메뉴 건너뛰기




Volumn 15, Issue 6, 2016, Pages 385-403

Ten years of anti-vascular endothelial growth factor therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; BEVACIZUMAB; PEGAPTANIB; PROTEIN INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RANIBIZUMAB; VASCULOTROPIN A; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR; MONOCLONAL ANTIBODY; VEGFA PROTEIN, HUMAN;

EID: 84954569855     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd.2015.17     Document Type: Review
Times cited : (781)

References (279)
  • 1
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman, J., & Klagsbrun, M. Angiogenic factors. Science 235, 442-447 (1987
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 2
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara, N. VEGF and the quest for tumour angiogenesis factors. Nat. Rev. Cancer 2, 795-803 (2002
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 3
    • 0000912662 scopus 로고
    • Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • Ide, A. G., Baker, N. H., & Warren, S. L. Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am. J. Roentgenol. 42, 891-899 (1939
    • (1939) Am. J. Roentgenol , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 4
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissues in vivo i vascular reactions of mice to wounds and to normal and neoplastic transplants
    • Algire, G. H., Chalkley, H. W., Legallais, F. Y., & Park, H. D. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J. Natl Cancer Inst. 6, 73-85 (1945
    • (1945) J. Natl Cancer Inst , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2    Legallais, F.Y.3    Park, H.D.4
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971
    • (1971) N. Engl. J. Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 7
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung, D. W., Cachianes, G., Kuang, W. J., Goeddel, D. V., & Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306-1309 (1989
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 8
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck, P. J., et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246, 1309-1312 (1989
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1
  • 9
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara, N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25, 581-611 (2004
    • (2004) Endocr. Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 10
    • 77957764473 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy
    • Ferrara, N. Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy. Nat. Med. 16, 1107-1111 (2010
    • (2010) Nat. Med , vol.16 , pp. 1107-1111
    • Ferrara, N.1
  • 11
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Kim, K. J., et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362, 841-844 (1993
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1
  • 12
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz, H., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335-2342 (2004
    • (2004) N. Engl. J. Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1
  • 13
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis, A. P., et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am. J. Ophthalmol. 118, 445-450 (1994
    • (1994) Am. J. Ophthalmol , vol.118 , pp. 445-450
    • Adamis, A.P.1
  • 14
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello, L. P., et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. New Engl. J. Med. 331, 1480-1487 (1994
    • (1994) New Engl. J. Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1
  • 15
    • 0030067257 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate
    • Adamis, A. P., et al. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch. Ophthalmol. 114, 66-71 (1996
    • (1996) Arch. Ophthalmol , vol.114 , pp. 66-71
    • Adamis, A.P.1
  • 16
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello, L. P., et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc. Natl Acad.Sci. USA 92, 10457-10461 (1995
    • (1995) Proc. Natl Acad.Sci. USA , vol.92 , pp. 10457-10461
    • Aiello, L.P.1
  • 17
    • 33645095226 scopus 로고    scopus 로고
    • Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
    • Ng, E. W., et al. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat. Rev. Drug Discov. 5, 123-132 (2006
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 123-132
    • Ng, E.W.1
  • 18
    • 0033527584 scopus 로고    scopus 로고
    • Selection and analysis of an optimized anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen
    • Chen, Y., et al. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J. Mol. Biol. 293, 865-881 (1999
    • (1999) J. Mol. Biol , vol.293 , pp. 865-881
    • Chen, Y.1
  • 19
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer, R. J., et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24, 16-24 (2006
    • (2006) J. Clin. Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1
  • 20
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the Phase III treatment approaches in renal cancer global evaluation trial
    • Escudier, B., et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the Phase III treatment approaches in renal cancer global evaluation trial. J. Clin. Oncol. 27, 3312-3318 (2009
    • (2009) J. Clin. Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1
  • 21
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash, J., et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc. Natl Acad. Sci. USA 99, 11393-11398 (2002
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11393-11398
    • Holash, J.1
  • 22
    • 67650674112 scopus 로고    scopus 로고
    • Ramucirumab a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR 2 for the potential treatment of cancer
    • Krupitskaya, Y., & Wakelee, H. A. Ramucirumab, a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR 2 for the potential treatment of cancer. Curr. Opin. Investig. Drugs 10, 597-605 (2009
    • (2009) Curr. Opin. Investig. Drugs , vol.10 , pp. 597-605
    • Krupitskaya, Y.1    Wakelee, H.A.2
  • 23
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger, D. R., et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, 983-985 (1983
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1
  • 24
    • 0025194878 scopus 로고
    • Purification and NH2 terminal amino acid sequence of Guinea pig tumor-secreted vascular permeability factor
    • Senger, D. R., Connolly, D. T., Van De Water, L., Feder, J., & Dvorak, H. F. Purification and NH2 terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 50, 1774-1778 (1990
    • (1990) Cancer Res , vol.50 , pp. 1774-1778
    • Senger, D.R.1    Connolly, D.T.2    Van De Water, L.3    Feder, J.4    Dvorak, H.F.5
  • 25
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara, N., & Henzel, W. J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161, 851-858 (1989
    • (1989) Biochem. Biophys. Res. Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 26
    • 0024306479 scopus 로고
    • Human vascular permeability factor isolation from u937 cells
    • Connolly, D. T., et al. Human vascular permeability factor. Isolation from U937 cells. J. Biol. Chem. 264, 20017-20024 (1989
    • (1989) J. Biol. Chem , vol.264 , pp. 20017-20024
    • Connolly, D.T.1
  • 28
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • Alitalo, K., Tammela, T., & Petrova, T. V. Lymphangiogenesis in development and human disease. Nature 438, 946-953 (2005
    • (2005) Nature , vol.438 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 29
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara, N., Gerber, H. P., & LeCouter, J. The biology of VEGF and its receptors. Nature Med. 9, 669-676 (2003
    • (2003) Nature Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Le Couter, J.3
  • 30
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld, G., Cohen, T., Gengrinovitch, S., & Poltorak, Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9-22 (1999
    • (1999) FASEB J. , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 31
    • 77649096200 scopus 로고    scopus 로고
    • Binding to the extracellular matrix and proteolytic processing: Two key mechanisms regulating vascular endothelial growth factor action
    • Ferrara, N. Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action. Mol. Biol. Cell 21, 687-690 (2010
    • (2010) Mol. Biol. Cell , vol.21 , pp. 687-690
    • Ferrara, N.1
  • 32
    • 0037098860 scopus 로고    scopus 로고
    • VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma
    • Bates, D. O., et al. VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. Cancer Res. 62, 4123-4131 (2002
    • (2002) Cancer Res , vol.62 , pp. 4123-4131
    • Bates, D.O.1
  • 33
    • 84903135940 scopus 로고    scopus 로고
    • Programmed translational readthrough generates antiangiogenic VEGF Ax
    • Eswarappa, S. M., et al. Programmed translational readthrough generates antiangiogenic VEGF Ax. Cell 157, 1605-1618 (2014
    • (2014) Cell , vol.157 , pp. 1605-1618
    • Eswarappa, S.M.1
  • 34
    • 0037872699 scopus 로고    scopus 로고
    • Angiogenesis in ischemic and neoplastic disorders
    • Semenza, G. L. Angiogenesis in ischemic and neoplastic disorders. Annu. Rev. Med. 54, 17-28 (2003
    • (2003) Annu. Rev. Med , vol.54 , pp. 17-28
    • Semenza, G.L.1
  • 35
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • Kaelin, W. G. Jr The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat. Rev. Cancer 8, 865-873 (2008
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 865-873
    • Kaelin, W.G.1
  • 36
    • 0026502754 scopus 로고
    • Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues
    • Jakeman, L. B., Winer, J., Bennett, G. L., Altar, C. A., & Ferrara, N. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. J. Clin. Invest. 89, 244-253 (1992
    • (1992) J. Clin. Invest , vol.89 , pp. 244-253
    • Jakeman, L.B.1    Winer, J.2    Bennett, G.L.3    Altar, C.A.4    Ferrara, N.5
  • 37
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • De Vries, C., et al. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255, 989-991 (1992
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1
  • 38
    • 0026702970 scopus 로고
    • Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
    • Terman, B. I., et al. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187, 1579-1586 (1992
    • (1992) Biochem. Biophys. Res. Commun , vol.187 , pp. 1579-1586
    • Terman, B.I.1
  • 39
    • 0026699255 scopus 로고
    • FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
    • Pajusola, K., et al. FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. Cancer Res. 52, 5738-5473 (1992
    • (1992) Cancer Res , vol.52 , pp. 5738-6473
    • Pajusola, K.1
  • 40
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin 1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker, S., Takashima, S., Miao, H. Q., Neufeld, G., & Klagsbrun, M. Neuropilin 1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92, 735-745 (1998
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 41
    • 0028134936 scopus 로고
    • Placenta growth factor potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to flt 1 but not to flk 1/kdr
    • Park, J. E., Chen, H. H., Winer, J., Houck, K. A., & Ferrara, N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt 1 but not to Flk 1/KDR. J. Biol. Chem. 269, 25646-25654 (1994
    • (1994) J. Biol. Chem , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 42
    • 0029790466 scopus 로고    scopus 로고
    • The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt 1 determines ligand binding and may initiate a signal transduction cascade
    • Davis-Smyth, T., Chen, H., Park, J., Presta, L. G., & Ferrara, N. The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt 1 determines ligand binding and may initiate a signal transduction cascade. EMBO J. 15, 4919-4927 (1996
    • (1996) EMBO J. , vol.15 , pp. 4919-4927
    • Davis-Smyth, T.1    Chen, H.2    Park, J.3    Presta, L.G.4    Ferrara, N.5
  • 43
    • 33750430869 scopus 로고    scopus 로고
    • Corneal avascularity is due to soluble VEGF receptor 1
    • Ambati, B. K., et al. Corneal avascularity is due to soluble VEGF receptor 1. Nature 443, 993-997 (2006
    • (2006) Nature , vol.443 , pp. 993-997
    • Ambati, B.K.1
  • 44
    • 80052015813 scopus 로고    scopus 로고
    • Molecular control of endothelial cell behaviour during blood vessel morphogenesis
    • Herbert, S. P., & Stainier, D. Y. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat. Rev. Mol. Cell Biol. 12, 551-564 (2011
    • (2011) Nat. Rev. Mol. Cell Biol , vol.12 , pp. 551-564
    • Herbert, S.P.1    Stainier, D.Y.2
  • 45
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet, P., et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439 (1996
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1
  • 46
    • 0030004485 scopus 로고    scopus 로고
    • Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
    • Ferrara, N., et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442 (1996
    • (1996) Nature , vol.380 , pp. 439-442
    • Ferrara, N.1
  • 47
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk 1 deficient mice
    • Shalaby, F., et al. Failure of blood-island formation and vasculogenesis in Flk 1 deficient mice. Nature 376, 62-66 (1995
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1
  • 48
    • 12844264070 scopus 로고    scopus 로고
    • Essential role of Flk 1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
    • Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N., & Shibuya, M. Essential role of Flk 1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Natl Acad. Sci. USA 102, 1076-1081 (2005
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1076-1081
    • Sakurai, Y.1    Ohgimoto, K.2    Kataoka, Y.3    Yoshida, N.4    Shibuya, M.5
  • 49
    • 0035956947 scopus 로고    scopus 로고
    • Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
    • Fukumura, D., et al. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc. Natl Acad. Sci. USA 98, 2604-2609 (2001
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2604-2609
    • Fukumura, D.1
  • 50
    • 0033393771 scopus 로고    scopus 로고
    • Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
    • Eliceiri, B. P., et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell 4, 915-924 (1999
    • (1999) Mol. Cell , vol.4 , pp. 915-924
    • Eliceiri, B.P.1
  • 51
    • 33750529948 scopus 로고    scopus 로고
    • VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE cadherin
    • Gavard, J., & Gutkind, J. S. VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE cadherin. Nat. Cell Biol. 8, 1223-1234 (2006
    • (2006) Nat. Cell Biol , vol.8 , pp. 1223-1234
    • Gavard, J.1    Gutkind, J.S.2
  • 52
    • 84864292241 scopus 로고    scopus 로고
    • VEGFR2 induces c Src signaling and vascular permeability in vivo via the adaptor protein TSAd
    • Sun, Z., et al. VEGFR2 induces c Src signaling and vascular permeability in vivo via the adaptor protein TSAd. J. Exp. Med. 209, 1363-1377 (2012
    • (2012) J. Exp. Med , vol.209 , pp. 1363-1377
    • Sun, Z.1
  • 53
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain, R. K. Molecular regulation of vessel maturation. Nat. Med. 9, 685-693 (2003
    • (2003) Nat. Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 54
    • 62549151252 scopus 로고    scopus 로고
    • Why are tumour blood vessels abnormal and why is it important to know?
    • Nagy, J. A., Chang, S. H., Dvorak, A. M., & Dvorak, H. F. Why are tumour blood vessels abnormal and why is it important to know? Br. J. Cancer 100, 865-869 (2009
    • (2009) Br. J. Cancer , vol.100 , pp. 865-869
    • Nagy, J.A.1    Chang, S.H.2    Dvorak, A.M.3    Dvorak, H.F.4
  • 55
    • 0029803087 scopus 로고    scopus 로고
    • Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate
    • Tolentino, M. J., et al. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology 103, 1820-1828 (1996
    • (1996) Ophthalmology , vol.103 , pp. 1820-1828
    • Tolentino, M.J.1
  • 56
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel, R. S. Tumor angiogenesis. N. Engl. J. Med. 358, 2039-2049 (2008
    • (2008) N. Engl. J. Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 57
    • 33749028188 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signaling pathways: Therapeutic perspective
    • Kowanetz, M., & Ferrara, N. Vascular endothelial growth factor signaling pathways: therapeutic perspective. Clin. Cancer Res. 12, 5018-5022 (2006
    • (2006) Clin. Cancer Res , vol.12 , pp. 5018-5022
    • Kowanetz, M.1    Ferrara, N.2
  • 58
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis, L. M., & Hicklin, D. J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer 8, 579-591 (2008
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 59
    • 0026708632 scopus 로고
    • The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
    • Kim, K. J., Li, B., Houck, K., Winer, J., & Ferrara, N. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 7, 53-64 (1992
    • (1992) Growth Factors , vol.7 , pp. 53-64
    • Kim, K.J.1    Li, B.2    Houck, K.3    Winer, J.4    Ferrara, N.5
  • 60
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren, R. S., Yuan, H., Matli, M. R., Gillett, N. A., & Ferrara, N. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J. Clin. Invest. 95, 1789-1797 (1995
    • (1995) J. Clin. Invest , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrara, N.5
  • 61
    • 0029816983 scopus 로고    scopus 로고
    • Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
    • Borgstrom, P., Hillan, K. J. Sriramarao, P., & Ferrara, N. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res. 56, 4032-4039 (1996
    • (1996) Cancer Res , vol.56 , pp. 4032-4039
    • Borgstrom, P.1    Hillan, K.J.2    Sriramarao, P.3    Ferrara, N.4
  • 62
    • 0033708398 scopus 로고    scopus 로고
    • Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor
    • Gerber, H. P., Kowalski, J., Sherman, D., Eberhard, D. A., & Ferrara, N. Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor. Cancer Res. 60, 6253-6258 (2000
    • (2000) Cancer Res , vol.60 , pp. 6253-6258
    • Gerber, H.P.1    Kowalski, J.2    Sherman, D.3    Eberhard, D.A.4    Ferrara, N.5
  • 63
    • 33644863498 scopus 로고    scopus 로고
    • Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
    • Liang, W. C., et al. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J. Biol. Chem. 281, 951-961 (2006
    • (2006) J. Biol. Chem , vol.281 , pp. 951-961
    • Liang, W.C.1
  • 64
    • 0029888871 scopus 로고    scopus 로고
    • Cloning and mRNA expression of vascular endothelial growth factor in ischemic retinas of Macaca fascicularis
    • Shima, D. T., et al. Cloning and mRNA expression of vascular endothelial growth factor in ischemic retinas of Macaca fascicularis. Invest. Ophthalmol. Vis. Sci. 37, 1334-1340 (1996
    • (1996) Invest. Ophthalmol. Vis. Sci , vol.37 , pp. 1334-1340
    • Shima, D.T.1
  • 65
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta, L. G., et al. Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 57, 4593-4599 (1997
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1
  • 66
    • 0022558297 scopus 로고
    • Replacing the complementarity-determining regions in a human antibody with those from a mouse
    • Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., & Winter, G. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature 321, 522-525 (1986
    • (1986) Nature , vol.321 , pp. 522-525
    • Jones, P.T.1    Dear, P.H.2    Foote, J.3    Neuberger, M.S.4    Winter, G.5
  • 67
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara, N., Hillan, K. J., Gerber, H. P., & Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 3, 391-400 (2004
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 68
    • 0035253739 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon, M. S., et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J. Clin. Oncol. 19, 843-850 (2001
    • (2001) J. Clin. Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1
  • 69
    • 34047175559 scopus 로고    scopus 로고
    • Targeting VEGF A to treat cancer and age-related macular degeneration
    • Ferrara, N., Mass, R. D., Campa, C., & Kim, R. Targeting VEGF A to treat cancer and age-related macular degeneration. Annu. Rev. Med. 58, 491-504 (2007
    • (2007) Annu. Rev. Med , vol.58 , pp. 491-504
    • Ferrara, N.1    Mass, R.D.2    Campa, C.3    Kim, R.4
  • 70
    • 0035253586 scopus 로고    scopus 로고
    • Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: Pharmacologic and long-term safety data
    • Margolin, K., et al. Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data. J. Clin. Oncol. 19, 851-856 (2001
    • (2001) J. Clin. Oncol , vol.19 , pp. 851-856
    • Margolin, K.1
  • 71
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara, N., & Kerbel, R. S. Angiogenesis as a therapeutic target. Nature 438, 967-974 (2005
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 72
    • 34548141828 scopus 로고    scopus 로고
    • Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • Scappaticci, F. A., et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J. Natl Cancer Inst. 99, 1232-1239 (2007
    • (2007) J. Natl Cancer Inst , vol.99 , pp. 1232-1239
    • Scappaticci, F.A.1
  • 73
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor 2 antibody induces sustained tumor regression without overt toxicity
    • Klement, G., et al. Continuous low-dose therapy with vinblastine and VEGF receptor 2 antibody induces sustained tumor regression without overt toxicity. J. Clin. Invest. 105, R15-R24 (2000
    • (2000) J. Clin. Invest , vol.105 , pp. R15-R24
    • Klement, G.1
  • 74
    • 0035870297 scopus 로고    scopus 로고
    • The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2 methoxyestradiol but antagonized by endothelial growth factors
    • Sweeney, C. J., et al. The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2 methoxyestradiol but antagonized by endothelial growth factors. Cancer Res. 61, 3369-3372 (2001
    • (2001) Cancer Res , vol.61 , pp. 3369-3372
    • Sweeney, C.J.1
  • 75
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber, H. P., & Ferrara, N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res. 65, 671-680 (2005
    • (2005) Cancer Res , vol.65 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 76
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, R. K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307, 58-62 (2005
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 77
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett, C. G., et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat. Med. 10, 145-147 (2004
    • (2004) Nat. Med , vol.10 , pp. 145-147
    • Willett, C.G.1
  • 78
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar, F., et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. 21, 60-65 (2003
    • (2003) J. Clin. Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1
  • 79
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (folfox4) for previously treated metastatic colorectal cancer: Results from the eastern cooperative oncology group study e3200
    • Giantonio, B. J., et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J. Clin. Oncol. 25, 1539-1544 (2007
    • (2007) J. Clin. Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1
  • 80
    • 84871720057 scopus 로고    scopus 로고
    • Continuation of bevacizumab after first progression in metastatic colorectal cancer (ml18147): A randomised phase 3 trial
    • Bennouna, J., et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised Phase 3 trial. Lancet Oncol. 14, 29-37 (2013
    • (2013) Lancet Oncol , vol.14 , pp. 29-37
    • Bennouna, J.1
  • 81
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell-lung cancer
    • Sandler, A., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell-lung cancer. N. Engl. J. Med. 355, 2542-2550 (2006
    • (2006) N. Engl. J. Med , vol.355 , pp. 2542-2550
    • Sandler, A.1
  • 82
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-VEGF antibody, for metastatic renal cancer
    • Yang, J. C., et al. A randomized trial of bevacizumab, an anti-VEGF antibody, for metastatic renal cancer. N. Engl. J. Med. 349, 427-434 (2003
    • (2003) N. Engl. J. Med , vol.349 , pp. 427-434
    • Yang, J.C.1
  • 83
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini, B. I., et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J. Clin. Oncol. 26, 5422-5428 (2008
    • (2008) J. Clin. Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1
  • 84
    • 77952300540 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa 2a in patients with metastatic renal cell carcinoma (AVOREN): Final analysis of overall survival
    • Escudier, B., et al. Phase III trial of bevacizumab plus interferon alfa 2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J. Clin. Oncol. 28, 2144-2150 (2010
    • (2010) J. Clin. Oncol , vol.28 , pp. 2144-2150
    • Escudier, B.1
  • 85
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • Friedman, H. S., et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J. Clin. Oncol. 27, 4733-4740 (2009
    • (2009) J. Clin. Oncol , vol.27 , pp. 4733-4740
    • Friedman, H.S.1
  • 86
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl, T. N., et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J. Clin. Oncol. 27, 740-745 (2009
    • (2009) J. Clin. Oncol , vol.27 , pp. 740-745
    • Kreisl, T.N.1
  • 87
    • 84894194756 scopus 로고    scopus 로고
    • Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
    • Chinot, O. L., et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N. Engl. J. Med. 370, 709-722 (2014
    • (2014) N. Engl. J. Med , vol.370 , pp. 709-722
    • Chinot, O.L.1
  • 88
    • 84894114159 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab for newly diagnosed glioblastoma
    • Gilbert, M. R., et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N. Engl. J. Med. 370, 699-708 (2014
    • (2014) N. Engl. J. Med , vol.370 , pp. 699-708
    • Gilbert, M.R.1
  • 89
    • 84894207820 scopus 로고    scopus 로고
    • Improved survival with bevacizumab in advanced cervical cancer
    • Tewari, K. S., et al. Improved survival with bevacizumab in advanced cervical cancer. N. Engl. J. Med. 370, 734-743 (2014
    • (2014) N. Engl. J. Med , vol.370 , pp. 734-743
    • Tewari, K.S.1
  • 90
    • 84899837376 scopus 로고    scopus 로고
    • Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized Phase III trial
    • Pujade-Lauraine, E., et al. Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: the AURELIA open-label randomized Phase III trial. J. Clin. Oncol. 32, 1302-1308 (2014
    • (2014) J. Clin. Oncol , vol.32 , pp. 1302-1308
    • Pujade-Lauraine, E.1
  • 91
    • 84861736119 scopus 로고    scopus 로고
    • Oceans: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
    • Aghajanian, C., et al. OCEANS: a randomized, double-blind, placebo-controlled Phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J. Clin. Oncol. 30, 2039-2045 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 2039-2045
    • Aghajanian, C.1
  • 92
    • 84855425106 scopus 로고    scopus 로고
    • Incorporation of bevacizumab in the primary treatment of ovarian cancer
    • Burger, R. A., et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N. Engl. J. Med. 365, 2473-2483 (2011
    • (2011) N. Engl. J. Med , vol.365 , pp. 2473-2483
    • Burger, R.A.1
  • 93
    • 67651173054 scopus 로고    scopus 로고
    • Hearing improvement after bevacizumab in patients with neurofibromatosis type 2
    • Plotkin, S. R., et al. Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N. Engl. J. Med. 361, 358-367 (2009
    • (2009) N. Engl. J. Med , vol.361 , pp. 358-367
    • Plotkin, S.R.1
  • 94
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller, K., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N. Engl. J. Med. 357, 2666-2676 (2007
    • (2007) N. Engl. J. Med , vol.357 , pp. 2666-2676
    • Miller, K.1
  • 95
    • 81155123190 scopus 로고    scopus 로고
    • Ribbon 2: A randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2 negative metastatic breast cancer
    • Brufsky, A. M., et al. RIBBON 2: a randomized, double-blind, placebo-controlled, Phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2 negative metastatic breast cancer. J. Clin. Oncol. 29, 4286-4293 (2011
    • (2011) J. Clin. Oncol , vol.29 , pp. 4286-4293
    • Brufsky, A.M.1
  • 96
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON 1: Randomized, double-blind, placebo-controlled, Phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2 negative, locally recurrent or metastatic breast cancer
    • Robert, N. J., et al. RIBBON 1: randomized, double-blind, placebo-controlled, Phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2 negative, locally recurrent or metastatic breast cancer. J. Clin. Oncol. 29, 1252-1260 (2011
    • (2011) J. Clin. Oncol , vol.29 , pp. 1252-1260
    • Robert, N.J.1
  • 97
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2 negative metastatic breast cancer
    • Miles, D. W., et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2 negative metastatic breast cancer. J. Clin. Oncol. 28, 3239-3247 (2010
    • (2010) J. Clin. Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1
  • 99
    • 79551521053 scopus 로고    scopus 로고
    • Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: Results of NSABP protocol C-08
    • Allegra, C. J., et al. Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J. Clin. Oncol. 29, 11-16 (2011
    • (2011) J. Clin. Oncol , vol.29 , pp. 11-16
    • Allegra, C.J.1
  • 100
    • 84873328631 scopus 로고    scopus 로고
    • Bevacizumab in stage II III colon cancer: 5 year update of the national surgical adjuvant breast and bowel project c-08 trial
    • Allegra, C. J., et al. Bevacizumab in stage II III colon cancer: 5 year update of the National Surgical Adjuvant Breast and Bowel Project C-08 trial. J. Clin. Oncol. 31, 359-364 (2013
    • (2013) J. Clin. Oncol , vol.31 , pp. 359-364
    • Allegra, C.J.1
  • 101
    • 84870244259 scopus 로고    scopus 로고
    • Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): A Phase 3 randomised controlled trial
    • De Gramont, A., et al. Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a Phase 3 randomised controlled trial. Lancet Oncol. 13, 1225-1233 (2012
    • (2012) Lancet Oncol , vol.13 , pp. 1225-1233
    • De Gramont, A.1
  • 102
    • 84937120961 scopus 로고    scopus 로고
    • Personalizing colon cancer adjuvant therapy: Selecting optimal treatments for individual patients
    • Dienstmann, R., Salazar, R., & Tabernero, J. Personalizing colon cancer adjuvant therapy: selecting optimal treatments for individual patients. J. Clin. Oncol. 33, 1787-1796 (2015
    • (2015) J. Clin. Oncol , vol.33 , pp. 1787-1796
    • Dienstmann, R.1    Salazar, R.2    Tabernero, J.3
  • 103
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • Gschwind, A., Fischer, O. M., & Ullrich, A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat. Rev. Cancer 4, 361-370 (2004
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 104
    • 8944248812 scopus 로고    scopus 로고
    • Flk 1 as a target for tumor growth inhibition
    • Strawn, L. M., et al. Flk 1 as a target for tumor growth inhibition. Cancer Res. 56, 3540-3545 (1996
    • (1996) Cancer Res , vol.56 , pp. 3540-3545
    • Strawn, L.M.1
  • 105
    • 33746347333 scopus 로고    scopus 로고
    • Tyrphostins and other tyrosine kinase inhibitors
    • Levitzki, A., & Mishani, E. Tyrphostins and other tyrosine kinase inhibitors. Annu. Rev. Biochem. 75, 93-109 (2006
    • (2006) Annu. Rev. Biochem , vol.75 , pp. 93-109
    • Levitzki, A.1    Mishani, E.2
  • 106
    • 0033103867 scopus 로고    scopus 로고
    • Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: A key enzyme in angiogenesis
    • McTigue, M. A., et al. Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. Structure 7, 319-330 (1999
    • (1999) Structure , vol.7 , pp. 319-330
    • McTigue, M.A.1
  • 107
    • 84872243145 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: Views of selectivity, sensitivity, and clinical performance
    • Levitzki, A. Tyrosine kinase inhibitors: views of selectivity, sensitivity, and clinical performance. Annu. Rev. Pharmacol. Toxicol. 53, 161-185 (2013
    • (2013) Annu. Rev. Pharmacol. Toxicol , vol.53 , pp. 161-185
    • Levitzki, A.1
  • 109
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm, S. M., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64, 7099-7109 (2004
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1
  • 110
    • 33644684217 scopus 로고    scopus 로고
    • Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment
    • Strumberg, D. Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today (Barc) 41, 773-784 (2005
    • (2005) Drugs Today (Barc , vol.41 , pp. 773-784
    • Strumberg, D.1
  • 111
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier, B., et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356, 125-134 (2007
    • (2007) N. Engl. J. Med , vol.356 , pp. 125-134
    • Escudier, B.1
  • 112
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet, J. M., et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390 (2008
    • (2008) N. Engl. J. Med , vol.359 , pp. 378-390
    • Llovet, J.M.1
  • 113
    • 84904855170 scopus 로고    scopus 로고
    • Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, Phase 3 trial
    • Brose, M. S., et al. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, Phase 3 trial. Lancet 384, 319-328 (2014
    • (2014) Lancet , vol.384 , pp. 319-328
    • Brose, M.S.1
  • 114
    • 84890560584 scopus 로고    scopus 로고
    • An update on clinical trials of targeted therapies in thyroid cancer
    • Haraldsdottir, S., & Shah, M. H. An update on clinical trials of targeted therapies in thyroid cancer. Curr. Opin. Oncol. 26, 36-44 (2014
    • (2014) Curr. Opin. Oncol , vol.26 , pp. 36-44
    • Haraldsdottir, S.1    Shah, M.H.2
  • 115
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel, D. B., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. 9, 327-337 (2003
    • (2003) Clin. Cancer Res , vol.9 , pp. 327-337
    • Mendel, D.B.1
  • 116
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • Faivre, S., et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J. Clin. Oncol. 24, 25-35 (2006
    • (2006) J. Clin. Oncol , vol.24 , pp. 25-35
    • Faivre, S.1
  • 117
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer, R. J., et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 356, 115-124 (2007
    • (2007) N. Engl. J. Med , vol.356 , pp. 115-124
    • Motzer, R.J.1
  • 118
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E., & Hanahan, D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111, 1287-1295 (2003
    • (2003) J. Clin. Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 119
    • 79851482955 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
    • Raymond, E., et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N. Engl. J. Med. 364, 501-513 (2011
    • (2011) N. Engl. J. Med , vol.364 , pp. 501-513
    • Raymond, E.1
  • 120
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized Phase III trial
    • Sternberg, C. N., et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized Phase III trial. J. Clin. Oncol. 28, 1061-1068 (2010
    • (2010) J. Clin. Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1
  • 121
    • 84891526313 scopus 로고    scopus 로고
    • Pazopanib versus sunitinib in renal cancer
    • Motzer, R. J., McCann, L., & Deen, K. Pazopanib versus sunitinib in renal cancer. N. Engl. J. Med. 369, 1970 (2013
    • (2013) N. Engl. J. Med , vol.369 , pp. 1970
    • Motzer, R.J.1    McCann, L.2    Deen, K.3
  • 122
    • 58149337448 scopus 로고    scopus 로고
    • Nonclinical antiangiogenesis and antitumor activities of axitinib (AG 013736) an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1 2 3
    • Hu Lowe, D. D., et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG 013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin. Cancer Res. 14, 7272-7283 (2008
    • (2008) Clin. Cancer Res , vol.14 , pp. 7272-7283
    • Hu Lowe, D.D.1
  • 123
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised Phase 3 trial
    • Rini, B. I., et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised Phase 3 trial. Lancet 378, 1931-1939 (2011
    • (2011) Lancet , vol.378 , pp. 1931-1939
    • Rini, B.I.1
  • 124
    • 79954499886 scopus 로고    scopus 로고
    • Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
    • Wilhelm, S. M., et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int. J. Cancer 129, 245-255 (2011
    • (2011) Int. J. Cancer , vol.129 , pp. 245-255
    • Wilhelm, S.M.1
  • 125
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (correct): An international, multicentre, randomised, placebo-controlled, Phase 3 trial
    • Grothey, A., et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, Phase 3 trial. Lancet 381, 303-312 (2013
    • (2013) Lancet , vol.381 , pp. 303-312
    • Grothey, A.1
  • 126
    • 80051713290 scopus 로고    scopus 로고
    • Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: A Phase III, randomized, open-label trial
    • Robert, N. J., et al. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a Phase III, randomized, open-label trial. Clin. Breast Cancer 11, 82-92 (2011
    • (2011) Clin. Breast Cancer , vol.11 , pp. 82-92
    • Robert, N.J.1
  • 127
    • 84860625265 scopus 로고    scopus 로고
    • First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: Results of a prospective, randomized Phase III study
    • Bergh, J., et al. First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: results of a prospective, randomized Phase III study. J. Clin. Oncol. 30, 921-929 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 921-929
    • Bergh, J.1
  • 128
    • 84876089340 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: A randomized, Phase III trial
    • Carrato, A., et al. Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized, Phase III trial. J. Clin. Oncol. 31, 1341-1347 (2013
    • (2013) J. Clin. Oncol , vol.31 , pp. 1341-1347
    • Carrato, A.1
  • 129
    • 84867115561 scopus 로고    scopus 로고
    • Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: A double-blind, randomized Phase III study (HORIZON III
    • Schmoll, H. J., et al. Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized Phase III study (HORIZON III). J. Clin. Oncol. 30, 3588-3595 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 3588-3595
    • Schmoll, H.J.1
  • 130
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos, J. M., et al. Accelerated metastasis after short term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15, 232-239 (2009
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1
  • 131
    • 84874254425 scopus 로고    scopus 로고
    • Sunitinib does not accelerate tumor growth in patients with metastatic renal cell carcinoma
    • Blagoev, K. B., et al. Sunitinib does not accelerate tumor growth in patients with metastatic renal cell carcinoma. Cell Rep. 3, 277-281 (2013
    • (2013) Cell Rep , vol.3 , pp. 277-281
    • Blagoev, K.B.1
  • 132
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg, F., et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68, 4774-4782 (2008
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1
  • 133
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): A Phase 3, double-blind, randomised controlled trial
    • Reck, M., et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a Phase 3, double-blind, randomised controlled trial. Lancet Oncol. 15, 143-155 (2014
    • (2014) Lancet Oncol , vol.15 , pp. 143-155
    • Reck, M.1
  • 134
    • 84901810710 scopus 로고    scopus 로고
    • Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
    • Richeldi, L., et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N. Engl. J. Med. 370, 2071-2082 (2014
    • (2014) N. Engl. J. Med , vol.370 , pp. 2071-2082
    • Richeldi, L.1
  • 135
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem, E., et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a Phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J. Clin. Oncol. 30, 3499-3506 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 3499-3506
    • Van Cutsem, E.1
  • 136
    • 84888098804 scopus 로고    scopus 로고
    • Aflibercept in the treatment of patients with metastatic colorectal cancer: Latest findings and interpretations
    • Tang, P. A., & Moore, M. J. Aflibercept in the treatment of patients with metastatic colorectal cancer: latest findings and interpretations. Therap. Adv. Gastroenterol. 6, 459-473 (2013
    • (2013) Therap. Adv. Gastroenterol , vol.6 , pp. 459-473
    • Tang, P.A.1    Moore, M.J.2
  • 137
    • 79960111080 scopus 로고    scopus 로고
    • Phase II study of aflibercept in recurrent malignant glioma: A North American brain tumor consortium study
    • De Groot, J. F., et al. Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J. Clin. Oncol. 29, 2689-2695 (2011
    • (2011) J. Clin. Oncol , vol.29 , pp. 2689-2695
    • De Groot, J.F.1
  • 138
    • 84867602821 scopus 로고    scopus 로고
    • Aflibercept and docetaxel versus docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: A randomized, controlled Phase III trial
    • Ramlau, R., et al. Aflibercept and docetaxel versus docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: a randomized, controlled Phase III trial. J. Clin. Oncol. 30, 3640-3647 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 3640-3647
    • Ramlau, R.1
  • 139
    • 84871622982 scopus 로고    scopus 로고
    • Ziv-aflibercept: Binding to more than VEGF A -does more matter?
    • Clarke, J. M., & Hurwitz, H. I. Ziv-aflibercept: binding to more than VEGF A -does more matter? Nat. Rev. Clin. Oncol. 10, 10-11 (2013
    • (2013) Nat. Rev. Clin. Oncol , vol.10 , pp. 10-11
    • Clarke, J.M.1    Hurwitz, H.I.2
  • 140
    • 35548982639 scopus 로고    scopus 로고
    • Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
    • Fischer, C., et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131, 463-475 (2007
    • (2007) Cell , vol.131 , pp. 463-475
    • Fischer, C.1
  • 141
    • 77950953984 scopus 로고    scopus 로고
    • PlGF blockade does not inhibit angiogenesis during primary tumor growth
    • Bais, C., et al. PlGF blockade does not inhibit angiogenesis during primary tumor growth. Cell 141, 166-177 (2010
    • (2010) Cell , vol.141 , pp. 166-177
    • Bais, C.1
  • 142
    • 84892852372 scopus 로고    scopus 로고
    • Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (regard): An international, randomised, multicentre, placebo controlled, phase 3 trial
    • Fuchs, C. S., et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo controlled, Phase 3 trial. Lancet 383, 31-39 (2013
    • (2013) Lancet , vol.383 , pp. 31-39
    • Fuchs, C.S.1
  • 143
    • 84908139963 scopus 로고    scopus 로고
    • Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (rainbow): A double-blind, randomised phase 3 trial
    • Wilke, H., et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised Phase 3 trial. Lancet Oncol. 15, 1224-1235 (2014
    • (2014) Lancet Oncol , vol.15 , pp. 1224-1235
    • Wilke, H.1
  • 144
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): A multicentre, double-blind, randomised Phase 3 trial
    • Garon, E. B., et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised Phase 3 trial. Lancet 384, 665-673 (2014
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1
  • 145
    • 84933673498 scopus 로고    scopus 로고
    • Ramucirumab versus placebo in combination with second-line folfiri in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (raise): A randomised, double-blind, multicentre, phase 3 study
    • Tabernero, J., et al. Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, Phase 3 study. Lancet Oncol. 16, 499-508 (2015
    • (2015) Lancet Oncol , vol.16 , pp. 499-508
    • Tabernero, J.1
  • 146
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled Phase III trial
    • Motzer, R. J., et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled Phase III trial. Lancet 372, 449-456 (2008
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1
  • 147
    • 84866693927 scopus 로고    scopus 로고
    • Controlling escape from angiogenesis inhibitors
    • Sennino, B., & McDonald, D. M. Controlling escape from angiogenesis inhibitors. Nat. Rev. Cancer 12, 699-709 (2012
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 699-709
    • Sennino, B.1    McDonald, D.M.2
  • 148
    • 84863754907 scopus 로고    scopus 로고
    • VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
    • Lu, K. V., et al. VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell 22, 21-35 (2012
    • (2012) Cancer Cell , vol.22 , pp. 21-35
    • Lu, K.V.1
  • 149
    • 84992357897 scopus 로고    scopus 로고
    • Onartuzumab plus bevacizumab versus placebo in recurrent glioblastoma (GBM): HGF and MGMT biomarker data
    • Cloughesy, T., et al. Onartuzumab plus bevacizumab versus placebo in recurrent glioblastoma (GBM): HGF and MGMT biomarker data. Proc. Am. Soc. Clin. Oncol. 33, 2015 (2015
    • (2015) Proc. Am. Soc. Clin. Oncol , vol.33 , pp. 2015
    • Cloughesy, T.1
  • 150
    • 84959867957 scopus 로고    scopus 로고
    • Targeting MET and EGFR in NSCLC -what can we learn from the recently reported Phase III trial of onartuzumab in combination with erlotinib in advanced non-small cell lung cancer?
    • Charakidis, M., & Boyer, M. Targeting MET and EGFR in NSCLC -what can we learn from the recently reported Phase III trial of onartuzumab in combination with erlotinib in advanced non-small cell lung cancer? Transl. Lung Cancer Res. 3, 395-396 (2014
    • (2014) Transl. Lung Cancer Res , vol.3 , pp. 395-396
    • Charakidis, M.1    Boyer, M.2
  • 151
    • 84936797491 scopus 로고    scopus 로고
    • Phase 1 dose-escalation study of the antiplacental growth factor monoclonal antibody RO5323441 combined with bevacizumab in patients with recurrent glioblastoma
    • Lassen, U., et al. Phase 1 dose-escalation study of the antiplacental growth factor monoclonal antibody RO5323441 combined with bevacizumab in patients with recurrent glioblastoma. Neuro Oncol. 17, 1007-1015 (2015
    • (2015) Neuro Oncol , vol.17 , pp. 1007-1015
    • Lassen, U.1
  • 152
    • 84874760414 scopus 로고    scopus 로고
    • Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
    • Snuderl, M., et al. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 152, 1065-1076 (2013
    • (2013) Cell , vol.152 , pp. 1065-1076
    • Snuderl, M.1
  • 153
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat. Rev. Mol. Cell Biol. 10, 165-177 (2009
    • (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 154
    • 77954890371 scopus 로고    scopus 로고
    • Targeting the ANGPT-TIE2 pathway in malignancy
    • Huang, H., Bhat, A., Woodnutt, G., & Lappe, R. Targeting the ANGPT-TIE2 pathway in malignancy. Nat. Rev. Cancer 10, 575-585 (2010
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 575-585
    • Huang, H.1    Bhat, A.2    Woodnutt, G.3    Lappe, R.4
  • 155
    • 84924616997 scopus 로고    scopus 로고
    • Role of angiopoietin 2 in adaptive tumor resistance to VEGF signaling blockade
    • Rigamonti, N., et al. Role of angiopoietin 2 in adaptive tumor resistance to VEGF signaling blockade. Cell Rep. 8, 696-706 (2014
    • (2014) Cell Rep , vol.8 , pp. 696-706
    • Rigamonti, N.1
  • 156
    • 33845969276 scopus 로고    scopus 로고
    • Function blocking antibodies to neuropilin 1 generated from a designed human synthetic antibody phage library
    • Liang, W. C., et al. Function blocking antibodies to neuropilin 1 generated from a designed human synthetic antibody phage library. J. Mol. Biol. 366, 815-829 (2007
    • (2007) J. Mol. Biol , vol.366 , pp. 815-829
    • Liang, W.C.1
  • 157
    • 84883547665 scopus 로고    scopus 로고
    • Anti EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
    • Johnson, L., et al. Anti EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy. J. Clin. Invest. 123, 3997-4009 (2013
    • (2013) J. Clin. Invest , vol.123 , pp. 3997-4009
    • Johnson, L.1
  • 158
    • 21244450758 scopus 로고    scopus 로고
    • Association of k RAS, b RAF, and p53 status with the treatment effect of bevacizumab
    • Ince, W. L., et al. Association of k RAS, b RAF, and p53 status with the treatment effect of bevacizumab. J. Natl Cancer Inst. 97, 981-989 (2005
    • (2005) J. Natl Cancer Inst , vol.97 , pp. 981-989
    • Ince, W.L.1
  • 159
    • 84874095390 scopus 로고    scopus 로고
    • Predictive impact of circulating vascular endothelial growth factor in four Phase III trials evaluating bevacizumab
    • Hegde, P. S., et al. Predictive impact of circulating vascular endothelial growth factor in four Phase III trials evaluating bevacizumab. Clin. Cancer Res. 19, 929-937 (2013
    • (2013) Clin. Cancer Res , vol.19 , pp. 929-937
    • Hegde, P.S.1
  • 160
    • 79955767772 scopus 로고    scopus 로고
    • Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
    • Rini, B. I., et al. Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J. Natl Cancer Inst. 103, 763-773 (2011
    • (2011) J. Natl Cancer Inst , vol.103 , pp. 763-773
    • Rini, B.I.1
  • 161
    • 78649537524 scopus 로고    scopus 로고
    • Biomarkers to predict the clinical efficacy of bevacizumab in cancer
    • Jubb, A. M., & Harris, A. L. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. Lancet Oncol. 11, 1172-1183 (2010
    • (2010) Lancet Oncol , vol.11 , pp. 1172-1183
    • Jubb, A.M.1    Harris, A.L.2
  • 162
    • 84913610076 scopus 로고    scopus 로고
    • The search for biomarkers to direct antiangiogenic treatment in epithelial ovarian cancer
    • Secord, A. A., Nixon, A. B., & Hurwitz, H. I. The search for biomarkers to direct antiangiogenic treatment in epithelial ovarian cancer. Gynecol. Oncol. 135, 349-358 (2014
    • (2014) Gynecol. Oncol , vol.135 , pp. 349-358
    • Secord, A.A.1    Nixon, A.B.2    Hurwitz, H.I.3
  • 163
    • 74949090109 scopus 로고    scopus 로고
    • Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer
    • Hanrahan, E. O., et al. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J. Clin. Oncol. 28, 193-201 (2010
    • (2010) J. Clin. Oncol , vol.28 , pp. 193-201
    • Hanrahan, E.O.1
  • 164
    • 70350225520 scopus 로고    scopus 로고
    • Direct evidence that bevacizumab, an anti-VEGF antibody, up regulates SDF1α, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
    • Xu, L., et al. Direct evidence that bevacizumab, an anti-VEGF antibody, up regulates SDF1α, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res. 69, 7905-7910 (2009
    • (2009) Cancer Res , vol.69 , pp. 7905-7910
    • Xu, L.1
  • 165
    • 67650380136 scopus 로고    scopus 로고
    • Biomarkers of response and resistance to antiangiogenic therapy
    • Jain, R. K., et al. Biomarkers of response and resistance to antiangiogenic therapy. Nat. Rev. Clin. Oncol. 6, 327-338 (2009
    • (2009) Nat. Rev. Clin. Oncol , vol.6 , pp. 327-338
    • Jain, R.K.1
  • 166
    • 84879850441 scopus 로고    scopus 로고
    • Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies
    • Brauer, M. J., et al. Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies. Clin. Cancer Res. 19, 3681-3692 (2013
    • (2013) Clin. Cancer Res , vol.19 , pp. 3681-3692
    • Brauer, M.J.1
  • 167
    • 84907591274 scopus 로고    scopus 로고
    • Genetic variability of VEGF pathway genes in six randomized Phase III trials assessing the addition of bevacizumab to standard therapy
    • De Haas, S., et al. Genetic variability of VEGF pathway genes in six randomized Phase III trials assessing the addition of bevacizumab to standard therapy. Angiogenesis 17, 909-920 (2014
    • (2014) Angiogenesis , vol.17 , pp. 909-920
    • De Haas, S.1
  • 168
    • 0029900738 scopus 로고    scopus 로고
    • Quantitation and physiological characterization of angiogenic vessels in mice: Effect of basic fibroblast growth factor vascular endothelial growth factor/vascular permeability factor and host microenvironment [see comments
    • Dellian, M., Witwer, B. P., Salehi, H. A., Yuan, F., & Jain, R. K. Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment [see comments]. Am. J. Pathol. 149, 59-71 (1996
    • (1996) Am. J. Pathol , vol.149 , pp. 59-71
    • Dellian, M.1    Witwer, B.P.2    Salehi, H.A.3    Yuan, F.4    Jain, R.K.5
  • 169
    • 84941359544 scopus 로고    scopus 로고
    • Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: Retrospective analysis of the AVAglio trial
    • Sandmann, T., et al. Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: retrospective analysis of the AVAglio trial. J. Clin. Oncol. (2015
    • (2015) J. Clin. Oncol
    • Sandmann, T.1
  • 170
    • 80051625929 scopus 로고    scopus 로고
    • Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
    • Wagle, N., et al. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J. Clin. Oncol. 29, 3085-3096 (2011
    • (2011) J. Clin. Oncol , vol.29 , pp. 3085-3096
    • Wagle, N.1
  • 171
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: Insights from physiological angiogenesis
    • Chung, A. S., Lee, J., & Ferrara, N. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat. Rev. Cancer 10, 505-514 (2010
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 172
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    • Shojaei, F., et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat. Biotech. 25, 911-920 (2007
    • (2007) Nat. Biotech , vol.25 , pp. 911-920
    • Shojaei, F.1
  • 173
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    • Shojaei, F., et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450, 825-831 (2007
    • (2007) Nature , vol.450 , pp. 825-831
    • Shojaei, F.1
  • 174
    • 79958052123 scopus 로고    scopus 로고
    • MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy
    • Finke, J., et al. MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy. Int. Immunopharmacol. 11, 856-861 (2011
    • (2011) Int. Immunopharmacol , vol.11 , pp. 856-861
    • Finke, J.1
  • 175
    • 77549088772 scopus 로고    scopus 로고
    • Pathways mediating VEGF-independent tumor angiogenesis
    • Ferrara, N. Pathways mediating VEGF-independent tumor angiogenesis. Cytokine Growth Factor Rev. 21, 21-26 (2010
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 21-26
    • Ferrara, N.1
  • 176
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes, M., et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220-231 (2009
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1
  • 177
    • 84863715967 scopus 로고    scopus 로고
    • Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models
    • Singh, M., et al. Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J. Pathol. 227, 417-430 (2012
    • (2012) J. Pathol , vol.227 , pp. 417-430
    • Singh, M.1
  • 178
    • 84863718886 scopus 로고    scopus 로고
    • Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors
    • Chung, A. S., et al. Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J. Pathol. 227, 404-416 (2012
    • (2012) J. Pathol , vol.227 , pp. 404-416
    • Chung, A.S.1
  • 179
    • 84947244281 scopus 로고    scopus 로고
    • Nintedanib is a highly effective therapeutic for neuroendocrine carcinoma of the pancreas (PNET) in the Rip1Tag2 transgenic mouse model
    • Bill, R., et al. Nintedanib is a highly effective therapeutic for neuroendocrine carcinoma of the pancreas (PNET) in the Rip1Tag2 transgenic mouse model. Clin. Cancer Res. 21, 4856-4865 (2015
    • (2015) Clin. Cancer Res , vol.21 , pp. 4856-4865
    • Bill, R.1
  • 180
    • 79951983770 scopus 로고    scopus 로고
    • Disease course patterns after discontinuation of bevacizumab: Pooled analysis of randomized Phase III trials
    • Miles, D., et al. Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized Phase III trials. J. Clin. Oncol. 29, 83-88 (2011
    • (2011) J. Clin. Oncol , vol.29 , pp. 83-88
    • Miles, D.1
  • 181
    • 84863691378 scopus 로고    scopus 로고
    • Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
    • Singh, M., & Ferrara, N. Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat. Biotech. 30, 648-657 (2012
    • (2012) Nat. Biotech , vol.30 , pp. 648-657
    • Singh, M.1    Ferrara, N.2
  • 182
    • 0002418099 scopus 로고    scopus 로고
    • eds Garner, A., & Klintworth, G. K.) Marcel Dekker
    • Garner, A. in Pathobiology of Ocular Disease (eds Garner, A., & Klintworth, G. K.) 1625-1710 (Marcel Dekker, 1994
    • Pathobiology of Ocular Disease , vol.1994 , pp. 1625-1710
    • Garner, A.1
  • 183
    • 0000230096 scopus 로고
    • The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders
    • Michaelson, I. C. The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders. Trans. Ophthalmol. Soc. UK 68, 137-180 (1948
    • (1948) Trans. Ophthalmol. Soc. UK , vol.68 , pp. 137-180
    • Michaelson, I.C.1
  • 184
    • 0000283010 scopus 로고
    • Observations on the choroidal circulation
    • Ashton, N. Observations on the choroidal circulation. Br. J. Ophthalmol. 36, 465-481 (1952
    • (1952) Br. J. Ophthalmol , vol.36 , pp. 465-481
    • Ashton, N.1
  • 185
    • 0000786901 scopus 로고
    • Retinal neovascularization
    • Wise, G. N. Retinal neovascularization. Trans. Am. Ophthalmol. Soc. 54, 729-826 (1956
    • (1956) Trans. Am. Ophthalmol. Soc , vol.54 , pp. 729-826
    • Wise, G.N.1
  • 186
    • 0027225863 scopus 로고
    • Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells
    • Adamis, A. P., et al. Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun. 193, 631-638 (1993
    • (1993) Biochem. Biophys. Res. Commun , vol.193 , pp. 631-638
    • Adamis, A.P.1
  • 187
    • 0028145249 scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model
    • Miller, J. W., et al. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am. J. Pathol. 145, 574-584 (1994
    • (1994) Am. J. Pathol , vol.145 , pp. 574-584
    • Miller, J.W.1
  • 188
    • 0027962667 scopus 로고
    • Detection of vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy
    • Malecaze, F., et al. Detection of vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch. Ophthalmol. 112, 1476-1482 (1994
    • (1994) Arch. Ophthalmol , vol.112 , pp. 1476-1482
    • Malecaze, F.1
  • 189
    • 0029739620 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate
    • Tolentino, M. J., et al. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch. Ophthalmol. 114, 964-970 (1996
    • (1996) Arch. Ophthalmol , vol.114 , pp. 964-970
    • Tolentino, M.J.1
  • 190
    • 0035106148 scopus 로고    scopus 로고
    • Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium
    • Schwesinger, C., et al. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am. J. Pathol. 158, 1161-1172 (2001
    • (2001) Am. J. Pathol , vol.158 , pp. 1161-1172
    • Schwesinger, C.1
  • 191
    • 0036129304 scopus 로고    scopus 로고
    • Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
    • Krzystolik, M. G., et al. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch. Ophthalmol. 120, 338-346 (2002
    • (2002) Arch. Ophthalmol , vol.120 , pp. 338-346
    • Krzystolik, M.G.1
  • 192
    • 0034854865 scopus 로고    scopus 로고
    • VEGF-initiated blood-retinal barrier breakdown in early diabetes
    • Qaum, T., et al. VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest. Ophthalmol. Vis. Sci. 42, 2408-2413 (2001
    • (2001) Invest. Ophthalmol. Vis. Sci , vol.42 , pp. 2408-2413
    • Qaum, T.1
  • 193
    • 84872021668 scopus 로고    scopus 로고
    • Vascular endothelial growth factor A in intraocular vascular disease
    • Miller, J. W., Le Couter, J., Strauss, E. C., & Ferrara, N. Vascular endothelial growth factor A in intraocular vascular disease. Ophthalmology 120, 106-114 (2013
    • (2013) Ophthalmology , vol.120 , pp. 106-114
    • Miller, J.W.1    Le Couter, J.2    Strauss, E.C.3    Ferrara, N.4
  • 194
    • 11144239923 scopus 로고    scopus 로고
    • Pegaptanib for neovascular age-related macular degeneration
    • Gragoudas, E. S., et al. Pegaptanib for neovascular age-related macular degeneration. N. Engl. J. Med. 351, 2805-2816 (2004
    • (2004) N. Engl. J. Med , vol.351 , pp. 2805-2816
    • Gragoudas, E.S.1
  • 195
    • 0032979775 scopus 로고    scopus 로고
    • Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody
    • Ryan, A. M., et al. Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody. Toxicol. Pathol. 27, 78-86 (1999
    • (1999) Toxicol. Pathol , vol.27 , pp. 78-86
    • Ryan, A.M.1
  • 196
    • 0030003260 scopus 로고    scopus 로고
    • Once-weekly intraocular injections of ganciclovir for maintenance therapy of cytomegalovirus retinitis: Clinical and ocular outcome
    • Hodge, W. G., Lalonde, R. G., Sampalis, J., & Deschenes, J. Once-weekly intraocular injections of ganciclovir for maintenance therapy of cytomegalovirus retinitis: clinical and ocular outcome. J. Infect. Dis. 174, 393-396 (1996
    • (1996) J. Infect. Dis , vol.174 , pp. 393-396
    • Hodge, W.G.1    Lalonde, R.G.2    Sampalis, J.3    Deschenes, J.4
  • 197
    • 33749632278 scopus 로고    scopus 로고
    • Developmemt of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • Ferrara, N., Damico, L., Shams, N., Lowman, H., & Kim, R. Developmemt of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina 26, 859-870 (2006
    • (2006) Retina , vol.26 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3    Lowman, H.4    Kim, R.5
  • 198
    • 0032864292 scopus 로고    scopus 로고
    • Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration
    • Mordenti, J., et al. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol. Pathol. 27, 536-544 (1999
    • (1999) Toxicol. Pathol , vol.27 , pp. 536-544
    • Mordenti, J.1
  • 199
    • 0029731813 scopus 로고    scopus 로고
    • Fc receptors and their interactions with immunoglobulins
    • Raghavan, M., & Bjorkman, P. J. Fc receptors and their interactions with immunoglobulins. Annu. Rev. Cell Dev. Biol. 12, 181-220 (1996
    • (1996) Annu. Rev. Cell Dev. Biol , vol.12 , pp. 181-220
    • Raghavan, M.1    Bjorkman, P.J.2
  • 200
    • 0036240463 scopus 로고    scopus 로고
    • Future of monoclonal antibodies in the treatment of hematologic malignancies
    • Reff, M. E., Hariharan, K., & Braslawsky, G. Future of monoclonal antibodies in the treatment of hematologic malignancies. Cancer Control 9, 152-166 (2002
    • (2002) Cancer Control , vol.9 , pp. 152-166
    • Reff, M.E.1    Hariharan, K.2    Braslawsky, G.3
  • 201
    • 33947146094 scopus 로고    scopus 로고
    • Ophthalmic timolol: Plasma concentration and systemic cardiopulmonary effects
    • Nieminen, T., et al. Ophthalmic timolol: plasma concentration and systemic cardiopulmonary effects. Scand. J. Clin. Lab Invest. 67, 237-245 (2007
    • (2007) Scand. J. Clin. Lab Invest , vol.67 , pp. 237-245
    • Nieminen, T.1
  • 202
    • 0030993418 scopus 로고    scopus 로고
    • Antibody humanization using monovalent phage display
    • Baca, M., Presta, L. G., O'Connor, S. J., & Wells, J. A. Antibody humanization using monovalent phage display. J. Biol. Chem. 272, 10678-10684 (1997
    • (1997) J. Biol. Chem , vol.272 , pp. 10678-10684
    • Baca, M.1    Presta, L.G.2    O'Connor, S.J.3    Wells, J.A.4
  • 203
    • 0032530717 scopus 로고    scopus 로고
    • VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 a resolution and mutational analysis of the interface
    • Muller, Y. A., et al. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 a resolution and mutational analysis of the interface. Structure 6, 1153-1167 (1998
    • (1998) Structure , vol.6 , pp. 1153-1167
    • Muller, Y.A.1
  • 204
    • 13944266313 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration
    • Gaudreault, J., Fei, D., Rusit, J., Suboc, P., & Shiu, V. Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration. Invest. Ophthalmol. Vis. Sci. 46, 726-733 (2005
    • (2005) Invest. Ophthalmol. Vis. Sci , vol.46 , pp. 726-733
    • Gaudreault, J.1    Fei, D.2    Rusit, J.3    Suboc, P.4    Shiu, V.5
  • 205
    • 20144368709 scopus 로고    scopus 로고
    • Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration
    • Rosenfeld, P. J., et al. Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration. Ophthalmology 112, 1048-1053 (2005
    • (2005) Ophthalmology , vol.112 , pp. 1048-1053
    • Rosenfeld, P.J.1
  • 206
    • 33645641520 scopus 로고    scopus 로고
    • Ranibizumab for treatment of neovascular age-related macular degeneration: A Phase I/II multicenter, controlled, multidose study
    • Heier, J. S., et al. Ranibizumab for treatment of neovascular age-related macular degeneration: a Phase I/II multicenter, controlled, multidose study. Opthalmology 113, 633-642.e4 (2006
    • (2006) Opthalmology , vol.113 , pp. 633-633e4
    • Heier, J.S.1
  • 207
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld, P. J., et al. Ranibizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1419-1431 (2006
    • (2006) N. Engl. J. Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1
  • 208
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown, D. M., et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1432-1444 (2006
    • (2006) N. Engl. J. Med , vol.355 , pp. 1432-1444
    • Brown, D.M.1
  • 209
    • 57949094834 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the anchor study
    • Brown, D. M., et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology 116, 57-65.e5 (2009
    • (2009) Ophthalmology , vol.116 , pp. 57-57e5
    • Brown, D.M.1
  • 210
    • 77952910606 scopus 로고    scopus 로고
    • Significant improvements in near vision, reading speed, central visual field and related quality of life after ranibizumab treatment of wet age-related macular degeneration
    • Frennesson, C., Nilsson, U. L., Peebo, B. B., & Nilsson, S. E. Significant improvements in near vision, reading speed, central visual field and related quality of life after ranibizumab treatment of wet age-related macular degeneration. Acta Ophthalmol. 88, 420-425 (2010
    • (2010) Acta Ophthalmol , vol.88 , pp. 420-425
    • Frennesson, C.1    Nilsson, U.L.2    Peebo, B.B.3    Nilsson, S.E.4
  • 211
    • 38349172455 scopus 로고    scopus 로고
    • Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 1
    • Regillo, C. D., et al. Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 1. Am. J. Ophthalmol. 145, 239-248 (2008
    • (2008) Am. J. Ophthalmol , vol.145 , pp. 239-248
    • Regillo, C.D.1
  • 212
    • 79955631484 scopus 로고    scopus 로고
    • Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: The EXCITE study
    • Schmidt-Erfurth, U., et al. Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study. Ophthalmology 118, 831-839 (2011
    • (2011) Ophthalmology , vol.118 , pp. 831-839
    • Schmidt-Erfurth, U.1
  • 213
    • 84877759606 scopus 로고    scopus 로고
    • Twelve-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration
    • Busbee, B. G., et al. Twelve-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration. Ophthalmology 120, 1046-1056 (2013
    • (2013) Ophthalmology , vol.120 , pp. 1046-1056
    • Busbee, B.G.1
  • 214
    • 84905108373 scopus 로고    scopus 로고
    • Anti-VEGF treatment in neovascular age-related macular degeneration: A treat-and-extend protocol over 2 years
    • Abedi, F., Wickremasinghe, S., Islam, A. F., Inglis, K. M., & Guymer, R. H. Anti-VEGF treatment in neovascular age-related macular degeneration: a treat-and-extend protocol over 2 years. Retina 34, 1531-1538 (2014
    • (2014) Retina , vol.34 , pp. 1531-1538
    • Abedi, F.1    Wickremasinghe, S.2    Islam, A.F.3    Inglis, K.M.4    Guymer, R.H.5
  • 215
    • 79958720455 scopus 로고    scopus 로고
    • Estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization: Non-hispanic white population in the United States with age-related macular degeneration
    • Bressler, N. M., et al. Estimated cases of legal blindness and visual impairment avoided using ranibizumab for choroidal neovascularization: non-Hispanic white population in the United States with age-related macular degeneration. Arch. Ophthalmol. 129, 709-717 (2011
    • (2011) Arch. Ophthalmol , vol.129 , pp. 709-717
    • Bressler, N.M.1
  • 216
    • 77952889477 scopus 로고    scopus 로고
    • Ranibizumab for macular edema following central retinal vein occlusion: Six-month primary end point results of a Phase III study
    • Brown, D. M., et al. Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a Phase III study. Ophthalmology 117, 1124-1133.e1 (2010
    • (2010) Ophthalmology , vol.117 , pp. 1124-1124e1
    • Brown, D.M.1
  • 217
    • 77952891051 scopus 로고    scopus 로고
    • Ranibizumab for macular edema following branch retinal vein occlusion: Six-month primary end point results of a Phase III study
    • Campochiaro, P. A., et al. Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a Phase III study. Ophthalmology 117, 1102-1112.e1 (2010
    • (2010) Ophthalmology , vol.117 , pp. 1102-1102e1
    • Campochiaro, P.A.1
  • 218
    • 84863401792 scopus 로고    scopus 로고
    • Ranibizumab for diabetic macular edema: Results from 2 Phase III randomized trials: RISE and RIDE
    • Nguyen, Q. D., et al. Ranibizumab for diabetic macular edema: results from 2 Phase III randomized trials: RISE and RIDE. Ophthalmology 119, 789-801 (2012
    • (2012) Ophthalmology , vol.119 , pp. 789-801
    • Nguyen, Q.D.1
  • 219
    • 82755164498 scopus 로고    scopus 로고
    • Rationale for the diabetic retinopathy clinical research network treatment protocol for center-involved diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network et al
    • Diabetic Retinopathy Clinical Research Network., et al. Rationale for the diabetic retinopathy clinical research network treatment protocol for center-involved diabetic macular edema. Ophthalmology 118, e5-e14 (2011
    • (2011) Ophthalmology , vol.118 , pp. e5-e14
  • 220
    • 84867100215 scopus 로고    scopus 로고
    • Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: Results from the BRAVO and CRUISE trials
    • Varma, R., et al. Improved vision-related function after ranibizumab for macular edema after retinal vein occlusion: results from the BRAVO and CRUISE trials. Ophthalmology 119, 2108-2118 (2012
    • (2012) Ophthalmology , vol.119 , pp. 2108-2118
    • Varma, R.1
  • 221
    • 84885022258 scopus 로고    scopus 로고
    • Long-term outcomes of ranibizumab therapy for diabetic macular edema: The 36 month results from two Phase III trials: RISE and RIDE
    • Brown, D. M., et al. Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36 month results from two Phase III trials: RISE and RIDE. Ophthalmology 120, 2013-2022 (2013
    • (2013) Ophthalmology , vol.120 , pp. 2013-2022
    • Brown, D.M.1
  • 222
    • 84922239880 scopus 로고    scopus 로고
    • Vision-related function after ranibizumab treatment for diabetic macular edema: Results from RIDE and RISE
    • Bressler, N. M., et al. Vision-related function after ranibizumab treatment for diabetic macular edema: results from RIDE and RISE. Ophthalmology 121, 2461-2472 (2014
    • (2014) Ophthalmology , vol.121 , pp. 2461-2472
    • Bressler, N.M.1
  • 223
    • 84891631064 scopus 로고    scopus 로고
    • Long-term outcomes in patients with retinal vein occlusion treated with ranibizumab: The RETAIN study
    • Campochiaro, P. A., et al. Long-term outcomes in patients with retinal vein occlusion treated with ranibizumab: the RETAIN study. Ophthalmology 121, 209-219 (2014
    • (2014) Ophthalmology , vol.121 , pp. 209-219
    • Campochiaro, P.A.1
  • 224
    • 79953299899 scopus 로고    scopus 로고
    • Expanded 2 year follow up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    • Elman, M. J., et al. Expanded 2 year follow up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 118, 609-614 (2011
    • (2011) Ophthalmology , vol.118 , pp. 609-614
    • Elman, M.J.1
  • 225
    • 84868208071 scopus 로고    scopus 로고
    • Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: Three-year randomized trial results
    • Diabetic Retinopathy Clinical Research Network et al
    • Diabetic Retinopathy Clinical Research Network., et al. Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: three-year randomized trial results. Ophthalmology 119, 2312-2318 (2012
    • (2012) Ophthalmology , vol.119 , pp. 2312-2318
  • 226
    • 77952779304 scopus 로고    scopus 로고
    • Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network et al.
    • Diabetic Retinopathy Clinical Research Network., et al. Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 117, 1064-1077.e35 (2010
    • (2010) Ophthalmology , vol.117 , pp. 1064-1064e35
  • 227
    • 84922231142 scopus 로고    scopus 로고
    • Monthly versus as needed ranibizumab injections in patients with retinal vein occlusion: The SHORE study
    • Campochiaro, P. A., et al. Monthly versus as needed ranibizumab injections in patients with retinal vein occlusion: the SHORE study. Ophthalmology 121, 2432-2442 (2014
    • (2014) Ophthalmology , vol.121 , pp. 2432-2442
    • Campochiaro, P.A.1
  • 228
    • 79956218863 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for neovascular age-related macular degeneration
    • Group, C. R., et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 364, 1897-1908 (2011
    • (2011) N. Engl. J. Med , vol.364 , pp. 1897-1908
    • Group, C.R.1
  • 229
    • 84863327423 scopus 로고    scopus 로고
    • Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: One-year findings from the IVAN randomized trial
    • IVAN Study Investigators et al
    • IVAN Study Investigators, et al. Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial. Ophthalmology 119, 1399-1411 (2012
    • (2012) Ophthalmology , vol.119 , pp. 1399-1411
  • 230
    • 84911988207 scopus 로고    scopus 로고
    • Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD
    • Avery, R. L., et al. Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD. Br. J. Ophthalmol. 98, 1636-1641 (2014
    • (2014) Br. J. Ophthalmol , vol.98 , pp. 1636-1641
    • Avery, R.L.1
  • 231
    • 84870723704 scopus 로고    scopus 로고
    • Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration
    • Heier, J. S., et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology 119, 2537-2548 (2012
    • (2012) Ophthalmology , vol.119 , pp. 2537-2548
    • Heier, J.S.1
  • 232
    • 84925423332 scopus 로고    scopus 로고
    • Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network et al
    • Diabetic Retinopathy Clinical Research Network., et al. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N. Engl. J. Med. 372, 1193-1203 (2015
    • (2015) N. Engl. J. Med , vol.372 , pp. 1193-1203
  • 233
    • 84926659796 scopus 로고    scopus 로고
    • Current Phase 1/2 research for neovascular age-related macular degeneration
    • Pecen, P. E., & Kaiser, P. K. Current Phase 1/2 research for neovascular age-related macular degeneration. Curr. Opin. Ophthalmol. 26, 188-193 (2015
    • (2015) Curr. Opin. Ophthalmol , vol.26 , pp. 188-193
    • Pecen, P.E.1    Kaiser, P.K.2
  • 234
    • 84921495108 scopus 로고    scopus 로고
    • Multi-country real-life experience of anti-vascular endothelial growth factor therapy for wet age-related macular degeneration
    • Holz, F. G., et al. Multi-country real-life experience of anti-vascular endothelial growth factor therapy for wet age-related macular degeneration. Br. J. Ophthalmol. 99, 220-226 (2015
    • (2015) Br. J. Ophthalmol , vol.99 , pp. 220-226
    • Holz, F.G.1
  • 235
    • 33744728068 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
    • Jo, N., et al. Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am. J. Pathol. 168, 2036-2053 (2006
    • (2006) Am. J. Pathol , vol.168 , pp. 2036-2053
    • Jo, N.1
  • 236
    • 77953530014 scopus 로고    scopus 로고
    • Combined inhibition of platelet derived (PDGF) and vascular endothelial (VEGF) growth factors for the treatment of neovascular age-related macular degeration (NV AMD) -results of a Phase i study
    • Boyer, D. S. Combined inhibition of platelet derived (PDGF) and vascular endothelial (VEGF) growth factors for the treatment of neovascular age-related macular degeration (NV AMD) -results of a Phase I study. Invest. Ophthalmol. Vis. Sci. 50, 1260 (2009
    • (2009) Invest. Ophthalmol. Vis. Sci , vol.50 , pp. 1260
    • Boyer, D.S.1
  • 237
    • 84897004083 scopus 로고    scopus 로고
    • A Phase 2b study of FovistaTM, a platelet derived growth factor (PDGF) inhibitor in combination with a vascular endothelial growth factor (VEGF) inhibitor for neovascular age-related macular degeneration (AMD
    • Boyer, D. S. A Phase 2b study of FovistaTM, a platelet derived growth factor (PDGF) inhibitor in combination with a vascular endothelial growth factor (VEGF) inhibitor for neovascular age-related macular degeneration (AMD). Invest. Ophthalmol. Vis. Sci. 54, 2175 (2013
    • (2013) Invest. Ophthalmol. Vis. Sci , vol.54 , pp. 2175
    • Boyer, D.S.1
  • 239
    • 34547702738 scopus 로고    scopus 로고
    • Vascular endothelial growth factor A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury
    • Nishijima, K., et al. Vascular endothelial growth factor A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. Am. J. Pathol. 171, 53-67 (2007
    • (2007) Am. J. Pathol , vol.171 , pp. 53-67
    • Nishijima, K.1
  • 240
    • 84863320414 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: Two-year results
    • Comparison of Age-related Macular Degeneration Treatments Trials Research Group., et al
    • Comparison of Age-related Macular Degeneration Treatments Trials Research Group., et al. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology 119, 1388-1398 (2012
    • (2012) Ophthalmology , vol.119 , pp. 1388-1398
  • 241
    • 77952509760 scopus 로고    scopus 로고
    • Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells
    • Miki, A., et al. Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells. J. Cell. Physiol. 224, 262-272 (2010
    • (2010) J. Cell. Physiol , vol.224 , pp. 262-272
    • Miki, A.1
  • 242
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • Boehm, T., Folkman, J., Browder, T., & O'Reilly, M. S. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390, 404-407 (1997
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 243
    • 84908465944 scopus 로고    scopus 로고
    • Twenty-four-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration
    • Ho, A. C., et al. Twenty-four-month efficacy and safety of 0.5 mg or 2.0 mg ranibizumab in patients with subfoveal neovascular age-related macular degeneration. Ophthalmology 121, 2181-2192 (2014
    • (2014) Ophthalmology , vol.121 , pp. 2181-2192
    • Ho, A.C.1
  • 244
    • 84856002562 scopus 로고    scopus 로고
    • Incidence of legal blindness from age-related macular degeneration in Denmark: Year 2000 to 2010
    • Bloch, S. B., Larsen, M., Munch, I. G. Incidence of legal blindness from age-related macular degeneration in Denmark: year 2000 to 2010. Am. J. Ophthalmol. 153, 209-213 (2012
    • (2012) Am. J. Ophthalmol , vol.153 , pp. 209-213
    • Bloch, S.B.1    Larsen, M.2    Munch, I.G.3
  • 245
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali, R. K., et al. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res. 70, 6171-6180 (2010
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1
  • 246
    • 84908134454 scopus 로고    scopus 로고
    • Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: A randomised Phase 2 study
    • Liu, J. F., et al. Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised Phase 2 study. Lancet Oncol. 15, 1207-1214 (2014
    • (2014) Lancet Oncol , vol.15 , pp. 1207-1214
    • Liu, J.F.1
  • 247
    • 84906690121 scopus 로고    scopus 로고
    • Guidelines for the management of neovascular age-related macular degeneration by the European society of retina specialists (euretina
    • Schmidt-Erfurth, U., et al. Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA). Br. J. Ophthalmol. 98, 1144-1167 (2014
    • (2014) Br. J. Ophthalmol , vol.98 , pp. 1144-1167
    • Schmidt-Erfurth, U.1
  • 248
    • 84892965801 scopus 로고    scopus 로고
    • Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis
    • Wong, W. L., et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob. Health 2, e106-e116 (2014
    • (2014) Lancet Glob. Health , vol.2 , pp. e106-e116
    • Wong, W.L.1
  • 249
    • 0021752680 scopus 로고
    • Age-related macular degeneration and blindness due to neovascular maculopathy
    • Ferris, F. L. 3rd, Fine, S. L., & Hyman, L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch. Ophthalmol. 102, 1640-1642 (1984
    • (1984) Arch. Ophthalmol , vol.102 , pp. 1640-1642
    • Ferris, F.L.1    Fine, S.L.2    Hyman, L.3
  • 250
    • 11144354339 scopus 로고    scopus 로고
    • Prevalence of age-related macular degeneration in the United States
    • Friedman, D. S., et al. Prevalence of age-related macular degeneration in the United States. Arch. Ophthalmol. 122, 564-572 (2004
    • (2004) Arch. Ophthalmol , vol.122 , pp. 564-572
    • Friedman, D.S.1
  • 251
    • 84859030420 scopus 로고    scopus 로고
    • Global prevalence and major risk factors of diabetic retinopathy
    • Yau, J. W., et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 35, 556-564 (2012
    • (2012) Diabetes Care , vol.35 , pp. 556-564
    • Yau, J.W.1
  • 252
    • 77953555650 scopus 로고    scopus 로고
    • Burden of illness of diabetic macular edema: Literature review
    • Chen, E., et al. Burden of illness of diabetic macular edema: literature review. Curr. Med. Res. Opin. 26, 1587-1597 (2010
    • (2010) Curr. Med. Res. Opin , vol.26 , pp. 1587-1597
    • Chen, E.1
  • 253
    • 75149172639 scopus 로고    scopus 로고
    • The prevalence of retinal vein occlusion: Pooled data from population studies from the United States, Europe, Asia, and Australia
    • e1
    • Rogers, S., et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 117, 313-319.e1 (2010
    • (2010) Ophthalmology , vol.117 , pp. 313-319
    • Rogers, S.1
  • 254
    • 84941218879 scopus 로고    scopus 로고
    • Long-term visual outcomes of intravitreal ranibizumab treatment for wet age-related macular degeneration and effect on blindness rates in south-east Scotland
    • Borooah, S., et al. Long-term visual outcomes of intravitreal ranibizumab treatment for wet age-related macular degeneration and effect on blindness rates in south-east Scotland. Eye (Lond.) 29, 1156-1161 (2015
    • (2015) Eye (Lond , vol.29 , pp. 1156-1161
    • Borooah, S.1
  • 255
    • 79953311138 scopus 로고    scopus 로고
    • The restore study: Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema
    • Mitchell, P., et al. The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology 118, 615-625 (2011
    • (2011) Ophthalmology , vol.118 , pp. 615-625
    • Mitchell, P.1
  • 256
    • 33747891752 scopus 로고    scopus 로고
    • Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration
    • Chakravarthy, U., et al. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration. Ophthalmology 113, 1508.e1-1508.e25 (2006
    • (2006) Ophthalmology , vol.113 , pp. 1508e1-1508e25
    • Chakravarthy, U.1
  • 257
    • 84873738185 scopus 로고    scopus 로고
    • Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1 year results from the phase 3 copernicus study
    • Brown, D. M., et al. Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1 year results from the Phase 3 COPERNICUS study. Am. J. Ophthalmol. 155, 429-437.e7 (2013
    • (2013) Am. J. Ophthalmol , vol.155 , pp. 429-429e7
    • Brown, D.M.1
  • 258
    • 84874647026 scopus 로고    scopus 로고
    • VEGF Trap-Eye for macular oedema secondary to central retinal vein occlusion: 6 month results of the Phase III GALILEO study
    • Holz, F. G., et al. VEGF Trap-Eye for macular oedema secondary to central retinal vein occlusion: 6 month results of the Phase III GALILEO study. Br. J. Ophthalmol. 97, 278-284 (2013
    • (2013) Br. J. Ophthalmol , vol.97 , pp. 278-284
    • Holz, F.G.1
  • 259
    • 84908897529 scopus 로고    scopus 로고
    • Intravitreal aflibercept for diabetic macular edema
    • Korobelnik, J. F., et al. Intravitreal aflibercept for diabetic macular edema. Ophthalmology 121, 2247-2254 (2014
    • (2014) Ophthalmology , vol.121 , pp. 2247-2254
    • Korobelnik, J.F.1
  • 260
    • 0026052391 scopus 로고
    • Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor
    • Maglione, D., Guerriero, V., Viglietto, G., Delli-Bovi, P., & Persico, M. G. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc. Natl Acad. Sci. USA 88, 9267-9271 (1991
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 9267-9271
    • Maglione, D.1    Guerriero, V.2    Viglietto, G.3    Delli-Bovi, P.4    Persico, M.G.5
  • 261
    • 9244227572 scopus 로고    scopus 로고
    • Vascular endothelial growth factor B, a novel growth factor for endothelial cells
    • Olofsson, B., et al. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc. Natl Acad. Sci. USA 93, 2576-2581 (1996
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 2576-2581
    • Olofsson, B.1
  • 262
    • 0030026897 scopus 로고    scopus 로고
    • A novel vascular endothelial growth factor, VEGF C, is a ligand for the Flt4 (VEGFR 3) and KDR (VEGFR 2) receptor tyrosine kinases
    • Joukov, V., et al. A novel vascular endothelial growth factor, VEGF C, is a ligand for the Flt4 (VEGFR 3) and KDR (VEGFR 2) receptor tyrosine kinases. EMBO J. 15, 290-298 (1996
    • (1996) EMBO J. , vol.15 , pp. 290-298
    • Joukov, V.1
  • 263
    • 0029859193 scopus 로고    scopus 로고
    • Identification of a c FOS-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family
    • erratum 94 1603 1997
    • Orlandini, M., Marconcini, L., Ferruzzi, R., & Oliviero, S. Identification of a c FOS-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family. Proc. Natl Acad. Sci. USA 93, 11675-11680 (1996); erratum 94, 1603 (1997
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 11675-11680
    • Orlandini, M.1    Marconcini, L.2    Ferruzzi, R.3    Oliviero, S.4
  • 264
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family
    • Shibuya, M., et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 8, 519-527 (1990
    • (1990) Oncogene , vol.8 , pp. 519-527
    • Shibuya, M.1
  • 265
    • 0025739016 scopus 로고
    • Identification of a new endothelial cell growth factor receptor tyrosine kinase
    • Terman, B. I., et al. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6, 1677-1683 (1991
    • (1991) Oncogene , vol.6 , pp. 1677-1683
    • Terman, B.I.1
  • 266
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki, D., Itin, A., Soffer, D., & Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843-845 (1992
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 267
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
    • Plate, K. H., Breier, G., Weich, H. A., & Risau, W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359, 845-848 (1992
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 268
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk 1 mutant
    • Millauer, B., Shawver, L. K., Plate, K. H., Risau, W., & Ullrich, A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk 1 mutant. Nature 367, 576-579 (1994
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 269
    • 0029021660 scopus 로고
    • Role of the Flt 1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong, G. H., Rossant, J., Gertsenstein, M., & Breitman, M. L. Role of the Flt 1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66-70 (1995
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 270
    • 0242468884 scopus 로고    scopus 로고
    • A Phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer
    • Cobleigh, M. A., et al. A Phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin. Oncol. 30, 117-124 (2003
    • (2003) Semin. Oncol , vol.30 , pp. 117-124
    • Cobleigh, M.A.1
  • 271
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer, R. J., et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295, 2516-2524 (2006
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1
  • 272
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri, G. D., et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368, 1329-1338 (2006
    • (2006) Lancet , vol.368 , pp. 1329-1338
    • Demetri, G.D.1
  • 273
    • 62449186539 scopus 로고    scopus 로고
    • Randomized Phase II trial of first-line treatment with sorafenib versus interferon alfa 2a in patients with metastatic renal cell carcinoma
    • Escudier, B., et al. Randomized Phase II trial of first-line treatment with sorafenib versus interferon alfa 2a in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27, 1280-1289 (2009
    • (2009) J. Clin. Oncol , vol.27 , pp. 1280-1289
    • Escudier, B.1
  • 274
    • 41249088330 scopus 로고    scopus 로고
    • Blocking neuropilin 2 function inhibits tumor cell metastasis
    • Caunt, M., et al. Blocking neuropilin 2 function inhibits tumor cell metastasis. Cancer Cell 13, 331-342 (2008
    • (2008) Cancer Cell , vol.13 , pp. 331-342
    • Caunt, M.1
  • 275
    • 0037423321 scopus 로고    scopus 로고
    • Angiogenesis-independent endothelial protection of liver: Role of VEGFR 1
    • LeCouter, J., et al. Angiogenesis-independent endothelial protection of liver: role of VEGFR 1. Science 299, 890-893 (2003
    • (2003) Science , vol.299 , pp. 890-893
    • LeCouter, J.1
  • 276
    • 79960984152 scopus 로고    scopus 로고
    • Expression of a functional VEGFR 1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy
    • Yao, J., et al. Expression of a functional VEGFR 1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy. Proc. Natl Acad. Sci. USA 108, 11590-11595 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 11590-11595
    • Yao, J.1
  • 277
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised Phase III trial (AVAiL
    • Reck, M., et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised Phase III trial (AVAiL). Ann. Oncol. 21, 1804-1809 (2010
    • (2010) Ann. Oncol , vol.21 , pp. 1804-1809
    • Reck, M.1
  • 278
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer, R. J., et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27, 3584-3590 (2009
    • (2009) J. Clin. Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1
  • 279
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the Phase III treatment approaches in renal cancer global evaluation trial
    • Escudier, B., et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the Phase III treatment approaches in renal cancer global evaluation trial. J. Clin. Oncol. 27, 3312-3318 (2009
    • (2009) J. Clin. Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.