Angiopoietin-2 in acute liver failure

Critical Care Medicine

Volumn 40, Issue 5, 2012, Pages 1499-1505

  Hadem, Johannes ^a   Bockmeyer, Clemens L ^a   Lukasz, Alexander ^a   Pischke, Sven ^a   Schneider, Andrea S ^a   Wedemeyer, Heiner ^a   Jonigk, Danny ^a   Manns, Michael P ^a   Kümpers, Philipp ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Acute hepatitis; disease severity score; hepatic failure; liver transplantation; multiple organ dysfunction syndrome

Indexed keywords

ANGIOPOIETIN 2;

ACUTE LIVER FAILURE; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HUMAN; MALE; MULTIPLE ORGAN FAILURE; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROTEIN SECRETION;

ADULT; ANGIOPOIETIN-2; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; LIVER; LIVER FAILURE, ACUTE; MALE; MULTIPLE ORGAN FAILURE; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC;

EID: 84860235284     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318241e34e     Document Type: Article

References (42)

1. Bernal W, Auzinger G, Dhawan A, et al: Acute liver failure. Lancet 2010; 376:190-201
2. Larsen FS, Bjerring PN: Acute liver failure. Current Opin Crit Care 2011; 17:160-164
3. Schmidt LE, Larsen FS: Blood lactate as a prognostic marker in acetaminopheninduced acute liver failure. Hepatology 2003; 37:1199-1201
4. McPhail MJW, Wendon JA, Bernal W: Metaanalysis of performance of Kings's College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure. J Hepatol 2010; 53:492-499
5. Hadem J, Stiefel P, Bahr MJ, et al: Prognostic implications of lactate, bilirubin and etiology in German patients with acute liver failure. Clin Gastroenterol Hepatol 2008; 6:339-345
6. Bernal W, Auzinger G, Wendon J: Prognostic utility of the bilirubin lactate and etiology score. Clin Gastroenterol Hepatol 2009; 7:249
7. Bechmann LP, Jochum C, Kocabayoglu P, et al: Cytokeratin 18-based modification of the MELD score improves prediction of spontaneous survival after acute liver injury. J Hepatol 2010; 53:639-647
8. Aird WC: Endothelium as an organ system. Crit Care Med 2004; 32:S271-S279
9. Augustin HG, Koh GY, Thurston G, et al: Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 2009; 10:165-177
10. Fiedler U, Reiss Y, Scharpfenecker M, et al: Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 2006; 12:235-239
11. Davis S, Aldrich TH, Jones PF, et al: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 1996; 87:1161-1169
12. Suri C, Jones PF, Patan S, et al: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996; 87:1171-1180
13. Thurston G, Suri C, Smith K, et al: Leakageresistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 1999; 286:2511-2514
14. Wong AL, Haroon ZA, Werner S, et al: Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ Res 1997; 81:567-574
15. Fiedler U, Scharpfenecker M, Koidl S, et al: The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 2004; 103:4150-4156
16. Fiedler U, Krissl T, Koidl S, et al: Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J Biol Chem 2003; 278:1721-1727
17. Parikh SM, Mammoto T, Schultz A, et al: Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med 2006; 3: 356-370
18. Roviezzo F, Tsigkos S, Kotanidou A, et al: Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage. J Pharmacol Exp Ther 2005; 314:738-744
19. Kumpers P, Lukasz A, David S, et al: Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients. Crit Care 2008; 12:R147
20. Kumpers P, Hafer C, David S, et al: Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: Relation to acute kidney injury, multiple organ dysfunction syndrome and outcome. Intensive Care Med 2010; 36:462-470
21. van der Heijden M, Nieuw Amerongen GP, Koolwijk P, et al: Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax 2008; 63:903-909
22. Ricciuto DR, dos Santos CC, Hawkes M, et al: Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med 2011; 39:702-710
23. David S, Ghosh CC, Kuempers P, et al: Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol 2011; 300:L851-L862
24. David S, Park JK, van Meurs MV, et al: Acute administration of recombinant Angiopoietin-1 ameliorates multipleorgan dysfunction syndrome and improves survival in murine sepsis. Cytokine 2011; 55:251-259
25. Huang YQ, Sauthoff H, Herscovici P, et al: Angiopoietin-1 increases survival and reduces the development of lung edema induced by endotoxin administration in a murine model of acute lung injury. Crit Care Med 2008; 36:262-267
26. Polson J, Lee WM: AASLD Position Paper: The management of acute liver failure. Hepatology 2005; 41:1179-1197
27. O'Grady JG, Alexander GJM, Hayllar KM, et al: Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989; 97:439-455
28. Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22:707-710
29. Moreno RP, Metnitz PGH, Almeida E, et al: SAPS 3-From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission. Intensive Care Medicine 2005; 31:1345-1355
30. Lee WM: Acute liver failure. N Engl J Med 1993; 329:1862-1872
31. Mehta RL, Kellum JA, Shah SV, et al: Acute kidney injury network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11:R31
32. Kumpers P, Nickel N, Lukasz A, et al: Circulating angiopoietins in idiopathic pulmonary arterial hypertension. Eur Heart J 2010; 31:2291-2300
33. Theophile K, Jonigk D, Kreipe H, et al: Amplification of mRNA from lasermicrodissected single or clustered cells in formalin-fixed and paraffin-embedded tissues for application in quantitative real-time PCR. Dign Mol Pathol 2008; 17:101-106
34. van Meurs M, Kumpers P, Ligtenberg JJ, et al: Bench-to-bedside review: Angiopoietin signalling in critical illness-A future target? Crit Care 2009; 13:207
35. Kumpers P, van Meurs M, David S, et al: Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis. Crit Care 2009; 13:R64
36. Orfanos SE, Kotanidou A, Glynos C, et al: Angiopoietin-2 is increased in severe sepsis: Correlation with inflammatory mediators. Crit Care Med 2007; 35:199-206
37. Sanz-Cameno P, Martin-Vilchez S, Lara-Pezzi E, et al: Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein. Am J Pathol 2006; 169:1215-1222
38. Escudie L, Francoz C, Vinel JP, et al: Amanita phalloides poisoning: reassessment of prognostic factors and indications for emergency liver transplantation. J Hepatol 2007; 46:466-473
39. Schmidt LE, Larsen FS: MELD score as a predictor of liver failure and death in patients with acetaminophen-induced liver injury. Hepatology 2007; 45:789-796
40. Nag S, Papneja T, Venugopalan R, et al: Increased angiopoietin2 expression is associated with endothelial apoptosis and blood-brain barrier breakdown. Lab Invest 2005; 85:1189-1198
41. Herbst RS, Hong D, Chap L, et al: Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 2009; 27:3557-3565
42. Scholz A, Rehm VA, Rieke S, et al: Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma. Am J Gastroenterol 2007; 102:2471-2481