메뉴 건너뛰기




Volumn 8, Issue 335, 2016, Pages

Amelioration of sepsis by TIE2 activation-induced vascular protection

(29)  Han, Sangyeul a,b   Lee, Seung Jun b,c   Kim, Kyung Eun a,i   Lee, Hyo Seon a,i   Oh, Nuri c,j   Park, Inwon c   Ko, Eun a,i   Oh, Seung Ja a   Lee, Yoon Sook a,i   Kim, David c   Lee, Seungjoo c   Lee, Dae Hyun c   Lee, Kwang Hoon a,k   Chae, Su Young a,i   Lee, Jung Hoon a,i   Kim, Su Jin a,i   Kim, Hyung Chan a,i   Kim, Seokkyun a,i   Kim, Sung Hyun a,l   Kim, Chungho d   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2 BINDING AND TIE 2 ACTIVATING ANTIBODY; ANGIOPOIETIN RECEPTOR; ANTIBODY; UNCLASSIFIED DRUG; ANG2 PROTEIN, MOUSE; ANGIOPOIETIN 2; C11ORF2 PROTEIN, HUMAN; PANCREATIC RIBONUCLEASE; VESICULAR TRANSPORT PROTEIN;

EID: 84964490181     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aad9260     Document Type: Article
Times cited : (165)

References (70)
  • 1
  • 2
    • 77958108729 scopus 로고    scopus 로고
    • Critical care and the global burden of critical illness in adults
    • N. K. J. Adhikari, R. A. Fowler, S. Bhagwanjee, G. D. Rubenfeld, Critical care and the global burden of critical illness in adults. Lancet 376, 1339-1346 (2010).
    • (2010) Lancet , vol.376 , pp. 1339-1346
    • Adhikari, N.K.J.1    Fowler, R.A.2    Bhagwanjee, S.3    Rubenfeld, G.D.4
  • 3
    • 84921815675 scopus 로고    scopus 로고
    • Strategies to improve drug development for sepsis
    • M. P. Fink, H. S. Warren, Strategies to improve drug development for sepsis. Nat. Rev. Drug Discov. 13, 741-758 (2014).
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 741-758
    • Fink, M.P.1    Warren, H.S.2
  • 8
    • 84923014522 scopus 로고    scopus 로고
    • Endothelial barrier dysfunction in septic shock
    • S. M. Opal, T. van der Poll, Endothelial barrier dysfunction in septic shock. J. Intern. Med. 277, 277-293 (2014).
    • (2014) J. Intern. Med. , vol.277 , pp. 277-293
    • Opal, S.M.1    Van Der Poll, T.2
  • 9
    • 77956635947 scopus 로고    scopus 로고
    • Sepsis and endothelial permeability
    • W. L. Lee, A. S. Slutsky, Sepsis and endothelial permeability. N. Engl. J. Med. 363, 689-691 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 689-691
    • Lee, W.L.1    Slutsky, A.S.2
  • 10
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • S. R. Coughlin, Thrombin signalling and protease-activated receptors. Nature 407, 258-264 (2000).
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 11
    • 0037588986 scopus 로고    scopus 로고
    • The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    • W. C. Aird, The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101, 3765-3777 (2003).
    • (2003) Blood , vol.101 , pp. 3765-3777
    • Aird, W.C.1
  • 12
    • 75749139748 scopus 로고    scopus 로고
    • Breaking the wall: Targeting of the endothelium by pathogenic bacteria
    • E. Lemichez, M. Lecuit, X. Nassif, S. Bourdoulous, Breaking the wall: Targeting of the endothelium by pathogenic bacteria. Nat. Rev. Microbiol. 8, 93-104 (2010).
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 93-104
    • Lemichez, E.1    Lecuit, M.2    Nassif, X.3    Bourdoulous, S.4
  • 13
    • 33646780950 scopus 로고    scopus 로고
    • Signaling and functions of angiopoietin-1 in vascular protection
    • N. P. J. Brindle, P. Saharinen, K. Alitalo, Signaling and functions of angiopoietin-1 in vascular protection. Circ. Res. 98, 1014-1023 (2006).
    • (2006) Circ. Res. , vol.98 , pp. 1014-1023
    • Brindle, N.P.J.1    Saharinen, P.2    Alitalo, K.3
  • 14
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • H. G. Augustin, G. Y. Koh, G. Thurston, K. Alitalo, Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat. Rev. Mol. Cell Biol. 10, 165-177 (2009).
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 20
    • 84882661563 scopus 로고    scopus 로고
    • Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS
    • S. M. Parikh, Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence 4, 517-524 (2013).
    • (2013) Virulence , vol.4 , pp. 517-524
    • Parikh, S.M.1
  • 24
    • 33751225092 scopus 로고    scopus 로고
    • Angiopoietins: A link between angiogenesis and inflammation
    • U. Fiedler, H. G. Augustin, Angiopoietins: A link between angiogenesis and inflammation. Trends Immunol. 27, 552-558 (2006).
    • (2006) Trends Immunol. , vol.27 , pp. 552-558
    • Fiedler, U.1    Augustin, H.G.2
  • 28
    • 64849117308 scopus 로고    scopus 로고
    • Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis
    • J. M. Siner, V. Bhandari, K. M. Engle, J. A. Elias, M. D. Siegel, Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock 31, 348-353 (2009).
    • (2009) Shock , vol.31 , pp. 348-353
    • Siner, J.M.1    Bhandari, V.2    Engle, K.M.3    Elias, J.A.4    Siegel, M.D.5
  • 30
    • 84891808520 scopus 로고    scopus 로고
    • Neutrophil-endothelial interactions mediate angiopoietin-2-associated pulmonary endothelial cell dysfunction in indirect acute lung injury in mice
    • J. Lomas-Neira, F. Venet, C.-S. Chung, R. Thakkar, D. Heffernan, A. Ayala, Neutrophil-endothelial interactions mediate angiopoietin-2-associated pulmonary endothelial cell dysfunction in indirect acute lung injury in mice. Am. J. Respir. Cell Mol. Biol. 50, 193-200 (2014).
    • (2014) Am. J. Respir. Cell Mol. Biol. , vol.50 , pp. 193-200
    • Lomas-Neira, J.1    Venet, F.2    Chung, C.-S.3    Thakkar, R.4    Heffernan, D.5    Ayala, A.6
  • 36
    • 0037160050 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding
    • X. Zhang, L. Gan, H. Pan, S. Guo, X. He, S. T. Olson, A. Mesecar, S. Adam, T. G. Unterman, Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J. Biol. Chem. 277, 45276-45284 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 45276-45284
    • Zhang, X.1    Gan, L.2    Pan, H.3    Guo, S.4    He, X.5    Olson, S.T.6    Mesecar, A.7    Adam, S.8    Unterman, T.G.9
  • 38
    • 84871719489 scopus 로고    scopus 로고
    • Orchestral actions of angiopoietin-1 in vascular regeneration
    • G. Y. Koh, Orchestral actions of angiopoietin-1 in vascular regeneration. Trends Mol. Med. 19, 31-39 (2013).
    • (2013) Trends Mol. Med. , vol.19 , pp. 31-39
    • Koh, G.Y.1
  • 39
    • 33749414768 scopus 로고    scopus 로고
    • Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
    • E. Bogdanovic, V. P. K. H. Nguyen, D. J. Dumont, Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization. J. Cell Sci. 119, 3551-3560 (2006).
    • (2006) J. Cell Sci. , vol.119 , pp. 3551-3560
    • Bogdanovic, E.1    Nguyen, V.P.K.H.2    Dumont, D.J.3
  • 40
    • 61449154547 scopus 로고    scopus 로고
    • Immunodesign of experimental sepsis by cecal ligation and puncture
    • D. Rittirsch, M. S. Huber-Lang, M. A. Flierl, P. A. Ward, Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 4, 31-36 (2008).
    • (2008) Nat. Protoc. , vol.4 , pp. 31-36
    • Rittirsch, D.1    Huber-Lang, M.S.2    Flierl, M.A.3    Ward, P.A.4
  • 42
    • 35348904935 scopus 로고    scopus 로고
    • The structure and function of the endothelial glycocalyx layer
    • S. Weinbaum, J. M. Tarbell, E. R. Damiano, The structure and function of the endothelial glycocalyx layer. Annu. Rev. Biomed. Eng. 9, 121-167 (2007).
    • (2007) Annu. Rev. Biomed. Eng. , vol.9 , pp. 121-167
    • Weinbaum, S.1    Tarbell, J.M.2    Damiano, E.R.3
  • 44
    • 67649345892 scopus 로고    scopus 로고
    • Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx
    • A. H. J. Salmon, C. R. Neal, L. M. Sage, C. A. Glass, S. J. Harper, D. O. Bates, Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx. Cardiovasc. Res. 83, 24-33 (2009).
    • (2009) Cardiovasc. Res. , vol.83 , pp. 24-33
    • Salmon, A.H.J.1    Neal, C.R.2    Sage, L.M.3    Glass, C.A.4    Harper, S.J.5    Bates, D.O.6
  • 47
    • 77952285642 scopus 로고    scopus 로고
    • Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity
    • J. S. Davis, T. W. Yeo, K. A. Piera, T. Woodberry, D. S. Celermajer, D. P. Stephens, N. M. Anstey, Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit. Care 14, R89 (2010).
    • (2010) Crit. Care , vol.14 , pp. R89
    • Davis, J.S.1    Yeo, T.W.2    Piera, K.A.3    Woodberry, T.4    Celermajer, D.S.5    Stephens, D.P.6    Anstey, N.M.7
  • 59
    • 84930179048 scopus 로고    scopus 로고
    • Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2
    • F. T. H. Wu, C. R. Lee, E. Bogdanovic, A. Prodeus, J. Gariépy, R. S. Kerbel, Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2. EMBO Mol. Med. 7, 770-787 (2015).
    • (2015) EMBO Mol. Med. , vol.7 , pp. 770-787
    • Wu, F.T.H.1    Lee, C.R.2    Bogdanovic, E.3    Prodeus, A.4    Gariépy, J.5    Kerbel, R.S.6
  • 60
    • 66149097041 scopus 로고    scopus 로고
    • Construction of a large synthetic human scFv library with six diversified CDRs and high functional diversity
    • H. Y. Yang, K. J. Kang, J. E. Chung, H. Shim, Construction of a large synthetic human scFv library with six diversified CDRs and high functional diversity. Mol. Cells 27, 225-235 (2009).
    • (2009) Mol. Cells , vol.27 , pp. 225-235
    • Yang, H.Y.1    Kang, K.J.2    Chung, J.E.3    Shim, H.4
  • 61
    • 84964450725 scopus 로고    scopus 로고
    • U. S. Patent
    • G. Thurston, C. Daly, U. S. Patent 12/843, 905 (2010).
    • (2010)
    • Thurston, G.1    Daly, C.2
  • 62
    • 51449106720 scopus 로고    scopus 로고
    • High-level expression and purification of a designed angiopoietin-1 chimeric protein, COMP-Ang1, produced in Chinese hamster ovary cells
    • S.-J. Hwang, S. H. Kim, H.-Z. Kim, M. O. Steinmetz, G. Y. Koh, G. M. Lee, High-level expression and purification of a designed angiopoietin-1 chimeric protein, COMP-Ang1, produced in Chinese hamster ovary cells. Protein J. 27, 319-326 (2008).
    • (2008) Protein J. , vol.27 , pp. 319-326
    • Hwang, S.-J.1    Kim, S.H.2    Kim, H.-Z.3    Steinmetz, M.O.4    Koh, G.Y.5    Lee, G.M.6
  • 68
    • 79955765434 scopus 로고    scopus 로고
    • Degradation of the endothelial glycocalyx is associated with chylomicron leakage in mouse cremaster muscle microcirculation
    • A. Constantinescu, J. A. E. Spaan, E. K. Arkenbout, H. Vink, J. W. G. E. van Teeffelen, Degradation of the endothelial glycocalyx is associated with chylomicron leakage in mouse cremaster muscle microcirculation. Thromb. Haemost. 105, 790-801 (2011).
    • (2011) Thromb. Haemost. , vol.105 , pp. 790-801
    • Constantinescu, A.1    Spaan, J.A.E.2    Arkenbout, E.K.3    Vink, H.4    Van Teeffelen, J.W.G.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.