Angiopoietin-2 plays an important role in retinal angiogenesis

Journal of Cellular Physiology

Volumn 192, Issue 2, 2002, Pages 182-187

  Hackett, Sean F ^a   Wiegand, Stanley ^b   Yancopoulos, George ^b   Campochiaro, Peter A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; GENE DISRUPTION; GENE TARGETING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RETINA BLOOD VESSEL; RETINA NEOVASCULARIZATION; RETINOPATHY;

ANGIOPOIETIN-2; ANIMALS; ISCHEMIA; MICE; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; PROTEINS; RETINA; RETINAL VESSELS;

EID: 0036306063     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10128     Document Type: Article

References (33)

1. Norrie's disease
2. Angiogenesis in embryos and ischemic disease
3. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
4. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
5. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
6. Persistence of fetal vasculature in the eyes of patients with incontinentia pigmenti
7. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
8. Role of the fit-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
9. Persistent fetal vasculature (PFV): An integrated interpretaion of signs and symptoms associated with persistent hyperplastic primary vitreous (PHPV). LIV Edward Jackson Memorial Lecture
10. Angiopoietin 2 expression in the retina: Upregulation during physiologic and pathologic neovascularization
11. Signaling vascular morphogenesis and maintenance
12. Norrie's disease
13. The wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years
14. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
15. Argon laser photocoagulation for neovascular maculopathy: Five-year results from randomized clinical trials
16. Causes of blindness in children: 25 years experience of Danish Institutes for the Blind
17. Transgenic mice with increased expression of vascular endothelial growth factor in the retina: A new model of intraretinal and subretinal neovascularization
18. Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization
19. Hypoxia inducible factor-1a is increased in ischemic retina: Temporal and spatial correlation with VEGF expression
20. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization
21. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells
22. Persistent hyperplastic primary vitreous
23. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
24. Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor
25. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
26. Oxygen-induced retinopathy in the mouse
27. Bilateral retinal vascular hypoplasia associated with persistence of the primary vitreous: A new clinical entity?
28. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
29. Requisite role of Angiopoietin-1, a ligand for the Tie2 receptor, during embryonic angiogenesis
30. Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors
31. Lissencephaly
32. The heterogeneity of microphthalmia in the mentally retarded