cells isolated from lymphatic malformations. Hum. Mol. Genet. 24, 926-938 (2015).
    • (2015) Hum. Mol. Genet. , vol.24 , pp. 926-938
    • Osborn, A.J.1
  • 210
    • 0030460775 scopus 로고    scopus 로고
    • Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2
    • Vikkula, M. et al. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell 87, 1181-1190 (1996).
    • (1996) Cell , vol.87 , pp. 1181-1190
    • Vikkula, M.1
  • 211
    • 66149094158 scopus 로고    scopus 로고
    • VE-PTP controls blood vessel development by balancing Tie-2 activity
    • Winderlich, M. et al. VE-PTP controls blood vessel development by balancing Tie-2 activity. J. Cell Biol. 185, 657-671 (2009).
    • (2009) J. Cell Biol. , vol.185 , pp. 657-671
    • Winderlich, M.1
  • 212
    • 58149291905 scopus 로고    scopus 로고
    • VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF
    • Nottebaum, A. F. et al. VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J. Exp. Med. 205, 2929-2945 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2929-2945
    • Nottebaum, A.F.1
  • 213
    • 84894470051 scopus 로고    scopus 로고
    • Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin
    • Wessel, F. et al. Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin. Nat. Immunol. 15, 223-230 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 223-230
    • Wessel, F.1
  • 214
    • 77949657364 scopus 로고    scopus 로고
    • Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects
    • Wouters, V. et al. Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects. Eur. J. Hum. Genet. 18, 414-420 (2010).
    • (2010) Eur. J. Hum. Genet. , vol.18 , pp. 414-420
    • Wouters, V.1
  • 215
    • 84941633958 scopus 로고    scopus 로고
    • Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects
    • Boscolo, E. et al. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. J. Clin. Invest. 125, 3491-3504 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 3491-3504
    • Boscolo, E.1
  • 216
    • 84949057867 scopus 로고    scopus 로고
    • Common and specific effects of TIE2 mutations causing venous malformations
    • Natynki, M. et al. Common and specific effects of TIE2 mutations causing venous malformations. Hum. Mol. Genet. 24, 6374-6389 (2015).
    • (2015) Hum. Mol. Genet. , vol.24 , pp. 6374-6389
    • Natynki, M.1
  • 217
    • 84975215345 scopus 로고    scopus 로고
    • Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion
    • Ubezio, B. et al. Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion. eLIFE 5, e12167 (2016).
    • (2016) ELIFE , vol.5 , pp. e12167
    • Ubezio, B.1
  • 218
    • 78149422176 scopus 로고    scopus 로고
    • Identification and functional analysis of endothelial tip cell-enriched genes
    • del Toro, R. et al. Identification and functional analysis of endothelial tip cell-enriched genes. Blood 116, 4025-4033 (2010).
    • (2010) Blood , vol.116 , pp. 4025-4033
    • Del Toro, R.1
  • 219
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • Morikawa, S. et al. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am. J. Pathol. 160, 985-1000 (2002).
    • (2002) Am. J. Pathol. , vol.160 , pp. 985-1000
    • Morikawa, S.1
  • 220
    • 0142151097 scopus 로고    scopus 로고
    • Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    • Baluk, P., Morikawa, S., Haskell, A., Mancuso, M. & McDonald, D. M. Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am. J. Pathol. 163, 1801-1815 (2003).
    • (2003) Am. J. Pathol. , vol.163 , pp. 1801-1815
    • Baluk, P.1    Morikawa, S.2    Haskell, A.3    Mancuso, M.4    McDonald, D.M.5
  • 221
    • 0037418914 scopus 로고    scopus 로고
    • The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-κB inhibitor ABIN-2
    • Hughes, D. P., Marron, M. B. & Brindle, N. P. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-κB inhibitor ABIN-2. Circ. Res. 92, 630-636 (2003).
    • (2003) Circ. Res. , vol.92 , pp. 630-636
    • Hughes, D.P.1    Marron, M.B.2    Brindle, N.P.3
  • 222
    • 0345599946 scopus 로고    scopus 로고
    • ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1
    • Tadros, A., Hughes, D. P., Dunmore, B. J. & Brindle, N. P. ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. Blood 102, 4407-4409 (2003).
    • (2003) Blood , vol.102 , pp. 4407-4409
    • Tadros, A.1    Hughes, D.P.2    Dunmore, B.J.3    Brindle, N.P.4
  • 223
    • 65549145050 scopus 로고    scopus 로고
    • Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2
    • Sako, K. et al. Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J. Biol. Chem. 284, 5592-5601 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 5592-5601
    • Sako, K.1
  • 224
    • 84944042723 scopus 로고    scopus 로고
    • MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2
    • Demolli, S. et al. MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2. J. Mol. Cell Cardiol. 88, 111-119 (2015).
    • (2015) J. Mol. Cell Cardiol. , vol.88 , pp. 111-119
    • Demolli, S.1
  • 225
    • 33745137492 scopus 로고    scopus 로고
    • Suppression and regression of choroidal neovascularization by systemic administration of an α5β1 integrin antagonist
    • Umeda, N. et al. Suppression and regression of choroidal neovascularization by systemic administration of an α5β1 integrin antagonist. Mol. Pharmacol. 69, 1820-1828 (2006).
    • (2006) Mol. Pharmacol. , vol.69 , pp. 1820-1828
    • Umeda, N.1
  • 226
    • 84862867113 scopus 로고    scopus 로고
    • Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses
    • Pietila, R. et al. Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses. J. Cell Sci. 125, 2212-2223 (2012).
    • (2012) J. Cell Sci. , vol.125 , pp. 2212-2223
    • Pietila, R.1
  • 227
    • 52749091381 scopus 로고    scopus 로고
    • Pericyte migration: A novel mechanism of pericyte loss in experimental diabetic retinopathy
    • Pfister, F. et al. Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes 57, 2495-2502 (2008).
    • (2008) Diabetes , vol.57 , pp. 2495-2502
    • Pfister, F.1
  • 228
    • 61749101239 scopus 로고    scopus 로고
    • Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function
    • Chan, B. & Sukhatme, V. P. Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function. FEBS Lett. 583, 1023-1028 (2009).
    • (2009) FEBS Lett. , vol.583 , pp. 1023-1028
    • Chan, B.1    Sukhatme, V.P.2
  • 229
    • 43549107002 scopus 로고    scopus 로고
    • Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules
    • Chan, B., Yuan, H. T., Ananth Karumanchi, S. & Sukhatme, V. P. Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules. Biochem. Biophys. Res. Commun. 371, 475-479 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.371 , pp. 475-479
    • Chan, B.1    Yuan, H.T.2    Ananth Karumanchi, S.3    Sukhatme, V.P.4
  • 230
    • 84855493801 scopus 로고    scopus 로고
    • Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo
    • Broermann, A. et al. Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J. Exp. Med. 208, 2393-2401 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 2393-2401
    • Broermann, A.1
  • 231
    • 84907011560 scopus 로고    scopus 로고
    • Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity
    • Park, D. Y. et al. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J. Clin. Invest. 124, 3960-3974 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 3960-3974
    • Park, D.Y.1
  • 233
    • 78751646275 scopus 로고    scopus 로고
    • Vitreous levels of angiopoietin-1 and angiopoietin-2 in eyes with retinopathy of prematurity
    • Sato, T., Shima, C. & Kusaka, S. Vitreous levels of angiopoietin-1 and angiopoietin-2 in eyes with retinopathy of prematurity. Am. J. Ophthalmol. 151, 353-357 (2011).
    • (2011) Am. J. Ophthalmol. , vol.151 , pp. 353-357
    • Sato, T.1    Shima, C.2    Kusaka, S.3
  • 234
    • 84902263299 scopus 로고    scopus 로고
    • Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment
    • Loukovaara, S. et al. Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment. Graefes Arch. Clin. Exp. Ophthalmol. 252, 881-888 (2014).
    • (2014) Graefes Arch. Clin. Exp. Ophthalmol. , vol.252 , pp. 881-888
    • Loukovaara, S.1
  • 235
    • 84890034596 scopus 로고    scopus 로고
    • Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population
    • Lorbeer, R. et al. Circulating angiopoietin-2, its soluble receptor Tie-2, and mortality in the general population. Eur. J. Heart Fail. 15, 1327-1334 (2013).
    • (2013) Eur. J. Heart Fail. , vol.15 , pp. 1327-1334
    • Lorbeer, R.1
  • 236
    • 84905588970 scopus 로고    scopus 로고
    • Predictive value of circulating angiopoietin-2 for endothelial damage-related complications in allogeneic hematopoietic stem cell transplantation
    • Ueda, N. et al. Predictive value of circulating angiopoietin-2 for endothelial damage-related complications in allogeneic hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant 20, 1335-1340 (2014).
    • (2014) Biol. Blood Marrow Transplant , vol.20 , pp. 1335-1340
    • Ueda, N.1
  • 237
    • 84955186607 scopus 로고    scopus 로고
    • Angiopoietin-2 in acute myocardial infarction complicated by cardiogenic shock-A biomarker substudy of the IABP-SHOCK II-Trial
    • Poss, J. et al. Angiopoietin-2 in acute myocardial infarction complicated by cardiogenic shock-a biomarker substudy of the IABP-SHOCK II-Trial. Eur. J. Heart Fail. 17, 1152-1160 (2015).
    • (2015) Eur. J. Heart Fail. , vol.17 , pp. 1152-1160
    • Poss, J.1
  • 238
    • 38549109998 scopus 로고    scopus 로고
    • Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?
    • Ganter, M. T. et al. Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma? Ann. Surg. 247, 320-326 (2008).
    • (2008) Ann. Surg. , vol.247 , pp. 320-326
    • Ganter, M.T.1
  • 239
    • 77952432851 scopus 로고    scopus 로고
    • The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
    • Mankhambo, L. A. et al. The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children. Crit. Care 14, R91 (2010).
    • (2010) Crit. Care , vol.14 , pp. R91
    • Mankhambo, L.A.1
  • 240
    • 84897412290 scopus 로고    scopus 로고
    • Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence
    • Golledge, J. et al. Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence. Stroke 45, 1064-1068 (2014).
    • (2014) Stroke , vol.45 , pp. 1064-1068
    • Golledge, J.1
  • 241
    • 79957511062 scopus 로고    scopus 로고
    • Angiopoietin-1 is associated with cerebral vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage
    • Fischer, M. et al. Angiopoietin-1 is associated with cerebral vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage. BMC Neurol. 11, 59 (2011).
    • (2011) BMC Neurol. , vol.11 , pp. 59
    • Fischer, M.1
  • 242
    • 84939253297 scopus 로고    scopus 로고
    • High Angiopoietin-1 levels predict a good functional outcome within 72 h of an aneurysmal subarachnoid hemorrhage: A prospective study from a single center
    • Wang, Y. et al. High Angiopoietin-1 levels predict a good functional outcome within 72 h of an aneurysmal subarachnoid hemorrhage: A prospective study from a single center. J. Neurol. Sci. 356, 72-76 (2015).
    • (2015) J. Neurol. Sci. , vol.356 , pp. 72-76
    • Wang, Y.1
  • 243
    • 79952777526 scopus 로고    scopus 로고
    • Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease
    • Westra, J. et al. Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease. Rheumatol. (Oxford) 50, 665-673 (2011).
    • (2011) Rheumatol. (Oxford) , vol.50 , pp. 665-673
    • Westra, J.1
  • 244
    • 84884943070 scopus 로고    scopus 로고
    • Angiopoietin-2 serum levels correlate with severity, early onset and cardiovascular disease in patients with rheumatoid arthritis
    • Lopez-Mejias, R. et al. Angiopoietin-2 serum levels correlate with severity, early onset and cardiovascular disease in patients with rheumatoid arthritis. Clin. Exp. Rheumatol 31, 761-766 (2013).
    • (2013) Clin. Exp. Rheumatol , vol.31 , pp. 761-766
    • Lopez-Mejias, R.1
  • 245
    • 84902536467 scopus 로고    scopus 로고
    • Disturbed balance between serum levels of receptor tyrosine kinases Tie-1, Tie-2 and angiopoietins in systemic sclerosis
    • Gerlicz, Z., Dziankowska-Bartkowiak, B., Dziankowska-Zaborszczyk, E. & Sysa-Jedrzejowska, A. Disturbed balance between serum levels of receptor tyrosine kinases Tie-1, Tie-2 and angiopoietins in systemic sclerosis. Dermatology 228, 233-239 (2014).
    • (2014) Dermatology , vol.228 , pp. 233-239
    • Gerlicz, Z.1    Dziankowska-Bartkowiak, B.2    Dziankowska-Zaborszczyk, E.3    Sysa-Jedrzejowska, A.4
  • 246
    • 35448947787 scopus 로고    scopus 로고
    • Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma
    • Scholz, A. et al. Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma. Am. J. Gastroenterol. 102, 2471-2481 (2007).
    • (2007) Am. J. Gastroenterol. , vol.102 , pp. 2471-2481
    • Scholz, A.1
  • 247
    • 84924591909 scopus 로고    scopus 로고
    • Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition
    • Pauta, M. et al. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. Liver Int. 35, 1383-1392 (2015).
    • (2015) Liver Int. , vol.35 , pp. 1383-1392
    • Pauta, M.1
  • 248
    • 84879156777 scopus 로고    scopus 로고
    • Angiopoietin-2 serum levels improve noninvasive fibrosis staging in chronic hepatitis C: A fibrogenic-angiogenic link
    • Hernandez-Bartolome, A. et al. Angiopoietin-2 serum levels improve noninvasive fibrosis staging in chronic hepatitis C: a fibrogenic-angiogenic link. PLoS ONE 8, e66143 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e66143
    • Hernandez-Bartolome, A.1
  • 249
    • 84902485569 scopus 로고    scopus 로고
    • Elevated plasma thrombomodulin and angiopoietin-2 predict the development of acute kidney injury in patients with acute myocardial infarction
    • Liu, K. L. et al. Elevated plasma thrombomodulin and angiopoietin-2 predict the development of acute kidney injury in patients with acute myocardial infarction. Crit. Care 18, R100 (2014).
    • (2014) Crit. Care , vol.18 , pp. R100
    • Liu, K.L.1
  • 250
    • 84943142552 scopus 로고    scopus 로고
    • Angiopoietin-2 as a prognostic biomarker of major adverse cardiovascular events and all-cause mortality in chronic kidney disease
    • Tsai, Y. C. et al. Angiopoietin-2 as a prognostic biomarker of major adverse cardiovascular events and all-cause mortality in chronic kidney disease. PLoS ONE 10, e0135181 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0135181
    • Tsai, Y.C.1
  • 251
    • 84908240977 scopus 로고    scopus 로고
    • Prognostic impact of angiopoietin-2 in multiple myeloma
    • Pappa, C. A. et al. Prognostic impact of angiopoietin-2 in multiple myeloma. J. Cancer Res. Clin. Oncol. 140, 1801-1805 (2014).
    • (2014) J. Cancer Res. Clin. Oncol. , vol.140 , pp. 1801-1805
    • Pappa, C.A.1
  • 252
    • 84875374634 scopus 로고    scopus 로고
    • Synergistic effect of vascular endothelial growth factor and angiopoietin-2 on progression free survival in multiple myeloma
    • Bhaskar, A. et al. Synergistic effect of vascular endothelial growth factor and angiopoietin-2 on progression free survival in multiple myeloma. Leuk. Res. 37, 410-415 (2013).
    • (2013) Leuk. Res. , vol.37 , pp. 410-415
    • Bhaskar, A.1
  • 253
    • 84896532455 scopus 로고    scopus 로고
    • Circulating Ang-2 mRNA expression levels: Looking ahead to a new prognostic factor for NSCLC
    • Coelho, A. L. et al. Circulating Ang-2 mRNA expression levels: looking ahead to a new prognostic factor for NSCLC. PLoS ONE 9, e90009 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e90009
    • Coelho, A.L.1
  • 254
    • 84894372582 scopus 로고    scopus 로고
    • High-circulating Tie2 is associated with pathologic complete response to chemotherapy and antiangiogenic therapy in breast cancer
    • Makhoul, I. et al. High-circulating Tie2 is associated with pathologic complete response to chemotherapy and antiangiogenic therapy in breast cancer. Am. J. Clin. Oncol. 39, 248-254 (2014).
    • (2014) Am. J. Clin. Oncol. , vol.39 , pp. 248-254
    • Makhoul, I.1
  • 255
    • 84923096914 scopus 로고    scopus 로고
    • Diagnostic and prognostic potential of serum angiopoietin-2 expression in human breast cancer
    • Li, P., He, Q., Luo, C. & Qian, L. Diagnostic and prognostic potential of serum angiopoietin-2 expression in human breast cancer. Int. J. Clin. Exp. Pathol. 8, 660-664 (2015).
    • (2015) Int. J. Clin. Exp. Pathol. , vol.8 , pp. 660-664
    • Li, P.1    He, Q.2    Luo, C.3    Qian, L.4
  • 256
    • 84927743238 scopus 로고    scopus 로고
    • Prognostic value of angiopoietin-2 for death risk stratification in patients with metastatic colorectal carcinoma
    • Jary, M. et al. Prognostic value of angiopoietin-2 for death risk stratification in patients with metastatic colorectal carcinoma. Cancer Epidemiol. Biomarkers Prev. 24, 603-612 (2015).
    • (2015) Cancer Epidemiol. Biomarkers Prev. , vol.24 , pp. 603-612
    • Jary, M.1
  • 257
    • 84928777163 scopus 로고    scopus 로고
    • Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma
    • Gayed, B. A. et al. Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma. BMC Urol. 15, 24 (2015).
    • (2015) BMC Urol. , vol.15 , pp. 24
    • Gayed, B.A.1
  • 258
    • 84885929021 scopus 로고    scopus 로고
    • Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma
    • Miyahara, K. et al. Pro-angiogenic cytokines for prediction of outcomes in patients with advanced hepatocellular carcinoma. Br. J. Cancer 109, 2072-2078 (2013).
    • (2013) Br. J. Cancer , vol.109 , pp. 2072-2078
    • Miyahara, K.1
  • 259
    • 77954891291 scopus 로고    scopus 로고
    • Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia
    • Maffei, R. et al. Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia. Blood 116, 584-592 (2010).
    • (2010) Blood , vol.116 , pp. 584-592
    • Maffei, R.1
  • 260
    • 40849088142 scopus 로고    scopus 로고
    • Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia
    • Hou, H. A. et al. Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia. Leuk. Res. 32, 904-912 (2008).
    • (2008) Leuk. Res. , vol.32 , pp. 904-912
    • Hou, H.A.1
  • 261
    • 84902766083 scopus 로고    scopus 로고
    • Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection
    • van de Weg, C. A. et al. Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection. J. Clin. Virol. 60, 328-335 (2014).
    • (2014) J. Clin. Virol. , vol.60 , pp. 328-335
    • Van De Weg, C.A.1
  • 262
    • 84956885531 scopus 로고    scopus 로고
    • Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality
    • Zinter, M. S. et al. Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality. Am. J. Physiol. Lung Cell. Mol. Physiol. 310, L224-L231 (2016).
    • (2016) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.310 , pp. L224-L231
    • Zinter, M.S.1
  • 263
    • 84887156187 scopus 로고    scopus 로고
    • A high angiopoietin-2/angiopoietin-1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia
    • Luz Fiusa, M. M. et al. A high angiopoietin-2/angiopoietin-1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia. Crit. Care 17, R169 (2013).
    • (2013) Crit. Care , vol.17 , pp. R169
    • Luz Fiusa, M.M.1
  • 264
    • 84892798419 scopus 로고    scopus 로고
    • The temporal kinetics of circulating angiopoietin levels in children with sepsis
    • Giuliano, J. S. Jr. et al. The temporal kinetics of circulating angiopoietin levels in children with sepsis. Pediatr. Crit. Care Med. 15, e1-e8 (2014).
    • (2014) Pediatr. Crit. Care Med. , vol.15 , pp. e1-e8
    • Giuliano, J.S.1
  • 265
    • 84924206063 scopus 로고    scopus 로고
    • Angiopoietin-2 associations with the underlying infection and sepsis severity
    • Lymperopoulou, K. et al. Angiopoietin-2 associations with the underlying infection and sepsis severity. Cytokine 73, 163-168 (2015).
    • (2015) Cytokine , vol.73 , pp. 163-168
    • Lymperopoulou, K.1
  • 266
    • 67649976574 scopus 로고    scopus 로고
    • Angiopoietin-2 is increased in septic shock: Evidence for the existence of a circulating factor stimulating its release from human monocytes
    • Kranidioti, H. et al. Angiopoietin-2 is increased in septic shock: evidence for the existence of a circulating factor stimulating its release from human monocytes. Immunol. Lett. 125, 65-71 (2009).
    • (2009) Immunol. Lett. , vol.125 , pp. 65-71
    • Kranidioti, H.1
  • 267
    • 36248988406 scopus 로고    scopus 로고
    • Admission angiopoietin levels in children with septic shock
    • Giuliano, J. S. Jr. et al. Admission angiopoietin levels in children with septic shock. Shock 28, 650-654 (2007).
    • (2007) Shock , vol.28 , pp. 650-654
    • Giuliano, J.S.1
  • 268
    • 33845940689 scopus 로고    scopus 로고
    • Angiopoietin-2 is increased in severe sepsis: Correlation with inflammatory mediators
    • Orfanos, S. E. et al. Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators. Crit. Care Med. 35, 199-206 (2007).
    • (2007) Crit. Care Med. , vol.35 , pp. 199-206
    • Orfanos, S.E.1
  • 269
    • 84937965811 scopus 로고    scopus 로고
    • Circulating angiopopietin-1 correlates with the clinical course of multiple organ dysfunction syndrome and mortality in patients with severe sepsis
    • Lin, S. M. et al. Circulating angiopopietin-1 correlates with the clinical course of multiple organ dysfunction syndrome and mortality in patients with severe sepsis. Med. (Baltimore) 94, e878 (2015).
    • (2015) Med. (Baltimore) , vol.94 , pp. e878
    • Lin, S.M.1
  • 270
    • 84944040728 scopus 로고    scopus 로고
    • Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency department
    • Fang, Y. et al. Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency department. Crit. Care 19, 367 (2015).
    • (2015) Crit. Care , vol.19 , pp. 367
    • Fang, Y.1
  • 271
    • 84861513903 scopus 로고    scopus 로고
    • Plasma angiopoietin-2 in clinical acute lung injury: Prognostic and pathogenetic significance
    • Calfee, C. S. et al. Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit. Care Med. 40, 1731-1737 (2012).
    • (2012) Crit. Care Med. , vol.40 , pp. 1731-1737
    • Calfee, C.S.1
  • 272
    • 77956231365 scopus 로고    scopus 로고
    • Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients
    • Ong, T. et al. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit. Care Med. 38, 1845-1851 (2010).
    • (2010) Crit. Care Med. , vol.38 , pp. 1845-1851
    • Ong, T.1
  • 273
    • 84860235284 scopus 로고    scopus 로고
    • Angiopoietin-2 in acute liver failure
    • Hadem, J. et al. Angiopoietin-2 in acute liver failure. Crit. Care Med. 40, 1499-1505 (2012).
    • (2012) Crit. Care Med. , vol.40 , pp. 1499-1505
    • Hadem, J.1
  • 274
    • 84860797968 scopus 로고    scopus 로고
    • Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)
    • Xie, Z. et al. Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood 119, 4321-4332 (2012).
    • (2012) Blood , vol.119 , pp. 4321-4332
    • Xie, Z.1
  • 275
    • 84859898999 scopus 로고    scopus 로고
    • Using angiogenic factors and their soluble receptors to predict organ dysfunction in patients with disseminated intravascular coagulation associated with severe trauma
    • Wada, T. et al. Using angiogenic factors and their soluble receptors to predict organ dysfunction in patients with disseminated intravascular coagulation associated with severe trauma. Crit. Care 16, R63 (2012).
    • (2012) Crit. Care , vol.16 , pp. R63
    • Wada, T.1
  • 276
    • 84866704782 scopus 로고    scopus 로고
    • Angiogenic factors and their soluble receptors predict organ dysfunction and mortality in post-cardiac arrest syndrome
    • Wada, T. et al. Angiogenic factors and their soluble receptors predict organ dysfunction and mortality in post-cardiac arrest syndrome. Crit. Care 16, R171 (2012).
    • (2012) Crit. Care , vol.16 , pp. R171
    • Wada, T.1
  • 277
    • 77951207233 scopus 로고    scopus 로고
    • Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: Relation to acute kidney injury, multiple organ dysfunction syndrome and outcome
    • Kumpers, P. et al. Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome. Intensive Care Med. 36, 462-470 (2010).
    • (2010) Intensive Care Med. , vol.36 , pp. 462-470
    • Kumpers, P.1
  • 278
    • 84890583673 scopus 로고    scopus 로고
    • Early angiopoietin-2 levels after onset predict the advent of severe pancreatitis, multiple organ failure, and infectious complications in patients with acute pancreatitis
    • Buddingh, K. T. et al. Early angiopoietin-2 levels after onset predict the advent of severe pancreatitis, multiple organ failure, and infectious complications in patients with acute pancreatitis. J. Am. Coll. Surg. 218, 26-32 (2014).
    • (2014) J. Am. Coll. Surg. , vol.218 , pp. 26-32
    • Buddingh, K.T.1
  • 279
    • 77957851368 scopus 로고    scopus 로고
    • Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany
    • Whitcomb, D. C. et al. Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany. Am. J. Gastroenterol. 105, 2287-2292 (2010).
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 2287-2292
    • Whitcomb, D.C.1
  • 280
    • 84873245993 scopus 로고    scopus 로고
    • A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria
    • Prapansilp, P. et al. A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria. Malar. J. 12, 50 (2013).
    • (2013) Malar. J. , vol.12 , pp. 50
    • Prapansilp, P.1
  • 281
    • 84878642213 scopus 로고    scopus 로고
    • Platelet activation determines angiopoietin-1 and VEGF levels in malaria: Implications for their use as biomarkers
    • Brouwers, J. et al. Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers. PLoS ONE 8, e64850 (2014).
    • (2014) PLoS ONE , vol.8 , pp. e64850
    • Brouwers, J.1
  • 282
    • 84857523393 scopus 로고    scopus 로고
    • Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: A retrospective case-control study
    • Conroy, A. L. et al. Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study. Crit. Care Med. 40, 952-959 (2012).
    • (2012) Crit. Care Med. , vol.40 , pp. 952-959
    • Conroy, A.L.1
  • 283
    • 84155191017 scopus 로고    scopus 로고
    • Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India
    • Jain, V. et al. Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India. Malar. J. 10, 383 (2011).
    • (2011) Malar. J. , vol.10 , pp. 383
    • Jain, V.1
  • 284
    • 84879488245 scopus 로고    scopus 로고
    • Angiopoietin-2 in adults with congenital heart disease and heart failure
    • Lukasz, A. et al. Angiopoietin-2 in adults with congenital heart disease and heart failure. PLoS ONE 8, e66861 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e66861
    • Lukasz, A.1
  • 285
    • 84939974121 scopus 로고    scopus 로고
    • Angiopoietin-2 and outcome in patients with acute decompensated heart failure
    • Poss, J. et al. Angiopoietin-2 and outcome in patients with acute decompensated heart failure. Clin. Res. Cardiol. 104, 380-387 (2015).
    • (2015) Clin. Res. Cardiol. , vol.104 , pp. 380-387
    • Poss, J.1
  • 286
    • 84893269771 scopus 로고    scopus 로고
    • Serum angiopoietin-2 and CRP levels during COPD exacerbations
    • Nikolakopoulou, S. et al. Serum angiopoietin-2 and CRP levels during COPD exacerbations. COPD 11, 46-51 (2014).
    • (2014) COPD , vol.11 , pp. 46-51
    • Nikolakopoulou, S.1
  • 287
    • 84910615043 scopus 로고    scopus 로고
    • Evaluation of angiopoietin 1 and 2, vascular endothelial growth factor, and tumor necrosis factor alpha levels in asthmatic children
    • Koksal, B. T., Ozbek, O. Y., Bayraktar, N. & Yazici, A. C. Evaluation of angiopoietin 1 and 2, vascular endothelial growth factor, and tumor necrosis factor alpha levels in asthmatic children. Allergy Asthma Proc. 35, 482-488 (2014).
    • (2014) Allergy Asthma Proc. , vol.35 , pp. 482-488
    • Koksal, B.T.1    Ozbek, O.Y.2    Bayraktar, N.3    Yazici, A.C.4
  • 289
    • 9444299031 scopus 로고    scopus 로고
    • Plasma vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in diabetes: Implications for cardiovascular risk and effects of multifactorial intervention
    • Lim, H. S., Blann, A. D., Chong, A. Y., Freestone, B. & Lip, G. Y. Plasma vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in diabetes: implications for cardiovascular risk and effects of multifactorial intervention. Diabetes Care 27, 2918-2924 (2004).
    • (2004) Diabetes Care , vol.27 , pp. 2918-2924
    • Lim, H.S.1    Blann, A.D.2    Chong, A.Y.3    Freestone, B.4    Lip, G.Y.5
  • 290
    • 84928618926 scopus 로고    scopus 로고
    • Serum angiopoietin-2 is associated with angiopathy in type 2 diabetes mellitus
    • Li, L., Qian, L. & Yu, Z. Q. Serum angiopoietin-2 is associated with angiopathy in type 2 diabetes mellitus. J. Diabetes Complications 29, 568-571 (2015).
    • (2015) J. Diabetes Complications , vol.29 , pp. 568-571
    • Li, L.1    Qian, L.2    Yu, Z.Q.3
  • 291
    • 67749103626 scopus 로고    scopus 로고
    • The absence of angiopoietin-2 leads to abnormal vascular maturation and persistent proliferative retinopathy
    • Feng, Y. et al. The absence of angiopoietin-2 leads to abnormal vascular maturation and persistent proliferative retinopathy. Thromb. Haemost. 102, 120-130 (2009).
    • (2009) Thromb. Haemost. , vol.102 , pp. 120-130
    • Feng, Y.1
  • 292
    • 38349136263 scopus 로고    scopus 로고
    • Angiopoietin-2 deficiency decelerates age-dependent vascular changes in the mouse retina
    • Feng, Y. et al. Angiopoietin-2 deficiency decelerates age-dependent vascular changes in the mouse retina. Cell Physiol. Biochem. 21, 129-136 (2008).
    • (2008) Cell Physiol. Biochem. , vol.21 , pp. 129-136
    • Feng, Y.1
  • 293
    • 66749176681 scopus 로고    scopus 로고
    • Decreased hypoxia-induced neovascularization in angiopoietin-2 heterozygous knockout mouse through reduced MMP activity
    • Feng, Y. et al. Decreased hypoxia-induced neovascularization in angiopoietin-2 heterozygous knockout mouse through reduced MMP activity. Cell Physiol. Biochem. 23, 277-284 (2009).
    • (2009) Cell Physiol. Biochem. , vol.23 , pp. 277-284
    • Feng, Y.1
  • 294
    • 33847006938 scopus 로고    scopus 로고
    • Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression
    • Feng, Y. et al. Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression. Thromb. Haemost. 97, 99-108 (2007).
    • (2007) Thromb. Haemost. , vol.97 , pp. 99-108
    • Feng, Y.1
  • 295
    • 76449101742 scopus 로고    scopus 로고
    • Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia
    • Pfister, F. et al. Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia. Acta Diabetol. 47, 59-64 (2010).
    • (2010) Acta Diabetol. , vol.47 , pp. 59-64
    • Pfister, F.1
  • 296
    • 2642557374 scopus 로고    scopus 로고
    • Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier
    • Nambu, H. et al. Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier. Gene Ther. 11, 865-873 (2004).
    • (2004) Gene Ther. , vol.11 , pp. 865-873
    • Nambu, H.1
  • 297
    • 84863012011 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer
    • Karlan, B. Y. et al. Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer. J. Clin. Oncol. 30, 362-371 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 362-371
    • Karlan, B.Y.1
  • 298
    • 84917690919 scopus 로고    scopus 로고
    • A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours
    • Hong, D. S. et al. A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours. Oncotarget 5, 11154-11167 (2014).
    • (2014) Oncotarget , vol.5 , pp. 11154-11167
    • Hong, D.S.1
  • 299
    • 84962232352 scopus 로고    scopus 로고
    • A phase i first-in-human study of nesvacumab (REGN910), a fully-human anti-angiopoietin-2 (Ang2) monoclonal antibody, in patients with advanced solid tumors
    • Papadopoulos, K. P. et al. A phase I first-in-human study of nesvacumab (REGN910), a fully-human anti-angiopoietin-2 (Ang2) monoclonal antibody, in patients with advanced solid tumors. Clin. Cancer Res. 22, 1348-1355 (2015).
    • (2015) Clin. Cancer Res. , vol.22 , pp. 1348-1355
    • Papadopoulos, K.P.1
  • 300
    • 84859488747 scopus 로고    scopus 로고
    • MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models
    • Leow, C. C. et al. MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models. Int. J. Oncol. 40, 1321-1330 (2012).
    • (2012) Int. J. Oncol. , vol.40 , pp. 1321-1330
    • Leow, C.C.1
  • 301
    • 84994100942 scopus 로고    scopus 로고
    • Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases
    • Regula, J. T. et al. Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases. EMBO Mol. Med. 381, 1265-1288 (2016).
    • (2016) EMBO Mol. Med. , vol.381 , pp. 1265-1288
    • Regula, J.T.1
  • 302
    • 84872892692 scopus 로고    scopus 로고
    • Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): An international, multicentre, randomised, placebo-controlled, phase 3 trial
    • Demetri, G. D. et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381, 295-302 (2013).
    • (2013) Lancet , vol.381 , pp. 295-302
    • Demetri, G.D.1
  • 303
    • 84942085999 scopus 로고    scopus 로고
    • Altiratinib inhibits tumor growth, invasion, angiogenesis, and microenvironment-mediated drug resistance via balanced inhibition of MET, TIE2, and VEGFR2
    • Smith, B. D. et al. Altiratinib inhibits tumor growth, invasion, angiogenesis, and microenvironment-mediated drug resistance via balanced inhibition of MET, TIE2, and VEGFR2. Mol. Cancer Ther. 14, 2023-2034 (2015).
    • (2015) Mol. Cancer Ther. , vol.14 , pp. 2023-2034
    • Smith, B.D.1
  • 304
    • 84929466299 scopus 로고    scopus 로고
    • A phase i study of oral ARRY-614, a p38 MAPK/Tie2 dual inhibitor, in patients with low or intermediate-1 risk myelodysplastic syndromes
    • Garcia-Manero, G. et al. A phase I study of oral ARRY-614, a p38 MAPK/Tie2 dual inhibitor, in patients with low or intermediate-1 risk myelodysplastic syndromes. Clin. Cancer Res. 21, 985-994 (2015).
    • (2015) Clin. Cancer Res. , vol.21 , pp. 985-994
    • Garcia-Manero, G.1
  • 305
    • 77955534812 scopus 로고    scopus 로고
    • Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage
    • Koh, Y. J. et al. Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage. Cancer Cell 18, 171-184 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 171-184
    • Koh, Y.J.1
  • 306
    • 85017547813 scopus 로고    scopus 로고
    • Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade
    • Schmittnaegel, M. et al. Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade. Sci. Transl Med. 9, eaak9670 (2017).
    • (2017) Sci. Transl Med. , vol.9 , pp. eaak9670
    • Schmittnaegel, M.1
  • 307
    • 85018812730 scopus 로고    scopus 로고
    • Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization
    • Leppänen, V. M., Saharinen, P. & Alitalo, K. Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc. Natl Acad. Sci. USA 114, 4376-4381 (2017).
    • (2017) Proc. Natl Acad. Sci. USA , vol.114 , pp. 4376-4381
    • Leppänen, V.M.1    Saharinen, P.2    Alitalo, K.3
  • 308
    • 85018811244 scopus 로고    scopus 로고
    • Dimerization of Tie2 mediated by its membrane-proximal FNIII domains
    • Moore, J. O., Lemmon, M. A. & Ferguson, K. M. Dimerization of Tie2 mediated by its membrane-proximal FNIII domains. Proc. Natl Acad. Sci. USA 114, 4382-4387 (2017).
    • (2017) Proc. Natl Acad. Sci. USA , vol.114 , pp. 4382-4387
    • Moore, J.O.1    Lemmon, M.A.2    Ferguson, K.M.3
  • 309
    • 85003894401 scopus 로고    scopus 로고
    • Normalization of tumor vessels by Tie2 activation and Ang2 inhibition enhances drug delivery and produces a favorable tumor microenvironment
    • Park, J. S. et al. Normalization of tumor vessels by Tie2 activation and Ang2 inhibition enhances drug delivery and produces a favorable tumor microenvironment. Cancer Cell 30, 953-967 (2016).
    • (2016) Cancer Cell , vol.30 , pp. 953-967
    • Park, J.S.1
  • 310
    • 73949105871 scopus 로고    scopus 로고
    • A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models
    • Brown, J. L. et al. A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models. Mol. Cancer Ther. 9, 145-156 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 145-156
    • Brown, J.L.1
  • 311
    • 84876893871 scopus 로고    scopus 로고
    • Structural basis for angiopoietin-1-mediated signaling initiation
    • Yu, X. et al. Structural basis for angiopoietin-1-mediated signaling initiation. Proc. Natl Acad. Sci. USA 110, 7205-7210 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 7205-7210
    • Yu, X.1
  • 312
    • 0034435424 scopus 로고    scopus 로고
    • Structure of the Tie2 RTK domain: Self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail
    • Shewchuk, L. M. et al. Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. Structure 8, 1105-1113 (2000).
    • (2000) Structure , vol.8 , pp. 1105-1113
    • Shewchuk, L.M.1
  • 313
    • 85016434659 scopus 로고    scopus 로고
    • The conformation of the epidermal growth factor receptor transmembrane domain dimer dynamically adapts to the local membrane environment
    • Bocharov, E. V. et al. The conformation of the epidermal growth factor receptor transmembrane domain dimer dynamically adapts to the local membrane environment. Biochemistry 56, 1697-1705 (2017).
    • (2017) Biochemistry , vol.56 , pp. 1697-1705
    • Bocharov, E.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.