Protective role of COMP-Ang1 in ischemic rat brain

Journal of Neuroscience Research

Volumn 88, Issue 5, 2010, Pages 1052-1063

  Shin, Hye Young ^a   Lee, Yoon Jin ^a   Kim, Hak Joo ^c   Park, Chul Kee ^a   Kim, Jong Hoon ^b   Wang, Kyu Chang ^a   Kim, Dong Gyu ^a   Koh, Gou Young ^c   Paek, Sun Ha ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Korea University   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Blood vessels; Cerebral ischemia; Gene transfer; Ischaemia; Neurogenesis; Neuroprotection

Indexed keywords

ADENOVIRUS VECTOR; ANGIOPOIETIN 1; BETA GALACTOSIDASE; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CARTILAGE OLIGOMERIC MATRIX PROTEIN ANGIOPOIETIN 1; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL COUNT; CONTROLLED STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEURAL STEM CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT;

ADENOVIRIDAE; ANIMALS; BRAIN; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL DEATH; CELL PROLIFERATION; CEREBRAL ARTERIES; CYTOPROTECTION; DISEASE MODELS, ANIMAL; GENE THERAPY; GENETIC VECTORS; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; RECOVERY OF FUNCTION; REGENERATION; STEM CELLS; TRANSFECTION; TREATMENT OUTCOME;

EID: 77950111925     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22274     Document Type: Article

References (32)

1. Alexandrov AV, Burgin WS, Demchuk AM, El-Mitwalli A, Grotta JC. 2001. Speed of intracranial clot lysis with intravenous tissue plasminogen activator therapy: sonographic classifi cation and short-term improvement. Circulation 103:2897-2902.
2. Byun SJ, Choi KS, Park SH, Cho NW, Hyun Yoo C, Yun KJ, Koh YJ, Koh GY, So BJ, Yoon KH. 2007. Cartilage oligometric matrix protein-angiopoietin-1 promotes revascularization through increased survivin expression in dermal endothelial cells of skin grafts in mice. Am J Pathol 171:1682-1690.
3. Carmeliet ,P. 2000. Mechanisms of angiogenesis and arteriogenesis. Nat Med 6:389-395.
4. Chae JK, Kim I, Lim ST, Chung MJ, Kim WH, ,Kim HG, Ko JK, Koh GY. 2000. Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization. Arterioscler Thromb Vasc Biol 20:2573-2578.
5. Cho CH, Kammerer RA, Lee HJ, Steinmetz MO, Ryu YS, Lee SH, Yasunaga K, Kim KT, Kim I, Choi HH, Kim W, Kim SH, Park SK, Lee GM, Koh GY. 2004a. COMP-ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. Proc Natl Acad Sci U S A 101:5547-5552.
6. Cho CH, Kammerer RA, Lee HJ, Yasunaga K, Kim KT, Choi HH, Kim W, Kim SH, Park SK, Lee GM, Koh GY. 2004b. Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis. Proc Natl Acad Sci U S A 101:5553-5558.
7. Cho CH, Kim KE, Byun J, Jang HS, Kim DK, Baluk P, Baffert F, Lee GM, Mochizuki N, Kim J, Jeon BH, McDonald DM, Koh GY. 2005. Long-term and sustained COMP-ang1 induces long-lasting vascular enlargement and enhanced blood flow. Circ Res 97:86-94.
8. Cho CH, Sung HK, Kim KT, Cheon HG, Oh GT, Hong HJ, Yoo OJ, Koh GY. 2006. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesi, and blood flow in a diabetic mouse model. Proc Natl Acad Sci U S A 103:4946-4951.
9. Demchuk AM, Burgin WS, Christou I, Felberg RA, Barber PA, Hill MD, Alexandrov AV. 2001. Thrombolysis in brain ischemia (TIBI) transcranial doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator. Stroke 32:89-93.
10. Gale NW, Yancopoulos GD. 1999. Growth factors acting via endothelial cellspecific receptor kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev 13:1055-1066.
11. Gropen TI, Gagliano PJ, Blake CA, Sacco RL, Kwiatkowski T, Richmond NJ, Leifer D, Libman R, Azhar S, Daley MB. 2006. NYS-DOH stroke center designation project workgroup. Quality improvement in acute stroke: the New York State Stroke Center Designation Project. Neurology 67:88-93.
12. Jeong SW, Chu K, Jung KH, Kim SU, Kim M, Roh JK. 2003. Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage. Stroke. 34:2258-2263.
13. Khaja AM, Grotta JC. 1991. Established treatments for acute ischaemic stroke. Lancet 369:319-330.
14. Kim I, Moon SO, Park SK, Chae SW, Koh GY. 2001. Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression. Circ Res 89:477-479.
15. Kim W, Moon SO, Lee SY, Jang KY, Cho CH, Koh GY, Choi KS, Yoon KH, Sung MJ, Kim DH, Lee S, Kang KP, Park SK. 2006. COMP-angiopoietin-1 ameliorates renal fibrosis in a unilateral ureteral obstruction model. J Am Soc Nephrol 17:2474-2483.
16. Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM. 1994. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke 25:1794-1798.
17. Ligier Y, Ratib O, Logean M, Girard C. 1994. Osiris: a medical image-manipulation system. MD Comput 11:212-218.
18. Longa EZ, Weinstein PR, Carlson S, Cummins R. 1989. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91.
19. Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E, Risau W. 2000. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 156:965-976.
20. Plate KH, Beck H, Danner S, Allegrini PR, Wiessner C. 1999. Cell type specific upregulation of vascular endothelial growth factor in an MCA occlusion model of cerebral infarct. J Neuropathol Exp Neurol 58:654-666.
21. Sacco RL, Chong JY, Prabhakaran S, Elkind MSV. 2007. Experimental treatments for acute ischaemic stroke. Lancet 369:331-341.
22. Shen Q, Goderie SK, Jin L, Karanth N, Sun Y, Abramova N, Vincent P, Pumiglia K, Temple S. 2004. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304:1338-1340.
23. Shin HY, Kim JH, Phi JH, Park CK, Kim JE, Kim JH, Paek SH, Wang KC, Kim DG. 2008. Endogenous neurogenesis and neovascularization in the neocortex of the rat after focal cerebral ischemia. J Neurosci Res 86:356-367.
24. Takahashi K, Ito Y, Morikawa M, Kobune M, Huang J, Tsukamoto M, Sasaki K, Nakamura K, Dehari H, Ikeda K, Uchida H, Hirai S, Abe T, Hamada H. 2003. Adenoviral-delivered angiopoietin-1 reduces the infarction and attenuates the progression of cardiac dysfunction in the rat model of acute myocardial infarction. Mol Ther 8:584-592.
25. Thurston G, Suri C, Smith K, McClain J, Sato TN, Yancopoulos GD, McDonald DM. 1999. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286:2511-2514.
26. Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, Glazer N, Holash J, McDonald DM, Yancopoulos GD. 2000. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6:460-463.
27. Warlow C, Sulow C, Dennis M, Wardlaw J, Sandercock P. 2003. Stroke. Lancet 362:1211-1224.
28. Wei L, Erinjeri JP, Rovainen CM, Woolsey TA. 2001. Collateral growth and angiogenesis around cortical stroke. Stroke 32:2179-2184.
29. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. 2000. Vascular-specific growth factors and blood vessel formation. Nature 407:242-248.
30. Yla-Herttuala S, Alitalo K. 2003. Gene transfer as a tool to induce therapeutic vascular growth. Nat Med 6:694-701.
31. Zhang ZG, Zhang L, Croll SD, Chopp M. 2002. Angiopoietin-1 reduces cerebral blood vessel leakage and ischemic lesion volume after focal cerebral embolic ischemia in mice. Neuroscience 113:683-687.
32. Zhou YF, Stabile E, Walker J, Shou M, Baffour R, Yu Z, Rott D, Yancopoulos GD, Rudge JS, Epstein SE. 2004. Effects of gene delivery on collateral development in chronic hypoperfusion: diverse effects of angiopoietin-1 versus vascular endothelial growth factor. J Am Coll Cardiol 44:897-903.