Angiopoietin 2 expression in the retina: Upregulation during physiologic and pathologic neovascularization

Journal of Cellular Physiology

Volumn 184, Issue 3, 2000, Pages 275-284

  Hackett, Sean F ^a   Ozaki, Hiroaki ^a   Strauss, Rupert W ^a   Wahlin, Karl ^a   Suri, Chitra ^b   Maisonpierre, Peter ^b   Yancopoulos, George ^b   Campochiaro, Peter A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; BETA GALACTOSIDASE; CALBINDIN; MESSENGER RNA; RECEPTOR;

ANGIOGENESIS; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; GENE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA; RETINA NEOVASCULARIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

EID: 0033882191     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4652(200009)184:3<275::AID-JCP1>3.0.CO;2-7     Document Type: Review

References (51)

1. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
2. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization
3. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
4. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
5. Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
6. Retinal vascularization in health and disease
7. Calmodulin, calbindin-D28k, calretinin, and neurocalcin in rat olfactory bulb during postnatal development
8. Hippocalcin in rat retina: Comparison with calbindin-D28k, calretinin, and neurocalcin
9. Vascular atrophy in the retinal degenerative rd mouse
10. Angiogenesis in embryos and ischemic disease
11. Corneal endothelial cell matrix promotes expression of differentiated features of retinal pigmented epithelial cells: Implication of laminin and basic fibroblast growth factor as active components
12. Platelet-derived growth factor is an autocrine growth stimulator in retinal pigmented epithelial cells
13. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
14. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
15. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
16. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
17. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
18. Role of the fit-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
19. Signaling vascular morphogenesis and maintenance
20. Vision disorders in diabetes
21. Localization of vascular endothelial growth factor in human retina and choroid
22. Argon laser photoco-agulation for neovascular maculopathy: Five year results from randomized clinical trials
23. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
24. Blood vascular abnormalities in the degenerative mouse retina (C57BL/6J-rd le)
25. The mode of development of the vascular system of the retina with some observations on its significance for certain retinal diseases
26. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model
27. Extracellular matrix-integrin binding modulates secretion of angiogenic growth factors by retinal pigmented epithelial cells
28. Visual cell effects of high oxygen pressures
29. Hypoxia and vascular endothelial growth factor selectively upregulate angiopoietin-2 in bovine microvascular endothelial cells
30. Transgenic mice with increased expression of vascular endothelial growth factor in the retina: A new model of intraretinal and subretinal neovascularization
31. Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization
32. Hypoxia inducible factor-1a is increased in ischemic retina: Temporal and spatial correlation with VEGF expression
33. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization
34. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization
35. Calmodulin and calbindin localization in retina from six vertebrate species
36. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells
37. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy
38. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
39. Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor
40. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
41. Oxygen-induced retinopathy in the mouse
42. Essential role of growth hormone in ischemia-induced retinal neovascularization
43. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
44. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
45. Requisite role of Angiopoietin-1, a ligand for the Tie2 receptor, during embryonic angiogenesis
46. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
47. Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors
48. Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate
49. Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease
50. Increased vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta) in experimental autoimmune uveoretinitis: Upregulation of VEGF without neovascularization
51. Hyperoxia causes decreased expression of vascular endothelial growth factor and endothelial cell apoptosis in adult retina