Structure of the Tie2 RTK domain - Self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail

Structure

Volumn 8, Issue 11, 2000, Pages 1105-1113

  Shewchuk, Lisa M ^a   Hassell, Anne M ^a   Ellis, Byron ^a   Holmes, W D ^a   Davis, Roderick ^a   Horne, Earnest L ^a   Kadwell, Sue H ^a   McKee, David D ^a   Moore, John T ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Angiogenesis; Kinase insert domain; Signal transduction; Tek; Tyrosine kinase; X ray structure

Indexed keywords

ADENOSINE TRIPHOSPHATE; NUCLEOTIDE BINDING PROTEIN; PHOSPHATASE; PROTEIN TYROSINE KINASE; SERINE; THREONINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SUBSTITUTION; BLOOD VESSELS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GENES, DOMINANT; HUMANS; HYDROGEN BONDING; MASS SPECTROMETRY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034435424     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00516-5     Document Type: Article

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