Donor Heart Treatment with COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts

American Journal of Transplantation

Volumn 15, Issue 8, 2015, Pages 2075-2084

  Syrjala S O ^a,b   Nykanen A I ^a,b   Tuuminen, R ^a,b   Raissadati, A ^a,b   Keranen M A I ^a,b   Arnaudova, R ^a,b   Krebs, R ^a,b   Koh, G Y ^c   Alitalo, K ^b   Lemstrom K B ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Animal models: murine; innate immunity; ischemia reperfusion injury (IRI); rejection; vascular biology

Indexed keywords

ANGIOPOIETIN 1; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CYCLOSPORIN A; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VASCULAR CELL ADHESION MOLECULE 1; COMP-ANG1 FUSION PROTEIN; HYBRID PROTEIN;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CAPILLARY DENSITY; CAPILLARY ENDOTHELIAL CELL; CARDIAC ALLOGRAFT VASCULOPATHY; CARDIAC GRAFT REJECTION; COLD ISCHEMIA; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFICACY; ENZYME ACTIVATION; EX VIVO STUDY; GRAFT SURVIVAL; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; INTRACORONARY DRUG ADMINISTRATION; MACROPHAGE MIGRATION; MALE; MICROANGIOPATHY; NEUTROPHIL CHEMOTAXIS; NO REFLOW PHENOMENON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TRANSMISSION ELECTRON MICROSCOPY; VASCULAR ENDOTHELIUM; ANIMAL; DONOR; GRAFT REJECTION;

ANIMALS; GRAFT REJECTION; HEART TRANSPLANTATION; RATS; RECOMBINANT FUSION PROTEINS; REPERFUSION INJURY; TISSUE DONORS;

EID: 84937521843     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13296     Document Type: Article

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