Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions

Circulation Research

Volumn 87, Issue 7, 2000, Pages 603-607

  Gamble, Jennifer R ^a   Drew, Jenny ^a   Trezise, Libby ^a   Underwood, Anne ^b   Parsons, Michelle ^a   Kasminkas, Lisa ^a   Rudge, John ^c   Yancopoulos, George ^c   Vadas, Mathew A ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b CSIRO   (Australia)

^c REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

Angiogenesis; Cell junctions; Endothelium; Inflammation; Permeability

Indexed keywords

ANGIOPOIETIN 1; CD31 ANTIGEN; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA;

ANGIOGENESIS; ARTICLE; CELL JUNCTION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; VASCULAR ENDOTHELIUM;

EID: 0034730784     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.7.603     Document Type: Article

References (40)

1. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
2. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
3. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
4. Leakage resistant blood vessels in mice transgenically over-expressing angiopoietin-1
5. Angiopoietin-1 protects the adult vasculature against plasma leakage
6. Endothelial adherens junctions: Implications in the control of vascular permeability and angiogenesis
7. Occludin as a possible determinant of tight junction permeability in endothelial cells
8. Histamine induces tyrosine phosphorylation of endothelial cell-to-cell adherens junctions
9. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells
10. Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins
11. Endothelial-dependent mechanisms regulate leukocyte transmigration: A process involving the proteosome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions
12. Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow
13. Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo
14. Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells
15. Novel cytokine-independent induction of endothelial adhesion molecules regulated by platelet/endothelial cell adhesion molecule CD31
16. Homophilic PECAM-1 CD31 interactions prevent endothelial cell apoptosis but do not support cell spreading or migration
17. Inhibition of endothelial cell adhesion and proliferation by extracellular matrix from vascular smooth muscle cells: Role of type V collagen
18. Direct actions of angiopoietin-1 on human endothelium: Evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors
19. Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organization
20. Transforming growth factor-β1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium
21. Activation of sphingosine kinase by tumor necrosis factor-β inhibits apoptosis in human endothelial cells
22. Switched at birth: A new family for PECAM-1
23. Cell adhesion in vascular biology the biology of PECAM-1
24. Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts
25. Platelet endothelial cell adhesion molecule-1 expression modulates endothelial cell migration in vitro
26. Non-inflammatory expression of E-selectin is regulated by cell growth
27. Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1
28. Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells
29. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway
30. Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage
31. Migration of neutrophils across endothelial monolayers is stimulated by treatment of the monolayers with interleukin-1 or tumor necrosis factor
32. PECAM-1 is required for transendothelial migration of leukocytes
33. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo
34. The cell adhesion molecule CD31 is phosphorylated after cell activation
35. Inhibition of cultured cell growth by vascular endothelial cadherin cadherin-5/VE-cadherin
36. Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype
37. Integrins, angiogenesis and vascular cell survival
38. Fibronectin controls capillary endothelial cell growth by modulating cell shape
39. Inhibition of anchorage dependent cell spreading triggers apoptosis in cultured endothelial cells
40. Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival