Biological characterization of angiopoietin-3 and angiopoietin-4

FASEB Journal

Volumn 18, Issue 11, 2004, Pages 1200-1208

  Lee, Hyuek Jong ^a   Cho, Chung Hyun ^a   Hwang, Su Jeong ^a   Choi, Han Ho ^a   Kim, Kyung Tae ^a   Ahn, So Young ^a   Kim, Ju Hyun ^a   Oh, Jong Lark ^a   Lee, Gyun Min ^a   Koh, Gou Young ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Ang1; Ang3; Ang4; Tie2

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 2; ANGIOPOIETIN 3; ANGIOPOIETIN 4; ANGIOPOIETIN RECEPTOR; DISULFIDE; GROWTH FACTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; CORNEA LIMBUS; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG BLOOD VESSEL; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANGIOPOIETINS; ANIMALS; APOPTOSIS; BLOOD PROTEINS; CAPILLARIES; CELL MOVEMENT; CELLS, CULTURED; CORNEAL NEOVASCULARIZATION; DIMERIZATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MALE; MICE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, TIE-2; RECOMBINANT FUSION PROTEINS; RIBONUCLEASES; SPECIES SPECIFICITY; TRANSFECTION; UMBILICAL VEINS;

ANIMALIA;

EID: 3442875258     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.03-1466com     Document Type: Article

References (37)

1. Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., et al. (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor by secretion-trap expression cloning. Cell 7, 1161-1169
2. Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) Angiopioetin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277, 55-60
3. Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., and Holash, J. (2000) Vascular-specific growth factors and blood vessel formation. Nature (London) 407, 242-248
4. Jones, N., Iljin, K., Dumont, D. J., and Alitalo, K. (2001) Tie receptors: new modulators of angiogenic and lymphangiogenic responses. Nat. Rev. Mol. Cell Biol. 2, 257-267
5. Ward, N. L., and Dumont, D. J. (2002) The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development. Semin. Cell Dev. Biol. 13, 19-27
6. Koh, G. Y., Kim, I., Kwak, H. J., Yun, M. J., and Leem J. C. (2002) Biomedical significance of endothelial cell specific growth factor, angiopoietin. Exp. Mol. Med. 34, 1-11
7. Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S., Sato, T. N., and Yancopoulos, G. D. (1996) Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171-1180
8. Kim, L., Kim, J. H., Moon, S. O., Kwak, H. J., Kim, N. G., and Koh, G. Y. (2000) Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Oncogene 19, 4549-4552
9. Teichert-Kuliszewska, K., Maisonpierre, P. C., Jones, N., Campbell, A. I., Master, Z., Bendeck, M. P., Alitalo, K., Dumont, D. J., Yancopoulos, G. D., and Stewart, D. J. (2001) Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2. Cardiovasc. Res. 49, 659-670
10. Gale, N. W., Thurston, G., Hackett, S. F., Renard, R., Wang, Q., McClain, J., Martin, C., Witte, C., Witte, M. H., Jackson, D., et al. (2002) Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev. Cell 3, 411-423
11. Valenzuela, D. M., Griffiths, J. A., Rojas, J., Aldrich, T. H. Jones, P. F., Zhou, H., McClain, J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., et al. (1999) Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc. Natl. Acad. Sci. USA 96, 1904-1909
12. Brown, L. F., Dezube, B. J., Tognazzi, K, Dvorak, H. F., and Yancopoulos, G. D. (2000) Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. Am. J. Pathol. 156, 2179-2183
13. Currie, M. J., Gunningham, S. P., Han, C., Scott, P. A., Robinson, B. A., Harris, A. L., and Fox, S. B. (2001) Angiopoietin-1 is inversely related to thymidine phosphorylase expression in human breast cancer, indicating a role in vascular remodeling. Clin. Cancer Res. 7, 918-927
14. Currie, M. J., Gunningham, S. P., Turner, K., Han, C., Scott, P. A., Robinson, B. A., Chong, W., Harris, A. L., and Fox, S. B. (2002) Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia. J. Pathol. 198, 502-510
15. Lund, E. L., Hog, A., Olsen, M. W., Hansen, L. T., Engelholm, S. A., and Kristjansen, P. E. (2004) Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma. Int. J. Cancer 108, 833-838
16. Gerritsen, M. E., Tomlinson, J. E., Zlot, C., Ziman, M., and Hwang, S. (2003) Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells. Br. J. Pharmacol. 140, 595-610
17. Yamakawa, M., Liu, L. X., Date, T., Belanger, A. J., Vincent, K. A., Akita, G. Y., Kuriyama, T., Cheng, S. H., Gregory, R. J., and Jiang, C. (2003) Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ. Res. 93, 664-673
18. Abdulmalek, K., Ashur, F., Ezer, N., Ye, F., Magder, S., and Hussain, S. N. (2001) Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats. Am. J. Physiol. 281, L582-L590
19. Kim, I., Moon, S. O., Koh, K. N., Kim, H., Kwak, H. J., and Koh, G. Y. (1999) Molecular cloning, expression and characterization of angiopoietin-related protein. J. Biol. Chem. 274, 26523-26528
20. Kim, I., Kim, H. G., Kim, H., Kim, H. H., Park, S. K., Uhm, C. S., Lee, Z. H., and Koh, G. Y. (2000) Hepatic expression, synthesis and secretion of novel angiopoietin-related protein prevents endothelial cell apoptosis. Biochem. J. 346, 603-610
21. Kim, I., Kim, H. G., So, J.-N., Kim, J. H., Kwak, H. J., and Koh, G. Y. (2000) Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Circ. Res. 86, 24-29
22. 2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ. Res. 91, 70-76
23. Kim, I., Moon, S. O., Han, C. Y., Kim, P. Y, Moon, S. K., Kim, J. J., and Koh, G. Y. (2001) The angiopoietin-Tie2 System in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis. Cardiovasc. Res. 49, 872-881
24. Kim, H. S., Shin, H. S., Kwak, H. J., Cho, C. H., Lee, C. O., and Koh, G. Y. (2003) Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3′-kinase in endothelial cell. FASEB J. 17, 318-320
25. Kim, I., Ryu, Y. S., Kwak, H. J., Ahn, S. Y., Oh, J. L., Yancopoulos, G. D., Gale, N. W., and Koh, G. Y. (2002) EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells. FASEB J. 16, 1126-1128
26. Muthukkaruppan, V., and Auerbach, R. (1979) Angiogenesis in the mouse cornea. Science 205, 1416-1418
27. Jones, N., Master, Z., Jones, J., Bouchard, D., Gunji, Y., Sasaki, H., Daly, R., Alitalo, K., and Dumont, D. J. (1999) Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J. Biol. Chem. 274, 30896-30905
28. Kim, I., Kim, H. G., Moon, S. O., Chae, S. W., So, J. N., Koh, K. N., Ahn, B. C., and Koh, G. Y. (2000) Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion. Circ. Res. 86, 952-959
29. Procopio, W. N., Pelavin, P. I., Lee, W. M., and Yeilding, N. M. (1999) Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. J. Biol. Chem. 274, 30196-30201
30. Davis, S., Papadopoulos, N., Aldrich, T. H., Maisonpierre, P. C., Huang, T., Kovac, L., Xu, A., Leidich, R., Radziejewska, E., Rafique, A., et al. (2003) Angiopoietins have distinct modular domains essential for receptor binding, dimerization and super-clustering. Nat. Struct. Biol. 10, 38-44
31. Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., and Yancopoulos, G. D. (1998) Increased vascularization in mice overexpressing angiopoietin-1. Science 282, 468-471
32. Asahara, T., Chen, D., Takahashi, T., Fujikawa, K., Kearney, M., Magner, M., Yancopoulos, G. D., and Isner, J. M. (1998) Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ. Res. 83, 233-240
33. Chae, J. K., Kim, L, Lim, S. T., Chung, M. J., Kim, W. H., Kim, H. G., Ko, J. K., and Koh, G. Y. (2000) Co-administration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization. Arterioscler. Thromb. Vasc. Biol. 20, 2573-2578
34. Shyu, K. G., Manor, O., Magner, M., Yancopoulos, G. D., and Isner, J. M. (1998) Direct intramuscular injection of plasmid DNA encoding angiopoietin-1 but not angiopoietin-2 augments revascularization in the rabbit ischemic hindlimb. Circulation 98, 2081-2087
35. Kwak, H. J., Lee, S. J., Lee, Y. H., Ryu, C. H., Koh, K. N., Choi, H. Y., and Koh, G. Y. (2000) Angiopoietin-1 inhibits radiation-, and mannitol-induced apoptosis in endothelial cells. Circulation 101, 2317-2324
36. Thurston, G., Suri, C., Smith, K, McClain, J., Sato, T. N., Yancopoulos, G. D., and McDonald, D. M. (1999) Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286, 2511-2514
37. Thurston, G., Rudge, J. S., Ioffe, E., Zhou, H., Ross, L., Croll, S. D., Glazer, N., Holash J., McDonald, D. M., and Yancopoulos, G. D. (2000) Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat. Med. 6, 460-463